Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation

Translating the Histone Code

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Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · see citing works

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253 · see citing works

Requirement of NAD and <i>SIR2</i> for Life-Span Extension by Calorie Restriction in <i>Saccharomyces cerevisiae</i>

Lin, S.-J., Defossez, P.-A., & Guarente, L. (2000) · Science · doi:10.1126/science.289.5487.2126 · Cited by 1,775 · see citing works

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637 · see citing works

Acetylation and deacetylation of non-histone proteins

Glozak, M. A., Sengupta, N., Zhang, X., & Seto, E. (2005) · Gene · doi:10.1016/j.gene.2005.09.010 · Cited by 1,584 · see citing works

The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

North, B. J., Marshall, B. L., Borra, M. T., Denu, J. M., & Verdin, E. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00038-8 · Cited by 1,542 · see citing works

The Sir2 Family of Protein Deacetylases

Blander, G., & Guarente, L. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073651 · Cited by 1,496 · see citing works

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

Frye, R. A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3000 · Cited by 1,409 · see citing works

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

Michishita, E., Park, J. Y., Burneskis, J. M., Barrett, J. C., & Horikawa, I. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0033 · Cited by 1,364 · see citing works

Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

Haigis, M. C., & Guarente, L. P. (2006) · Genes &amp; Development · doi:10.1101/gad.1467506 · Cited by 1,295 · see citing works

Global histone modification patterns predict risk of prostate cancer recurrence

Seligson, D. B., Horvath, S., Shi, T., Yu, H., Tze, S., Grunstein, M. R., & Kurdistani, S. K. (2005) · Nature · doi:10.1038/nature03672 · Cited by 1,090 · see citing works

Mechanism of Human SIRT1 Activation by Resveratrol

Borra, M. T., Smith, B. C., & Denu, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501250200 · Cited by 1,065 · see citing works

Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor

Gehm, B. D., McAndrews, J. M., Chien, P.-Y., & Jameson, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.14138 · Cited by 1,053 · see citing works

Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

Rosenfeld, M. G., Lunyak, V. V., & Glass, C. K. (2006) · Genes &amp; Development · doi:10.1101/gad.1424806 · Cited by 952 · see citing works

A Topoisomerase IIß-Mediated dsDNA Break Required for Regulated Transcription

Ju, B., Lunyak, V. V., Perissi, V., García-Bassets, I., Rose, D. W., Glass, C. K., & Rosenfeld, M. G. (2006) · Science · doi:10.1126/science.1127196 · Cited by 842 · see citing works

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

Hallows, W. C., Lee, S., & Denu, J. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604392103 · Cited by 792 · see citing works

Substrate-specific activation of sirtuins by resveratrol

Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500655200 · Cited by 745 · see citing works

Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family

Gao, L., Cueto, M. A., Asselbergs, F., & Atadja, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111871200 · Cited by 744 · see citing works

Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

Bordone, L., Motta, M. C., Picard, F., Robinson, A., Jhala, U. S., Apfeld, J., McDonagh, T., Lemieux, M., McBurney, M., Szilvasi, A., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0040031 · Cited by 715 · see citing works

SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes

Shi, T., Wang, F., Stieren, E., & Tong, Q. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414670200 · Cited by 712 · see citing works

Regulation of activity of the transcription factor GATA-1 by acetylation

Boyes, J., Byfield, P., Nakatani, Y., & Ogryzko, V. (1998) · Nature · doi:10.1038/25166 · Cited by 694 · see citing works

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosisPreprint

Vaquero, A., Scher, M. B., Lee, D. H., Sutton, A., Cheng, H.-L., Alt, F. W., Serrano, L., Sternglanz, R., & Reinberg, D. (2006) · Genes & Development · doi:10.1101/gad.1412706 · Cited by 670 · see citing works

Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes

Altenberg, B., & Greulich, K. O. (2004) · Genomics · doi:10.1016/j.ygeno.2004.08.010 · Cited by 662 · see citing works

Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression

Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P. J., & Adcock, I. M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050466 · Cited by 638 · see citing works

