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CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination
Open accessAbstract
After central nervous system (CNS) demyelination-such as occurs during multiple sclerosis-there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann cells. The origins of the remyelinating cells have not previously been established. We have used Cre-lox fate mapping in transgenic mice to show that PDGFRA/NG2-expressing glia, a distributed population of stem/progenitor cells in the adult CNS, produce the remyelinating oligodendrocytes and almost all of the Schwann cells in chemically induced demyelinated lesions. In contrast, the great majority of reactive astrocytes in the vicinity of the lesions are derived from preexisting FGFR3-expressing cells, likely to be astrocytes. These data resolve a long-running debate about the origins of the main players in CNS remyelination and reveal a surprising capacity of CNS precursors to generate Schwann cells, which normally develop from the embryonic neural crest and are restricted to the peripheral nervous system.
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“A short time later (P120+7), 19.9% ± 3.2% of all optic nerve OPs (defined by NG2 immunolabeling) were YFP labeled (mean ±SD, n = 3 mice), less than in the adult corpus callosum (∼45%; Rivers et al., 2008) or spinal cord (∼39%; Zawadzka et al., 2010; Tripathi et al., 2010).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Zawadzka et al., 2010
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“The Cre/lox system been used in reporter mice to track oligodendrogenesis and myelin synthesis during development [45, 81], after CNS demyelination [82, 83], and after SCI [44, 84, 85].”
From Delayed short-term tamoxifen treatment does not promote remyelination or neuron sparing after spinal cord injury (2020) · cites this paper as [82]
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Cites
RAFF, M. C., Miller, R. H., & Noble, M. (1983) · Nature · doi:10.1038/303390a0 · Cited by 2,030
Multiple Sclerosis: An Immune or Neurodegenerative Disorder?
Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Self-citationKessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., & Richardson, W. D. (2006) · Nature Neuroscience · doi:10.1038/nn1620 · Cited by 1,195
Self-citationPDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D. (2008) · Nature Neuroscience · doi:10.1038/nn.2220 · Cited by 961
Self-citationOligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells
Kondo, T., & RAFF, M. C. (2000) · Science · doi:10.1126/science.289.5485.1754 · Cited by 880
Remyelination is extensive in a subset of multiple sclerosis patients
Patrikios, P., Stadelmann, C., Kutzelnigg, A., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., Bruck, W., Lucchinetti, C., & Lassmann, H. (2006) · Brain · doi:10.1093/brain/awl217 · Cited by 807
Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
Buffo, A., Rite, I., Tripathi, P., Lepier, A., Colak, D., Horn, A.-P., Mori, T., & Götz, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709002105 · Cited by 789
Levison, S. W., & Goldman, J. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90311-e · Cited by 725
NG2 cells generate both oligodendrocytes and gray matter astrocytes
Zhu, X., Bergles, D. E., & Nishiyama, A. (2007) · Development · doi:10.1242/dev.004895 · Cited by 699
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The Biology of Regeneration Failure and Success After Spinal Cord Injury
Tran, A. P., Warren, P. M., & Silver, J. (2018) · Physiological Reviews · doi:10.1152/physrev.00017.2017 · Cited by 896
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 919
“Consistent with that, we found that adult-born OLs elaborated much shorter but many more internodes than OLs generated during early postnatal life.”
