The DOI matches its Crossref record; 80 of the 81 references it cites were found in a registry or an index.
Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy
Open accessAbstract
Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem cells (satellite cells), a process that becomes less efficient with aging. Here, we show that mitochondrial dynamics are essential for the successful regenerative capacity of satellite cells. The loss of mitochondrial fission in satellite cells-due to aging or genetic impairment-deregulates the mitochondrial electron transport chain (ETC), leading to inefficient oxidative phosphorylation (OXPHOS) metabolism and mitophagy and increased oxidative stress. This state results in muscle regenerative failure, which is caused by the reduced proliferation and functional loss of satellite cells. Regenerative functions can be restored in fission-impaired or aged satellite cells by the re-establishment of mitochondrial dynamics (by activating fission or preventing fusion), OXPHOS, or mitophagy. Thus, mitochondrial shape and physical networking controls stem cell regenerative functions by regulating metabolism and proteostasis. As mitochondrial fission occurs less frequently in the satellite cells in older humans, our findings have implications for regeneration therapies in sarcopenia.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“During ageing, tissue regenerative functions decline, in part due to stem cell-intrinsic accumulation of damage (for example, DNA damage, loss of proteostasis and oxidative damage), functional decay of niche cells and increased inflammation (inflammageing)4–9 through uncharacterized mechanisms.”
From Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration (2023) · cites this paper as [9]
In the citing paper
“This process is essential for regulating muscle stem cell regeneration by regulating metabolism, protein balance, and mitophagy for regenerative therapies in sarcopenia [56].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [56]
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
Li, B., & Dewey, C. N. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-323 · Cited by 22,179
Molecular signatures database (MSigDB) 3.0
Liberzon, A., Subramanian, A., Pinchback, R., Thorvaldsdóttir, H., Tamayo, P., & Mesirov, J. P. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr260 · Cited by 7,111
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167
Raudvere, U., Kolberg, L., Kuzmin, I., Arak, T., Adler, P., Peterson, H., & Vilo, J. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz369 · Cited by 5,045
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
Hockenbery, D., Nuñez, G., Milliman, C., Schreiber, R. D., & Korsmeyer, S. J. (1990) · Nature · doi:10.1038/348334a0 · Cited by 3,720
Mitochondrial Fission, Fusion, and Stress
Youle, R. J., & van der Bliek, A. M. (2012) · Science · doi:10.1126/science.1219855 · Cited by 3,674
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082
Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
Merico, D., Isserlin, R., Stueker, O., Emili, A., & Bader, G. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013984 · Cited by 2,235
The reactome pathway knowledgebase
Jassal, B., Matthews, L. R., Viteri, G., Gong, C., Lorente, P., Fabregat, A., Sidiropoulos, K., Cook, J., Gillespie, M. E., Haw, R., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1031 · Cited by 2,183
Reimand, J., Isserlin, R., Voisin, V., Kucera, M., Tannus-Lopes, C., Rostamianfar, A., Wadi, L., Meyer, M., Wong, J., Xu, C., et al. (2019) · Nature Protocols · doi:10.1038/s41596-018-0103-9 · Cited by 1,970
Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, C. A., Sou, Y.-S., Saiki, S., Kawajiri, S., Sato, F., et al. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200910140 · Cited by 1,969
FoxO3 Controls Autophagy in Skeletal Muscle In Vivo
Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953
Mitochondria as sensors and regulators of calcium signalling
Rizzuto, R., De Stefani, D., Raffaello, A., & Mammucari, C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3412 · Cited by 1,781
The cell biology of mitochondrial membrane dynamics
Giacomello, M., Pyakurel, A., Glytsou, C., & Scorrano, L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0210-7 · Cited by 1,550
Functions and dysfunctions of mitochondrial dynamics
Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369
Autophagy maintains stemness by preventing senescence
García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., et al. (2016) · Nature · doi:10.1038/nature16187 · Cited by 1,355
Self-citationMitochondrial ROS Signaling in Organismal Homeostasis
Shadel, G. S., & Horvath, T. L. (2015) · Cell · doi:10.1016/j.cell.2015.10.001 · Cited by 1,353
Cogliati, S., Frezza, C., Soriano, M. E., Varanita, T., Quintana-Cabrera, R., Corrado, M., Cipolat, S., Costa, V., Casarin, A., Gomes, L. C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.032 · Cited by 1,265
Mitochondria and calcium: from cell signalling to cell death
Duchen, M. R. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00057.x · Cited by 1,261
NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice
Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255
Fusion and fission: interlinked processes critical for mitochondrial health
Chan, D. C. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132529 · Cited by 1,196
Cunningham, F., Amode, M. R., Barrell, D., Beal, K., Billis, K., Brent, S., Carvalho-Silva, D., Clapham, P., Coates, G., Fitzgerald, S., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1010 · Cited by 1,115
Ryu, D., Mouchiroud, L., Andreux, P. A., Katsyuba, E., Moullan, N., Nicolet-dit-Félix, A. A., Williams, E. G., Jha, P., Lo Sasso, G., Huzard, D., et al. (2016) · Nature Medicine · doi:10.1038/nm.4132 · Cited by 1,105
AMP-activated protein kinase mediates mitochondrial fission in response to energy stress
Toyama, E. Q., Herzig, S., Courchet, J., Lewis, T. L., Losón, O. C., Hellberg, K., Young, N. P., Chen, H., Polleux, F., Chan, D. C., et al. (2016) · Science · doi:10.1126/science.aab4138 · Cited by 1,085
Ishihara, N., Nomura, M., Jofuku, A., Kato, H., Suzuki, S. O., Masuda, K., Otera, H., Nakanishi, Y., Nonaka, I., Goto, Y.-I., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1907 · Cited by 1,066
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011
Geriatric muscle stem cells switch reversible quiescence into senescence
Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A. L., et al. (2014) · Nature · doi:10.1038/nature13013 · Cited by 1,010
Self-citationThe machineries, regulation and cellular functions of mitochondrial calcium
Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941
mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert
Rodgers, J. T., King, K. Y., Brett, J. O., Cromie, M. J., Charville, G. W., Maguire, K. K., Brunson, C., Mastey, N., Liu, L., Tsai, C.-R., et al. (2014) · Nature · doi:10.1038/nature13255 · Cited by 776
Mitochondrial fusion and fission: The fine‐tune balance for cellular homeostasis
Adebayo, M., Singh, S., Singh, A. P., & Dasgupta, S. (2021) · The FASEB Journal · doi:10.1096/fj.202100067r · Cited by 733
Okatsu, K., Oka, T., Iguchi, M., Imamura, K., Kosako, H., Tani, N., Kimura, M., Go, E., Koyano, F., Funayama, M., et al. (2012) · Nature Communications · doi:10.1038/ncomms2016 · Cited by 629
Ryall, J. G., Dell’Orso, S., Derfoul, A., Juan, A., Zare, H., Feng, X., Clermont, D., Koulnis, M., Gutierrez-Cruz, G., Fulco, M., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.12.004 · Cited by 575
Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice
Sacco, A., Mourkioti, F., Tran, R., Choi, J., Llewellyn, M., Kraft, P., Shkreli, M., Delp, S., Pomerantz, J. H., Artandi, S. E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.11.039 · Cited by 512
Rocheteau, P., Gayraud-Morel, B., Siegl-Cachedenier, I., Blasco, M. A., & Tajbakhsh, S. (2012) · Cell · doi:10.1016/j.cell.2011.11.049 · Cited by 510
Control of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476
Self-citationThe Mitochondrial Inner Membrane Protein Mitofilin Controls Cristae Morphology
John, G. B., Shang, Y., Li, L., Renken, C. W., Mannella, C. A., Selker, J. M. L., Rangell, L. K., Bennett, M. J., & Zha, J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0697 · Cited by 459
Parone, P. A., Da Cruz, S., Tondera, D., Mattenberger, Y., James, D. I., Maechler, P., Barja, F., & Martinou, J.-C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003257 · Cited by 415
Benayoun, B. A., Pollina, E. A., Singh, P. P., Mahmoudi, S., Harel, I., Casey, K. M., Dulken, B. W., Kundaje, A., & Brunet, A. (2019) · Genome Research · doi:10.1101/gr.240093.118 · Cited by 360
Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function
Rambold, A. S., & Pearce, E. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.006 · Cited by 357
AutoAnnotate: A Cytoscape app for summarizing networks with semantic annotations
Kucera, M., Isserlin, R., Arkhangorodsky, A., & Bader, G. D. (2016) · F1000Research · doi:10.12688/f1000research.9090.1 · Cited by 351
Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing
Chandel, N. S., Jasper, H., Ho, T. T., & Passegué, E. (2016) · Nature Cell Biology · doi:10.1038/ncb3385 · Cited by 326
Balsa, E., Soustek, M. S., Thomas, A. J., Cogliati, S., García‐Poyatos, C., Martín-García, E., Jedrychowski, M. P., Gygi, S. P., Enrı́quez, J. A., & Puigserver, P. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.03.031 · Cited by 322
Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence
Song, M., Franco, A., Fleischer, J. A., Zhang, L., & Dorn, G. W. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.023 · Cited by 309
Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation
Tang, A. H., & Rando, T. A. (2014) · The EMBO Journal · doi:10.15252/embj.201488278 · Cited by 294
Perdiguero, E., Sousa-Victor, P., Ruiz-Bonilla, V., Jardí, M., Caelles, C., Serrano, A. L., & Muñoz-Cánoves, P. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201104053 · Cited by 236
Self-citationLiu, S., D’Amico, D., Shankland, E., Bhayana, S., Garcia, J. M., Aebischer, P., Rinsch, C., Singh, A., & Marcinek, D. J. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.44279 · Cited by 235
The Spectrum of Mitochondrial Ultrastructural Defects in Mitochondrial Myopathy
Vincent, A. E., Ng, Y. S., White, K., Davey, T., Mannella, C. A., Falkous, G., Feeney, C. L., Schaefer, A. M., McFarland, R., Gorman, G. S., et al. (2016) · Scientific Reports · doi:10.1038/srep30610 · Cited by 234
Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy
Luan, P., D’Amico, D., Andreux, P. A., Laurila, P., Wohlwend, M., Li, H., de Lima, T. I., Place, N., Rinsch, C., Zanou, N., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abb0319 · Cited by 208
Ishihara, T., Ban-Ishihara, R., Maeda, M., Matsunaga, Y., Ichimura, A., Kyogoku, S., Aoki, H., Katada, S., Nakada, K., Nomura, M., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01054-14 · Cited by 200
Pala, F., Di Girolamo, D., Mella, S., Yennek, S., Chatre, L., Ricchetti, M., & Tajbakhsh, S. (2018) · Journal of Cell Science · doi:10.1242/jcs.212977 · Cited by 184
Sahu, A., Mamiya, H., Shinde, S. N., Cheikhi, A., Winter, L., Vo, N. V., Stolz, D. B., Roginskaya, V. Y., Tang, W., Croix, C. M. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07253-3 · Cited by 178
Li, H., Ruan, Y., Zhang, K., Jian, F., Hu, C., Miao, L., Gong, L., Sun, L., Zhang, X., Chen, S., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.102 · Cited by 171
Shavlakadze, T., Morris, M., Fang, J., Wang, S. X., Zhu, J., Zhou, W., Tse, H. W., Mondragon-Gonzalez, R., Roma, G., & Glass, D. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.043 · Cited by 170
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age
García-Prat, L., Perdiguero, E., Alonso-Martín, S., Dell’Orso, S., Ravichandran, S., Brooks, S. R., Juan, A. H., Campanario, S., Jiang, K., Hong, X., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-00593-7 · Cited by 161
Self-citationTranscriptional Signatures of Aging
Stegeman, R., & Weake, V. M. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.06.019 · Cited by 146
Skeletal muscle stem cells in comfort and stress
Evano, B., & Tajbakhsh, S. (2018) · npj Regenerative Medicine · doi:10.1038/s41536-018-0062-3 · Cited by 144
AMPK Promotes Autophagy by Facilitating Mitochondrial Fission
Zhang, C., & Lin, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.02.017 · Cited by 142
Biomarker system for studying muscle, stem cells, and cancer in vivo
Nishijo, K., Hosoyama, T., Bjornson, C. R. R., Schaffer, B. S., Prajapati, S. I., Bahadur, A. N., Hansen, M. S. T., Blandford, M. C., McCleish, A. T., Rubin, B. P., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-128116 · Cited by 132
Proteostatic and Metabolic Control of Stemness
García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.04.011 · Cited by 125
In vitro-reconstituted nucleoids can block mitochondrial DNA replication and transcription.