Calorie restriction extends yeast life span by lowering the level of NADH

Lin, S.-J., Ford, E., Haigis, M., Liszt, G., & Guarente, L. (2004) · Genes &amp; Development · doi:10.1101/gad.1164804 · Cited by 632 · see citing works

Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice

Moynihan, K. A., Grimm, A. A., Plueger, M. M., Bernal‐Mizrachi, E., Ford, E. L., CRAS-MÉNEUR, C. M. H., Permutt, M. A., & Imai, S. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.07.001 · Cited by 630 · see citing works

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide–dependent deacetylase

Schwer, B., North, B. J., Frye, R. A., Ott, M., & Verdin, E. M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205057 · Cited by 599 · see citing works

Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State

Fulco, M., Schiltz, R. L., Iezzi, S., King, M. T., Zhao, P., Kashiwaya, Y., Hoffman, E. P., Veech, R. L., & Sartorelli, V. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00226-0 · Cited by 590 · see citing works

Parallel SUMOylation-Dependent Pathways Mediate Gene- and Signal-Specific Transrepression by LXRs and PPARγ

Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M.-E., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.11.022 · Cited by 561 · see citing works

Nuclear Trapping of the Forkhead Transcription Factor FoxO1 via Sirt-dependent Deacetylation Promotes Expression of Glucogenetic Genes*

Frescas, D., Valenti, L. N., & Accili, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412357200 · Cited by 554 · see citing works

Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase

Liszt, G., Ford, E., Kurtev, M., & Guarente, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413296200 · Cited by 548 · see citing works

Resveratrol Acts as a Mixed Agonist/Antagonist for Estrogen Receptors α and β*

Bowers, J. L., Tyulmenkov, V. V., Jernigan, S. C., & Klinge, C. M. (2000) · Endocrinology · doi:10.1210/endo.141.10.7721 · Cited by 527 · see citing works

Sirtuins as potential targets for metabolic syndrome

Guarente, L. (2006) · Nature · doi:10.1038/nature05486 · Cited by 468 · see citing works

Histone Methylation-Dependent Mechanisms Impose Ligand Dependency for Gene Activation by Nuclear Receptors

García-Bassets, I., Kwon, Y., Telese, F., Préfontaine, G. G., Hutt, K. R., Cheng, C. S., Ju, B., Ohgi, K. A., Wang, J., Escoubet‐Lozach, L., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.038 · Cited by 438 · see citing works

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

Luo, J., Li, M., Tang, Y., Laszkowska, M., Roeder, R. G., & Gu, W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308762101 · Cited by 419 · see citing works

p300 and p300/cAMP-response Element-binding Protein-associated Factor Acetylate the Androgen Receptor at Sites Governing Hormone-dependent Transactivation

Fu, M., Wang, C., Reutens, A. T., Wang, J., Angeletti, R. H., Siconolfi-Baez, L., Ogryzko, V. V., Avantaggiati, M. L., & Pestell, R. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000660200 · Cited by 409 · see citing works

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages

Bellizzi, D., Rose, G., Cavalcante, P., Covello, G., Dato, S., De Rango, F., Greco, V., Maggiolini, M., Feraco, E., Mari, V., et al. (2005) · Genomics · doi:10.1016/j.ygeno.2004.11.003 · Cited by 367 · see citing works

Direct Acetylation of the Estrogen Receptor α Hinge Region by p300 Regulates Transactivation and Hormone Sensitivity

Wang, C., Fu, M., Angeletti, R. H., Siconolfi-Baez, L., Reutens, A. T., Albanese, C., Lisanti, M. P., Katzenellenbogen, B. S., Kato, S., Hopp, T., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100800200 · Cited by 365 · see citing works

SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1

Bouras, T., Fu, M., Sauve, A. A., Wang, F., Quong, A. A., Perkins, N. D., Hay, R. T., Gu, W. J., & Pestell, R. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m408748200 · Cited by 354 · see citing works

A local mechanism mediates NAD-dependent protection of axon degeneration

Wang, J., Zhai, Q., Chen, Y., Lin, E., Gu, W., McBurney, M. W., & He, Z. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504028 · Cited by 352 · see citing works

Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

Zhang, W., & Bieker, J. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.9855 · Cited by 342 · see citing works

Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.

