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CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination
Open accessAbstract
After central nervous system (CNS) demyelination-such as occurs during multiple sclerosis-there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, the great majority of reactive astrocytes in the vicinity of the lesions are derived from preexisting FGFR3-expressing cells, likely to be astrocytes. These data resolve a long-running debate about the origins of the main players in CNS remyelination and reveal a surprising capacity of CNS precursors to generate Schwann cells, which normally develop from the embryonic neural crest and are restricted to the peripheral nervous system.
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“A short time later (P120+7), 19.9% ± 3.2% of all optic nerve OPs (defined by NG2 immunolabeling) were YFP labeled (mean ±SD, n = 3 mice), less than in the adult corpus callosum (∼45%; Rivers et al., 2008) or spinal cord (∼39%; Zawadzka et al., 2010; Tripathi et al., 2010).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Zawadzka et al., 2010
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“The Cre/lox system been used in reporter mice to track oligodendrogenesis and myelin synthesis during development [45, 81], after CNS demyelination [82, 83], and after SCI [44, 84, 85].”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [82]
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Cites
RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Nature · doi:10.1038/303390a0 · Cited by 2,030
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Self-citationKessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., & Richardson, W. D. (2006) · Nature Neuroscience · doi:10.1038/nn1620 · Cited by 1,195
Self-citationPDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Self-citationOligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells
Kondo, T., & RAFF, M. C. (2000) · Science · doi:10.1126/science.289.5485.1754 · Cited by 880
Remyelination is extensive in a subset of multiple sclerosis patients
Patrikios, P., Stadelmann, C., Kutzelnigg, A., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., Bruck, W., Lucchinetti, C., & Lassmann, H. (2006) · Brain · doi:10.1093/brain/awl217 · Cited by 807
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
Buffo, A., Rite, I., Tripathi, P., Lepier, A., Colak, D., Horn, A.-P., Mori, T., & Götz, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709002105 · Cited by 789
Levison, S. W., & Goldman, J. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90311-e · Cited by 725
NG2 cells generate both oligodendrocytes and gray matter astrocytes
Zhu, X., Bergles, D. E., & Nishiyama, A. (2007) · Development · doi:10.1242/dev.004895 · Cited by 699
Axon-Glial Signaling and the Glial Support of Axon Function
Nave, K., & Trapp, B. D. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094309 · Cited by 664
Nunes, M. C., Roy, N. S., Keyoung, H. M., Goodman, R. R., McKhann, G. M., Jiang, L., Kang, J., Nedergaard, M., & Goldman, S. A. (2003) · Nature Medicine · doi:10.1038/nm837 · Cited by 659
Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625
Self-citationDimou, L., Simon, C., Kirchhoff, F., Takebayashi, H., & Götz, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2831-08.2008 · Cited by 551
Endogenous progenitors remyelinate demyelinated axons in the adult CNS
Gensert, J. M., & Goldman, J. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80359-1 · Cited by 544
Belachew, S. M., Chittajallu, R., Aguirre, A. A., Yuan, X. Q., Kirby, M., Anderson, S. M., & Gallo, V. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210110 · Cited by 498
Nagelhus, E. A., Veruki, M. L., Torp, R., Haug, F. Š., Laake, J. H., Nielsen, S. M., Agre, P. C., & Ottersen, O. P. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02506.1998 · Cited by 459
Pringle, N. P., Mudhar, H. S., Collarini, E. J., & Richardson, W. D. (1992) · Development · doi:10.1242/dev.115.2.535 · Cited by 443
Self-citationbHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS
Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D. (2004) · Science · doi:10.1126/science.1103709 · Cited by 416
Self-citationCentral remyelination restores secure conduction
Smith, K. J., Blakemore, W. F., & MCDONALD, W. I. (1979) · Nature · doi:10.1038/280395a0 · Cited by 332
Fancy, S. P. J., Zhao, C., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.06.015 · Cited by 302
Self-citationRemyelination in Experimental Models of Toxin-Induced Demyelination
Blakemore, W. F., & Franklin, R. J. M. (2008) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-540-73677-6_8 · Cited by 275
Self-citationLeone, D. P., Genoud, S., Atanasoski, S., Grausenburger, R., Berger, P., METZGER, D., Macklin, W. B., Chambon, P., & Suter, U. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00029-0 · Cited by 275
Self-citationThe proliferation of astrocytes around a needle wound in the rat brain.
