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PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease
Open accessAbstract
Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there are no efficient therapies for AD. Most studies have focused on neuronal cells, but astrocytes have also been suggested to contribute to AD pathology. We describe here the generation of functional astrocytes from induced pluripotent stem cells (iPSCs) derived from AD patients with PSEN1 ΔE9 mutation, as well as healthy and gene-corrected isogenic controls. AD astrocytes manifest hallmarks of disease pathology, including increased β-amyloid production, altered cytokine release, and dysregulated Ca 2+ homeostasis. Furthermore, due to altered metabolism, AD astrocytes show increased oxidative stress and reduced lactate secretion, as well as compromised neuronal supportive function, as evidenced by altering Ca 2+ transients in healthy neurons. Our results reveal an important role for astrocytes in AD pathology and highlight the strength of iPSC-derived models for brain diseases.
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“In our study, the continuum of GFAF/S100B-positive cells, ranging from roundish/polarized ones to highly arborized cells, agrees with previous studies [27,28].”
From Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease (2022) · cites this paper as [27]
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“Ast-AD revealed fewer GFAP-positive cells than S100B-positive ones, with low HMGB1 and IL-10 and elevated IL-6 and C/EBPα gene levels, already pointing to some altered properties [27,72,120].”
From Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease (2022) · cites this paper as [27]
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“Characterization for genetic stability and pluripotency markers of these iPSCs was previously documented in studies using iPSC differentiation into astrocytes and microglia for the screening of AD-associated glial aberrancies [26,27].”
From Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease (2022) · cites this paper as [27]
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“The cells displayed heterogeneous shapes, but mostly the stellate morphology characteristic of glial cells [27] (Figure 6B), and the astrocyte-associated GFAP and S100B markers (Figure 6C)”
From Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease (2022) · cites this paper as [27]
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“some authors have stimulated astrocytes with TNF-α and IL-1β to make their pathological profiles more visible [27].”
From Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease (2022) · cites this paper as [27]
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“because astrocytes are known to contribute to neuroinflammation when reactive”
From Emerging Role of miR-21-5p in Neuron–Glia Dysregulation and Exosome Transfer Using Multiple Models of Alzheimer’s Disease (2022) · cites this paper as [27]
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009) · Nature Biotechnology · doi:10.1038/nbt.1529 · Cited by 3,620
Blennow, K., de Leon, M. J., & Zetterberg, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69113-7 · Cited by 3,134
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Sevigny, J., Chiao, P., Bussière, T., Weinreb, P. H., Williams, L., Maier, M., Dunstan, R., Salloway, S., Chen, T., Ling, Y., et al. (2016) · Nature · doi:10.1038/nature19323 · Cited by 3,059
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313
Zhang, Y., Sloan, S. A., Clarke, L. E., Caneda, C., Plaza, C. A., Blumenthal, P. D., Vogel, H., Steinberg, G. K., Edwards, M. S. B., Li, G., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.013 · Cited by 2,295