Bhat, K., Lantvit, D. D., Christov, K. T., Mehta, R. G., Moon, R. C., & Pezzuto, J. M. (2001) · PubMed · Cited by 330 · see citing works

Acetylation of HMG I(Y) by CBP Turns off IFNβ Expression by Disrupting the Enhanceosome

Munshi, N., Merika, M., Yie, J., Senger, K., Chen, G., & Thanos, D. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80145-8 · Cited by 321 · see citing works

Fatty acid synthase: A metabolic oncogene in prostate cancer?

Baron, A., Migita, T., Tang, D., & Loda, M. F. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10708 · Cited by 293 · see citing works

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate

Knights, C. D., Catania, J., Giovanni, S. D., Muratoglu, S. C., Perez, R. E., Swartzbeck, A., Quong, A. A., Zhang, X., Beerman, T. A., Pestell, R. G., et al. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512059 · Cited by 284 · see citing works

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

Rose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V, Passarino, G., Feraco, E., Mari, V, Barbi, C., et al. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00209-2 · Cited by 282 · see citing works

Antiproliferative effect of synthetic resveratrol on human breast epithelial cells.

Mgbonyebi, O. P., Russo, J., & Russo, I. H. (1998) · International Journal of Oncology · doi:10.3892/ijo.12.4.865 · Cited by 276 · see citing works

Acetylation of Androgen Receptor Enhances Coactivator Binding and Promotes Prostate Cancer Cell Growth

Fu, M., Rao, M., Wang, C., Sakamaki, T., Wang, J., Vizio, D. D., Zhang, X., Albanese, C., Balk, S. P., Chang, C., et al. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8563-8575.2003 · Cited by 274 · see citing works

Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat.

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Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene

Hiratsuka, M., Inoue, T., Toda, T., Kimura, N., Shirayoshi, Y., Kamitani, H., Watanabe, T., Ohama, E., Tahimic, C. G. T., Kurimasa, A., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.029 · Cited by 261 · see citing works

Hormonal Control of Androgen Receptor Function through SIRT1

Fu, M., Liu, M., Sauve, A. A., Jiao, X., Zhang, X., Wu, X., Powell, M. J., Yang, T., Gu, W. J., Avantaggiati, M. L., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00289-06 · Cited by 234 · see citing works

A hypersensitive estrogen receptor-alpha mutation in premalignant breast lesions.

Fuqua, S. A. W., Wiltschke, C., ZHANG, Q. X., Borg, Å., Castles, C. G., Friedrichs, W. E., Hopp, T., Hilsenbeck, S. G., Mohsin, S. K., O'Connell, P., et al. (2000) · PubMed · Cited by 234 · see citing works

Acetylation of nuclear receptors in cellular growth and apoptosis

Fu, M., Wang, C., Zhang, X., & Pestell, R. G. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.05.037 · Cited by 183 · see citing works

SIRT1 and endocrine signaling

Yang, T., Fu, M., Pestell, R. G., & Sauve, A. A. (2006) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2006.04.002 · Cited by 181 · see citing works

Androgen Receptor Acetylation Governs trans Activation and MEKK1-Induced Apoptosis without Affecting In Vitro Sumoylation and trans-Repression Function

Fu, M., Wang, C., Wang, J., Zhang, X., Sakamaki, T., Yeung, Y. G., Chang, C., Hopp, T., Fuqua, S. A. W., Jaffray, E., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3373-3388.2002 · Cited by 170 · see citing works

Coenzyme Specificity of Sir2 Protein Deacetylases

Schmidt, M. T., Smith, B. C., Jackson, M. D., & Denu, J. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407484200 · Cited by 146 · see citing works

Histone acetyltransferase complexes

Grant, P. A., & Berger, S. L. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0298 · Cited by 136 · see citing works

