The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila
Open accessAbstract
Many tissues in higher animals undergo dynamic homeostatic growth, wherein damaged or aged cells are replaced by the progeny of resident stem cells. To maintain homeostasis, stem cells must respond to tissue needs. Here we show that in response to damage or stress in the intestinal (midgut) epithelium of adult Drosophila, multiple EGFR ligands and rhomboids (intramembrane proteases that activate some EGFR ligands) are induced, leading to the activation of EGFR signaling in intestinal stem cells (ISCs). Activation of EGFR signaling promotes ISC division and midgut epithelium regeneration, thus maintaining tissue homeostasis. ISCs defective in EGFR signaling cannot grow or divide, are poorly maintained, and cannot support midgut epithelium regeneration following enteric infection by the bacterium, Pseudomonas entomophila. Furthermore, ISC proliferation induced by Jak/Stat signaling is dependent upon EGFR signaling. Thus the EGFR/Ras/MAPK signaling pathway plays central, essential roles in ISC maintenance and the feedback system that mediates intestinal homeostasis.
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Cites
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
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Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer
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BackgroundInfluentialImaging individual mRNA molecules using multiple singly labeled probes
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Wild-Type BRAF Is Required for Response to Panitumumab or Cetuximab in Metastatic Colorectal Cancer
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BackgroundHaigis, K. M., Kendall, K. R., Wang, Y., Cheung, A., Haigis, M. C., Glickman, J. N., Niwa-Kawakita, M., Sweet-Cordero, A., Sebolt-Leopold, J., Shannon, K. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.115 · Cited by 610
The tortoise and the hair: slow-cycling cells in the stem cell race
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A two-step model for colon adenoma initiation and progression caused by APC loss
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Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
Miguel-Aliaga, I., Jasper, H., & Lemaitre, B. (2018) · Genetics · doi:10.1534/genetics.118.300224 · Cited by 491
PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan
Guo, L., Karpac, J., Tran, S. L., & Jasper, H. (2014) · Cell · doi:10.1016/j.cell.2013.12.018 · Cited by 462
Altered Modes of Stem Cell Division Drive Adaptive Intestinal Growth
O'Brien, L. E., Soliman, S. S., Li, X., & Bilder, D. (2011) · Cell · doi:10.1016/j.cell.2011.08.048 · Cited by 440
Programmed cell death in aging
Tower, J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.002 · Cited by 426
Metadata
- Authors
- Jiang, H., Grenley, M. O., Bravo, M.-J., Blumhagen, R. Z., & Edgar, B. A.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 8
- Issue
- 1
- Pages
- 84-95
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W1985234259
- Cited by
- 467
- References
- 9
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. https://app.cochat.ai/papers/10.1016/j.stem.2010.11.026
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- Jiang, H., Grenley, M. O., Bravo, M.-J., Blumhagen, R. Z., & Edgar, B. A. (2011). EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. Cell Stem Cell. https://doi.org/10.1016/j.stem.2010.11.026
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
