PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity
Open accessAbstract
Activity-dependent modification of excitatory synaptic transmission is a fundamental mechanism for developmental plasticity of the neural circuits and experience-dependent plasticity. Synaptic glutamatergic receptors including AMPA receptors and NMDA receptors (AMPARs and NMDARs) are embedded in the postsynaptic density, a highly organized protein network. Overwhelming data have shown that PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs), a major family of scaffold proteins at glutamatergic synapses, regulate basal synaptic AMPAR function and trafficking. It is now clear that PSD-MAGUKs have multifaceted functions in regulating both basal synaptic transmission and synaptic plasticity. Here we discuss recent advancements in understanding the roles of PSD-95 and other family members of PSD-MAGUKs in synaptic plasticity, both as an anchoring protein for synaptic AMPARs and as a signaling scaffold for mediating the interaction of the signaling complex and NMDARs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activation of mTORC1 leads to translation of synaptic proteins that are important molecular contributors to memory processes.
“Furthermore, we show that the activation of mTORC1 leads to the translation of synaptic proteins that are important molecular contributors to memory processes32-35.”
From Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse (2013) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
Study, P. A. R. I. S., Jamain, S., Quach, H., Betancur, C., Råstam, M., Colineaux, C., Gillberg, I. C., Soderstrom, H., Giros, B., Leboyer, M., et al. (2003) · Nature Genetics · doi:10.1038/ng1136 · Cited by 1,851 · see citing works
Durand, C. M., Betancur, C., Boeckers, T. M., Bockmann, J., Chaste, P., Fauchereau, F., Nygren, G., Rastam, M., Gillberg, I. C., Anckarsäter, H., et al. (2007) · Nature Genetics · doi:10.1038/ng1933 · Cited by 1,602 · see citing works
PDZ domain proteins of synapses
Kim, E., & Sheng, M. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1517 · Cited by 1,565 · see citing works
Migaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G. M., Morrison, J. H., et al. (1998) · Nature · doi:10.1038/24790 · Cited by 1,160 · see citing works
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111 · see citing works
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system
Ehlers, M. D. (2003) · Nature Neuroscience · doi:10.1038/nn1013 · Cited by 977 · see citing works
Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number
Schnell, E., Sizemore, M., Karimzadegan, S., Chen, L., Bredt, D. S., & Nicoll, R. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172511199 · Cited by 691 · see citing works
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S. M., & Yahata, N. (2000) · RePEc: Research Papers in Economics · Cited by 680 · see citing works
Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
Yashiro, K., & Philpot, B. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.046 · Cited by 649 · see citing works
Synaptic Strength Regulated by Palmitate Cycling on PSD-95
El-Husseini, A., Schnell, E., Dakoji, S., Sweeney, N. T., Zhou, Q., Prange, O., Gauthier-Campbell, C., Aguilera-Moreno, A., Nicoll, R. A., & Bredt, D. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00683-9 · Cited by 569 · see citing works
Ubiquitination Regulates PSD-95 Degradation and AMPA Receptor Surface Expression
Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., & Scott, J. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00687-1 · Cited by 567 · see citing works
Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation
Berkel, S., Marshall, C. R., Weiss, B., Howe, J., Roeth, R., Moog, U., Endris, V., Roberts, W., Szatmari, P., Pinto, D., et al. (2010) · Nature Genetics · doi:10.1038/ng.589 · Cited by 563 · see citing works
A developmental change in NMDA receptor-associated proteins at hippocampal synapses
Sans, N., Petralia, R. S., Wang, Y.-X., Blahos, J., Hell, J. W., & Wenthold, R. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-03-01260.2000 · Cited by 537 · see citing works
PSD-95 is required for activity-driven synapse stabilization.
Ehrlich, I., Klein, M., Rumpel, S., & Malinow, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609307104 · Cited by 470 · see citing works
Postsynaptic organisation and regulation of excitatory synapses
Scannevin, R. H., & Huganir, R. L. (2000) · Nature reviews. Neuroscience · doi:10.1038/35039075 · Cited by 460 · see citing works
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S., & Yahata, N. (2000) · Nature · doi:10.1038/35046031 · Cited by 447 · see citing works
Elias, G. M., Funke, L., Stein, V., Grant, S., Bredt, D., & Nicoll, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.012 · Cited by 413 · see citing works
Synapse-specific regulation of AMPA receptor function by PSD-95.
