Building Models of Brain Disorders with Three-Dimensional Organoids

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works

Initial sequencing and comparative analysis of the mouse genome

Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187 · see citing works

Cerebral organoids model human brain development and microcephaly

Lancaster, M. A., Renner, M., Martin, C.-A., Wenzel, D., Bicknell, L. S., Hurles, M. E., Homfray, T., Penninger, J. M., Jackson, A. P., & Knoblich, J. A. (2013) · Nature · doi:10.1038/nature12517 · Cited by 5,372 · see citing works

Modeling Development and Disease with Organoids

Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196 · see citing works

Organogenesis in a dish: Modeling development and disease using organoid technologies

Lancaster, M. A., & Knoblich, J. A. (2014) · Science · doi:10.1126/science.1247125 · Cited by 2,931 · see citing works

Autism spectrum disorder

Lord, C., Elsabbagh, M., Baird, G., & Veenstra-Vanderweele, J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31129-2 · Cited by 2,819 · see citing works

Model of autism: increased ratio of excitation/inhibition in key neural systems

Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works

Estimating the true global burden of mental illness

Vigo, D., Thornicroft, G., & Atun, R. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(15)00505-2 · Cited by 2,494 · see citing works

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Qian, X., Nguyen, H. N., Song, M. M., Hadiono, C., Ogden, S. C., Hammack, C., Yao, B., Hamersky, G. R., Jacob, F., Zhong, C., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.032 · Cited by 2,127 · see citing works

Animal models of neuropsychiatric disorders

Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works

Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism

Hallmayer, J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.76 · Cited by 1,970 · see citing works

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

Kriks, S., Shim, J., Piao, J., Ganat, Y. M., Wakeman, D. R., Xie, Z., Carrillo‐Reid, L., Auyeung, G., Antonacci, C. L., Buch, A., et al. (2011) · Nature · doi:10.1038/nature10648 · Cited by 1,912 · see citing works

The Microenvironmental Landscape of Brain Tumors

Quail, D. F., & Joyce, J. A. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.02.009 · Cited by 1,875 · see citing works

The neuropathology of schizophrenia

Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677 · see citing works

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

Paşca, A. M., Sloan, S. A., Clarke, L. E., Tian, Y., Makinson, C. D., Huber, N., Kim, C. H., Park, J.-Y., O'Rourke, N. A., Nguyen, K. D., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3415 · Cited by 1,609 · see citing works

Self-formation of optic cups and storable stratified neural retina from human ESCs

Nakano, T., Ando, S., Takata, N., Kawada, M., Muguruma, K., Sekiguchi, K., Saito, K., Yonemura, S., Eiraku, M., & Sasai, Y. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.009 · Cited by 1,447 · see citing works

Modelling schizophrenia using human induced pluripotent stem cells

Brennand, K. J., Simone, A., Jou, J., Gelboin-Burkhart, C., Tran, N., Sangar, S., Li, Y., Mu, Y., Chen, G., Yu, D., et al. (2011) · Nature · doi:10.1038/nature09915 · Cited by 1,375 · see citing works

Assembly of functionally integrated human forebrain spheroids

Birey, F., Andersen, J., Makinson, C. D., Islam, S., Wei, W., Huber, N., Fan, H. C., Metzler, K. R. C., Panagiotakos, G., Thom, N., et al. (2017) · Nature · doi:10.1038/nature22330 · Cited by 1,365 · see citing works

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

Marchetto, M. C. N., Carromeu, C., Acab, A., Yu, D., Yeo, G. W., Mu, Y., Chen, G., Gage, F. H., & Muotri, A. R. (2010) · Cell · doi:10.1016/j.cell.2010.10.016 · Cited by 1,329 · see citing works

The Brazilian Zika virus strain causes birth defects in experimental models

Cugola, F. R., Fernandes, I. R., Russo, F. B., Freitas, B. C., Dias, J. L. M., Guimarães, K. P., Benazzato, C., Almeida, N., Pignatari, G. C., Romero, S., et al. (2016) · Nature · doi:10.1038/nature18296 · Cited by 1,326 · see citing works

Cell diversity and network dynamics in photosensitive human brain organoids

Quadrato, G., Nguyen, T., Macosko, E. Z., Sherwood, J. L., Min Yang, S., Berger, D. R., Maria, N., Scholvin, J., Goldman, M., Kinney, J. P., et al. (2017) · Nature · doi:10.1038/nature22047 · Cited by 1,321 · see citing works

Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth

Tang, H., Hammack, C., Ogden, S. C., Wen, Z., Qian, X., Li, Y., Yao, B., Shin, J., Zhang, F., Lee, E. M., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.02.016 · Cited by 1,292 · see citing works

An in vivo model of functional and vascularized human brain organoids

Mansour, A. A., Gonçalves, J. T., Bloyd, C. W., Li, H., Fernandes, S., Quang, D., Johnston, S., Parylak, S. L., Jin, X., & Gage, F. H. (2018) · Nature Biotechnology · doi:10.1038/nbt.4127 · Cited by 1,211 · see citing works

Biology of Zika Virus Infection in Human Skin Cells

Hamel, R., Dejarnac, O., Wichit, S., Ekchariyawat, P., Neyret, A., Luplertlop, N., Perera-Lecoin, M., Surasombatpattana, P., Talignani, L., Frédéric Thomas, A., et al. (2015) · Journal of Virology · doi:10.1128/jvi.00354-15 · Cited by 1,199 · see citing works

A three-dimensional human neural cell culture model of Alzheimer’s disease

Choi, S. H., Kim, Y. H., Hebisch, M., Sliwinski, C., Lee, S., D’Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., et al. (2014) · Nature · doi:10.1038/nature13800 · Cited by 1,195 · see citing works

Zika virus impairs growth in human neurospheres and brain organoids

Garcez, P. P., Loiola, E. C., Madeiro da Costa, R., Higa, L. M., Trindade, P., Delvecchio, R., Nascimento, J. M., Brindeiro, R., Tanuri, A., & Rehen, S. K. (2016) · Science · doi:10.1126/science.aaf6116 · Cited by 1,184 · see citing works

Genetic architectures of psychiatric disorders: the emerging picture and its implications

Sullivan, P. F., Daly, M. J., & O'Donovan, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3240 · Cited by 1,177 · see citing works

iPSC-derived human microglia-like cells to study neurological diseases

Abud, E. M., Ramirez, R. N., Martinez, E. S., Healy, L. M., Nguyen, C. H. H., Newman, S. A., Yeromin, A. V., Scarfone, V. M., Marsh, S. E., Fimbres, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.042 · Cited by 1,154 · see citing works

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

Mariani, J., Coppola, G., Zhang, P., Abyzov, A., Provini, L., Tomasini, L., Amenduni, M., Szekely, A., Palejev, D., Wilson, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.06.034 · Cited by 1,149 · see citing works

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

Camp, J. G., Badsha, F., Florio, M., Kanton, S., Gerber, T., Wilsch-Bräuninger, M., Lewitus, E., Sykes, A., Hevers, W., Lancaster, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520760112 · Cited by 1,130 · see citing works

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Lin, Y.-T., Seo, J., Gao, F., Feldman, H. M., Wen, H.-L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.008 · Cited by 1,125 · see citing works

Zika Virus in the Americas — Yet Another Arbovirus Threat

Fauci, A. S., & Morens, D. M. (2016) · New England Journal of Medicine · doi:10.1056/nejmp1600297 · Cited by 1,075 · see citing works

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell–derived neocortex

Kadoshima, T., Sakaguchi, H., Nakano, T., Soen, M., Ando, S., Eiraku, M., & Sasai, Y. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315710110 · Cited by 999 · see citing works

Molecular Identity of Human Outer Radial Glia during Cortical Development

Pollen, A. A., Nowakowski, T. J., Chen, J., Retallack, H., Sandoval-Espinosa, C., Nicholas, C. R., Shuga, J., Liu, S. J., Oldham, M. C., Diaz, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.004 · Cited by 908 · see citing works

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

Jo, J., Xiao, Y., Sun, A. X., Cukuroglu, E., Tran, H.-D., Göke, J., Tan, Z. Y., Saw, T. Y., Tan, C.-P., Lokman, H., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.07.005 · Cited by 861 · see citing works

Neuropathology of Alzheimer's Disease

Perl, D. P. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20157 · Cited by 825 · see citing works

The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

Silbereis, J. C., Pochareddy, S., Zhu, Y., Li, M., & Sestan, N. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.008 · Cited by 818 · see citing works

Alzheimer's disease: experimental models and reality

Drummond, E., & Wisniewski, T. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1662-x · Cited by 810 · see citing works

Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline <i>PTEN</i> tumour suppressor gene mutations

Butler, M. G., Dasouki, M. J., Zhou, X.-P., Talebizadeh, Z., Brown, M., Takahashi, T. N., Miles, J. H., Wang, C. H., Stratton, R., Pilarski, R., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.024646 · Cited by 778 · see citing works

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.

Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., McGrath, S., Campbell, B., Lee, H., Herdy, J. R., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2015.09.001 · Cited by 765 · see citing works

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3

Dang, J., Tiwari, S. K., Lichinchi, G., Qin, Y., Patil, V. S., Eroshkin, A. M., & Rana, T. M. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.04.014 · Cited by 731 · see citing works

Patient-derived xenografts undergo mouse-specific tumor evolution

Ben-David, U., Ha, G., Tseng, Y.-Y., Greenwald, N. F., Oh, C., Shih, J., McFarland, J. M., Wong, B., Boehm, J. S., Beroukhim, R., et al. (2017) · Nature Genetics · doi:10.1038/ng.3967 · Cited by 716 · see citing works

Genetics of autism spectrum disorders

Geschwind, D. H. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.07.003 · Cited by 696 · see citing works

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

Muguruma, K., Nishiyama, A., Kawakami, H., Hashimoto, K., & Sasai, Y. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.051 · Cited by 692 · see citing works

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

Park, J., Wetzel, I., Marriott, I., Dréau, D., D’Avanzo, C., Kim, D. Y., Tanzi, R. E., & Cho, H. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0175-4 · Cited by 644 · see citing works

Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen

Xu, M., Lee, E. M., Wen, Z., Cheng, Y., Huang, W.-K., Qian, X., Julia, T. C. W., Kouznetsova, J., Ogden, S. C., Hammack, C., et al. (2016) · Nature Medicine · doi:10.1038/nm.4184 · Cited by 642 · see citing works

Retinitis Pigmentosa: Genes and Disease Mechanisms

Parmeggiani, F., Sorrentino, F. S., Ponzin, D., Barbaro, V., Ferrari, S., & Iorio, E. D. (2011) · Current Genomics · doi:10.2174/138920211795860107 · Cited by 636 · see citing works

Neurological and neuropsychiatric aspects of tuberous sclerosis complex

Curatolo, P., Moavero, R., & de Vries, P. J. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00069-1 · Cited by 600 · see citing works

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells

Maroof, A. M., Keros, S., Tyson, J. A., Ying, S.-W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.04.008 · Cited by 596 · see citing works

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

Sloan, S. A., Darmanis, S., Huber, N., Khan, T. A., Birey, F., Caneda, C., Reimer, R., Quake, S. R., Barres, B. A., & Paşca, S. P. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.035 · Cited by 593 · see citing works

Common genetic variation drives molecular heterogeneity in human iPSCs

Kilpinen, H., Goncalves, A., Leha, A., Afzal, V., Alasoo, K., Ashford, S., Bala, S., Bensaddek, D., Casale, F. P., Culley, O. J., et al. (2017) · Nature · doi:10.1038/nature22403 · Cited by 586 · see citing works

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

Paşca, S. P., Portmann, T., Voineagu, I., Yazawa, M., Shcheglovitov, A., Paşca, A. M., Cord, B., Palmer, T. D., Chikahisa, S., Nishino, S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2576 · Cited by 585 · see citing works

ASPM is a major determinant of cerebral cortical size

Bond, J., Roberts, E., Mochida, G. H., Hampshire, D. J., Scott, S., Askham, J. M., Springell, K., Mahadevan, M., Crow, Y. J., Markham, A. F., et al. (2002) · Nature Genetics · doi:10.1038/ng995 · Cited by 581 · see citing works

Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia

Bershteyn, M., Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Nene, A., Wynshaw-Boris, A., & Kriegstein, A. R. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2016.12.007 · Cited by 566 · see citing works

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

Study, T. P. O. B. D., Mertens, J., Wang, Q.-W., Kim, Y., Yu, D. X., Pham, S., Yang, B., Zheng, Y., Diffenderfer, K. E., Zhang, J., et al. (2015) · Nature · doi:10.1038/nature15526 · Cited by 562 · see citing works

Synaptic dysregulation in a human iPS cell model of mental disorders

Wen, Z., Nguyen, H. N., Guo, Z., Lalli, M. A., Wang, X., Su, Y., Kim, N.-S., Yoon, K.-J., Shin, J., Zhang, C., et al. (2014) · Nature · doi:10.1038/nature13716 · Cited by 549 · see citing works

Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy

Liang, Q., Luo, Z., Zeng, J., Chen, W., Foo, S., Lee, S.-A., Ge, J., Wang, S., Goldman, S. A., Zloković, B. V., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.07.019 · Cited by 538 · see citing works

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Sandoval-Espinosa, C., Bershteyn, M., & Kriegstein, A. R. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.03.012 · Cited by 529 · see citing works

Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development

Nicholas, C. R., Chen, J., Tang, Y., Southwell, D. G., Chalmers, N., Vogt, D. L., Arnold, C. M., Chen, Y.-J. J., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.005 · Cited by 513 · see citing works

The rise of three-dimensional human brain cultures

Pașca, S. P. (2018) · Nature · doi:10.1038/nature25032 · Cited by 509 · see citing works

Genetic insights into the neurodevelopmental origins of schizophrenia

Birnbaum, R., & Weinberger, D. R. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.125 · Cited by 493 · see citing works

Mouse models of Tay–Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

Sango, K., Yamanaka, S., Hoffmann, A., Okuda, Y., Grinberg, A., Westphal, H., McDonald, M. P., Crawley, J. N., Sandhoff, K., Suzuki, K., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-170 · Cited by 468 · see citing works

Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells

Du, Z., Chen, H., Liu, H., Lü, J., Qian, K. X., Huang, C., Zhong, X., Fan, F., & Zhang, S. (2015) · Nature Communications · doi:10.1038/ncomms7626 · Cited by 459 · see citing works

Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses

Meertens, L., Labeau, A., Dejarnac, O., Cipriani, S., Sinigaglia, L., Bonnet-Madin, L., Le Charpentier, T., Hafirassou, M. L., Zamborlini, A., Cao-Lormeau, V.-M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.045 · Cited by 450 · see citing works

Induction of Expansion and Folding in Human Cerebral Organoids

Li, Y., Muffat, J., Omer, A., Bosch, I., Lancaster, M. A., Sur, M., Gehrke, L., Knoblich, J. A., & Jaenisch, R. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2016.11.017 · Cited by 436 · see citing works

Genetics and genomics of psychiatric disease

Geschwind, D. H., & Flint, J. (2015) · Science · doi:10.1126/science.aaa8954 · Cited by 424 · see citing works

Human brain organoids on a chip reveal the physics of folding

Karzbrun, E., Kshirsagar, A., Cohen, S., Hanna, J. H., & Reiner, O. (2018) · Nature Physics · doi:10.1038/s41567-018-0046-7 · Cited by 421 · see citing works

Genetically engineered cerebral organoids model brain tumor formation

Bian, S., Repic, M., Guo, Z., Kavirayani, A. M., Burkard, T. R., Bagley, J. A., Krauditsch, C., & Knoblich, J. A. (2018) · Nature Methods · doi:10.1038/s41592-018-0070-7 · Cited by 419 · see citing works

Generation of human vascularized brain organoids

Pham, M. T., Pollock, K., Rose, M. D., Cary, W., Stewart, H., Zhou, P., Nolta, J., & Waldau, B. (2018) · NeuroReport · doi:10.1097/wnr.0000000000001014 · Cited by 412 · see citing works

14-3-3ε is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller–Dieker syndrome

