The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets
Open accessAbstract
How proteins specifically localize to the phospholipid monolayer surface of lipid droplets (LDs) is being unraveled. We review here the major known pathways of protein targeting to LDs and suggest a classification framework based on the localization origin for the protein. Class I proteins often have a membrane-embedded, hydrophobic ‘hairpin’ motif, and access LDs from the endoplasmic reticulum (ER) either during LD formation or after formation via ER-LD membrane bridges. Class II proteins access the LD surface from the cytosol and bind through amphipathic helices or other hydrophobic domains. Other proteins require lipid modifications or protein-protein interactions to bind to LDs. We summarize knowledge for targeting and removal of the different classes, and highlight areas needing investigation.
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Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
THE FUNCTION OF CYTIDINE COENZYMES IN THE BIOSYNTHESIS OF PHOSPHOLIPIDES
Kennedy, E. P., & Weiss, S. B. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50785-2 · Cited by 1,810
Lipid Droplets and Cellular Lipid Metabolism
Walther, T. C., & Farese, R. V. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061009-102430 · Cited by 1,661
Self-citationProteomic characterization of the human centrosome by protein correlation profiling
Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A., & Mann, M. (2003) · Nature · doi:10.1038/nature02166 · Cited by 1,319
Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance
Yang, L., Li, P., Fu, S., Calay, E. S., & Hotamisligil, G. S. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.005 · Cited by 1,274 · cited 1×
“Yang et al. (2010)a Details to be added 101.”
Rambold, A. S., Cohen, S., & Lippincott-Schwartz, J. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.029 · Cited by 1,038
The biophysics and cell biology of lipid droplets
Thiam, A. R., Farese Jr, R. V., & Walther, T. C. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3699 · Cited by 986
Self-citationSegrest, J., Jones, M., De Loof, H., Brouillette, C., Venkatachalapathi, Y., & Anantharamaiah, G. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41536-6 · Cited by 866
Wilfling, F., Wang, H., Haas, J. T., Krahmer, N., Gould, T. J., Uchida, A., Cheng, J.-X., Graham, M., Christiano, R., Fröhlich, F., et al. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.01.013 · Cited by 806
Self-citationBrasaemle, D. L., Dolios, G., Shapiro, L., & Wang, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409340200 · Cited by 804
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Insulin action and resistance in obesity and type 2 diabetes
Czech, M. P. (2017) · Nature Medicine · doi:10.1038/nm.4350 · Cited by 1,258
Lipid droplets and liver disease: from basic biology to clinical implications
Gluchowski, N. L., Becuwe, M., Walther, T. C., & Farese, R. V. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.32 · Cited by 677
Self-citationLipid droplet functions beyond energy storage
Welte, M. A., & Gould, A. P. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.07.006 · Cited by 577
Veglia, F., Tyurin, V. A., Mohammadyani, D., Blasi, M., Duperret, E. K., Donthireddy, L., Hashimoto, A., Kapralov, A., Amoscato, A., Angelini, R., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02186-9 · Cited by 308
Plant Lipid Droplets and Their Associated Proteins: Potential for Rapid Advances
Huang, A. H. C. (2018) · Plant Physiology · doi:10.1104/pp.17.01677 · Cited by 287
Metadata
- Authors
- Kory, N., Farese, R. V., & Walther, T. C.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 26
- Issue
- 7
- Pages
- 535-546
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2297029819
- Cited by
- 317
- References
- 118
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- green
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