The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
p53-Mediated Hematopoietic Stem and Progenitor Cell Competition
Open accessAbstract
Cell competition was originally described in Drosophila as a process for selection of the fittest cells. It is likely to play an important role in tissue homeostasis in all metazoans, but little is known about its role and regulation in mammals. By using genetic mosaic mouse models and bone marrow chimeras, we describe here a form of cell competition that selects for the least damaged cells. This competition is controlled by p53 but is distinct from the classical p53-mediated DNA damage response: it persists for months, is specific to the hematopoietic stem and progenitor cells, and depends on the relative rather than absolute level of p53 in competing cells. The competition appears to be mediated by a non-cell-autonomous induction of growth arrest and senescence-related gene expression in outcompeted cells with higher p53 activity. p53-mediated cell competition of this type could potentially contribute to the clonal expansion of incipient cancer cells.
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“Tp53 is also involved in cell competition regulation in both hematopoietic and non-hemopoietic tissues (Bondar & Medzhitov, 2010, Zhang, Xie et al., 2017).”
From Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals (2023) · cites this paper as Bondar & Medzhitov, 2010
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In the citing paper
“we further showed that the chronic elimination of pu.1 -deficent microglia in zebrafish is mediated by Tp53-dependent cell competition”
From Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals (2023) · cites this paper as Bondar & Medzhitov, 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Tp53 is also involved in cell competition regulation in both hematopoietic and non-hemopoietic tissues (Bondar and Medzhitov, 2010; Zhang et al., 2017).”
From Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals (2025) · cites this paper as Bondar and Medzhitov, 2010
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“which has been shown to depend on the relative level of Tp53 in competing cells (Bondar & Medzhitov, 2010, Zhang et al., 2017).”
From Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals (2023) · cites this paper as Bondar & Medzhitov, 2010
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In the citing paper
“which has been shown to depend on the relative level of Tp53 in competing cells (Bondar and Medzhitov, 2010; Zhang et al., 2017).”
From Pu.1/Spi1 dosage controls the turnover and maintenance of microglia in zebrafish and mammals (2025) · cites this paper as Bondar and Medzhitov, 2010
In the citing paper
“and p53 upregulation in the haematopoietic system engenders myeloablation82,83”
From MDM2, MDMX and p53 in oncogenesis and cancer therapy (2013) · cites this paper as [82]
In the citing paper
“HSCs from mice with mutations in both Tp53 42 and Ppm1d, a gene encoding a regulator of p53 and other members of the DNA damage response pathway, 43,44 are able to enter cell cycle despite the presence of DNA damage, leading to a stem cell advantage in the setting of cytotoxic drugs.”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [42]
In the citing paper
“The desired cohort size was determined based on observations from previously reported experiments20”
From Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia (2015) · cites this paper as [20]
In the citing paper
“Importantly, a prior study similarly showed that Tp53+/− HSCs also have a competitive advantage following irradiation, which appeared to be due, at least in part, to reduced irradiation-induced senescence in Tp53+/− HSCs 20,21.”
From Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia (2015) · cites this paper as [20]
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Citations
Cites
Blinded by the Light: The Growing Complexity of p53
Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Social controls on cell survival and cell death
RAFF, M. C. (1992) · Nature · doi:10.1038/356397a0 · Cited by 2,591
The first 30 years of p53: growing ever more complex.
Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967
Clonal selection and learning in the antibody system
Rajewsky, K. (1996) · Nature · doi:10.1038/381751a0 · Cited by 1,701
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis
Armitage, P., & Doll, R. (1954) · British Journal of Cancer · doi:10.1038/bjc.1954.1 · Cited by 1,549
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
de Oca Luna, R. M., Wagner, D. S., & Lozano, G. (1995) · Nature · doi:10.1038/378203a0 · Cited by 1,420
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
Olive, K. P., Tuveson, D. A., Ruhe, Z. C., Yin, B., Willis, N. A., Bronson, R. T., Crowley, D., & Jacks, T. (2004) · Cell · doi:10.1016/j.cell.2004.11.004 · Cited by 1,308
The age distribution of cancer and a multi-stage theory of carcinogenesis
Armitage, P., & Doll, R. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602297 · Cited by 1,292
Cell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · cited 1×
“In addition, P-selectin and Sdpr, which are upregulated in aged HSCs (Chambers et al., 2007; Rossi et al., 2005), were also upregulated in loser and downregulated in winner HSPC cells (Figure 6B).”
