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Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy
Open accessAbstract
Summary To investigate the role of immune cells in lung regeneration, we used a unilateral pneumonectomy model that promotes the formation of new alveoli in the remaining lobes. Immunofluorescence and single cell RNA- sequencing found CD115+ and CCR2+ monocytes and M2-like macrophages accumulating in the lung during the peak of type 2 alveolar epithelial stem cell (AEC2) proliferation. Genetic loss of function in mice and adoptive transfer studies revealed that bone marrow-derived macrophages traffic to the lung through a CCL2-CCR2 chemokine axis and are required for optimal lung regeneration, along with Il4ra-expressing leukocytes. Our data suggest that these cells modulate AEC2 proliferation and differentiation. Finally, we provide evidence that group 2 innate lymphoid cells are a source of IL13 that promotes lung regeneration. Together, our data highlight the potential for immunomodulatory therapies to stimulate alveologenesis in adults.
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Metadata
- Authors
- Lechner, A. J., Driver, I. H., Lee, J., Conroy, C. M., Nagle, A., Locksley, R. M., & Rock, J. R.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 21
- Issue
- 1
- Pages
- 120-134.e7
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2613529980
- Cited by
- 256
- References
- 33
- FWCI
- 14.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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