Jb, C. (1970) · PubMed · Cited by 273
Keirstead, H. S., & Blakemore, W. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199711000-00003 · Cited by 272
Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion
Watanabe, M., Toyama, Y., & Nishiyama, A. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10338 · Cited by 261
Nishiyama, A., Lin, X., Giese, N. A., Heldin, C., & Stallcup, W. B. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960201)43:3 · Cited by 244
Development of NG2 neural progenitor cells requires Olig gene function
Ligon, K., Kesari, S., Kitada, M., Sun, T., Arnett, H., Alberta, J., Anderson, D. J., Stiles, C., & Rowitch, D. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0511001103 · Cited by 225
Self-citationZhang, S., Ge, B., & Duncan, I. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4089 · Cited by 217
Diffusion barriers evoked in the rat cortex by reactive astrogliosis
Roitbak, T., & Sykov�, E. (1999) · Glia · doi:10.1002/(sici)1098-1136(199910)28:1 · Cited by 211
Ousman, S. S., & David, S. (2000) · Glia · doi:10.1002/(sici)1098-1136(200003)30:1 · Cited by 209
Talbott, J. F., Loy, D. N., Liu, Y., Qiu, M. S., Bunge, M. B., Rao, M. S., & Whittemore, S. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.038 · Cited by 195
Masahira, N., Takebayashi, H., Ono, K., Watanabe, K., Ding, L., Furusho, M., Ogawa, Y., Nabeshima, Y., Álvarez-Buylla, A., Shimizu, K., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.02.029 · Cited by 182
Keirstead, H. S., Ben‐Hur, T., Rogister, B., O'Leary, M. T., Dubois-Dalcq, M. E., & Blakemore, W. F. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07529.1999 · Cited by 175
A Common Neural Progenitor for the CNS and PNS
Mujtaba, T., Mayer‐Pröschel, M., & Rao, M. S. R. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8913 · Cited by 174
Periaxin, a novel protein of myelinating schwann cells with a possible role in axonal ensheathment
Gillespie, C. S., Sherman, D. L., Blair, G. E., & Brophy, P. (1994) · Neuron · doi:10.1016/0896-6273(94)90208-9 · Cited by 166
Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide
Felts, P. A., Woolston, A.-M., Fernando, H. B., Asquith, S., Gregson, N. A., Mizzi, O., & Smith, K. J. (2005) · Brain · doi:10.1093/brain/awh516 · Cited by 162
Requirements for schwann cell migration within cns environments: A viewpoint
Franklin, R. J. M., & Blakemore, W. F. (1993) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(93)90052-f · Cited by 154
Self-citationBlakemore, W. F. (1975) · Journal of Neurocytology · doi:10.1007/bf01181634 · Cited by 145
Schwann cell remyelination of demyelinated axons in spinal cord multiple sclerosis lesions
Itoyama, Y., Webster, H. D., Richardson, E., & Trapp, B. (1983) · Annals of Neurology · doi:10.1002/ana.410140313 · Cited by 143
Lee, M.-J., Brennan, A., Blanchard, A. D., Zoidl, G., Dong, Z., Tabernero, A., Zoidl, C., Dent, M. A. R., Jessen, K. R., & Mirsky, R. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1996.0589 · Cited by 132
Chen, Y., Miles, D. K., Hoang, T., Shi, J., Hurlock, E. C., Kernie, S. G., & Lu, Q. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3545-08.2008 · Cited by 122
Neurogenesis in the adult spinal cord in an experimental model of multiple sclerosis
Danilov, A. I., Covacu, R., Moe, M. C., Langmoen, I. A., Johansson, C. B., Olsson, T. P., & Brundin, L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04563.x · Cited by 112
Schwann cell invasion of the central nervous system of the myelin mutants
Duncan, I. D., & Hoffman, R. L. (1997) · Journal of Anatomy · doi:10.1046/j.1469-7580.1997.19010035.x · Cited by 101
An Fgfr3‐iCreERT2 transgenic mouse line for studies of neural stem cells and astrocytes
Young, K. M., Mitsumori, T., Pringle, N. P., Grist, M., Kessaris, N., & Richardson, W. D. (2010) · Glia · doi:10.1002/glia.20976 · Cited by 98
