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Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53

Zanier, Katia, ould M'hamed ould Sidi, Abdellahi, Boulade-Ladame, Charlotte, Rybin, Vladimir, Chappelle, Anne, Atkinson, Andrew, Kieffer, Bruno, Travé, Gilles·2012·Structure
DOI 10.1016/j.str.2012.02.001PMC PMC3325491
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  1. Bosch, 1995, Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group, J. Natl. Cancer Inst., 87, 796, 10.1093/jnci/87.11.796 · DOI
  2. Brimer, 2007, Association of E6AP (UBE3A) with human papillomavirus type 11 E6 protein, Virology, 358, 303, 10.1016/j.virol.2006.08.038 · DOI · Paper page
  3. Camus, 2007, Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6, Oncogene, 26, 4059, 10.1038/sj.onc.1210188 · DOI
  4. Chakrabarti, 2003, Molecular interactions of ‘high risk’ human papillomaviruses E6 and E7 oncoproteins: implications for tumour progression, J. Biosci., 28, 337, 10.1007/BF02970152 · DOI
  5. Chen, 1998, Identification of an alpha helical motif sufficient for association with papillomavirus E6, J. Biol. Chem., 273, 13537, 10.1074/jbc.273.22.13537 · DOI · Paper page
  6. Cooper, 2003, Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53, Virology, 306, 87, 10.1016/S0042-6822(02)00012-0 · DOI
  7. de Souza, 2010, Diversity and evolution of chromatin proteins encoded by DNA viruses, Biochim. Biophys. Acta, 1799, 302, 10.1016/j.bbagrm.2009.10.006 · DOI
  8. de Villiers, 2004, Classification of papillomaviruses, Virology, 324, 17, 10.1016/j.virol.2004.03.033 · DOI
  9. de Vries, 2010, The HADDOCK web server for data-driven biomolecular docking, Nat. Protoc., 5, 883, 10.1038/nprot.2010.32 · DOI
  10. Farrow, 1994, Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation, Biochemistry, 33, 5984, 10.1021/bi00185a040 · DOI
  11. García-Alai, 2007, High-risk HPV E6 oncoproteins assemble into large oligomers that allow localization of endogenous species in prototypic HPV-transformed cell lines, Biochemistry, 46, 341, 10.1021/bi602457q · DOI
  12. Giovane, 1999, Targetting of the N-terminal domain of the human papillomavirus type 16 E6 oncoprotein with monomeric ScFvs blocks the E6-mediated degradation of cellular p53, J. Mol. Recognit., 12, 141, 10.1002/(SICI)1099-1352(199903/04)12:2<141::AID-JMR453>3.0.CO;2-O · DOI
  13. Glaunsinger, 2000, Interactions of the PDZ-protein MAGI-1 with adenovirus E4-ORF1 and high-risk papillomavirus E6 oncoproteins, Oncogene, 19, 5270, 10.1038/sj.onc.1203906 · DOI · Paper page
  14. Grishin, 2001, Treble clef finger—a functionally diverse zinc-binding structural motif, Nucleic Acids Res., 29, 1703, 10.1093/nar/29.8.1703 · DOI
  15. Gross-Mesilaty, 1998, Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway, Proc. Natl. Acad. Sci. USA, 95, 8058, 10.1073/pnas.95.14.8058 · DOI · Paper page
  16. Gu, 2001, A sequence element of p53 that determines its susceptibility to viral oncoprotein-targeted degradation, Oncogene, 20, 3519, 10.1038/sj.onc.1204454 · DOI
  17. Herrmann, 2002, Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA, J. Mol. Biol., 319, 209, 10.1016/S0022-2836(02)00241-3 · DOI
  18. Herrmann, 2002, Protein NMR structure determination with automated NOE-identification in the NOESY spectra using the new software ATNOS, J. Biomol. NMR, 24, 171, 10.1023/A:1021614115432 · DOI
  19. Huibregtse, 1993, Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins, Mol. Cell. Biol., 13, 4918
  20. Jing, 2007, Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins, J. Virol., 81, 2231, 10.1128/JVI.01979-06 · DOI
  21. Kao, 2000, Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase, J. Virol., 74, 6408, 10.1128/JVI.74.14.6408-6417.2000 · DOI
  22. Kiyono, 1997, Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein, Proc. Natl. Acad. Sci. USA, 94, 11612, 10.1073/pnas.94.21.11612 · DOI · Paper page
  23. Koradi, 1996, MOLMOL: a program for display and analysis of macromolecular structures, J. Mol. Graph., 14, 51, 10.1016/0263-7855(96)00009-4 · DOI
  24. Li, 1996, High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation, J. Virol., 70, 4509, 10.1128/jvi.70.7.4509-4516.1996 · DOI
  25. Linge, 2003, Refinement of protein structures in explicit solvent, Proteins, 50, 496, 10.1002/prot.10299 · DOI
  26. Lipari, 2001, Purification and biophysical characterization of a minimal functional domain and of an N-terminal Zn2+-binding fragment from the human papillomavirus type 16 E6 protein, Biochemistry, 40, 1196, 10.1021/bi001837+ · DOI
  27. Liu, 1999, Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells, J. Virol., 73, 7297, 10.1128/JVI.73.9.7297-7307.1999 · DOI · Paper page
  28. Liu, 2009, Determinants of stability for the E6 protein of papillomavirus type 16, J. Mol. Biol., 386, 1123, 10.1016/j.jmb.2009.01.018 · DOI
  29. Massimi, 2008, HPV E6 degradation of p53 and PDZ containing substrates in an E6AP null background, Oncogene, 27, 1800, 10.1038/sj.onc.1210810 · DOI