BackgroundResultInfluentialSelf-citationKang, S. H., Fukaya, M., Yang, J. K., Rothstein, J. D., & Bergles, D. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.009 · Cited by 815
Lee, Y., Petkova, A. P., Mottillo, E. P., & Granneman, J. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.009 · Cited by 710
Regenerating CNS myelin — from mechanisms to experimental medicines
Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647
Self-citationMicropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis
Mei, F., Fancy, S. P. J., Shen, Y. A., Niu, J., Zhao, C., Presley, B., Miao, E., Lee, S., Mayoral, S. R., Redmond, S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3618 · Cited by 595
Self-citationOligodendrocyte Development and PlasticityPreprint
Bergles, D. E., & Richardson, W. D. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020453 · Cited by 604
Self-citationDisease-specific oligodendrocyte lineage cells arise in multiple sclerosis
Falcão, A. M., van Bruggen, D., Marques, S., Meijer, M., Jäkel, S., Agirre, E., Samudyata, Floriddia, E. M., Vanichkina, D. P., ffrench-Constant, C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0236-y · Cited by 579
The stem cell potential of glia: lessons from reactive gliosis
Robel, S., Berninger, B., & Götz, M. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn2978 · Cited by 536
Metformin restores CNS remyelination capacity by rejuvenating aged stem cells
Neumann, B., Baror, R., Zhao, C., Segel, M., Dietmann, S., Rawji, K. S., Foerster, S., McClain, C. R., Chalut, K., van Wijngaarden, P., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.08.015 · Cited by 449
Self-citationOligodendrocyte, Astrocyte, and Microglia Crosstalk in Myelin Development, Damage, and Repair
Domingues, H. S., Portugal, C. C., Socodato, R., & Relvas, J. B. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00071 · Cited by 460
The diversity and disparity of the glial scar
Adams, K. L., & Gallo, V. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0033-9 · Cited by 448
Dynamics of oligodendrocyte generation in multiple sclerosis
Yeung, M. S. Y., Djelloul, M., Steiner, E., Bernard, S., Salehpour, M., Possnert, G., Brundin, L., & Frisén, J. (2019) · Nature · doi:10.1038/s41586-018-0842-3 · Cited by 376
Oligodendrocyte Progenitor Cells Become Regionally Diverse and Heterogeneous with Age
Spitzer, S. O., Sitnikov, S., Kamen, Y., Evans, K. A., Kronenberg-Versteeg, D., Dietmann, S., de Faria, O., Agathou, S., & Káradóttir, R. T. (2019) · Neuron · doi:10.1016/j.neuron.2018.12.020 · Cited by 364
Remyelination in multiple sclerosis: From basic science to clinical translation
Lubetzki, C., Zalc, B., Williams, A., Stadelmann, C., & Stankoff, B. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30140-x · Cited by 350
Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo
Czopka, T., ffrench‐Constant, C., & Lyons, D. A. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.05.013 · Cited by 354
Myelin Regeneration: A Recapitulation of Development?
Fancy, S. P. J., Chan, J. R., Baranzini, S. E., Franklin, R. J. M., & Rowitch, D. H. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113629 · Cited by 339
Self-citationMotor learning promotes remyelination via new and surviving oligodendrocytes
Bacmeister, C. M., Barr, H. J., McClain, C. R., Thornton, M. A., Nettles, D., Welle, C. G., & Hughes, E. G. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0637-3 · Cited by 322
Simon, C., Götz, M., & Dimou, L. (2011) · Glia · doi:10.1002/glia.21156 · Cited by 313
Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors
Gautier, H. O. B., Evans, K. A., Volbracht, K., James, R., Sitnikov, S., Lundgaard, I., James, F., Lao‐Peregrín, C., Reynolds, R., Franklin, R. J. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9518 · Cited by 316
Self-citationNG2-glia as multipotent neural stem cells: fact or fantasy?
Richardson, W. D., Young, K. M., Tripathi, R. B., & McKenzie, I. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.013 · Cited by 300
Self-citationMoyon, S., Dubessy, A., Aigrot, M. S., Trotter, M. W. B., Huang, J. K., Dauphinot, L., Potier, M., Kerninon, C., Parsadaniantz, S. M., Franklin, R. J. M., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0849-14.2015 · Cited by 295
Self-citationMolecular Control of Oligodendrocyte Development
Elbaz, B., & Popko, B. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.01.002 · Cited by 302
Remyelination therapies: a new direction and challenge in multiple sclerosis
Plemel, J. R., Liu, W., & Yong, V. W. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.115 · Cited by 293
Identification of an Adipogenic Niche for Adipose Tissue Remodeling and Restoration
Lee, Y., Petkova, A. P., & Granneman, J. G. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.003 · Cited by 292
Neuroprotection and repair in multiple sclerosis
Franklin, R. J. M., ffrench‐Constant, C., Edgar, J. M., & Smith, K. J. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.200 · Cited by 285