Béïque, J.-C., Lin, D.-T., Kang, M.-G., Aizawa, H., Takamiya, K., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608492103 · Cited by 398 · see citing works
Identification of PSD-95 as a Regulator of Dopamine-Mediated Synaptic and Behavioral Plasticity
Yao, W., Gainetdinov, R. R., Arbuckle, M. I., Sotnikova, T. D., Cyr, M., Beaulieu, J., Torres, G. E., Grant, S. G. N., & Caron, M. G. (2004) · Neuron · doi:10.1016/s0896-6273(04)00048-0 · Cited by 380 · see citing works
Leonard, A. S., Davare, M. A., Horne, M. C., Garner, C. C., & Hell, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19518 · Cited by 374 · see citing works
Yoshii, A., & Constantine-Paton, M. (2007) · Nature Neuroscience · doi:10.1038/nn1903 · Cited by 345 · see citing works
Protein palmitoylation: a regulator of neuronal development and function
El-Husseini, A., & Bredt, D. S. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn940 · Cited by 341 · see citing works
Stein, V., House, D. R. C., Bredt, D. S., & Nicoll, R. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05503.2003 · Cited by 341 · see citing works
PSD‐95 regulates synaptic transmission and plasticity in rat cerebral cortex
Béïque, J.-C., & Andrade, R. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.031369 · Cited by 313 · see citing works
Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins
Elias, G. M., & Nicoll, R. A. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.005 · Cited by 288 · see citing works
Homeostatic signaling: the positive side of negative feedback
Turrigiano, G. G. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.004 · Cited by 285 · see citing works
Kim, M. J., Futai, K., Jo, J., Hayashi, Y., Cho, K., & Sheng, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.007 · Cited by 278 · see citing works
Sans, N., Racca, C., Petralia, R. S., Wang, Y., McCallum, J. D., & Wenthold, R. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07506.2001 · Cited by 262 · see citing works
Steiner, P., Higley, M. J., Xu, W., Czervionke, B. L., Malenka, R. C., & Sabatini, B. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.014 · Cited by 259 · see citing works
Self-citationSchlüter, O. M., Xu, W., & Malenka, R. C. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.016 · Cited by 254 · see citing works
Self-citationReceptor compartmentalization and trafficking at glutamate synapses: a developmental proposal
van Zundert, B., Yoshii, A., & Constantine‐Paton, M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.010 · Cited by 252 · see citing works
NMDA Di-Heteromeric Receptor Populations and Associated Proteins in Rat Hippocampus
Al‐Hallaq, R. A., Conrads, T. P., Veenstra, T. D., & Wenthold, R. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2155-07.2007 · Cited by 244 · see citing works
Mass of the postsynaptic density and enumeration of three key molecules
Chen, X., Vinade, L., Leapman, R. D., Petersen, J. D., Nakagawa, T., Phillips, T. M., Sheng, M., & Reese, T. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505359102 · Cited by 236 · see citing works
Elias, G. M., Elias, L. A. B., Apostolides, P. F., Kriegstein, A. R., & Nicoll, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811025106 · Cited by 223 · see citing works
Tavalin, S. J., Colledge, M., Hell, J. W., Langeberg, L. K., Huganir, R. L., & Scott, J. D. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03044.2002 · Cited by 222 · see citing works
Kristiansen, L. V., Beneyto, M., Haroutunian, V, & Meador-Woodruff, J. H. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001844 · Cited by 220 · see citing works
Opazo, P., Watabe, A. M., Grant, S. G. N., & O'Dell, T. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-09-03679.2003 · Cited by 215 · see citing works
Nakagawa, T., Futai, K., Lashuel, H. A., Lo, I., Okamoto, K., Walz, T., Hayashi, Y., & Sheng, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.012 · Cited by 214 · see citing works
<i>Sapap3</i> and pathological grooming in humans: Results from the OCD collaborative genetics study
Bienvenu, O. J., Wang, Y., Shugart, Y. Y., Welch, J. M., Grados, M. A., Fyer, A. J., Rauch, S. L., McCracken, J. T., Rasmussen, S. A., Murphy, D. L., et al. (2009) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30897 · Cited by 207 · see citing works
Kuriu, T., Inoue, A., Bito, H., Sobue, K., & Okabe, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0522-06.2006 · Cited by 206 · see citing works
Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD.