Oxidative Damage Is the Earliest Event in Alzheimer Disease
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885
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Items 101–200 of 337
Jacquet, A. D. R., Denis, H. L., Cicchetti, F., & Alpaugh, M. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00999-7 · Cited by 36
Dantrolene : From Malignant Hyperthermia to Alzheimer’s Disease
Shi, Y., Wang, Y., & Wei, H. (2018) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527317666180619162649 · Cited by 36
Neural Metabolic Networks: Key Elements of Healthy Brain Function
Madrer, N., Perera, N. D., Uccelli, N. A., Abbondanza, A., Andersen, J. V., Carsana, E. V., Demmings, M. D., Fernandez, R. F., de Fragas, M. G., Gbadamosi, I., et al. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70084 · Cited by 37
Korhonen, P., Malm, T., & White, A. R. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.08.012 · Cited by 34
García‐León, J. A., Cáceres-Palomo, L., Sánchez‐Mejías, E., Mejias‐Ortega, M., Nuñez‐Diaz, C., Fernandez-Valenzuela, J. J., Sanchez-Varo, R. M., Dávila, J. C., Vitórica, J., & Gutiérrez, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186867 · Cited by 35
Contribution of astrocytes to familial risk and clinical manifestation of schizophrenia
Koskuvi, M., Lehtonen, Š., Trontti, K., Keuters, M. H., Wu, Y., Koivisto, H., Ludwig, A., Plotnikova, L. M., Virtanen, P. L. J., Räsänen, N., et al. (2021) · Glia · doi:10.1002/glia.24131 · Cited by 34
Self-citationThe regulatory effects of lactic acid on neuropsychiatric disorders
Chen, X., Zhang, Y., Wang, H., Liu, L., Li, W., & Xie, P. P. (2022) · Discover Mental Health · doi:10.1007/s44192-022-00011-4 · Cited by 34
Ghaffari, L., Starr, A., Nelson, A. T., & Sattler, R. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00056 · Cited by 35
Gomes, C., Sequeira, C., Barbosa, M., Cunha, C., Vaz, A. R., & Brites, D. M. T. O. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112209 · Cited by 40
Bell, S., Wareing, H. E., Capriglia, F., Hughes, R. M., Barnes, K., Hamshaw, A., Adair, L. D., Shaw, A. C., Olejnik, A., De, S., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02746-8 · Cited by 35
Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans
Sarasija, S., & Norman, K. R. (2018) · Antioxidants · doi:10.3390/antiox7090111 · Cited by 31
Alzheimer’s in a dish – induced pluripotent stem cell-based disease modeling
de Leeuw, S., & Tackenberg, C. (2019) · Translational Neurodegeneration · doi:10.1186/s40035-019-0161-0 · Cited by 31
Mullane, K., & Williams, M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.09.027 · Cited by 32
Intracellular Ca2+ signalling: unexpected new roles for the usual suspect
Moccia, F. D., Fiorio, A., Lim, D., Lodola, F., & Gerbino, A. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1210085 · Cited by 36
Soto‐Mercado, V., Mendivil‐Perez, M., Velez‐Pardo, C., Lopera, F. J., & Jiménez-Del-Río, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0221669 · Cited by 33
The role of cell type-specific mitochondrial dysfunction in the pathogenesis of Alzheimer's disease
Kim, D., & Mook‐Jung, I. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.12.282 · Cited by 31
Means, J. C., Lopez, A. A., & Koulen, P. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00781-6 · Cited by 32
Gomes, C., Sequeira, C., Likhite, S. B., Dennys, C. N., Kolb, S. J., Shaw, P. J., Vaz, A. R., Kaspar, B. K., Meyer, K., & Brites, D. M. T. O. (2022) · Cells · doi:10.3390/cells11071186 · Cited by 32
Astrocytes: From the Physiology to the Disease
Trujillo‐Estrada, L., Gómez-Arboledas, Á., Forner, S., Martini, A. C., Gutiérrez, A., Baglietto‐Vargas, D., & LaFerla, F. M. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190830110152 · Cited by 30
Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?
