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Cited by 123Sleep and related disordersSleep and Wakefulness ResearchPain Mechanisms and Treatments

Polysomnographic characteristics in nonmalignant chronic pain populations: A review of controlled studies

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Bjurstrom, Martin F., Irwin, Michael R.·2016·Sleep Medicine Reviews
DOI 10.1016/j.smrv.2015.03.004PMC PMC4598249
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Abstract

Sleep and pain are critical homeostatic systems that interact in a bidirectional manner. Complaints of sleep disturbance are ubiquitous among patients with chronic pain disorders, and conversely, patients with persistent insomnia symptoms commonly report suffering from chronic pain. Sleep deprivation paradigms demonstrate that partial or complete sleep loss induce hyperalgesia, possibly due to shared mechanistic pathways including neuroanatomic and molecular substrates. Further, chronic pain conditions and sleep disturbances are intertwined through comorbidities, which together cause detrimental psychological and physical consequences. This critical review examines 29 polysomnography studies to evaluate whether nonmalignant chronic pain patients, as compared to controls, show differences in objective measures of sleep continuity and sleep architecture. Whereas these controlled studies did not reveal a consistent pattern of objective sleep disturbances, alterations of sleep continuity were commonly reported. Alterations of sleep architecture such as increases in light sleep or decreases in slow-wave sleep were less commonly reported and findings were mixed and also inconsistent. Methodological flaws were identified, which complicated interpretation and limited conclusions; hence, recommendations for future research are suggested. Knowledge of abnormalities in the sleep process has implications for understanding the pathophysiology of chronic pain conditions, which might also direct the development of novel intervention strategies.

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Crossref · 10.1016/j.smrv.2015.03.004

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  • Objective PSG and actigraphy show indicators of disrupted sleep in RA patients compared with healthy controls, including increases in α-EEG intrusion, arousals, sleep stage shifts, sleep fragmentation, and nocturnal wake time.

    “Based on objective PSG and actigraphy assessment, various indicators of disrupted sleep have been reported in RA patients compared with healthy control participants, including increases in α-EEG intrusion, arousals, sleep stage shifts, sleep fragmentation, and nocturnal wake time (54, 160, 237, 351, 472).”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [54]

  • Cellular inflammation, indicated by spontaneous or stimulated production of TNF or IL-6 by monocytes, is higher in RA patients than in matched healthy controls.

    “In a recent investigation, cellular inflammation, as indicated by spontaneous or stimulated production of TNF or IL-6 by monocytes, was higher in RA patients compared with matched healthy controls”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [54]

  • Cellular inflammation in RA shows a complex time-of-day-dependent association with sleep efficiency and SWS amount.

    “and showed a complex time-of-day-dependent association with sleep efficiency and SWS amount.”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [54]

  • Higher sleep efficiency is associated with lower stimulated monocytic TNF production in the morning but with higher production in the evening.

    “For example, higher sleep efficiency was associated with lower stimulated monocytic TNF production in the morning, but with higher production when assessed in the evening.”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [54]

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Authors
Bjurstrom, M. F., & Irwin, M. R.
Affiliations
University of California, Los Angeles (US)
ORCID
Irwin, Michael R.
Venue
Sleep Medicine Reviews
Publisher
Elsevier BV
Published
2016-04
Volume
26
Pages
74-86
ISSN
1087-0792 (ISSN-L)
DOI
10.1016/j.smrv.2015.03.004
PMC
PMC4598249
OpenAlex
W1985990153
Cited by
123
References
110
Citations by year
2026: 10 · 2025: 17 · 2024: 10 · 2023: 17 · 2022: 10 · 2021: 17 · 2020: 6 · 2019: 11 · 2018: 11 · 2017: 7 · 2016: 4 · 2015: 2
FWCI
1.03
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Sleep Medicine Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
Funders
  • UCLA Older Americans Independence Center (P30 AG028748)
  • UCLA Clinical and Translational Science Institute (UL1TR000124)
  • National Institute of Health (R01 AG034588, R01 AG026364, R01 CA160245, R01 HL095799, R01 DA032922)
  • Cousins Center for Psychoneuroimmunology
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
Keywords
chronic pain, polysomnography, sleep architecture, sleep continuity, sleep disorders, insomnia, sleep deprivation, hyperalgesia, slow-wave sleep, light sleep
MeSH terms
Humans, Sleep Initiation and Maintenance Disorders, Sleep Deprivation, Comorbidity, Randomized Controlled Trials as Topic, Polysomnography, Chronic Pain

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