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
Lang, G. A., Iwakuma, T., Suh, Y.-A., Liu, G., Rao, V. A., Parant, J. M., Valentin-Vega, Y. A., Terzian, T., Caldwell, L. C., Strong, L. C., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.006 · Cited by 1,069
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
Chang, H. H., Hemberg, M., Barahona, M., Ingber, D. E., & Huang, S. (2008) · Nature · doi:10.1038/nature06965 · Cited by 1,067
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M., & Sorger, P. K. (2009) · Nature · doi:10.1038/nature08012 · Cited by 1,023
Minutes: Mutants of Drosophila autonomously affecting cell division rate
Morata, G., & Ripoll, P. L. (1975) · Developmental Biology · doi:10.1016/0012-1606(75)90330-9 · Cited by 983
Bracken, A. P., Kleine-Kohlbrecher, D., Dietrich, N., Pasini, D., Gargiulo, G., Beekman, C., Theilgaard-Mönch, K., Minucci, S., Porse, B. T., Marine, J.-C., et al. (2007) · Genes & Development · doi:10.1101/gad.415507 · Cited by 850
Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
Chambers, S. M., Shaw, C. A., Gatza, C. E., Fisk, C. J., Donehower, L. A., & Goodell, M. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050201 · Cited by 799
How stem cells age and why this makes us grow old
Sharpless, N. E., & DePinho, R. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2241 · Cited by 743
The P53 pathway: what questions remain to be explored?
Levine, A. J., Hu, W., & Feng, Z. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401910 · Cited by 661
Kortlever, R. M., Higgins, P. J., & Bernards, R. (2006) · Nature Cell Biology · doi:10.1038/ncb1448 · Cited by 637 · cited 1×
“For example, regulation of expression of PAI-1 by p53 is essential for p53-mediated senescence (Kortlever et al., 2006).”
Drosophila Myc Regulates Organ Size by Inducing Cell Competition
de la Cova, C., Abril, M., Bellosta, P., Gallant, P., & Johnston, L. A. (2004) · Cell · doi:10.1016/s0092-8674(04)00214-4 · Cited by 610
Increased cell-to-cell variation in gene expression in ageing mouse heart
Bahar, R., Hartmann, C. H., Rodriguez, K. A., Denny, A. D., Busuttil, R. A., Dollé, M. E. T., Calder, R. B., Chisholm, G. B., Pollock, B. H., Klein, C. A., et al. (2006) · Nature · doi:10.1038/nature04844 · Cited by 603
dMyc Transforms Cells into Super-Competitors
Moreno, E., & Basler, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00262-4 · Cited by 597
Species- and cell type-specific requirements for cellular transformation
Rangarajan, A., Hong, S. J., Gifford, A., & Weinberg, R. A. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.07.009 · Cited by 576
The expanding universe of p53 targets
Menendez, D., Inga, A., & Resnick, M. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2730 · Cited by 568
DNA repair is limiting for haematopoietic stem cells during ageing
Nijnik, A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N. P., Crockford, T. L., Cabuy, E., Vindigni, A., et al. (2007) · Nature · doi:10.1038/nature05875 · Cited by 518
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
Christophorou, M. A., Ringshausen, I., Finch, A. J., Swigart, L. B., & Evan, G. I. (2006) · Nature · doi:10.1038/nature05077 · Cited by 382
The polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion
Kamminga, L. M., Bystrykh, L. V., de Boer, A., Houwer, S., Douma, J., Weersing, E., Dontje, B., & de Haan, G. (2006) · Blood · doi:10.1182/blood-2005-09-3585 · Cited by 376
Regulation of cellular senescence by p53
Itahana, K., Dimri, G., & Campisi, J. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02228.x · Cited by 365
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4
Marine, J.-C., Francoz, S., Maetens, M., Wahl, G., Toledo, F., & Lozano, G. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401912 · Cited by 352
Total body irradiation selectively induces murine hematopoietic stem cell senescence.