Farge, G., Mehmedović, M., Baclayon, M., van den Wildenberg, S., Roos, W., Gustafsson, C., Wuite, G., & Falkenberg, M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.046 · Cited by 112
The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells
White, J. P., Billin, A. N., Campbell, M. E., Russell, A. J., Huffman, K. M., & Kraus, W. E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.014 · Cited by 104
Mitofusin gain and loss of function drive pathogenesis in Drosophila models of CMT2A neuropathy
Fissi, N. E., Rojo, M., Aouane, A., Karataş, E., Poliacikova, G., David, C., Royet, J., & Rival, T. (2018) · EMBO Reports · doi:10.15252/embr.201745241 · Cited by 96
Busch, K. B., Kowald, A., & Spelbrink, J. N. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0442 · Cited by 87
Trends in tissue repair and regeneration
Galliot, B., Crescenzi, M., Jacinto, A., & Tajbakhsh, S. (2017) · Development · doi:10.1242/dev.144279 · Cited by 81
Stem cell aging in the skeletal muscle: The importance of communication
Hong, X., Campanario, S., Ramírez‐Pardo, I., Grima-Terrén, M., Isern, J., & Muñoz‐Cánoves, P. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101528 · Cited by 73
uPA deficiency exacerbates muscular dystrophy in MDX mice
Suelves, M., Vidal, B., Serrano, A. L., Tjwa, M., Roma, J. M., López‐Alemany, R., Luttun, A., de Lagrán, M. M., Díaz, M. À., Jardı́, M., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705127 · Cited by 70
Corrado, M., Samardžić, D., Giacomello, M., Rana, N., Pearce, E. L., & Scorrano, L. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00747-6 · Cited by 49
Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential
Kuroda, Y., Sako, W., Goto, S., Sawada, T., Uchida, D., Izumi, Y., Takahashi, T., Kagawa, N., Matsumoto, M., Matsumoto, M., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr530 · Cited by 28
Freeze Injury of the Tibialis Anterior Muscle
Le, G., Lowe, D. A., & Kyba, M. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3810-0_3 · Cited by 25
Muscle stem cell aging: identifying ways to induce tissue rejuvenation
Sousa‐Victor, P., Neves, J., & Muñoz‐Cánoves, P. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111246 · Cited by 18
Mitochondrial dynamics: roles in exercise physiology and muscle mass regulation
Djalalvandi, A., & Scorrano, L. (2022) · Current Opinion in Physiology · doi:10.1016/j.cophys.2022.100550 · Cited by 14
Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy
Liaghati, A., Pileggi, C. A., Parmar, G., Patten, D. A., Hadžimustafić, N., Cuillerier, A., Menzies, K. J., Burelle, Y., & Harper, M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.604210 · Cited by 13
Cited by
Sorted by citations
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
Xu, X., Pang, Y., & Fan, X. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02253-4 · Cited by 1,016
Mitophagy in human health, ageing and disease
Picca, A., Faitg, J., Auwerx, J., Ferrucci, L., & D’Amico, D. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00930-8 · Cited by 635
“This indicates that the age-related decrease in satellite cell regenerative capacity can be partly ascribed to reduced mitochondrial signalling control 43 .”
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction
Monzel, A. S., Enrı́quez, J. A., & Picard, M. A. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00783-1 · Cited by 632
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
Moiseeva, V., Cisneros, A., Sica, V., Deryagin, O., Lai, Y., Jung, S., Andrés, E., An, J., Segalés, J., Ortet, L., et al. (2023) · Nature · doi:10.1038/s41586-022-05535-x · Cited by 423
Sarcopenic obesity: Emerging mechanisms and therapeutic potential
Axelrod, C. L., Dantas, W. S., & Kirwan, J. P. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155639 · Cited by 204
“Consistently, restoration of oxidative phosphorylation (OXPHOS) capacity and mitochondrial quality control rescues the regenerative failure of excessive mitochondrial fission in aged satellite cells [43].”
Background
Metadata
- Authors
- Hong, X., Isern, J., Campanario, S., Perdiguero, E., Ramírez-Pardo, I., Segalés, J., Hernansanz-Agustín, P., Curtabbi, A., Deryagin, O., Pollán, A., González-Reyes, J. A., Villalba, J. M., Sandri, M., Serrano, A. L., Enríquez, J. A., & Muñoz-Cánoves, P.
- Affiliations
- Spanish National Centre for Cardiovascular Research (ES)
- Universitat Pompeu Fabra (ES)
- University of Córdoba (ES)
- University of Padua (IT)
- ORCID
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 29
- Issue
- 9
- Pages
- 1298-1314.e10
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W4292646798
- Cited by
- 213
- References
- 81
- Citations by year
- 2026: 53 · 2025: 68 · 2024: 51 · 2023: 36 · 2022: 5
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Update notices
- erratum (2022-10-06)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by-nc-nd)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES16/10/00282)
- Milky Way Research Foundation
- European Commission (H2020, 202033, 825825)
- Associazione Italiana per la Ricerca sul Cancro
- Centro Nacional de Investigaciones Cardiovasculares (MDM-2014-0370, SEV‐2015‐0505, HR17-00040, ERC-2016-AdG-741966, UPGRADE-H2020-825825)
- Horizon 2020 Framework Programme (UPGRADE-H2020-825825, 825825)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- mitochondrial dynamics, satellite cells, muscle regeneration, aging, mitochondrial fission, mitochondrial fusion, mitophagy, oxidative phosphorylation, electron transport chain, oxidative stress, stem cell quiescence, sarcopenia, skeletal muscle stem cells
- MeSH terms
- Aged, Humans, Mitochondria, Muscles, Stem Cells, Muscle, Skeletal, Mitochondrial Dynamics, Mitophagy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