Acetylation of GATA‐3 affects T‐cell survival and homing to secondary lymphoid organs

Yamagata, T., Mitani, K., Oda, H., Suzuki, T., Honda, H., Asai, T., Maki, K., Nakamoto, T., & Hirai, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4676 · Cited by 119 · see citing works

Resveratrol Acts as a Mixed Agonist/Antagonist for Estrogen Receptors and

Bowers, J. L. (2000) · Endocrinology · doi:10.1210/en.141.10.3657 · Cited by 111 · see citing works

Functional regulation of GATA-2 by acetylation

Hayakawa, F., Towatari, M., Ozawa, Y., Tomita, A., Privalsky, M. L., & Saito, H. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603389 · Cited by 99 · see citing works

The Androgen Receptor Acetylation Site Regulates cAMP and AKT but Not ERK-induced Activity

Fu, M., Rao, M., Wu, K., Wang, C., Zhang, X., Hessien, M., Yeung, Y.-G., Gioeli, D. G., Weber, M. J., & Pestell, R. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313466200 · Cited by 83 · see citing works

Activation of p300 histone acetyltransferase activity and acetylation of the androgen receptor by bombesin in prostate cancer cells

Gong, J.-Y., Zhu, J., Goodman, O. B., Pestell, R. G., Schlegel, P. N., Nanus, D. M., & Shen, R. (2006) · Oncogene · doi:10.1038/sj.onc.1209231 · Cited by 72 · see citing works

Pleiotropic effects of resveratrol

Granados‐Soto, V. (2003) · Drug News & Perspectives · doi:10.1358/dnp.2003.16.5.829318 · Cited by 71 · see citing works

The BRCA2 is a histone acetyltransferase

Siddique, H., Zou, J.-P., Rao, V. N., & Reddy, E. S. P. (1998) · Oncogene · doi:10.1038/sj.onc.1202003 · Cited by 63 · see citing works

Histone Deacetylase Inhibitors in Cancer Therapy

Fouladi, M. (2006) · Cancer Investigation · doi:10.1080/07357900600814979 · Cited by 54 · see citing works

Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A

Zhong, S., Goto, H., Inagaki, M., & Dong, Z. (2003) · Oncogene · doi:10.1038/sj.onc.1206507 · Cited by 52 · see citing works

Acetylation of nuclear hormone receptor superfamily members: Thyroid hormone causes acetylation of its own receptor by a mitogen-activated protein kinase-dependent mechanism

Lin, H., Hopkins, R. L., Cao, H., Tang, H., ALEXANDER, C., DAVIS, F., & Davis, P. J. (2005) · Steroids · doi:10.1016/j.steroids.2005.03.001 · Cited by 50 · see citing works

Association of common variation in the PPARAgene with incident myocardial infarction in individuals with type 2 diabetes: A Go-DARTS study

Doney, A. S. F., Fischer, B., Lee, S. P., Morris, A. D., Leese, G., & Palmer, C. N. (2005) · Nuclear Receptor · doi:10.1186/1478-1336-3-4 · Cited by 48 · see citing works

Chaperoning steroid hormone signaling via reversible acetylation

Kovacs, J. J., Cohen, T. J., & Yao, T. (2005) · Nuclear Receptor Signaling · doi:10.1621/nrs.03004 · Cited by 39 · see citing works

Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

Yang, X.-J., & Seto, E. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.07.002 · Cited by 1,006 · see citing works

Cellular and molecular biology of aging endothelial cells

Donato, A. J., Morgan, R. G., Walker, A. E., & Lesniewski, L. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.021 · Cited by 538 · see citing works

SIRT‐1 and vascular endothelial dysfunction with ageing in mice and humans

Donato, A. J., Magerko, K. A., Lawson, B. R., Durrant, J., Lesniewski, L. A., & Seals, D. R. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.211219 · Cited by 270 · see citing works

Epigenetic impact of dietary polyphenols in cancer chemoprevention: Lifelong remodeling of our epigenomes