Wang, Y., Schulte, B. A., LaRue, A. C., Ogawa, M., & Zhou, D. (2006) · Blood · doi:10.1182/blood-2005-04-1418 · Cited by 351
Willis, A. C., Jung, E. J., Wakefield, T., & Chen, X. (2004) · Oncogene · doi:10.1038/sj.onc.1207396 · Cited by 342
Sasaki, Y., Derudder, E., Hobeika, E., Pelanda, R., Reth, M. G., Rajewsky, K., & Schmidt‐Supprian, M. (2006) · Immunity · doi:10.1016/j.immuni.2006.04.005 · Cited by 322
Domen, J., Gandy, K. L., & Weissman, I. L. (1998) · Blood · doi:10.1182/blood.v91.7.2272 · Cited by 293
Randall, T. D., & Weissman, I. L. (1997) · Blood · doi:10.1182/blood.v89.10.3596 · Cited by 290
Ribosomal protein L24 defect in Belly spot and tail (Bst), a mouse Minute
Oliver, E. R., Saunders, T. L., Tarlé, S. A., & Glaser, T. (2004) · Development · doi:10.1242/dev.01268 · Cited by 288
Badea, T. C., Wang, Y., & Nathans, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-06-02314.2003 · Cited by 256
Differential mitotic rates and patterns of growth in compartments in the Drosophila wing
Simpson, P., & Morata, G. (1981) · Developmental Biology · doi:10.1016/0012-1606(81)90261-x · Cited by 228
Maintaining a behaviour polymorphism by frequency-dependent selection on a single gene
Fitzpatrick, M. J., Feder, E., Rowe, L., & Sokolowski, M. B. (2007) · Nature · doi:10.1038/nature05764 · Cited by 225
Oertel, M., Menthena, A., Dabeva, M. D., & Shafritz, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.049 · Cited by 210
Tumor suppression and normal aging in mice with constitutively high p53 activity
Mendrysa, S. M., O'Leary, K. A., McElwee, M. K., Michalowski, J., Eisenman, R. N., Powell, D. A., & Perry, M. E. (2006) · Genes & Development · doi:10.1101/gad.1378506 · Cited by 210
Transcription regulation by mutant p53
Weisz, L., Oren, M., & Rotter, V. (2007) · Oncogene · doi:10.1038/sj.onc.1210294 · Cited by 207
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function
de Vries, A., Flores, E. R., Miranda, B., Hsieh, H.-M., van Oostrom, C. T. M., Sage, J., & Jacks, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052713099 · Cited by 207
Is cell competition relevant to cancer?