Self-citationTripathi, R. B., Rivers, L. E., Young, K. M., Jamen, F., & Richardson, W. D. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3411-10.2010 · Cited by 277
Self-citationXing, Y. L., Röth, P. T., Stratton, J. A. S., Chuang, B. H. A., Danne, J., Ellis, S. L., Ng, S. W., Kilpatrick, T. J., & Merson, T. D. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3491-13.2014 · Cited by 275
Neural Stem Cell Engraftment and Myelination in the Human Brain
Gupta, N. M., Henry, R. G., Strober, J. B., Kang, S., Lim, D. A., Bucci, M., Caverzasi, E., Gaetano, L., Mandelli, M. L., Ryan, T., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004373 · Cited by 277
Self-citationGlial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain
Dimou, L., & Götz, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2013 · Cited by 285
Najm, F. J., Lager, A. M., Zaremba, A., Wyatt, K., Caprariello, A. V., Factor, D. C., Karl, R. T., Maeda, T., Miller, R. H., & Tesar, P. J. (2013) · Nature Biotechnology · doi:10.1038/nbt.2561 · Cited by 275
Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis
Philips, T., Bento‐Abreu, A., Nonneman, A., Haeck, W., Staats, K. A., Geelen, V., Hersmus, N., Küsters, B., Bosch, L. V. D., Damme, P. V., et al. (2013) · Brain · doi:10.1093/brain/aws339 · Cited by 282
Self-citationNG 2‐glia and their functions in the central nervous system
Dimou, L., & Gallo, V. (2015) · Glia · doi:10.1002/glia.22859 · Cited by 275
Glial cells in amyotrophic lateral sclerosis
Philips, T., & Rothstein, J. D. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.05.015 · Cited by 266
The Axon-Myelin Unit in Development and Degenerative Disease
Stassart, R. M., Möbius, W., Nave, K.-A., & Edgar, J. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00467 · Cited by 246
Marisca, R., Hoche, T., Agirre, E., Hoodless, L. J., Barkey, W., Auer, F., Castelo‐Branco, G., & Czopka, T. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0581-2 · Cited by 243
Oligodendrocyte lineage cells and depression
Zhou, B., Zhu, Z., Ransom, B. R., & Tong, X. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00930-0 · Cited by 245
Neurosteroids as regulators of neuroinflammation
Yılmaz, C., Karali, K., Fodelianaki, G., Gravanis, A., Chavakis, T., Charalampopoulos, I., & Alexaki, V. I. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100788 · Cited by 261
Martino, G., Pluchino, S., Bonfanti, L., & Schwartz, M. (2011) · Physiological Reviews · doi:10.1152/physrev.00032.2010 · Cited by 246
Myelin damage and repair in pathologic CNS: challenges and prospects
Alizadeh, A., Dyck, S. M., & Karimi‐Abdolrezaee, S. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00035 · Cited by 246
Glial Cells Shape Pathology and Repair After Spinal Cord Injury
Gaudet, A. D., & Fonken, L. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0630-7 · Cited by 242
Asymmetry-Defective Oligodendrocyte Progenitors Are Glioma Precursors
Sugiarto, S., Persson, A. I., González-Muñoz, E., Waldhuber, M., Lamagna, C., Andor, N., Hanecker, P., Ayers-Ringler, J. R., Phillips, J. J., Siu, J. J., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.011 · Cited by 223
On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function
Almeida, R. G., & Lyons, D. A. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3185-16.2017 · Cited by 221
Natrajan, M. S., de la Fuente, A. G., Crawford, A. H., Linehan, E., Núñez, V., Johnson, K. R., Wu, T., Fitzgerald, D. C., Ricote, M., Bielekova, B., et al. (2015) · Brain · doi:10.1093/brain/awv289 · Cited by 225
Self-citationBehrendt, G., Baer, K., Buffo, A., Curtis, M. A., Faull, R. L., Rees, M. I., Götz, M., & Dimou, L. (2013) · Glia · doi:10.1002/glia.22432 · Cited by 219
Glia Disease and Repair—RemyelinationPreprint
Franklin, R. J. M., & Goldman, S. A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020594 · Cited by 217
Self-citationFibronectin aggregation in multiple sclerosis lesions impairs remyelination
Stoffels, J. M. J., de Jonge, J. C., Stancic, M., Nomden, A., van Strien, M. E., Ma, D., Šišková, Z., Maier, O., ffrench‐Constant, C., Franklin, R. J. M., et al. (2013) · Brain · doi:10.1093/brain/aws313 · Cited by 214
Self-citationPetersen, M. A., Ryu, J. K., Chang, K.-J., Etxeberría, A., Bardehle, S., Mendiola, A. S., Kamau-Devers, W., Fancy, S. P. J., Thor, A., Bushong, E. A., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.008 · Cited by 203
Self-citationSkeletal muscle pericyte subtypes differ in their differentiation potential
Birbrair, A., Zhang, T., Wang, Z., Messi, M. L., Enikolopov, G., Mintz, A., & Delbono, O. (2012) · Stem Cell Research · doi:10.1016/j.scr.2012.09.003 · Cited by 204
Chedly, J., Soares, S., Montembault, A., von Boxberg, Y., Ravaille‐Veron, M., Mouffle, C., Benassy, M., Taxi, J., David, L., & Nothias, F. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.024 · Cited by 205
Remyelination after spinal cord injury: Is it a target for repair?
