AMP-activated protein kinase: also regulated by ADP?

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Hudson et al.

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

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Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

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AMPK in Health and Disease

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LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

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Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

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A central integrator of transcription networks in plant stress and energy signalling

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Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

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Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

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5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

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Metformin Inhibits Hepatic Gluconeogenesis in Mice Independently of the LKB1/AMPK Pathway via a Decrease in Hepatic Energy State

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The LKB1 tumor suppressor negatively regulates mTOR signaling

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Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi

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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

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The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases

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Structure of mammalian AMPK and its regulation by ADP

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Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

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Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

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CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

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A Yeast Gene That Is Essential for Release from Glucose Repression Encodes a Protein Kinase

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Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

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AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

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The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

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Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

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A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis

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5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2C α and native bovine protein phosphatase‐2A c

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Structural basis for AMP binding to mammalian AMP-activated protein kinase

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The structure of a domain common to archaebacteria and the homocystinuria disease protein.

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Metformin in cancer therapy: a new perspective for an old antidiabetic drug?

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Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle

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Dissecting the Role of 5′-AMP for Allosteric Stimulation, Activation, and Deactivation of AMP-activated Protein Kinase

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Mechanism of Action of A-769662, a Valuable Tool for Activation of AMP-activated Protein Kinase

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Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

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5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

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The Glycogen-Binding Domain on the AMPK β Subunit Allows the Kinase to Act as a Glycogen Sensor

McBride, A., Ghilagaber, S., Nikolaev, A., & Hardie, D. G. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.11.008 · Cited by 432

AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen

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5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.

Lochhead, P. A., Salt, I. P., Walker, K. S., Hardie, D. G., & Sutherland, C. D. (2000) · Diabetes · doi:10.2337/diabetes.49.6.896 · Cited by 391

Mechanism of inhibition of bovine F 1 -ATPase by resveratrol and related polyphenols

Gledhill, J. R., Montgomery, M. G., Leslie, A. G. W., & Walker, J. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706290104 · Cited by 386

Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio

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Effect of Exercise Intensity on Skeletal Muscle AMPK Signaling in Humans

Chen, Z.-P., Stephens, T. J., Murthy, S., Canny, B. J., Hargreaves, M., Witters, L. A., Kemp, B. E., & McConell, G. K. (2003) · Diabetes · doi:10.2337/diabetes.52.9.2205 · Cited by 369

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

Oakhill, J. S., Chen, Z., Scott, J. W., Steel, R., Castelli, L. A., Ling, N. X. Y., Macaulay, S. L., & Kemp, B. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009705107 · Cited by 337

A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias

Hudson, E. R., Pan, D. A., James, J., Lucocq, J. M., Hawley, S. A., Green, K. A., Baba, O., Terashima, T., & Hardie, D. G. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00249-5 · Cited by 332

Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex

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Multiple Pathways Are Co-regulated by the Protein Kinase Snf1 and the Transcription Factors Adr1 and Cat8

Young, E. T., Dombek, K. M., Tachibana, C. Y., & Ideker, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301981200 · Cited by 278

Regulation of Snf1 Kinase

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Method for the Quantitative Extraction of Resveratrol and Piceid Isomers in Grape Berry Skins. Effect of Powdery Mildew on the Stilbene Content

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The α2–5′AMP-Activated Protein Kinase Is a Site 2 Glycogen Synthase Kinase in Skeletal Muscle and Is Responsive to Glucose Loading

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Regulatory Interactions between the Reg1-Glc7 Protein Phosphatase and the Snf1 Protein Kinase

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Structural insight into the autoinhibition mechanism of AMP-activated protein kinase

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Regulation of spinach SNF1‐related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5′‐AMP

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Structural Basis for Glycogen Recognition by AMP-Activated Protein Kinase

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Crystal Structures of the Adenylate Sensor from Fission Yeast AMP-Activated Protein Kinase

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Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling

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The AMP-activated protein kinase: a multisubstrate regulator of lipid metabolism

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Intrasteric control of AMPK via the γ1 subunit AMP allosteric regulatory site

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Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1

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Snf1‐related protein kinase 1 is needed for growth in a normal day–night light cycle

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Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by the adenylate energy charge.

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Short‐term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen

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Access Denied: Snf1 Activation Loop Phosphorylation Is Controlled by Availability of the Phosphorylated Threonine 210 to the PP1 Phosphatase

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Activation of rat liver cytosolic 3-hydroxy-3-methylglutaryl Coenzyme A reductase kinase by adenosine 5′-monophosphate

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Conserved α-Helix Acts as Autoinhibitory Sequence in AMP-activated Protein Kinase α Subunits

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Evidence for a protein kinase cascade in higher plants

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The Relationship between AMP-activated Protein Kinase Activity and AMP Concentration in the Isolated Perfused Rat Heart

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Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in vitro. An adenine nucleotide-dependent reaction catalyzed by a factor in human fibroblasts.

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Hispidulin Potently Inhibits Human Glioblastoma Multiforme Cells through Activation of AMP-Activated Protein Kinase (AMPK)

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Uncoupling of oxidative phosphorylation by curcumin: Implication of its cellular mechanism of action

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The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe

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The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 β cells

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The evolution of putative starch‐binding domains

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AMPK Structure and Regulation from Three Angles

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AMP-activated Protein Kinase Phosphorylates R5/PTG, the Glycogen Targeting Subunit of the R5/PTG-Protein Phosphatase 1 Holoenzyme, and Accelerates Its Down-regulation by the Laforin-Malin Complex*

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Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes

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Association of AMP-activated Protein Kinase Subunits With Glycogen Particles as Revealed In Situ by Immunoelectron Microscopy

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Regulation of rat liver acetyl CoA carboxylase

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Activation of 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase in vitro

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AMPK: a nutrient and energy sensor that maintains energy homeostasis

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AMPK: guardian of metabolism and mitochondrial homeostasis

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Mitochondria: In Sickness and in Health

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The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

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AMP-activated protein kinase: nature's energy sensor

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AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

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AMP-activated protein kinase – not just an energy sensor

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How cells sense energy

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Molecular Regulation of Energy Balance

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