Toyo‐oka, K., Shionoya, A., Gambello, M. J., Cardoso, C., Leventer, R. J., Ward, H. L., Ayala, R., Tsai, L., Dobyns, W. B., Ledbetter, D. H., et al. (2003) · Nature Genetics · doi:10.1038/ng1169 · Cited by 403 · see citing works

Self-organized cerebral organoids with human specific features predict effective drugs to combat Zika virus infection

Watanabe, M., Buth, J. E., Vishlaghi, N., de la Torre-Ubieta, L., Taxidis, J., Khakh, B. S., Coppola, G., Pearson, C. A., Yamauchi, K., Gong, D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.047 · Cited by 401 · see citing works

Psychiatric genetics and the structure of psychopathology

Smoller, J. W., Andreassen, O. A., Edenberg, H. J., Faraone, S. V., Glatt, S. J., & Kendler, K. S. (2019) · Molecular Psychiatry · doi:10.1038/s41380-017-0010-4 · Cited by 398 · see citing works

Glioblastoma Model Using Human Cerebral Organoids

Ogawa, J., Pao, G. M., Shokhirev, M. N., & Verma, I. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.105 · Cited by 391 · see citing works

Stem Cell Models of Human Brain Development

Kelava, I., & Lancaster, M. A. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.05.022 · Cited by 372 · see citing works

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

Luo, C., Lancaster, M. A., Castanon, R., Nery, J. R., Knoblich, J. A., & Ecker, J. R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.12.001 · Cited by 370 · see citing works

Mitotic Spindle Regulation by Nde1 Controls Cerebral Cortical Size

Feng, Y., & Walsh, C. A. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.023 · Cited by 353 · see citing works

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics

Savidis, G., McDougall, W. M., Meraner, P., Perreira, J. M., Portmann, J. M., Trincucci, G., John, S. P., Aker, A. M., Renzette, N., Robbins, D. R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.028 · Cited by 353 · see citing works

Human tissues in a dish: The research and ethical implications of organoid technology

Bredenoord, A. L., Clevers, H., & Knoblich, J. A. (2017) · Science · doi:10.1126/science.aaf9414 · Cited by 334 · see citing works

Modeling of TREX1-dependent autoimmune disease using human stem cells highlights L1 accumulation as a source of neuroinflammation

Thomas, C. A., Tejwani, L., Trujillo, C. A., Negraes, P. D., Herai, R. H., Mesci, P., Macia, A., Crow, Y. J., & Muotri, A. R. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.07.009 · Cited by 330 · see citing works

Human brain organoid-on-a-chip to model prenatal nicotine exposure

Wang, Y., Wang, L., Zhu, Y., & Qin, J. (2018) · Lab on a Chip · doi:10.1039/c7lc01084b · Cited by 328 · see citing works

Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics

Alda, M. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.4 · Cited by 317 · see citing works

The human brain in a dish: The promise of iPSC-derived neurons

Dolmetsch, R., & Geschwind, D. (2011) · Cell · doi:10.1016/j.cell.2011.05.034 · Cited by 313 · see citing works

Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups

Parfitt, D. A., Lane, A., Ramsden, C. M., Carr, A. F., Munro, P., Jovanovic, K., Schwarz, N., Kanuga, N., Muthiah, M. N., Hull, S., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.03.021 · Cited by 302 · see citing works

Physiological and pathological phosphorylation of tau by Cdk5

Kimura, T., Ishiguro, K., & Hisanaga, S. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00065 · Cited by 297 · see citing works

Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids

Gabriel, E., Ramani, A., Karow, U., Gottardo, M., Natarajan, K., Gooi, L. M., Goranci-Buzhala, G., Krut, O., Peters, F., Nikolić, M., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.12.005 · Cited by 292 · see citing works

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

Onorati, M., Li, Z., Liu, F., Sousa, A. M. M., Nakagawa, N., Li, M., Dell’Anno, M. T., Gulden, F. O., Pochareddy, S., Tebbenkamp, A. T. N., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.038 · Cited by 292 · see citing works

Neural Subtype Specification from Human Pluripotent Stem Cells

Tao, Y., & Zhang, S.-C. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.10.015 · Cited by 287 · see citing works

Applications of CRISPR–Cas systems in neuroscience

Heidenreich, M., & Zhang, F. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn.2015.2 · Cited by 282 · see citing works

In vivo models of primary brain tumors: pitfalls and perspectives

Huszthy, P. C., Daphu, I., Niclou, S. P., Stieber, D., Nigro, J. M., Sakariassen, P. Ø., Miletić, H., Thorsen, F. A., & Bjerkvig, R. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos135 · Cited by 280 · see citing works

Neuroepithelial Stem Cell Proliferation Requires LIS1 for Precise Spindle Orientation and Symmetric Division

Yingling, J., Youn, Y. H., Darling, D. L., Toyo‐oka, K., Pramparo, T., Hirotsune, S., & Wynshaw-Boris, A. J. (2008) · Cell · doi:10.1016/j.cell.2008.01.026 · Cited by 271 · see citing works

Brains, Genes, and Primates

Belmonte, J. C. I., Callaway, E. M., Caddick, S. J., Churchland, P. S., Feng, G., Homanics, G. E., Lee, K., Leopold, D. A., Miller, C. T., Mitchell, J. F., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.021 · Cited by 269 · see citing works

Genetic Ablation of AXL Does Not Protect Human Neural Progenitor Cells and Cerebral Organoids from Zika Virus Infection

Wells, M. F., Salick, M. R., Wiskow, O., Ho, D. J., Worringer, K. A., Ihry, R. J., Kommineni, S., Bilican, B., Klim, J. R., Hill, E. J., et al. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.11.011 · Cited by 269 · see citing works

Cell of Origin for Malignant Gliomas and Its Implication in Therapeutic DevelopmentPreprint

Zong, H., Parada, L. F., & Baker, S. J. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020610 · Cited by 267 · see citing works

The Infancy of the Human Brain

Dehaene-Lambertz, G., & Spelke, E. S. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.026 · Cited by 264 · see citing works

High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain

Zhou, T., Tan, L., Cederquist, G. Y., Fan, Y., Hartley, B. J., Mukherjee, S., Tomishima, M., Brennand, K. J., Zhang, Q., Schwartz, R. E., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.06.017 · Cited by 263 · see citing works

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

Iefremova, V., Manikakis, G., Krefft, O., Jabali, A., Weynans, K., Wilkens, R., Marsoner, F., Brändl, B., Müller, F.-J., Koch, P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.047 · Cited by 261 · see citing works

Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients

Deng, W.-L., Gao, M., Lei, X., Lv, J., Zhao, H., He, K.-W., Xia, X.-X., Li, L., Chen, Y., Li, Y.-P., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.02.003 · Cited by 257 · see citing works

CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in cerebral organoids derived from iPS cells

Wang, P., Mokhtari, R., Pedrosa, E., Kirschenbaum, M. A., Bayrak, C., Zheng, D., & Lachman, H. M. (2017) · Molecular Autism · doi:10.1186/s13229-017-0124-1 · Cited by 255 · see citing works

Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons

Krey, J. F., Pașca, S. P., Shcheglovitov, A., Yazawa, M., Schwemberger, R., Rasmusson, R. L., & Dolmetsch, R. E. (2013) · Nature Neuroscience · doi:10.1038/nn.3307 · Cited by 252 · see citing works

The core FOXG1 syndrome phenotype consists of postnatal microcephaly, severe mental retardation, absent language, dyskinesia, and corpus callosum hypogenesis

Kortüm, F., Das, S., Flindt, M., Morris-Rosendahl, D. J., Stefanova, I., Goldstein, A. C., Horn, D., Klopocki, E., Kluger, G. J., Martin, P., et al. (2011) · Journal of Medical Genetics · doi:10.1136/jmg.2010.087528 · Cited by 239 · see citing works

CPAP promotes timely cilium disassembly to maintain neural progenitor pool

Gabriel, E., Wason, A., Ramani, A., Gooi, L. M., Keller, P., Pozniakovsky, A., Poser, I., Noack, F., Telugu, N. S., Calegari, F., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201593679 · Cited by 238 · see citing works