Xu, W., Schlüter, O. M., Steiner, P., Czervionke, B. L., Sabatini, B., & Malenka, R. C. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.027 · Cited by 193 · see citing works
Self-citationA critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors
Bhattacharyya, S., Biou, V., Xu, W., Schlüter, O., & Malenka, R. C. (2009) · Nature Neuroscience · doi:10.1038/nn.2249 · Cited by 185 · see citing works
Self-citationMutations in the DLG3 Gene Cause Nonsyndromic X-Linked Mental Retardation
Tarpey, P., Parnau, J., Blow, M., Woffendin, H., Bignell, G., Cox, C., Cox, J., Davies, H., Edkins, S., Holden, S., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/422703 · Cited by 176 · see citing works
Carlisle, H. J., Fink, A. E., Grant, S. G. N., & O’Dell, T. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163469 · Cited by 172 · see citing works
Cuthbert, P. C., Stanford, L. E., Coba, M. P., Ainge, J. A., Fink, A. E., Opazo, P., Delgado, J. Y., Komiyama, N. H., O’Dell, T. J., & Grant, S. G. N. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4457-06.2007 · Cited by 157 · see citing works
Smith, K. E., Gibson, E. S., & Dell’Acqua, M. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3092-05.2006 · Cited by 141 · see citing works
MAGUKs in synapse assembly and function: an emerging view
Montgomery, J. M., Zamorano, P. L., & Garner, C. C. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3364-5 · Cited by 128 · see citing works
The role of SAP97 in synaptic glutamate receptor dynamics
Howard, M. A., Elias, G. M., Elias, L. A. B., Swat, W., & Nicoll, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914422107 · Cited by 119 · see citing works
PSD93 Regulates Synaptic Stability at Neuronal Cholinergic Synapses
Parker, M. J., Zhao, S., Bredt, D. S., Sanes, J. R., & Feng, G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3865-03.2004 · Cited by 118 · see citing works
Eye opening induces a rapid dendritic localization of PSD-95 in central visual neurons
Yoshii, A., Sheng, M., & Constantine‐Paton, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0335785100 · Cited by 111 · see citing works
Muscarinic receptors induce LTD of NMDAR EPSCs via a mechanism involving hippocalcin, AP2 and PSD-95
Jo, J., Son, G. H., Winters, B. L., Kim, M. J., Whitcomb, D. J., Dickinson, B. A., Lee, Y., Futai, K., Amici, M., Sheng, M., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2636 · Cited by 111 · see citing works
AKAP150‐anchored PKA activity is important for LTD during its induction phase
Lü, Y., Zhang, M., Lim, I. A., Hall, D. D., Allen, M., Medvedeva, Y. V., McKnight, G. S., Usachev, Y. M., & Hell, J. W. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.151662 · Cited by 72 · see citing works
SAP102 Is a Highly Mobile MAGUK in Spines
Zheng, C.-Y., Petralia, R. S., Wang, Y., Kachar, B., & Wenthold, R. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6108-09.2010 · Cited by 70 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
AMPARs and Synaptic Plasticity: The Last 25 Years
Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968 · see citing works
Astrocytic abnormalities and global DNA methylation patterns in depression and suicide
Nagy, C., Suderman, M., Yang, J., Szyf, M., Mechawar, N., Ernst, C., & Turecki, G. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.21 · Cited by 301 · see citing works
Regulation of AMPA receptor surface diffusion by PSD-95 slots
Opazo, P., Sainlos, M., & Choquet, D. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.010 · Cited by 234 · see citing works
Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse
Barak, S., Liu, F., Hamida, S. B., Yowell, Q. V., Neasta, J., Kharazia, V., Janak, P. H., & Ron, D. (2013) · Nature Neuroscience · doi:10.1038/nn.3439 · Cited by 172 · see citing works
Chocyk, A., Bobula, B., Dudys, D., Przyborowska, A., Majcher-Maślanka, I., Hess, G., & Wędzony, K. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12208 · Cited by 153 · see citing works
Howell, B. W., & Smith, K. M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.019 · Cited by 35 · see citing works
lncRNA Neat1 regulates neuronal dysfunction post-sepsis via stabilization of hemoglobin subunit beta
Wu, Y., Li, P., Liu, L., Goodwin, A. J., Halushka, P. V., Hirose, T., Nakagawa, S., Zhou, J., Liu, M., & Fan, H. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.03.011 · Cited by 28 · see citing works
- Authors
- Xu, W.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Xu, Weifeng
- ORCID
- Xu, Weifeng
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 21
- Issue
- 2
- Pages
- 306-312
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC3138136
- OpenAlex
- W1979644674
- Cited by
- 171
- References
- 53
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 13 · 2021: 12 · 2020: 7 · 2019: 10 · 2018: 13 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 11 · 2013: 25 · 2012: 14
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- PMC
- Funders
- National Institute of Mental Health (MH080310)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- PSD-95, synaptic plasticity, postsynaptic density, AMPA receptors, NMDA receptor, glutamatergic synapses, synaptic scaffolds, AMPA receptor trafficking, synaptic transmission, signaling scaffolds
- MeSH terms
- SAP90-PSD95 Associated Proteins, Animals, Humans, Nerve Tissue Proteins, Synaptic Transmission, Neuronal Plasticity, Receptors, N-Methyl-D-Aspartate, Receptors, AMPA
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