Berghe, W. V. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.03.007 · Cited by 241 · see citing works

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works

From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

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Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works

Nature or nurture: Let food be your epigenetic medicine in chronic inflammatory disorders

Szic, K. S. V., Ndlovu, ’. N., Haegeman, G., & Berghe, W. V. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.07.029 · Cited by 138 · see citing works

Metabolic Agents that Enhance ATP can Improve Cognitive Functioning: A Review of the Evidence for Glucose, Oxygen, Pyruvate, Creatine, and L-Carnitine

Owen, L., & Sunram-Lea, S.-I. (2011) · Nutrients · doi:10.3390/nu3080735 · Cited by 141 · see citing works

Altered sirtuin deacetylase gene expression in patients with a mood disorder

Abe, N., Uchida, S., Otsuki, K., Hobara, T., Yamagata, H., Higuchi, F., Shibata, T., & Watanabe, Y. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.01.016 · Cited by 131 · see citing works

Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications☆

Bolaños, J. P., Moro, M. Á., Lizasoaín, I., & Almeida, Á. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.009 · Cited by 119 · see citing works

Histone deacetylase inhibitors: Apoptotic effects and clinical implications (Review)

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Regulation of histone acetylation in the hippocampus of chronically stressed rats: a potential role of sirtuins

Ferland‐Beckham, C., & Schrader, L. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.10.077 · Cited by 86 · see citing works

The Cell Fate Determination Factor Dachshund Inhibits Androgen Receptor Signaling and Prostate Cancer Cellular Growth

Wu, K., Katiyar, S., Witkiewicz, A., Li, A., McCue, P. A., Song, L., Tian, L., Jin, M. L., & Pestell, R. G. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3821 · Cited by 80 · see citing works

Epigenetic Mechanisms

Lubin, F. D., Gupta, S., Parrish, R. R., Grissom, N. M., & Davis, R. L. (2011) · The Neuroscientist · doi:10.1177/1073858411386967 · Cited by 97 · see citing works

The Dachshund gene in development and hormone-responsive tumorigenesis

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Epigenetic gene regulation in the adult mammalian brain: Multiple roles in memory formation

Lubin, F. D. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.03.001 · Cited by 70 · see citing works

Disruption of a Sirt1 Dependent Autophagy Checkpoint in the Prostate Results in Prostatic Intraepithelial Neoplasia Lesion Formation

Powell, M., Casimiro, M., Cordon-Cardo, C., He, X.-H., Yeow, W.-S., Wang, C.-G., Mccue, P., McBurney, M., & Pestell, R. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-3172 · Cited by 77 · see citing works

SIRT1 expression is associated with a poor prognosis, whereas DBC1 is associated with favorable outcomes in gastric cancer

Noguchi, A., Kikuchi, K., Zheng, H., Takahashi, H., Miyagi, Y., Aoki, I., & Takano, Y. (2014) · Cancer Medicine · doi:10.1002/cam4.310 · Cited by 64 · see citing works

Loss of Sirt1 Promotes Prostatic Intraepithelial Neoplasia, Reduces Mitophagy, and Delays Park2 Translocation to Mitochondria

Sante, G. D., Pestell, T. G., Casimiro, M. C., Bisetto, S., Powell, M. J., Lisanti, M. P., Cordon‐Cardo, C., Castillo-Martín, M., Bonal, D. M., Debattisti, V., et al. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.09.014 · Cited by 63 · see citing works

The Cell Fate Determination Factor DACH1 Is Expressed in Estrogen Receptor-α–Positive Breast Cancer and Represses Estrogen Receptor-α Signaling

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Function of Sirtuins in Biological Tissues

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SIRT2 is involved in the modulation of depressive behaviors

Liu, R., Dang, W., Du, Y., Zhou, Q., Jiao, K., & Liu, Z. (2015) · Scientific Reports · doi:10.1038/srep08415 · Cited by 56 · see citing works

Nutrition and health during mid-life: searching for solutions and meeting challenges for the aging population

