The tortoise and the hair: slow-cycling cells in the stem cell race
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Given the importance of stem cells to adult tissues, it has long been postulated that stem cells divide infrequently to preserve their long-term proliferation potential and to prevent the acquisition of errors during DNA replication. Yet, some stem cells must be able to continually churn out progeny in tissues that rapidly turn over or are subject to sudden injuries or growth spurts. This Review explores the challenges that mammalian stem cells face in balancing the competing demands of proliferation and differentiation in tissues.
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During homeostasis, stem cells in multiple systems maintain a noncycling quiescent state.
“During homeostasis, stem cells in multiple systems maintain a noncycling quiescent state (Fuchs, 2009).”
From Aging induces aberrant state transition kinetics in murine muscle stem cells (2020) · cites this paper as Fuchs, 2009
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- Greco V Chen T Rendl M Schober M Pasolli HA Stokes N dela Cruz-Racelis J Fuchs E 2009 Dissecting the hair cycle activation step in the stem cell niche Cell Stem Cell 4 155 169 19200804 PMC2668200
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- Authors
- Fuchs, E.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Fuchs, Elaine
- ORCID
- Fuchs, Elaine
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 137
- Issue
- 5
- Pages
- 811-819
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2716122
- OpenAlex
- W2016835212
- Cited by
- 371
- References
- 63
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 10 · 2021: 7 · 2020: 12 · 2019: 11 · 2018: 18 · 2017: 21 · 2016: 21 · 2015: 31 · 2014: 33 · 2013: 36 · 2012: 59
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1538 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01ar050452-21)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01-AR050452)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- stem cells, slow-cycling cells, cell proliferation, cell differentiation, tissue regeneration, stem cell self-renewal, DNA replication errors, tissue turnover
- MeSH terms
- Animals, Cell Cycle, Hematopoietic Stem Cells, Humans, Intestine, Small, Organ Specificity, Hair Follicle, Cell Proliferation, Adult Stem Cells
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