Moreno, E. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2252 · Cited by 204
Stem Cells Are Units of Natural Selection in a Colonial Ascidian
Laird, D. J., Tomaso, A. W. D., & Weissman, I. L. (2005) · Cell · doi:10.1016/j.cell.2005.10.026 · Cited by 198
Competitive Interactions Between Cells: Death, Growth, and Geography
Johnston, L. A. (2009) · Science · doi:10.1126/science.1163862 · Cited by 194
Zhao, H., & Reed, R. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00262-8 · Cited by 194
Activated p53 suppresses the histone methyltransferase EZH2 gene
Tang, X., Milyavsky, M., Shats, I., Erez, N., Goldfinger, N., & Rotter, V. (2004) · Oncogene · doi:10.1038/sj.onc.1207706 · Cited by 193
Genes Affecting Cell Competition in Drosophila
Tyler, D. M., Li, W., Zhuo, N., Pellock, B. J., & Baker, N. E. (2006) · Genetics · doi:10.1534/genetics.106.061929 · Cited by 192
Rossi, D. J., Seita, J., Czechowicz, A. D., Bhattacharya, D., Bryder, D., & Weissman, I. L. (2007) · Cell Cycle · doi:10.4161/cc.6.19.4759 · Cited by 187
Jin, Z., Kirilly, D., Weng, C., Kawase, E., Song, X., Smith, S. E., Schwartz, J. W., & Xie, T. (2008) · Cell stem cell · doi:10.1016/j.stem.2007.10.021 · Cited by 185
Bypass of lethality with mosaic mice generated by Cre– loxP -mediated recombination
Betz, U. A. K., Vosshenrich, C. A. J., Rajewsky, K., & Müller, W. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70717-3 · Cited by 184
Temporal dissection of p53 function in vitro and in vivo
Christophorou, M. A., Martı́n-Zanca, D., Soucek, L., Lawlor, E. R., Swigart, L. B., Verschuren, E. W., & Evan, G. I. (2005) · Nature Genetics · doi:10.1038/ng1572 · Cited by 184
Sprent, J., Schaefer, M. L., Hurd, M., Surh, C. D., & Ron, Y. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.3.717 · Cited by 175
Stem-cell ecology and stem cells in motion
Papayannopoulou, T., & Scadden, D. T. (2008) · Blood · doi:10.1182/blood-2007-08-078147 · Cited by 173
JAK-STAT Signal Inhibition Regulates Competition in the Drosophila Testis Stem Cell Niche
Issigonis, M., Tulina, N. M., de Cuevas, M., Brawley, C. M., Sandler, L., & Matunis, E. L. (2009) · Science · doi:10.1126/science.1176817 · Cited by 172
Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae
Santorelli, L. A., Thompson, C. R. L., Villegas, E., Svetz, J., Dinh, C. Q., Parikh, A., Sucgang, R., Kuspa, A., Strassmann, J. E., Queller, D. C., et al. (2008) · Nature · doi:10.1038/nature06558 · Cited by 162
Irradiation selects for p53-deficient hematopoietic progenitors.
Marusyk, A., Porter, C. C., Zaberezhnyy, V., & DeGregori, J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000324 · Cited by 151
Sheng, X., Brawley, C. M., & Matunis, E. L. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.024 · Cited by 149
Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice
TeKippe, M., Harrison, D. E., & Chen, J. (2003) · Experimental Hematology · doi:10.1016/s0301-472x(03)00072-9 · Cited by 135
Hematopoietic Stem Cell Heterogeneity: Subtypes, Not Unpredictable Behavior
Schroeder, T. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.02.006 · Cited by 109
Persistent competition among stem cells and their daughters in the Drosophila ovary germline niche
Rhiner, C., Díaz, B., Portela, M., Poyatos, J. F., Fernández-Ruíz, I., López-Gay, J. M., Gerlitz, O., & Moreno, E. (2009) · Development · doi:10.1242/dev.033340 · Cited by 90
Radiation Sensitivity of the Hemopoietic Stem Cell
van Bekkum, D. W. (1991) · Radiation Research · doi:10.2307/3577994 · Cited by 90
Repopulating defect of mismatch repair–deficient hematopoietic stem cells
Reese, J., Liu, L., & Gerson, S. L. (2003) · Blood · doi:10.1182/blood-2002-10-3035 · Cited by 89
Versatile functions of p53 protein in multicellular organisms
Chumakov, P. M. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907130019 · Cited by 85
Cell Competition and Its Possible Relation to Cancer
Baker, N. E., & Li, W. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6348 · Cited by 85
The effects of x-irradiation on hematopoietic stem cell compartments in the mouse.