Chedraui, P. A., & Pérez-López, F. R. (2013) · Climacteric · doi:10.3109/13697137.2013.802884 · Cited by 39 · see citing works

Acetylation in Nuclear Receptor Signaling and the Role of Sirtuins

Wang, C., Powell, M. J., Popov, V. M., & Pestell, R. G. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0379 · Cited by 39 · see citing works

Sirtuin Activity in Dentate Gyrus Contributes to Chronic Stress-Induced Behavior and Extracellular Signal-Regulated Protein Kinases 1 and 2 Cascade Changes in the Hippocampus

Ferland‐Beckham, C., Hawley, W. R., Puckett, R. E., Wineberg, K., Lubin, F. D., Dohanich, G. P., & Schrader, L. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.029 · Cited by 37 · see citing works

Sirt1-Deficient Mice Have Hypogonadotropic Hypogonadism due to Defective GnRH Neuronal Migration

Sante, G. D., Wang, L., Wang, C., Jiao, X., Casimiro, M. C., Chen, K., Pestell, T. G., Yaman, İ., Rocco, A. D., Sun, X., et al. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1228 · Cited by 35 · see citing works

Zyxin is a novel interacting partner for SIRT1

Fujita, Y., Yamaguchi, A., Hata, K., Endo, M., Yamaguchi, N., & Yamashita, T. (2009) · BMC Cell Biology · doi:10.1186/1471-2121-10-6 · Cited by 34 · see citing works

Targeting Epigenetic Regulatory Enzymes for Cancer Therapeutics: Novel Small-Molecule Epidrug Development

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Screening Analysis of Sirtuins Family Expression on Anti-Inflammation of Resveratrol in Endothelial Cells

Yu, H., Pan, W., Huang, H., Chen, J., Sun, B., Yang, L., & Zhu, P. (2019) · Medical Science Monitor · doi:10.12659/msm.913240 · Cited by 29 · see citing works

Peripheral blood SIRT1 mRNA levels in depression and treatment with electroconvulsive therapy

McGrory, C. L., Ryan, K. M., Kolshus, E., Finnegan, M., & McLoughlin, D. M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.06.007 · Cited by 28 · see citing works

Inflammation, Advancing Age and Nutrition

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Residues K128, 132, and 134 in the Thyroid Hormone Receptor-α Are Essential for Receptor Acetylation and Activity

Sánchez‐Pacheco, A., Martínez-Iglesias, O. A., Méndez‐Pertuz, M., & Aranda, A. (2009) · Endocrinology · doi:10.1210/en.2009-0117 · Cited by 24 · see citing works

Overexpression of SIRT6 in the hippocampal CA1 impairs the formation of long-term contextual fear memory

Yin, X., Gao, Y., Shi, H., Song, L., Wang, J.-C., Shao, J., Geng, X.-H., Xue, G., Li, J.-L., & Yan-ning, H. (2016) · Scientific Reports · doi:10.1038/srep18982 · Cited by 23 · see citing works

PBEF/NAMPT/Visfatin: A Promising Drug Target For Treating Rheumatoid Arthritis?

Nowell, M. A., Evans, L., & Williams, A. S. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.34 · Cited by 19 · see citing works

The Sirtuin 2 Inhibitor AK-7 Leads to an Antidepressant-Like Effect in Mice via Upregulation of CREB1, BDNF, and NTRK2 Pathways

Güçlü, E., İnan, S. Y., & Vural, H. C. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03026-8 · Cited by 18 · see citing works

Epigenetic aging in major depressive disorder: Clocks, mechanisms and therapeutic perspectives

Shaikh, M., & Doshi, G. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176757 · Cited by 12 · see citing works

Resveratrol attenuated smokeless tobacco–induced vascular and metabolic complications in ovariectomized rats

Majumdar, A. S., Joshi, P. A., & Giri, P. R. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31827fdda4 · Cited by 11 · see citing works

Phytochemicals and Cancer Chemoprevention: Epigenetic Friends or Foe?