Rodríguez-Jiménez, F. J., Ureña‐Peralta, J. R., Jendelová, P., & Erceg, S. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.01.006 · Cited by 33
García‐León, J. A., Vitórica, J., & Gutiérrez, A. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0520 · Cited by 30
Corrupted ER‐mitochondrial calcium homeostasis promotes the collapse of proteostasis
Ashkavand, Z., Sarasija, S., Ryan, K. C., Laboy, J. T., & Norman, K. R. (2019) · Aging Cell · doi:10.1111/acel.13065 · Cited by 28
Mitochondrial Calcium Signaling as a Therapeutic Target for Alzheimer’s Disease
Wu, A. J., Tong, B. C., Huang, S., Li, M., & Cheung, K. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666191210091302 · Cited by 30
Emerging hiPSC Models for Drug Discovery in Neurodegenerative Diseases
Trudler, D., Ghatak, S., & Lipton, S. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158196 · Cited by 30
Ryan, K. C., Ashkavand, Z., Sarasija, S., Laboy, J. T., Samarakoon, R., & Norman, K. R. (2021) · Aging Cell · doi:10.1111/acel.13472 · Cited by 27
Animal and Cellular Models of Alzheimer’s Disease: Progress, Promise, and Future Approaches
Trujillo‐Estrada, L., Sánchez‐Mejías, E., Sanchez-Varo, R. M., García‐León, J. A., Nuñez‐Diaz, C., Dávila, J. C., Vitórica, J., LaFerla, F. M., Moreno‐González, I., Gutiérrez, A., et al. (2021) · The Neuroscientist · doi:10.1177/10738584211001753 · Cited by 30
Li, S., Zhou, W., Li, D., Pan, T., Guo, J., Zou, H., Tian, Z., Li, K., Xu, J., Li, X., et al. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.03.002 · Cited by 29
A metagenomic study of gut viral markers in amyloid-positive Alzheimer’s disease patients
Ghorbani, M., Ferreira, D., & Maioli, S. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01285-8 · Cited by 29
Pushparaj, P. N., Gauthaman, K., Sait, K., & Rasool, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.720170 · Cited by 27
Manipulation of the diet–microbiota–brain axis in Alzheimer’s disease
Lee, D. D., Lee, V. M. ‐., & Hur, S. K. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1042865 · Cited by 27
Modeling Neurological Disorders with Human Pluripotent Stem Cell-Derived Astrocytes
Suga, M., Kondo, T., & Inoue, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163862 · Cited by 27
The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer’s Disease Modeling
Lee, C., Willerth, S. M., & Nygaard, H. B. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101804 · Cited by 24
Grubman, A., Vandekolk, T. H., Schröder, J., Sun, G., Hatwell-Humble, J., Chan, J. M., Oksanen, M., Lehtonen, Š., Hunt, C. P. J., Koıstınaho, J., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.04.007 · Cited by 26
Self-citationHasan, U., & Singh, S. K. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9068-9_1 · Cited by 23
Qu, W., Canoll, P., & Hargus, G. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2022.05.006 · Cited by 24
ORAI2 Down-Regulation Potentiates SOCE and Decreases Aβ42 Accumulation in Human Neuroglioma Cells
Scremin, E., Agostini, M., Leparulo, A., Pozzan, T., Greotti, E., & Fasolato, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155288 · Cited by 25
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Li, L., & Shi, Y. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103565 · Cited by 24
iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype
Sullivan, M. A., Lane, S. D., McKenzie, A. D. J., Ball, S. R., Sunde, M., Neely, G. G., Moreno, C. L., Maximova, A., Werry, E. L., & Kassiou, M. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02951-2 · Cited by 23
Modeling human-specific interlaminar astrocytes in the mouse cerebral cortex.
Padmashri, R., Ren, B., Oldham, B., Jung, Y., Gough, R., & Dunaevsky, A. (2021) · Journal of Comparative Neurology · doi:10.1002/cne.24979 · Cited by 21
Yan, Y., Bejoy, J., Marzano, M., & Li, Y. (2019) · Cells · doi:10.3390/cells8030242 · Cited by 21
Zhang, L., Xu, M., Ren, Q., Liu, G., Meng, S., Xiahou, K., Zhang, Y., Jiang, N., & Zhou, W. (2020) · Stem Cells and Development · doi:10.1089/scd.2020.0103 · Cited by 20