The genomic landscape of tuberous sclerosis complex

Martin, K. R., Zhou, W., Bowman, M. J., Shih, J., Au, K. S., Dittenhafer-Reed, K. E., Sisson, K. A., Koeman, J., Weisenberger, D. J., Cottingham, S. L., et al. (2017) · Nature Communications · doi:10.1038/ncomms15816 · Cited by 238 · see citing works

Molecular genetics of human primary microcephaly: an overview

Faheem, M., Naseer, M. I., Rasool, M., Chaudhary, A., Kumosani, T., Ilyas, A. M., Pushparaj, P. N., Ahmed, F., Algahtani, H. A., Al-Qahtani, M. H., et al. (2015) · BMC Medical Genomics · doi:10.1186/1755-8794-8-s1-s4 · Cited by 234 · see citing works

Cerebral organoids: ethical issues and consciousness assessment

Lavazza, A., & Massimini, M. (2018) · Journal of Medical Ethics · doi:10.1136/medethics-2017-104555 · Cited by 217 · see citing works

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

Huh, C. J., Zhang, B., Victor, M. B., Dahiya, S., Batista, L. F., Horvath, S., & Yoo, A. S. (2016) · eLife · doi:10.7554/elife.18648 · Cited by 213 · see citing works

The ethics of experimenting with human brain tissue

Farahany, N. A., Greely, H. T., Hyman, S. E., Christof Koch, A., Grady, C., Pașca, S. P., Šestan, N., Arlotta, P., Bernat, J. L., Ting, J. T., et al. (2018) · Nature · doi:10.1038/d41586-018-04813-x · Cited by 212 · see citing works

Genetically engineered human cortical spheroid models of tuberous sclerosis

Blair, J. D., Hockemeyer, D. F., & Bateup, H. S. (2018) · Nature Medicine · doi:10.1038/s41591-018-0139-y · Cited by 207 · see citing works

Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins

Yoon, K., Song, G., Qian, X., Pan, J., Xu, D., Rho, H.-S., Kim, N.-S., Habela, C. W., Zheng, L., Jacob, F., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.014 · Cited by 206 · see citing works

The Challenges and Promise of Neuroimaging in Psychiatry

Linden, D. E. J. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.014 · Cited by 204 · see citing works

Human Disease Phenotypes Associated With Mutations in TREX1

Rice, G., Rodero, M. P., & Crow, Y. J. (2015) · Journal of Clinical Immunology · doi:10.1007/s10875-015-0147-3 · Cited by 203 · see citing works

Human TLR3 recognizes dengue virus and modulates viral replicationin vitro

Tsai, Y.-T., Chang, S., Lee, C., & Kao, C. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01277.x · Cited by 203 · see citing works

Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline

Pulvers, J. N., Bryk, J., Fish, J. L., Wilsch‐Bräuninger, M., Arai, Y., Schreier, D., Naumann, R., Helppi, J., Habermann, B. H., Vogt, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010494107 · Cited by 194 · see citing works

DISC1-binding proteins in neural development, signalling and schizophrenia

Bradshaw, N. J., & Porteous, D. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.027 · Cited by 188 · see citing works

A brief history of levodopa

Hornykiewicz, O. (2010) · Journal of Neurology · doi:10.1007/s00415-010-5741-y · Cited by 185 · see citing works

Silencing of CDK5 Reduces Neurofibrillary Tangles in Transgenic Alzheimer's Mice

Piedrahita, D., Hernández, I., Tobon, A., Fedorov, D., Obara, B., Manjunath, B. S., Boudreau, R. L., Davidson, B. L., LaFerla, F. M., Gallego-Gómez, J. C., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3637-10.2010 · Cited by 184 · see citing works

Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells

Ogura, T., Sakaguchi, H., Miyamoto, S., & Takahashi, J. (2018) · Development · doi:10.1242/dev.162214 · Cited by 183 · see citing works

From maps to multi-dimensional network mechanisms of mental disorders

Braun, U., Schaefer, A., Betzel, R. F., Tost, H., Meyer-Lindenberg, A., & Bassett, D. S. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.007 · Cited by 177 · see citing works

Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution

Chandler, C. H., Chari, S., & Dworkin, I. M. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.01.009 · Cited by 174 · see citing works

How Genes and Environmental Factors Determine the Different Neurodevelopmental Trajectories of Schizophrenia and Bipolar Disorder

Demjaha, A., MacCabe, J. H., & Murray, R. M. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr100 · Cited by 172 · see citing works

Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size

Johnson, M. B., Sun, X., Kodani, A., Borges-Monroy, R., Girskis, K. M., Ryu, S. C., Wang, P. P., Patel, K., Gonzalez, D. M., Woo, Y. M., et al. (2018) · Nature · doi:10.1038/s41586-018-0035-0 · Cited by 172 · see citing works

Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders

Rubenstein, J. L. R. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02307.x · Cited by 170 · see citing works

Natural History of Infantile GM2 Gangliosidosis

Bley, A. E., Giannikopoulos, O., Hayden, D. L., Kubilus, K., Tifft, C. J., & Eichler, F. (2011) · PEDIATRICS · doi:10.1542/peds.2011-0078 · Cited by 166 · see citing works

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

Seo, J., Kritskiy, O., Watson, L. A., Barker, S. J., Dey, D. C., Raja, W. K., Lin, Y.-T., Ko, T., Cho, S., Penney, J., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0621-17.2017 · Cited by 165 · see citing works

The Emerging Biology of Autism Spectrum Disorders

State, M. W., & Šestan, N. (2012) · Science · doi:10.1126/science.1224989 · Cited by 164 · see citing works

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis

Ye, F., Kang, E., Yu, C., Qian, X., Jacob, F., Yu, C., Mao, M., Poon, R. Y. C., Kim, J., Song, H., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.010 · Cited by 163 · see citing works

CDK5RAP2 Regulates Centriole Engagement and Cohesion in Mice

Barrera, J. A., Kao, L.-R., Hammer, R. E., Seemann, J., Fuchs, J. L., & Megraw, T. L. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.017 · Cited by 162 · see citing works

Splice-Modulating Oligonucleotide QR-110 Restores CEP290 mRNA and Function in Human c.2991+1655A>G LCA10 Models

Dulla, K., Aguilà, M., Lane, A., Jovanovic, K., Parfitt, D. A., Schulkens, I. A. E., Chan, H. L., Schmidt, I., Beumer, W., Vorthoren, L., et al. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.07.010 · Cited by 161 · see citing works

Generation of serotonin neurons from human pluripotent stem cells

Lü, J., Zhong, X., Liu, H., Hao, L., Huang, C. T.-L., Sherafat, M. A., Jones, J. R., Ayala, M., Li, L., & Zhang, S. (2015) · Nature Biotechnology · doi:10.1038/nbt.3435 · Cited by 159 · see citing works

Adhesion molecules in the stem cell niche – more than just staying in shape?

Marthiens, V., Kazanis, I., Moss, L., Long, K. R., & ffrench‐Constant, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.054312 · Cited by 155 · see citing works

Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease

Li, R., Sun, L., Fang, A., Li, P., Wu, Q., & Wang, X. (2017) · Protein & Cell · doi:10.1007/s13238-017-0479-2 · Cited by 154 · see citing works

In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations

Shimada, H., Lü, Q., Insinna-Kettenhofen, C., Nagashima, K., English, M. A., Semler, E. M., Mahgerefteh, J., Cideciyan, A. V., Li, T., Brooks, B. P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.045 · Cited by 148 · see citing works

Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections

Muffat, J., Li, Y., Omer, A., Durbin, A. F., Bosch, I., Bakiasi, G., Richards, E. J., Meyer, A. S., Gehrke, L., & Jaenisch, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719266115 · Cited by 148 · see citing works

Molecular complexes that direct rhodopsin transport to primary cilia

Wang, J., & Deretic, D. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.08.004 · Cited by 146 · see citing works

Renewed focus on the developing human neocortex

Clowry, G. J., Molnár, Z., & RAKIC, P. T. (2010) · Journal of Anatomy · doi:10.1111/j.1469-7580.2010.01281.x · Cited by 141 · see citing works

Opportunities and challenges in modeling human brain disorders in transgenic primates

Jennings, C. G. B., Landman, R., Zhou, Y., Sharma, J., Hyman, J. B., Movshon, J. A., Qiu, Z., Roberts, A., Roe, A. W., Wang, X., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4362 · Cited by 140 · see citing works

Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT

Dakic, V., Minardi Nascimento, J., Costa Sartore, R., Maciel, R. D. M., de Araujo, D. B., Ribeiro, S., Martins-de-Souza, D., & Rehen, S. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-12779-5 · Cited by 134 · see citing works

Pluripotent stem cells in neuropsychiatric disorders

Soliman, M. A., Aboharb, F., Zeltner, N., & Studer, L. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.40 · Cited by 129 · see citing works

Conical expansion of the outer subventricular zone and the role of neocortical folding in evolution and development

Lewitus, É., Kelava, I., & Huttner, W. Β. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00424 · Cited by 121 · see citing works

Cytoskeleton in action: lissencephaly, a neuronal migration disorder

Moon, H. M., & Wynshaw-Boris, A. J. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.67 · Cited by 119 · see citing works

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

Srikanth, P., Han, K., Callahan, D. G., Makovkina, E., Muratore, C., Lalli, M. A., Zhou, H., Boyd, J. D., Kosik, K. S., Selkoe, D. J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.061 · Cited by 118 · see citing works

A glimmer of light for neuropsychiatric disorders

Hyman, S. E. (2008) · Nature · doi:10.1038/nature07454 · Cited by 110 · see citing works

Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation

Allende, M. L., Cook, E. K., Larman, B. C., Nugent, A., Brady, J. M., Golebiowski, D., Sena‐Esteves, M., Tifft, C. J., & Proia, R. L. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m081323 · Cited by 108 · see citing works

Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging

Nicodemus, K. K., Callicott, J. H., Higier, R. G., Luna, A., Nixon, D. C., Lipska, B. K., Vakkalanka, R., Giegling, I., Rujescu, D., Clair, D. S., et al. (2010) · Human Genetics · doi:10.1007/s00439-009-0782-y · Cited by 106 · see citing works

Cell-autonomous correction of ring chromosomes in human induced pluripotent stem cells

Bershteyn, M., Hayashi, Y., Desachy, G., Hsiao, E. C., Sami, S., Tsang, K. M., Weiss, L. A., Kriegstein, A. R., Yamanaka, S., & Wynshaw-Boris, A. J. (2014) · Nature · doi:10.1038/nature12923 · Cited by 96 · see citing works

Twenty-Five Years of Progress: The View from NIMH and NINDS

Insel, T. R., & Landis, S. C. (2013) · Neuron · doi:10.1016/j.neuron.2013.09.041 · Cited by 87 · see citing works

Probing impaired neurogenesis in human brain organoids exposed to alcohol

Zhu, Y., Wang, L., Yin, F., Yu, Y., Wang, Y., Shepard, M. J., Zhuang, Z., & Qin, J. (2017) · Integrative Biology · doi:10.1039/c7ib00105c · Cited by 87 · see citing works

CYP3A5 Mediates Effects of Cocaine on Human Neocorticogenesis: Studies using an In Vitro 3D Self-Organized hPSC Model with a Single Cortex-Like Unit

Lee, C.-T., Chen, J., Kindberg, A. A., Bendriem, R. M., Spivak, C. E., Williams, M. P., Richie, C. T., Handreck, A., Mallon, B. S., Lupica, C. R., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.156 · Cited by 86 · see citing works

On being a circuit psychiatrist

Gordon, J. A. (2016) · Nature Neuroscience · doi:10.1038/nn.4419 · Cited by 78 · see citing works

Insulin-Like Growth Factor 1 and Related Compounds in the Treatment of Childhood-Onset Neurodevelopmental Disorders

Vahdatpour, C., Dyer, A. H., & Tropea, D. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00450 · Cited by 76 · see citing works

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids

Srikanth, P., Lagomarsino, V. N., Muratore, C., Ryu, S. C., He, A., Taylor, W. M., Zhou, C. Q., Arellano, M., & Young‐Pearse, T. L. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0122-x · Cited by 67 · see citing works

New considerations for hiPSC-based models of neuropsychiatric disorders

Hoffman, G. E., Schrode, N., Flaherty, E. K., & Brennand, K. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0029-1 · Cited by 65 · see citing works

Lithium treatment for bipolar disorder.

Mitchell, P. B., & Hadži-Pavlović, D. (2000) · PubMed · Cited by 56 · see citing works

Direct Neuronal Reprogramming for Disease Modeling Studies Using Patient-Derived Neurons: What Have We Learned?

Drouin‐Ouellet, J., Pircs, K., Barker, R. A., Jakobsson, J., & Parmar, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00530 · Cited by 54 · see citing works

Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients

Deng, W.-L., Gao, M., Lei, X., Lv, J., Zhao, H., He, K.-W., Xia, X.-X., Li, L., Chen, Y., Li, Y.-P., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.05.012 · Cited by 49 · see citing works

Diagnosis and Treatment of Neuropsychiatric Disorders

Taber, K. H., Hurley, R. A., & Yudofsky, S. C. (2010) · Annual Review of Medicine · doi:10.1146/annurev.med.051408.105018 · Cited by 48 · see citing works

Animal models of GM2 gangliosidosis: utility and limitations

Lawson, C. A., & Martin, D. R. (2016) · The Application of Clinical Genetics · doi:10.2147/tacg.s85354 · Cited by 45 · see citing works

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis

Ye, F., Kang, E., Yu, C., Qian, X., Jacob, F., Yu, C., Mao, M., Poon, R. Y. C., Kim, J., Song, H., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.034 · Cited by 35 · see citing works

Global analysis of neurological disease: burden and benefit

Neurology, T. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30338-1 · Cited by 12 · see citing works

Generation of a Three-Dimensional Retinal Tissue from Self-Organizing Human ESC Culture

Kuwahara, A., Nakano, T., & Eiraku, M. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6949-4_2 · Cited by 9 · see citing works

Neuroinvasion of SARS-CoV-2 in human and mouse brain

Song, E., Zhang, C., Israelow, B., Lu-Culligan, A., Prado, A. V., Skriabine, S., Lu, P., Weizman, O.-E., Liu, F., Dai, Y., et al. (2020) · doi:10.1101/2020.06.25.169946 · Cited by 1,064 · see citing works

Generation of Functional Human 3D Cortico-Motor Assembloids

Andersen, J., Revah, O., Miura, Y., Thom, N., Amin, N. D., Kelley, K. W., Singh, M., Chen, X., Thete, M. V., Walczak, E. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.11.017 · Cited by 593 · see citing works

Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells

Miura, Y., Li, M.-Y., Birey, F., Ikeda, K., Revah, O., Thete, M. V., Park, J.-Y., Puno, A., Lee, S. H., Porteus, M. H., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-00763-w · Cited by 418 · see citing works

Generation of vascularized brain organoids to study neurovascular interactions

Sun, X.-Y., Ju, X.-C., Li, Y., Zeng, P.-M., Wu, J., Zhou, Y., Shen, L., Dong, J., Chen, Y., & Luo, Z. (2022) · eLife · doi:10.7554/elife.76707 · Cited by 390 · see citing works

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

Marton, R. M., Miura, Y., Sloan, S. A., Li, Q., Revah, O., Levy, R. J., Huguenard, J. R., & Pașca, S. P. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0316-9 · Cited by 362 · see citing works

Identification of neural oscillations and epileptiform changes in human brain organoids

Samarasinghe, R. A., Miranda, O. A., Buth, J. E., Mitchell, S. A., Ferando, I., Watanabe, M., Allison, T. F., Kurdian, A., Fotion, N. N., Gandal, M. J., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00906-5 · Cited by 278 · see citing works

Williams syndrome

Kozel, B. A., Barak, B., Kim, C. A., Mervis, C. Β., Osborne, L. R., Porter, M. A., & Pober, B. R. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00276-z · Cited by 251 · see citing works

Human brain organogenesis: Toward a cellular understanding of development and disease

Kelley, K. W., & Pașca, S. P. (2021) · Cell · doi:10.1016/j.cell.2021.10.003 · Cited by 233 · see citing works

Bioengineering Approaches for the Advanced Organoid Research

Yi, S. A., Zhang, Y., Rathnam, C., Pongkulapa, T., & Lee, K. (2021) · Advanced Materials · doi:10.1002/adma.202007949 · Cited by 218 · see citing works