Self-citationSnyder, D. H., Valsamis, M. P., Stone, S. H., & Raine, C. S. (1975) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197505000-00001 · Cited by 97
Magnus, T., Coksaygan, T., Korn, T., Xue, H., Arumugam, T., Mughal, M. R., Eckley, D., Tang, S.-C., Detolla, L., Rao, M. S., et al. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21368 · Cited by 87
Astrocytes as stem cells: Nomenclature, phenotype, and translation
Steindler, D. A., & Laywell, E. D. (2003) · Glia · doi:10.1002/glia.10242 · Cited by 82
Itoyama, Y., Ohnishi, A., Tateishi, J., Kuroiwa, Y., & de Webster, H. F. (1985) · Acta Neuropathologica · doi:10.1007/bf00687001 · Cited by 81
Talbott, J. F., Cao, Q., Enzmann, G. U., Benton, R. L., Achim, V., Cheng, X. X., Mills, M. D., Rao, M. S., & Whittemore, S. R. (2006) · Glia · doi:10.1002/glia.20369 · Cited by 79
Cassiani‐Ingoni, R., Coksaygan, T., XUE, H., Reichert-Scrivner, S. A., Wiendl, H., RAO, M., & Magnus, T. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.04.030 · Cited by 67
Dusart, I., Marty, S., & Peschanski, M. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90478-k · Cited by 67
A role for Noggin in the development of oligodendrocyte precursor cells
Kondo, T., & Raff, M. C. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2003.11.013 · Cited by 64
Chandran, S., Compston, A., Jauniaux, E. R. M., Gilson, J. M., Blakemore, W. F., & Svendsen, C. N. (2004) · Glia · doi:10.1002/glia.20011 · Cited by 59
Sim, F. J. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1145 · Cited by 48
Crang, A. J., Gilson, J. M., Li, W., & Blakemore, W. F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03606.x · Cited by 45
Raivich, G., & Kreutzberg, G. W. (1987) · Journal of Neurocytology · doi:10.1007/bf01637661 · Cited by 21
Weruaga, E., Eggli, P. S., & Celio, M. R. (1996) · Glia · doi:10.1002/(sici)1098-1136(199602)16:2 · Cited by 14
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“Consistent with that, we found that adult-born OLs elaborated much shorter but many more internodes than OLs generated during early postnatal life.”
BackgroundResultInfluentialSelf-citationKang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 815
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Metadata
- Authors
- Zawadzka, M., Rivers, L. E., Fancy, S. P. J., Zhao, C., Tripathi, R., Jamen, F., Young, K., Goncharevich, A., Pohl, H., Rizzi, M., Rowitch, D. H., Kessaris, N., Suter, U., Richardson, W. D., & Franklin, R. J. M.
- Affiliations
- University College London (GB)
- Howard Hughes Medical Institute (US)
- University of Cambridge (GB)
- ETH Zurich (CH)
- Corresponding author
- Richardson, William D.
- Franklin, Robin J.M.
- ORCID
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 6
- Issue
- 6
- Pages
- 578-590
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC3856868
- OpenAlex
- W2152131288
- Cited by
- 650
- References
- 61
- Citations by year
- 2026: 25 · 2025: 25 · 2024: 35 · 2023: 40 · 2022: 38 · 2021: 39 · 2020: 56 · 2019: 53 · 2018: 49 · 2017: 56 · 2016: 34 · 2015: 35 · 2014: 49 · 2013: 46 · 2012: 33
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1178 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Wellcome Trust (080513)
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- central nervous system demyelination, remyelination, oligodendrocyte precursor cells, Schwann cells, glial progenitor cells, reactive astrocytes, multiple sclerosis, cell of origin, fate mapping
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Astrocytes, Cells, Cultured, Central Nervous System, Demyelinating Diseases, Disease Models, Animal, Female, Lysophosphatidylcholines, Mice, Transgenic, Microscopy, Multiple Sclerosis, Nerve Regeneration, Nerve Tissue Proteins, Oligodendroglia, Schwann Cells, Integrases, Receptor, Platelet-Derived Growth Factor alpha, Mice, Receptor, Fibroblast Growth Factor, Type 3, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Adult Stem Cells
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