Tian, Q., Li, J., Wu, B., Wang, J., Xiao, Q., Tian, N., Yi, L., Luo, M., Li, Z., Pang, Y., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202301173rrr · Cited by 20
Neural In Vitro Models for Studying Substances Acting on the Central Nervous System
Fritsche, E., Tigges, J., Hartmann, J., Kapr, J., Serafini, M. M., & Viviani, B. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_367 · Cited by 21
Elsworthy, R. J., King, M. C., Grainger, A. I., Fisher, E., Crowe, J. A., Alqattan, S., Ludlam, A., Hill, E. J., & Aldred, S. (2021) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2021.103631 · Cited by 19
Kramann, N., Menken, L., Pförtner, R., Schmid, S. N., Stadelmann, C., Wegner, C., & Brück, W. (2019) · Glia · doi:10.1002/glia.23605 · Cited by 20
Brezováková, V., Syková, E., & Jadhav, S. (2022) · Cells · doi:10.3390/cells11091429 · Cited by 19
Glial metabolic alterations during glaucoma pathogenesis
Rombaut, A., Brautaset, R., Williams, P. A., & Tribble, J. R. (2023) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1290465 · Cited by 20
Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders
Kumar, M., Nguyen, T. P. N., Milanese, M., & Bonanno, G. (2022) · Biomolecules · doi:10.3390/biom12030344 · Cited by 20
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Arnst, N., Redolfi, N., Lia, A., Bedetta, M., Greotti, E., & Pizzo, P. (2022) · Biomedicines · doi:10.3390/biomedicines10123025 · Cited by 19
Stem cells in the treatment of Alzheimer's disease – Promises and pitfalls
Bhatti, J. S., Khullar, N., Mishra, J., Kaur, S., Sehrawat, A., Sharma, E., Bhatti, G. K., Selman, A., & Reddy, P. H. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166712 · Cited by 19
Laparra, I. C., Juárez‐Escoto, E., Vicario‐Abejón, C., Moratalla, R., & García‐Sanz, P. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1087072 · Cited by 17
Wheeler, H. B., Madrigal, A. A., & Chaim, I. A. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317860121 · Cited by 18
Hawkins, K., & Duchen, M. R. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i5.236 · Cited by 18
Replicates in stem cell models—How complicated!
Chan, J. C. W., & Teo, A. K. K. (2020) · Stem Cells · doi:10.1002/stem.3237 · Cited by 16
Human stem cell transplantation models of Alzheimer’s disease
Ifediora, N., Canoll, P., & Hargus, G. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1354164 · Cited by 18
Ataei, B., Hokmabadi, M., Asadi, S., Asadifard, E., Zarch, S. M. A., Najafi, S., & Bagheri‐Mohammadi, S. (2024) · Gene · doi:10.1016/j.gene.2024.148368 · Cited by 18
Han, F., Liu, C., Huang, J., Chen, J., Wei, C., Geng, X., Liu, Y., Han, D., & Li, M. (2019) · Brain Science Advances · doi:10.1177/2096595819896178 · Cited by 16
Wu, Z., Palanimuthu, D., Braidy, N., Salikin, N. H., Egan, S., Huang, M., & Richardson, D. R. (2020) · British Journal of Pharmacology · doi:10.1111/bph.14963 · Cited by 14
Grekhnev, D. A., Kaznacheyeva, E. V., & Vigont, V. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020624 · Cited by 16
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Human-induced pluripotent stem cells as a model for studying sporadic Alzheimer’s disease
Riemens, R. J. M., Kenis, G., & van den Beucken, T. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107318 · Cited by 16
Mendivil‐Perez, M., Velez‐Pardo, C., Kosik, K. S., Lopera, F. J., & Jiménez-Del-Río, M. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.03.032 · Cited by 15
Wuli, W., Tsai, S., Chiou, T., & Harn, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041327 · Cited by 16
Elsworthy, R. J., Crowe, J. A., King, M. C., Dunleavy, C., Fisher, E., Ludlam, A., Parri, H. R., Hill, E. J., & Aldred, S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02050-5 · Cited by 13
Discovery of new epigenomics-based biomarkers and the early diagnosis of neurodegenerative diseases
Lee, D., Choi, Y. H., Seo, J., Kim, J. K., & Lee, S. B. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101069 · Cited by 14
Chen, S.-D., Li, H., Cui, M., Dong, Q., & Yu, J. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1767579 · Cited by 15