An FDA/CDER perspective on nonclinical testing strategies: Classical toxicology approaches and new approach methodologies (NAMs)

Avila, A. M., Bebenek, I., Bonzo, J. A., Bourcier, T., Bruno, K. L. D., Carlson, D. B., Dubinion, J. H., Elayan, I., Harrouk, W. A., Lee, S., et al. (2020) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2020.104662 · Cited by 197 · see citing works

OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

Xu, R., Brawner, A. T., Li, S., Liu, J.-J., Kim, H., Xue, H., Pang, Z. P., Kim, W.-Y., Hart, R. P., Liu, Y., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.014 · Cited by 193 · see citing works

Ethical issues related to brain organoid research

Hyun, I., Scharf-Deering, J. C., & Lunshof, J. E. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146653 · Cited by 186 · see citing works

Human 3D cellular model of hypoxic brain injury of prematurity

Pașca, A. M., Park, J.-Y., Shin, H.-W., Qi, Q., Revah, O., Krasnoff, R., O’Hara, R., Willsey, A. J., Palmer, T. D., & Pașca, S. P. (2019) · Nature Medicine · doi:10.1038/s41591-019-0436-0 · Cited by 174 · see citing works

Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease

Sidhaye, J., & Knoblich, J. A. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0566-4 · Cited by 167 · see citing works

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

Krenn, V., Bosone, C., Burkard, T. R., Spanier, J., Kalinke, U., Calistri, A., Salata, C., Christoff, R. R., Garcez, P. P., Mirazimi, A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.03.004 · Cited by 158 · see citing works

LifeTime and improving European healthcare through cell-based interceptive medicine

Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., et al. (2020) · Nature · doi:10.1038/s41586-020-2715-9 · Cited by 156 · see citing works

DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome

Tang, X.-Y., Xu, L., Wang, J., Hong, Y., Wang, Y., Zhu, Q., Wang, D., Zhang, X.-Y., Liu, C.-Y., Fang, K.-H., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci135763 · Cited by 143 · see citing works

Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism

Urresti, J., Zhang, P., Losada, P. M., Yu, N., Negraes, P. D., Trujillo, C. A., Antaki, D., Amar, M., Chau, K. K., Pramod, A. B., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01243-6 · Cited by 133 · see citing works

A framework for the investigation of rare genetic disorders in neuropsychiatry

Sanders, S., Şahin, M., Hostyk, J. A., Thurm, A. E., Jacquemont, S., Avillach, P., Douard, E. A., Martin, C. L., Modi, M. E., Moreno-De-Luca, A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0581-5 · Cited by 119 · see citing works

Extension of retinofugal projections in an assembled model of human pluripotent stem cell-derived organoids

Fligor, C. M., Lavekar, S. S., Harkin, J., Shields, P. K., VanderWall, K. B., Huang, K.-C., Gomes, C., & Meyer, J. S. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.05.009 · Cited by 125 · see citing works

Advancing models of neural development with biomaterials

Roth, J. G., Huang, M. S., Li, T. L., Feig, V. R., Jiang, Y., Cui, B., Greely, H. T., Bao, Z., Pașca, S. P., & Heilshorn, S. C. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00496-y · Cited by 120 · see citing works

Extracellular matrix dynamics in cell migration, invasion and tissue morphogenesis

Yamada, K. M., Collins, J. W., Walma, D. A. C., Doyle, A. D., Morales, S. R. G., Lu, J., Matsumoto, K., Nazari, S., Sekiguchi, R., Shinsato, Y., et al. (2019) · International Journal of Experimental Pathology · doi:10.1111/iep.12329 · Cited by 117 · see citing works

Human cerebral organoids establish subcortical projections in the mouse brain after transplantation

Dong, X., Xu, S., Chen, X., Tao, M., Tang, X.-Y., Fang, K.-H., Xu, M., Pan, Y., Chen, Y., He, S., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00910-4 · Cited by 118 · see citing works

Human Brain Surrogates Research: The Onrushing Ethical Dilemma

Greely, H. T. (2020) · The American Journal of Bioethics · doi:10.1080/15265161.2020.1845853 · Cited by 115 · see citing works

Modeling HIV-1 neuropathogenesis using three-dimensional human brain organoids (hBORGs) with HIV-1 infected microglia

dos Reis, R. S., Sant, S., Keeney, H., Wagner, M. C. E., & Ayyavoo, V. (2020) · Scientific Reports · doi:10.1038/s41598-020-72214-0 · Cited by 113 · see citing works

Modeling and Targeting Alzheimer’s Disease With Organoids

Papaspyropoulos, A., Tsolaki, M., Foroglou, N., & Pantazaki, Α. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00396 · Cited by 107 · see citing works

Cell diversity in the human cerebral cortex: from the embryo to brain organoids

Arlotta, P., & Pașca, S. P. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.03.001 · Cited by 96 · see citing works

Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicine

Sakalem, M., Sibio, M. D. D., da Costa, F. A. D. S., & de Oliveira, M. (2020) · Biotechnology Journal · doi:10.1002/biot.202000463 · Cited by 86 · see citing works

Modeling alcohol-induced neurotoxicity using human induced pluripotent stem cell-derived three-dimensional cerebral organoids

Arzua, T., Yan, Y., Jiang, C., Logan, S., Allison, R. L., Wells, C. W., Kumar, S. N., Schäfer, R., & Bai, X. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01029-4 · Cited by 98 · see citing works

Tubular human brain organoids to model microglia-mediated neuroinflammation

Ao, Z., Cai, H., Wu, Z., Song, S., Karahan, H., Kim, B., Lu, H.-C., Kim, J., Mackie, K., & Guo, F. (2021) · Lab on a Chip · doi:10.1039/d1lc00030f · Cited by 87 · see citing works

Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids

Costamagna, G., Comi, G. P., & Corti, S. P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052659 · Cited by 89 · see citing works

Human pluripotent stem cell–derived models and drug screening in CNS precision medicine

Silva, M. C., & Haggarty, S. J. (2019) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14012 · Cited by 82 · see citing works

Neurodevelopmental impairment induced by prenatal valproic acid exposure shown with the human cortical organoid-on-a-chip model

Cui, K., Wang, Y., Zhu, Y., Tao, T., Yin, F., Guo, Y., Liu, H., Li, F., Wang, P., Chen, Y., et al. (2020) · Microsystems & Nanoengineering · doi:10.1038/s41378-020-0165-z · Cited by 81 · see citing works

Cerebral organoids transplantation repairs infarcted cortex and restores impaired function after stroke

Cao, S.-Y., Yang, D., Huang, Z., Lin, Y., Wu, H., Chang, L., Luo, C., Xu, Y., Liu, Y., & Zhu, D. (2023) · npj Regenerative Medicine · doi:10.1038/s41536-023-00301-7 · Cited by 86 · see citing works

Robust production of uniform human cerebral organoids from pluripotent stem cells

Sivitilli, A., Gosio, J., Ghoshal, B., Evstratova, A., Trcka, D., Ghiasi, P., Hernández, J. J., Beaulieu, J., Wrana, J. L., & Attisano, L. (2020) · Life Science Alliance · doi:10.26508/lsa.202000707 · Cited by 82 · see citing works

CNS organoids: an innovative tool for neurological disease modeling and drug neurotoxicity screening

Chhibber, T., Bagchi, S., Lahooti, B., Verma, A., Al-Ahmad, A. J., Paul, M. K., Pendyala, G., & Jayant, R. D. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.11.010 · Cited by 78 · see citing works

Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD

Culotta, L., & Penzes, P. (2020) · Molecular Autism · doi:10.1186/s13229-020-00339-0 · Cited by 77 · see citing works

Generating human neural diversity with a multiplexed morphogen screen in organoids

Amin, N. D., Kelley, K. W., Kaganovsky, K., Onesto, M. M., Hao, J., Miura, Y., McQueen, J. P., Reis, N., Narazaki, G., Li, T., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.10.016 · Cited by 70 · see citing works

Advances in development and application of human organoids

Shankaran, A., Prasad, K., Chaudhari, S., Brand, A. M., & Satyamoorthy, K. (2021) · 3 Biotech · doi:10.1007/s13205-021-02815-7 · Cited by 74 · see citing works

Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation

McDiarmid, T. A., Belmadani, M., Liang, J., Meili, F., Mathews, E., Mullen, G. P., Hendi, A., Wong, W.-R., Rand, J. B., Mizumoto, K., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1912049116 · Cited by 67 · see citing works

Lung organoids, useful tools for investigating epithelial repair after lung injury

Kong, J., Wen, S., Cao, W., Yue, P., Xu, X., Zhang, Y., Luo, L., Chen, T., Li, L., Wang, F., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02172-5 · Cited by 72 · see citing works

Recent advances in gene therapy for neurodevelopmental disorders with epilepsy

Turner, T. J., Zourray, C., Schorge, S., & Lignani, G. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15168 · Cited by 71 · see citing works

Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

Elfarrash, S., Jensen, N. M., Ferreira, N., Betzer, C., Thevathasan, J. V., Diekmann, R., Adel, M., Omar, N. M., Boraie, M. Z., Gad, S., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0865-5 · Cited by 69 · see citing works

Mitochondrial HSF1 triggers mitochondrial dysfunction and neurodegeneration in Huntington's disease

Liu, C., Fu, Z., Wu, S., Wang, X., Zhang, S., Chu, C., Hong, Y., Wu, W., Chen, S., Jiang, Y., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202215851 · Cited by 70 · see citing works

Behavior and lineage progression of neural progenitors in the mammalian cortex

Lin, Y., Yang, J., Shen, Z., Ma, J., Simons, B. D., & Shi, S. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.10.017 · Cited by 63 · see citing works

Lipid‐Bilayer‐Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions

Zhou, L., Wolfes, A. C., Li, Y., Chan, D. C. W., Ko, H., Szele, F. G., & Bayley, H. (2020) · Advanced Materials · doi:10.1002/adma.202002183 · Cited by 63 · see citing works

Advances in 3D neuronal microphysiological systems: towards a functional nervous system on a chip

Anderson, W. A., Bosak, A. J., Högberg, H. T., Härtung, T., & Moore, M. J. (2021) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-020-00532-8 · Cited by 64 · see citing works

Dynamic Characterization of Structural, Molecular, and Electrophysiological Phenotypes of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids, and Comparison with Fetal and Adult Gene Profiles

Logan, S., Arzua, T., Yan, Y., Jiang, C., Liu, X., Yu, L., Liu, Q.-S., & Bai, X. (2020) · Cells · doi:10.3390/cells9051301 · Cited by 62 · see citing works

Breaking the mold: 3D cell cultures reshaping the future of cancer research

Cordeiro, S. Z., Oliveira, B. B. P. P., Valente, R., Ferreira, D., Luz, A., Baptista, P. V., & Fernandes, A. R. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1507388 · Cited by 64 · see citing works

Organoid Models of Glioblastoma to Study Brain Tumor Stem Cells

Azzarelli, R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00220 · Cited by 60 · see citing works

Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C

Lu, K., Hong, Y., Tao, M., Shen, L., Zheng, Z., Fang, K.-H., Yuan, F., Xu, M., Wang, C., Zhu, D., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202216364 · Cited by 59 · see citing works

Enhanced Neuronal Activity and Asynchronous Calcium Transients Revealed in a 3D Organoid Model of Alzheimer’s Disease

Yin, J., & VanDongen, A. M. J. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c01583 · Cited by 59 · see citing works

Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis

Latour, Y. L., Yoon, R., Thomas, S., Grant, C. L., Li, C., Sena‐Esteves, M., Allende, M. L., Proia, R. L., & Tifft, C. J. (2019) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2019.100513 · Cited by 56 · see citing works

Modeling genetic epileptic encephalopathies using brain organoids

Steinberg, D. J., Repudi, S., Saleem, A., Kustanovich, I. M., Viukov, S. V., Abudiab, B., Banne, E., Mahajnah, M. M., Hanna, J. H., Stern, S., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202013610 · Cited by 55 · see citing works

Modeling of Hypoxic Brain Injury through 3D Human Neural Organoids

Kim, M. S., Kim, D., Kang, H. K., Kook, M. G., Choi, S. W., & Kang, K. (2021) · Cells · doi:10.3390/cells10020234 · Cited by 55 · see citing works

Vincristine Impairs Microtubules and Causes Neurotoxicity in Cerebral Organoids

Liu, F., Huang, J., & Liu, Z. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.12.047 · Cited by 56 · see citing works

Mouse vs man: Organoid models of brain development & disease

Marshall, J. J., & Mason, J. O. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146427 · Cited by 54 · see citing works

Cellular complexity in brain organoids: Current progress and unsolved issues

Mansour, A. A., Schafer, S. T., & Gage, F. H. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.05.013 · Cited by 52 · see citing works

Engineering three-dimensional microenvironments towards in vitro disease models of the central nervous system

Yildirimer, L., Zhang, Q., Kuang, S., Cheung, J. C., Chu, K. A., He, Y., Yang, M., & Zhao, X. (2019) · Biofabrication · doi:10.1088/1758-5090/ab17aa · Cited by 53 · see citing works

All Together Now: Modeling the Interaction of Neural With Non-neural Systems Using Organoid Models

Chukwurah, E., Osmundsen, A. M., Davis, S. W., & Lizarraga, S. B. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00582 · Cited by 51 · see citing works

Heterocellular spheroids of the neurovascular blood-brain barrier as a platform for personalized nanoneuromedicine

Kumarasamy, M., & Sosnik, A. (2021) · iScience · doi:10.1016/j.isci.2021.102183 · Cited by 51 · see citing works

Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology

Forró, C., Caron, D., Angotzi, G. N., Gallo, V., Berdondini, L., Santoro, F., Palazzolo, G., & Panuccio, G. (2021) · Micromachines · doi:10.3390/mi12020124 · Cited by 50 · see citing works

Translating Embryogenesis to Generate Organoids: Novel Approaches to Personalized Medicine

Sahu, S., & Sharan, S. K. (2020) · iScience · doi:10.1016/j.isci.2020.101485 · Cited by 49 · see citing works

Emerging technologies to study glial cells

Hirbec, H., Déglon, N., Foo, L. C., Goshen, I., Grutzendler, J., Hangen, E., Kreisel, T., Linck, N., Muffat, J., Regio, S., et al. (2020) · Glia · doi:10.1002/glia.23780 · Cited by 47 · see citing works

From Brain Organoids to Networking Assembloids: Implications for Neuroendocrinology and Stress Medicine

Makrygianni, E. A., & Chrousos, G. P. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.621970 · Cited by 47 · see citing works

Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research

Bi, F.-C., Yang, X.-H., Cheng, X.-Y., Deng, W.-B., Guo, X.-L., Yang, H., Wang, Y., Li, J., & Yao, Y. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00252-3 · Cited by 47 · see citing works

Experimental and Computational Methods for the Study of Cerebral Organoids: A Review

Poli, D., Magliaro, C., & Ahluwalia, A. D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00162 · Cited by 46 · see citing works

Neuroprotective effects of resveratrol against oxygen glucose deprivation induced mitochondrial dysfunction by activation of AMPK in SH-SY5Y cells with 3D gelatin scaffold

Lin, C., Nicol, C. J. B., Cheng, Y., Yen, C., Wang, Y., & Chiang, M. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146492 · Cited by 45 · see citing works

Modeling Controlled Cortical Impact Injury in 3D Brain‐Like Tissue Cultures

Liaudanskaya, V., Chung, J. Y., Mizzoni, C., Rouleau, N., Berk, A. N., Wu, L., Turner, J. A., Georgakoudi, I., Whalen, M. J., Nieland, T. J. F., et al. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000122 · Cited by 45 · see citing works

Application of Fused Organoid Models to Study Human Brain Development and Neural Disorders

Chen, A., Guo, Z., Fang, L., & Bian, S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00133 · Cited by 44 · see citing works

Human in vitro models for understanding mechanisms of autism spectrum disorder

Gordon, A., & Geschwind, D. H. (2020) · Molecular Autism · doi:10.1186/s13229-020-00332-7 · Cited by 43 · see citing works

Evolution of organoid technology: Lessons learnt in Co-Culture systems from developmental biology