Plemel, J. R., Keough, M. B., Duncan, G. J., Sparling, J. S., Yong, V. W., Stys, P. K., & Tetzlaff, W. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.02.006 · Cited by 206
Macrophages and CNS remyelination
Miron, V. E., & Franklin, R. J. M. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12705 · Cited by 206
Self-citationShimada, I. S., LeComte, M. D., Granger, J. C., Quinlan, N. J., & Spees, J. L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4303-11.2012 · Cited by 192
Glial cells in adult neurogenesis
Morrens, J., Broeck, W. V. D., & Kempermann, G. (2011) · Glia · doi:10.1002/glia.21247 · Cited by 187
Enhancing remyelination in disease--can we wrap it up?
Kotter, M., Stadelmann, C., & Hartung, H. ‐. (2011) · Brain · doi:10.1093/brain/awr014 · Cited by 182
Oligodendrogenesis in the normal and pathological central nervous system
Waly, B. E., Macchi, M., Cayre, M., & Durbec, P. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00145 · Cited by 191
Neural stem cells in the adult spinal cord
Sabelström, H., Stenudd, M., & Frisén, J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.026 · Cited by 187
CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes
Dimas, P., Montani, L., Pereira, J. A., Moreno, D., Trötzmüller, M., Gerber, J., Semenkovich, C. F., Köfeler, H. C., & Suter, U. (2019) · eLife · doi:10.7554/elife.44702 · Cited by 178
Self-citationCsf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery
Nissen, J. C., Thompson, K. K., West, B. L., & Tsirka, S. E. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.05.021 · Cited by 168
The sacral autonomic outflow is sympathetic
Espinosa-Medina, I., Saha, O., Boismoreau, F., Chettouh, Z., Rossi, F., Richardson, W. D., & Brunet, J. (2016) · Science · doi:10.1126/science.aah5454 · Cited by 179
Self-citationWhite matter plasticity in adulthood
Wang, S., & Young, K. M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.018 · Cited by 179
Self-citationSeparated at birth? The functional and molecular divergence of OLIG1 and OLIG2
Meijer, D. H., Kane, M., Mehta, S. V., Liu, H., Harrington, E., Taylor, C. M., Stiles, C. D., & Rowitch, D. H. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3386 · Cited by 180
Self-citationCNS remyelination and inflammation: From basic mechanisms to therapeutic opportunities
Franklin, R. J. M., & Simons, M. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.023 · Cited by 184
Self-citationInhibition of Gli1 mobilizes endogenous neural stem cells for remyelination
Samanta, J., Grund, E. M., Silva, H. M., Lafaille, J. J., Fishell, G., & Salzer, J. L. (2015) · Nature · doi:10.1038/nature14957 · Cited by 170
Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor
González-Pérez, Ó., & Álvarez-Buylla, A. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.01.001 · Cited by 176
A latent lineage potential in resident neural stem cells enables spinal cord repair
Llorens-Bobadilla, E., Chell, J. M., Merre, P. L., Wu, Y., Zamboni, M., Bergenstråhle, J., Stenudd, M., Sopova, E., Lundeberg, J., Shupliakov, O., et al. (2020) · Science · doi:10.1126/science.abb8795 · Cited by 167
Crawford, A., Tripathi, R., Richardson, W., & Franklin, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.069 · Cited by 140
Self-citationFloriddia, E. M., Lourenço, T., Zhang, S., van Bruggen, D., Hilscher, M. M., Kukanja, P., dos Santos, J. P. G., Altınkök, M., Yokota, C., Llorens-Bobadilla, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19453-x · Cited by 163
Promoting remyelination in multiple sclerosis
Cunniffe, N. G., & Coles, A. J. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09421-x · Cited by 172
Glia in the pathogenesis of neurodegenerative diseases
Verkhratsky, A., Parpura, V., Pekna, M., Pekny, M., & Sofroniew, M. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140107 · Cited by 141
The translational biology of remyelination: past, present, and future