Meijne, E. I. M., Groenewegen, R. J. V. D. W.-V., Ploemacher, R., Vos, O., David, J. A., & Huiskamp, R. (1991) · PubMed · Cited by 80
Marusyk, A., & DeGregori, J. V. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2007.09.001 · Cited by 73
Down, J. D., Boudewijn, A., van Os, R. P., Thames, H. D., & Ploemacher, R. (1995) · Blood · doi:10.1182/blood.v86.1.122.bloodjournal861122 · Cited by 72
Anderson, R. E., Olson, G. B., Autry, J. R., Howarth, J. L., Troup, G. M., & Bartels, P. H. (1977) · PubMed · Cited by 67
Ploemacher, R., van Os, R. P., Beurden, C. A. J. V. D. L.-V., & Down, J. D. (1992) · International Journal of Radiation Biology · doi:10.1080/09553009214551251 · Cited by 67
The radiosensitivity of T and B lymphocytes in mice.
Kataoka, Y., & Sado, T. (1975) · PubMed · Cited by 64
Hodgson, G., & Tr, B. (1984) · PubMed · Cited by 58
Role of p53 in Hematopoietic Recovery After Cytotoxic Treatment
Wlodarski, P. K., Wasik, M. A., Ratajczak, M. Z., Sevignani, C., Hoser, G., Kawiak, J., Gewirtz, A. M., Calabretta, B., & Skórski, T. (1998) · Blood · doi:10.1182/blood.v91.8.2998.2998_2998_3006 · Cited by 53
Radiosensitivity of T and B Lymphocytes
Anderson, R. E., Olson, G. B., Autry, J. R., Howarth, J. L., Troup, G. M., & Bartels, P. H. (1977) · The Journal of Immunology · doi:10.4049/jimmunol.118.4.1191 · Cited by 52
Involvement of stromal p53 in tumor-stroma interactions
Bar, J., Moskovits, N. B.-C., & Oren, M. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.11.006 · Cited by 49
Adachi‐Yamada, T. (2004) · The Journal of Biochemistry · doi:10.1093/jb/mvh099 · Cited by 49
Fujikawa, K., Hasegawa, Y., Matsuzawa, S., Fukunaga, A., Itoh, T., & Kondo, S. (2000) · Journal of Radiation Research · doi:10.1269/jrr.41.113 · Cited by 39
First among equals: competition between genetically identical cells
Khare, A., & Shaulsky, G. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1875 · Cited by 31
Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells
Stirewalt, D. L., Choi, Y. E., Sharpless, N. E., Pogosova‐Agadjanyan, E. L., Cronk, M. R., Yukawa, M., Larson, E. B., Wood, B. L., Appelbaum, F. R., Radich, J. P., et al. (2008) · Leukemia · doi:10.1038/leu.2008.176 · Cited by 28
Cell Competition: The Embrace of Death
Morata, G., & Martín, F. A. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.06.002 · Cited by 26
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Metadata
- Authors
- Bondar, T., & Medzhitov, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Medzhitov, Ruslan
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 6
- Issue
- 4
- Pages
- 309-322
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC2872065
- OpenAlex
- W2163067447
- Cited by
- 342
- References
- 83
- Citations by year
- 2026: 15 · 2025: 17 · 2024: 14 · 2023: 23 · 2022: 22 · 2021: 25 · 2020: 29 · 2019: 22 · 2018: 18 · 2017: 21 · 2016: 24 · 2015: 25 · 2014: 23 · 2013: 20 · 2012: 12
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
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- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1203 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
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- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases (R01AI055502, R01AI046688)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071754, P30DK072442)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- cell competition, p53, hematopoietic stem cells, hematopoietic progenitor cells, clonal selection, DNA damage response, cellular senescence, growth arrest, bone marrow chimeras, genetic mosaicism, tissue homeostasis
- MeSH terms
- Animals, Cell Communication, Clone Cells, DNA Damage, Genes, Dominant, Hematopoietic Stem Cells, Models, Biological, Mutation, Phenotype, Radiation, Ionizing, Stress, Physiological, Tumor Suppressor Protein p53, Cellular Senescence, Apoptosis, Gene Expression Regulation, Developmental, Gene Expression Profiling, Cell Proliferation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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