Zahmatkesh, E., Rad, N. K., Mirzaei, H., Shpichka, A. I., Timashev, P. S., Mahmoudi, T., & Vosough, M. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2021.03.001 · Cited by 44 · see citing works

3D biomaterial models of human brain disease

Kajtez, J., Nilsson, F., Fiorenzano, A., Parmar, M., & Emnéus, J. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105043 · Cited by 44 · see citing works

Extracellular protein homeostasis in neurodegenerative diseases

Wilson, M. R., Satapathy, S., & Vendruscolo, M. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00786-2 · Cited by 42 · see citing works

Probing disrupted neurodevelopment in autism using human stem cell‐derived neurons and organoids: An outlook into future diagnostics and drug development

Yang, G., & Shcheglovitov, A. (2019) · Developmental Dynamics · doi:10.1002/dvdy.100 · Cited by 44 · see citing works

The NIH BRAIN Initiative: Integrating Neuroethics and Neuroscience

Ramos, K. M., Grady, C., Greely, H. T., Chiong, W., Eberwine, J. H., Farahany, N. A., Johnson, L. S. M., Hyman, B. T., Hyman, S. E., Rommelfanger, K. S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.024 · Cited by 42 · see citing works

iPSCs-Based Neural 3D Systems: A Multidimensional Approach for Disease Modeling and Drug Discovery

Costamagna, G., Andreoli, L., Corti, S. P., & Faravelli, I. (2019) · Cells · doi:10.3390/cells8111438 · Cited by 40 · see citing works

Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer’s disease (AD) risk

Raman, S., Brookhouser, N., & Brafman, D. A. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104788 · Cited by 40 · see citing works

Patient-Derived Midbrain Organoids to Explore the Molecular Basis of Parkinson's Disease

Galet, B., Cheval, H., & Ravassard, P. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.01005 · Cited by 45 · see citing works

Methadone interrupts neural growth and function in human cortical organoids

Yao, H., Wu, W., Cerf, I., Zhao, H. W., Wang, J., Negraes, P. D., Muotri, A. R., & Haddad, G. G. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.102065 · Cited by 41 · see citing works

TGFβ superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids

Watanabe, M., Buth, J. E., Haney, J. R., Vishlaghi, N., Turcios, F., Elahi, L. S., Gu, W., Pearson, C. A., Kurdian, A., Baliaouri, N. V., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.08.013 · Cited by 44 · see citing works

Development of brain organoid technology derived from iPSC for the neurodegenerative disease modelling: a glance through

Jusop, A. S., Thanaskody, K., Tye, G. J., Dass, S. A., Zaman, W. S. W. K., & Nordin, F. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1173433 · Cited by 42 · see citing works

Deconstructing and reconstructing the human brain with regionally specified brain organoids

Xiang, Y., Çakır, B., & Park, I. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.05.023 · Cited by 38 · see citing works

Shaping the Neurovascular Unit Exploiting Human Brain Organoids

Rizzuti, M., Melzi, V., Brambilla, L., Quetti, L., Sali, L., Ottoboni, L., Meneri, M., Ratti, A., Verde, F., Ticozzi, N., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-03998-9 · Cited by 38 · see citing works

Using induced pluripotent stem cell neuronal models to study neurodegenerative diseases

Zhang, X., Hu, D., Shang, Y., & Qi, X. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.03.004 · Cited by 36 · see citing works

GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons

Akamine, S., Okuzono, S., Yamamoto, H., Setoyama, D., Sagata, N., Ohgidani, M., Kato, T. A., Ishitani, T., Kato, H., Masuda, K., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202001113r · Cited by 39 · see citing works

O-GlcNAc transferase Ogt regulates embryonic neuronal development through modulating Wnt/β-catenin signaling

Shen, H., Zhao, X., Chen, J., Qu, W., Huang, X., Wang, M., Shao, Z., Shu, Q., & Li, X. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab223 · Cited by 39 · see citing works

Benchmarking brain organoid recapitulation of fetal corticogenesis

Cheroni, C., Trattaro, S., Caporale, N., Tobon, A., Tenderini, E., Sebastiani, S., Troglio, F., Gabriele, M., Bressan, R. B., Pollard, S. M., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02279-0 · Cited by 37 · see citing works

Past, Present, and Future of Neuronal Models In Vitro.

Keller, J., & Frega, M. (2019) · Advances in neurobiology · doi:10.1007/978-3-030-11135-9_1 · Cited by 31 · see citing works

Modeling genetic epilepsies in a dish

Niu, W., & Parent, J. M. (2019) · Developmental Dynamics · doi:10.1002/dvdy.79 · Cited by 38 · see citing works

Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex

Fiock, K. L., Smalley, M. E., Crary, J. F., Pașca, A. M., & Hefti, M. M. (2020) · eNeuro · doi:10.1523/eneuro.0058-20.2020 · Cited by 38 · see citing works

Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A

Lent, J. V., Vendredy, L., Adriaenssens, E., Authier, T. D. S., Asselbergh, B., Kaji, M., Weckhuysen, S., van den Bosch, L., Baets, J., & Timmerman, V. (2022) · Brain : a journal of neurology · doi:10.1093/brain/awac475 · Cited by 32 · see citing works

Modeling Alzheimer’s disease with human iPS cells: advancements, lessons, and applications

Essayan-Perez, S., Zhou, B., Nabet, A. M., Wernig, M., & Huang, Y. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104503 · Cited by 37 · see citing works

On the road to the brain-on-a-chip: a review on strategies, methods, and applications

Brofiga, M., Pisano, M., Raiteri, R., & Massobrio, P. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/ac15e4 · Cited by 37 · see citing works

Remodeling of mitochondrial morphology and function: an emerging hallmark of cellular reprogramming

Rastogi, A., Joshi, P. K., Contreras, E., & Gama, V. (2019) · Cell Stress · doi:10.15698/cst2019.06.189 · Cited by 34 · see citing works

Optogenetics in the Era of Cerebral Organoids

Shiri, Z., Simorgh, S., Naderi, S., & Baharvand, H. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2019.05.009 · Cited by 36 · see citing works

Brain organoids: Human 3D models to investigate neuronal circuits assembly, function and dysfunction

Tambalo, M., & Lodato, S. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147028 · Cited by 34 · see citing works

Unravelling Pathophysiology of Neurological and Psychiatric Complications of COVID-19 Using Brain Organoids

Ng, J., Sun, A. X., Je, H. S., & Tan, E. (2021) · The Neuroscientist · doi:10.1177/10738584211015136 · Cited by 35 · see citing works

Familial Alzheimer’s disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling

Hurley, E. M., Mozolewski, P., Dobrowolski, R., & Hsieh, J. (2023) · Stem Cell Reports · doi:10.1016/j.stemcr.2023.05.018 · Cited by 35 · see citing works

Simple modeling of familial Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technology

Choe, M. S., Yeo, H. C., Kim, J., Lee, J., Lee, H. J., Kim, H., Baek, K. M., Jung, N., Choi, M., & Lee, M. Y. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03732-1 · Cited by 37 · see citing works

Modeling neurological disorders using brain organoids

Zhang, D. Y., Song, H., & Ming, G. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.05.026 · Cited by 52 · see citing works

Modeling Neurological Diseases With Human Brain Organoids

Wang, H. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00015 · Cited by 172 · see citing works

Brain Organoids: Filling the Need for a Human Model of Neurological Disorder

Jalink, P., & Caiazzo, M. (2021) · Biology · doi:10.3390/biology10080740 · Cited by 30 · see citing works

Three-Dimensional Models for Studying Neurodegenerative and Neurodevelopmental Diseases

Tsaridou, S., Skamnelou, M., Iliadou, M., Lokka, G., Parlapani, E., Mougkogianni, M., Danalatos, R.-I., Kanellou, A., Chlorogiannis, D., Kyrousi, C., et al. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-32633-3_6 · Cited by 3 · see citing works

Brain Organoids: Tiny Mirrors of Human Neurodevelopment and Neurological Disorders

Yadav, A., Seth, B., & Chaturvedi, R. K. (2020) · The Neuroscientist · doi:10.1177/1073858420943192 · Cited by 19 · see citing works