Franklin, R. J. M., & Gallo, V. (2014) · Glia · doi:10.1002/glia.22622 · Cited by 162
Self-citationRevisiting remyelination: Towards a consensus on the regeneration of CNS myelin
Franklin, R. J. M., Frisén, J., & Lyons, D. A. (2021) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2020.09.009 · Cited by 154
Self-citationde la Fuente, A. G., Errea, O., van Wijngaarden, P., González, G. A., Kerninon, C., Jarjour, A. A., Lewis, H. J., Jones, C. A., Nait‐Oumesmar, B., Zhao, C., et al. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201505119 · Cited by 158
Self-citationMyelinogenic Plasticity of Oligodendrocyte Precursor Cells following Spinal Cord Contusion Injury
Assinck, P., Duncan, G. J., Plemel, J. R., Lee, M. J., Stratton, J. A., Manesh, S. B., Liu, J., Ramer, L. M., Kang, S. H., Bergles, D. E., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2409-16.2017 · Cited by 151
Cell-based transplantation strategies to promote plasticity following spinal cord injury
Ruff, C. A., Wilcox, J. T., & Fehlings, M. G. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.02.010 · Cited by 149
Oligodendrogenesis after cerebral ischemia
Zhang, R., Chopp, M., & Zhang, Z. G. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00201 · Cited by 159
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Podbielska, M., Banik, N. L., Kurowska, E., & Hogan, E. (2013) · Brain Sciences · doi:10.3390/brainsci3031282 · Cited by 170
Phan, B. N., Bohlen, J. F., Davis, B. A., Ye, Z., Chen, H.-Y., Mayfield, B., Sripathy, S. R., Page, S. C., Campbell, M. N., Smith, H. L., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0578-x · Cited by 146
Sielska, M., Przanowski, P., Wylot, B., Gabrusiewicz, K. R., Maleszewska, M., Kijewska, M., Zawadzka, M., Kucharska, J., Vinnakota, K., Kettenmann, H., et al. (2013) · The Journal of Pathology · doi:10.1002/path.4192 · Cited by 146
Self-citationCell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune functionPreprint
Akay, L. A., Effenberger, A. H., & Tsai, L. (2021) · Genes & Development · doi:10.1101/gad.344218.120 · Cited by 150
Olig2-dependent developmental fate switch of NG2 cells
Zhu, X., Zuo, H., Maher, B. J., Serwanski, D. R., LoTurco, J. J., Lu, Q. R., & Nishiyama, A. (2012) · Development · doi:10.1242/dev.078873 · Cited by 147
Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle
Birbrair, A., Zhang, T., Wang, Z., Messi, M. L., Mintz, A., & Delbono, O. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00245 · Cited by 145
Ischemia-Induced Neural Stem/Progenitor Cells in the Pia Mater Following Cortical Infarction
Nakagomi, T., Molnár, Z., Nakano‐Doi, A., Taguchi, A., Saino, O., Kubo, S., Clausen, M., Yoshikawa, H., Nakagomi, N., & Matsuyama, T. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0279 · Cited by 137
Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination
de la Fuente, A. G., Lange, S., Silva, M. E., González, G. A., Tempfer, H., van Wijngaarden, P., Zhao, C., Canio, L. D., Trost, A., Bieler, L., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.007 · Cited by 135
Self-citationMechanical Environment Modulates Biological Properties of Oligodendrocyte Progenitor Cells
Jagielska, A., Norman, A. L., Whyte, G., Vliet, K. J. V., Guck, J. R., & Franklin, R. J. M. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0189 · Cited by 134
Self-citationDulamea, A. O. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-47861-6_7 · Cited by 128
Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin
Bielecki, B., Mattern, C., Ghoumari, A. M., Javaid, S., Śmietanka, K., Abi‐Ghanem, C., Mhaouty‐Kodja, S., Ghandour, M. S., Baulieu, É.-É., Franklin, R. J. M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614826113 · Cited by 127
Self-citationJames, N. D., Bartus, K., Grist, J., Bennett, D., McMahon, S. B., & Bradbury, E. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4306-11.2011 · Cited by 128
Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions
Acaz‐Fonseca, E., Ávila-Rodriguez, M., García‐Segura, L. M., & Barreto, G. E. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.002 · Cited by 131
Morabito, G., Giannelli, S. G., Ordazzo, G., Bido, S., Castoldi, V., Indrigo, M. T., Cabassi, T., Cattaneo, S., Luoni, M., Cancellieri, C., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.08.004 · Cited by 128
Extracellular matrix and the neural stem cell niche
Kazanis, I., & ffrench‐Constant, C. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20970 · Cited by 127
Fletcher, J. L., Murray, S. S., & Xiao, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124131 · Cited by 128
Lineage, fate, and fate potential of NG2-glia
Nishiyama, A., Boshans, L. L., Gonçalves, C. M., Wegrzyn, J., & Patel, K. D. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.013 · Cited by 128
Oligodendrocyte-protection and remyelination post-spinal cord injuries: A review
Mekhail, M., Almazán, G., & Tabrizian, M. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.01.008 · Cited by 124
García‐León, J. A., Kumar, M., Boon, R., Chau, D., One, J., Wolfs, E., Eggermont, K., Berckmans, P., Gunhanlar, N., de Vrij, F. M. S., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.12.014 · Cited by 123
Jeffries, M. A., Urbanek, K., Torres, L., Wendell, S. G., Rubio, M. E., & Fyffe-Maricich, S. L. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1444-16.2016 · Cited by 126
O’Shea, T. M., Ao, Y., Wang, S., Ren, Y., Cheng, A. L., Kawaguchi, R., Shi, Z., Swarup, V., & Sofroniew, M. V. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01684-6 · Cited by 123
The extracellular matrix compartment of neural stem and glial progenitor cells
Faissner, A., & Reinhard, J. (2015) · Glia · doi:10.1002/glia.22839 · Cited by 116
Schwann cell plasticity‐roles in tissue homeostasis, regeneration, and disease
Stierli, S., Imperatore, V., & Lloyd, A. C. (2019) · Glia · doi:10.1002/glia.23643 · Cited by 124
The fate and function of oligodendrocyte progenitor cells after traumatic spinal cord injury
Duncan, G. J., Manesh, S. B., Hilton, B. J., Assinck, P., Plemel, J. R., & Tetzlaff, W. (2019) · Glia · doi:10.1002/glia.23706 · Cited by 119
Metadata
- Authors
- Zawadzka, M., Rivers, L. E., Fancy, S. P. J., Zhao, C., Tripathi, R., Jamen, F., Young, K., Goncharevich, A., Pohl, H., Rizzi, M., Rowitch, D. H., Kessaris, N., Suter, U., Richardson, W. D., & Franklin, R. J. M.
- Affiliations
- University College London (GB)
- Howard Hughes Medical Institute (US)
- University of Cambridge (GB)
- ETH Zurich (CH)
- Corresponding author
- Richardson, William D.
- Franklin, Robin J.M.
- ORCID
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 6
- Issue
- 6
- Pages
- 578-590
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC3856868
- OpenAlex
- W2152131288
- Cited by
- 650
- References
- 61
- Citations by year
- 2026: 25 · 2025: 25 · 2024: 35 · 2023: 40 · 2022: 38 · 2021: 39 · 2020: 56 · 2019: 53 · 2018: 49 · 2017: 56 · 2016: 34 · 2015: 35 · 2014: 49 · 2013: 46 · 2012: 33
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1178 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Wellcome Trust (080513)
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Keywords
- central nervous system demyelination, remyelination, oligodendrocyte precursor cells, Schwann cells, glial progenitor cells, reactive astrocytes, multiple sclerosis, cell of origin, fate mapping
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Animals, Astrocytes, Cells, Cultured, Central Nervous System, Demyelinating Diseases, Disease Models, Animal, Female, Lysophosphatidylcholines, Mice, Transgenic, Microscopy, Multiple Sclerosis, Nerve Regeneration, Nerve Tissue Proteins, Oligodendroglia, Schwann Cells, Integrases, Receptor, Platelet-Derived Growth Factor alpha, Mice, Receptor, Fibroblast Growth Factor, Type 3, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, Adult Stem Cells
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