Szic, K. S. V., Palagani, A., Hassannia, B., Sabbe, L., Heyninck, K., Haegeman, G., & Vanden, W. (2011) · InTech eBooks · doi:10.5772/28499 · Cited by 6 · see citing works

Targeted downregulation of estradiol binding Na + /H + exchanger nhx-2, mimics calorie restriction, extends reproductive longevity and ameliorates effects associated with alpha synuclein aggregation in C. elegansPreprint

Shukla, S., Kumar, L., Sarkar, A., Srividya, K., & Nazir, A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.30.229344 · Cited by 4 · see citing works

Effect of SIRT1 on white matter neural network in adolescent patients with depression

Ji, L., Jiang, W., Liu, D., & Hou, K. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.966315 · Cited by 2 · see citing works

Dieta hipocalórica y longevidad

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Heterochromatin-Mediated Gene Silencing Is Not Affected by Drosophila CBP Activity

Smolik, S. M. (2009) · Journal of Heredity · doi:10.1093/jhered/esp016 · Cited by 2 · see citing works

Connecting Phytochemicals, Epigenetics, and Healthy Aging

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Sarcopenia in COPD : functional and metabolic implications

Franssen, F. M. E. (2009) · doi:10.26481/dis.20090130ff · Cited by 2 · see citing works

The Role of Epigenetic Modifications in Cancer

Powell, M. J., Popov, V. M., Wang, X., McMahon, S. B., Mazo, A., & Pestell, R. G. (2011) · doi:10.1002/9781118005743.ch7 · Cited by 1 · see citing works

Régulation dynamique de l’activité du récepteur des estrogènes beta (ERβ) par la phosphorylation,l’ubiquitination et la sumoylation

Picard, N. (2011) · doi:10.71781/29245

Targeted Downregulation of Estradiol Binding Na+/H+ Exchanger Nhx-2, Mimics Calorie Restriction, Extends Reproductive Longevity and Ameliorates Effects Associated With Alpha Synuclein Aggregation In C. ElegansPreprint

Shukla, S., Kumar, L., Sarkar, A., Srivi, K., & Nazir, A. (2021) · Research Square · doi:10.21203/rs.3.rs-517539/v1

Data from The Cell Fate Determination Factor Dachshund Inhibits Androgen Receptor Signaling and Prostate Cancer Cellular Growth

Wu, K., Katiyar, S., Witkiewicz, A., Li, A., McCue, P. A., Song, L., Tian, L., Jin, M., & Pestell, R. G. (2023) · doi:10.1158/0008-5472.c.6499454.v1

Data from The Cell Fate Determination Factor Dachshund Inhibits Androgen Receptor Signaling and Prostate Cancer Cellular Growth

Wu, K., Katiyar, S., Witkiewicz, A., Li, A., McCue, P. A., Song, L., Tian, L., Jin, M., & Pestell, R. G. (2023) · doi:10.1158/0008-5472.c.6499454

The functional significance of nuclear receptor acetylation

Popov, V. M., Wang, C., Shirley, L. A., Rosenberg, A., Lisanti, M. P., Nevalainen, M. T., Fu, M., & Pestell, R. G. (2007) · Steroids · doi:10.1016/j.steroids.2006.12.001 · Cited by 80 · see citing works

Acetylation in Nuclear Receptor Signaling and the Role of Sirtuins

Wang, C., Powell, M. J., Popov, V. M., & Pestell, R. G. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0379 · Cited by 39 · see citing works

Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer

Moore, R. L., Dai, Y., & Faller, D. V. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0217 · Cited by 81 · see citing works

Acetylation and nuclear receptor action

Wang, C., Tian, L., Popov, V. M., & Pestell, R. G. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.12.003 · Cited by 67 · see citing works

Acetylation of nuclear receptors in health and disease: an update

Ashton, A., Dhanjal, H. K., Rossner, B., Mahmood, H., Patel, V. I., Nadim, M., Lota, M., Shahid, F., Li, Z.-P., Joyce, D., et al. (2022) · The FEBS Journal · doi:10.1111/febs.16695 · Cited by 21 · see citing works