  30. Masson, 2003, Preferential nuclear sublocalization of HPV16 E6 oncoprotein in cervical carcinoma cells, J. Gen. Virol., 84, 2099, 10.1099/vir.0.18961-0 · DOI
  31. Nabuurs, 2004, DRESS: a database of REfined solution NMR structures, Proteins, 55, 483, 10.1002/prot.20118 · DOI
  32. Nominé, 2001, A strategy for optimizing the monodispersity of fusion proteins: application to purification of recombinant HPV E6 oncoprotein, Protein Eng., 14, 297, 10.1093/protein/14.4.297 · DOI
  33. Nominé, 2001, Formation of soluble inclusion bodies by hpv e6 oncoprotein fused to maltose-binding protein, Protein Expr. Purif., 23, 22, 10.1006/prep.2001.1451 · DOI
  34. Nominé, 2003, Domain substructure of HPV E6 oncoprotein: biophysical characterization of the E6 C-terminal DNA-binding domain, Biochemistry, 42, 4909, 10.1021/bi026980c · DOI · Paper page
  35. Nominé, 2005, 1H and 15N resonance assignment, secondary structure and dynamic behaviour of the C-terminal domain of human papillomavirus oncoprotein, 31, 129
  36. Ristriani, 2009, A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa cervical cancer cells, Oncogene, 28, 762, 10.1038/onc.2008.422 · DOI
  37. Sattler, 1999, Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients, Prog. Nucl. Magn. Reson. Spectrosc., 34, 93, 10.1016/S0079-6565(98)00025-9 · DOI
  38. Scheffner, 1993, The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53, Cell, 75, 495, 10.1016/0092-8674(93)90384-3 · DOI · Paper page
  39. Scheffner, 1995, Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade, Nature, 373, 81, 10.1038/373081a0 · DOI
  40. Schuck, 2000, Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling, Biophys. J., 78, 1606, 10.1016/S0006-3495(00)76713-0 · DOI
  41. Schwieters, 2003, The Xplor-NIH NMR molecular structure determination package, J. Magn. Reson., 160, 65, 10.1016/S1090-7807(02)00014-9 · DOI
  42. Shai, 2007, HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP, Oncogene, 26, 3321, 10.1038/sj.onc.1210130 · DOI
  43. Sidi, 2011, Strategies for bacterial expression of protein-peptide complexes: application to solubilization of papillomavirus E6, Protein Expr. Purif., 80, 8, 10.1016/j.pep.2011.06.013 · DOI
  44. Stewart, 2004, Ubiquitination and proteasome degradation of the E6 proteins of human papillomavirus types 11 and 18, J. Gen. Virol., 85, 1419, 10.1099/vir.0.19679-0 · DOI
  45. Thomas, 1998, Inhibition of Bak-induced apoptosis by HPV-18 E6, Oncogene, 17, 2943, 10.1038/sj.onc.1202223 · DOI · Paper page
  46. Thomas, 2005, E6 oncoprotein represses p53-dependent gene activation via inhibition of protein acetylation independently of inducing p53 degradation, Mol. Cell, 17, 251, 10.1016/j.molcel.2004.12.016 · DOI · Paper page
  47. Thomas, 2002, Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation, Oncogene, 21, 5088, 10.1038/sj.onc.1205668 · DOI
  48. Tomaić, 2009, The stability of the human papillomavirus E6 oncoprotein is E6AP dependent, Virology, 393, 7, 10.1016/j.virol.2009.07.029 · DOI · Paper page
  49. Tomaic, 2011, Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD, J. Virol., 85, 3120, 10.1128/JVI.02004-10 · DOI
  50. Töpffer, 2007, Protein tyrosine phosphatase H1 is a target of the E6 oncoprotein of high-risk genital human papillomaviruses, J. Gen. Virol., 88, 2956, 10.1099/vir.0.83123-0 · DOI
  51. Vos, 2009, The ubiquitin-specific peptidase USP15 regulates human papillomavirus type 16 E6 protein stability, J. Virol., 83, 8885, 10.1128/JVI.00605-09 · DOI
  52. Werness, 1990, Association of human papillomavirus types 16 and 18 E6 proteins with p53, Science, 248, 76, 10.1126/science.2157286 · DOI · Paper page
  53. Zanier, 2005, Kinetic analysis of the interactions of human papillomavirus E6 oncoproteins with the ubiquitin ligase E6AP using surface plasmon resonance, J. Mol. Biol., 349, 401, 10.1016/j.jmb.2005.03.071 · DOI
  54. Zanier, 2007, Formation of well-defined soluble aggregates upon fusion to MBP is a generic property of E6 proteins from various human papillomavirus species, Protein Expr. Purif., 51, 59, 10.1016/j.pep.2006.07.029 · DOI
  55. Zanier, 2010, E6 proteins from diverse papillomaviruses self-associate both in vitro and in vivo, J. Mol. Biol., 396, 90, 10.1016/j.jmb.2009.11.022 · DOI

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Metadata

Authors
Zanier, K., ould M'hamed ould Sidi, A., Boulade-Ladame, C., Rybin, V., Chappelle, A., Atkinson, A., Kieffer, B., & Travé, G.
Venue
Structure
Publisher
Elsevier BV
Published
2012-04
Volume
20
Issue
4
Pages
604-617
ISSN
0969-2126
DOI
10.1016/j.str.2012.02.001
PMC
PMC3325491
Cited by
125
References
5
Language
en
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CoChat. (2026). Citation check: Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53. https://app.cochat.ai/papers/10.1016/j.str.2012.02.001
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Zanier, K., ould M'hamed ould Sidi, A., Boulade-Ladame, C., Rybin, V., Chappelle, A., Atkinson, A., Kieffer, B., & Travé, G. (2012). Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53. Structure. https://doi.org/10.1016/j.str.2012.02.001