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Rõlova, T., Lehtonen, Š., Goldsteins, G., Kettunen, P., & Koıstınaho, J. (2020) · Stem Cells · doi:10.1002/stem.3309 · Cited by 14
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Liang, K. X., Chen, A., Kianian, A., Kristiansen, C. K., Yangzom, T., Furriol, J., Høyland, L. E., Ziegler, M., Kråkenes, T., Tzoulis, C., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.93445 · Cited by 15
Niskanen, J., Peltonen, S., Ohtonen, S., Fazaludeen, M. F., Luk, K. C., Giudice, L., Koıstınaho, J., Malm, T., Goldsteins, G., Albert, K., et al. (2024) · Glia · doi:10.1002/glia.24626 · Cited by 16
Self-citationTimofeeva, A. M., Aulova, K. S., & Nevinsky, G. A. (2025) · Brain Sciences · doi:10.3390/brainsci15050486 · Cited by 17
Potential of astrocytes in targeting therapy for Alzheimer’s disease
Bi, W., Lei, T., Cai, S., Zhang, X., Yang, Y., Xiao, Z., Wang, L., & Du, H. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109368 · Cited by 13
Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility
Adegunsoye, A., Gonzales, N. M., & Gilad, Y. (2023) · Annual Review of Genetics · doi:10.1146/annurev-genet-022123-090319 · Cited by 16
Important advances in Alzheimer’s disease from the use of induced pluripotent stem cells
Majolo, F., Marinowic, D. R., Machado, D. C., & da Costa, J. C. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0501-5 · Cited by 15
Barthelson, K., Dong, Y., Newman, M., & Lardelli, M. T. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210128 · Cited by 13
Ryu, W., Cohen, B. M., & Sonntag, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.697578 · Cited by 14
Liu, K., Aierken, A., Liu, M.-Y., Parhat, N., Kong, W., Yin, X., Liu, G., Yu, D., Hong, J., Ni, J.-J., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109281 · Cited by 13
Wasielewska, J. M., Szostak, K., McInnes, L. E., Quek, H., Chaves, J. C. S., Liddell, J. R., Koıstınaho, J., Oikari, L. E., Donnelly, P. S., & White, A. R. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00743 · Cited by 11
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Wasielewska, J. M., Chaves, J., White, A. R., & Oikari, L. E. (2020) · Exon Publications eBooks · doi:10.36255/exonpublications.alzheimersdisease.2020.ch7 · Cited by 13
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Metadata
- Authors
- Oksanen, M., Petersen, A. J., Naumenko, N., Puttonen, K., Lehtonen, Š., Gubert Olivé, M., Shakirzyanova, A., Leskelä, S., Sarajärvi, T., Viitanen, M., Rinne, J. O., Hiltunen, M., Haapasalo, A., Giniatullin, R., Tavi, P., Zhang, S.-C., Kanninen, K. M., Hämäläinen, R. H., & Koistinaho, J.
- Affiliations
- University of Eastern Finland (FI)
- University of Wisconsin–Madison (US)
- Karolinska University Hospital (SE)
- University of Turku (FI)
- University of Wisconsin System (US)
- ORCID
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 9
- Issue
- 6
- Pages
- 1885-1897
- ISSN
- 2213-6711 (ISSN-L)
- PMC
- PMC5785689
- OpenAlex
- W2768957663
- Cited by
- 332
- References
- 65
- Citations by year
- 2026: 27 · 2025: 22 · 2024: 46 · 2023: 37 · 2022: 49 · 2021: 41 · 2020: 50 · 2019: 43 · 2018: 17
- FWCI
- 22.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- UEF eRepo (University of Eastern Finland) (submittedVersion, cc-by-nc-nd)
- UTUPub (University of Turku) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Itä-Suomen Yliopisto
- Academy of Finland
- Tekes
- Emil Aaltosen Säätiö
- Sigrid Juséliuksen Säätiö
- Horizon 2020 (643417)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, astrocytes, induced pluripotent stem cells, iPSC-derived astrocytes, amyloid-beta production, cytokine production, calcium homeostasis, oxidative stress, lactate secretion, disease modeling, isogenic controls
- MeSH terms
- Alzheimer Disease, Animals, Astrocytes, Brain, Calcium, Gene Expression Regulation, Humans, Mitochondria, Neurons, Amyloid beta-Peptides, Oxidative Stress, Lactic Acid, Presenilin-1, Induced Pluripotent Stem Cells
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