New insights into and novel applications for platelet-rich fibrin therapies

Tissue engineering

Langer, R., & Vacanti, J. P. (1993) · Science · doi:10.1126/science.8493529 · Cited by 9,893

Regulation of Wound Healing by Growth Factors and Cytokines

WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629

Burden of major musculoskeletal conditions.

(2003) · Europe PMC (PubMed Central) · Cited by 3,521

Platelet-rich plasma

Marx, R. E., Carlson, E. R., Eichstaedt, R. M., Schimmele, S. R., Strauss, J. E., & Georgeff, K. R. (1998) · Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology · doi:10.1016/s1079-2104(98)90029-4 · Cited by 2,598

Autologous platelets as a source of proteins for healing and tissue regeneration

Anitua, E., Andia, I., Ardanza, B., Nurden, P., & Nurden, A. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-07-0440 · Cited by 1,495

Tissue-engineered bone regeneration

Petite, H., Viateau, V., Bensaïd, W., Meunier, A., de Pollak, C., Bourguignon, M., Oudina, K., Sedel, L., & Guillemin, G. (2000) · Nature Biotechnology · doi:10.1038/79449 · Cited by 1,475

TENDON INJURY AND TENDINOPATHY: HEALING AND REPAIR

SHARMA, P., & MAFFULLI, N. (2005) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200501000-00030 · Cited by 1,074

Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants.

Anitua, E. (1999) · PubMed · Cited by 988

THE ROLE OF GROWTH FACTORS IN THE REPAIR OF BONE: BIOLOGY AND CLINICAL APPLICATIONS

LIEBERMAN, J. R., DALUISKI, A., & EINHORN, T. A. (2002) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200206000-00022 · Cited by 932

Musculoskeletal Conditions in the United States

Praemer, A., Furner, S. E., & Rice, D. P. (1992) · Medical Entomology and Zoology · Cited by 930

Angiogenesis and bone repair

Carano, R. A. D., & Filvaroff, E. H. (2003) · Drug Discovery Today · doi:10.1016/s1359-6446(03)02866-6 · Cited by 746

Platelet lysates promote mesenchymal stem cell expansion: A safety substitute for animal serum in cell-based therapy applications

Doucet, C., Ernou, I., Zhang, Y., Llense, J.-R., Begot, L., Holy, X., & Lataillade, J.-J. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20391 · Cited by 689

Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration

Weibrich, G., Hansen, T., Kleis, W., Buch, R., & Hitzler, W. E. (2004) · Bone · doi:10.1016/j.bone.2003.12.010 · Cited by 628

Is platelet-rich plasma the perfect enhancement factor? A current review.

(2003) · The Journal of Prosthetic Dentistry · doi:10.1016/s0022-3913(03)00338-x · Cited by 566

Autologous preparations rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture

Anitua, E., Andí, I., Sanchez, M., Azofra, J., del Mar Zalduendo, M., de la Fuente, M., Nurden, P., & Nurden, A. T. (2005) · Journal of Orthopaedic Research · doi:10.1016/j.orthres.2004.08.015 · Cited by 505

The Use of Autologous Platelet-Rich Plasma (Platelet Gel) and Autologous Platelet-Poor Plasma (Fibrin Glue) in Cosmetic Surgery

Man, D., Plosker, H., & Winland-Brown, J. E. (2001) · Plastic and Reconstructive Surgery · doi:10.1097/00006534-200101000-00037 · Cited by 448

A Phase I/II Clinical Trial to Evaluate a Combination of Recombinant Human Platelet‐Derived Growth Factor‐BB and Recombinant Human Insulin‐Like Growth Factor‐I in Patients with Periodontal Disease

Howell, T. H., Fiorellini, J. P., Paquette, D. W., Offenbacher, S., Giannobile, W. V., & Lynch, S. E. (1997) · Journal of Periodontology · doi:10.1902/jop.1997.68.12.1186 · Cited by 406

Platelet-derived growth factors enhance proliferation of human stromal stem cells

Lucarelli, E., Beccheroni, A., Donati, D., Sangiorgi, L., Cenacchi, A., Del Vento, A. M., Meotti, C., Bertoja, A. Z., Giardino, R., Fornasari, P. M., et al. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00114-5 · Cited by 404

Repair of patellar tendon injuries using a cell–collagen composite

Awad, H. A., Boivin, G. P., Dressler, M. R., Smith, F. N. L., Young, R. G., & Butler, D. L. (2003) · Journal of Orthopaedic Research · doi:10.1016/s0736-0266(02)00163-8 · Cited by 396

Angiogenesis in Fracture Repair

Glowacki, J. (1998) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-199810001-00010 · Cited by 386

Tissue Regeneration Based on Growth Factor Release

Tabata, Y. (2003) · Tissue Engineering · doi:10.1089/10763270360696941 · Cited by 360

Effectiveness of Platelet Releasate for the Treatment of Diabetic Neuropathic Foot Ulcers

Margolis, D. J., Kantor, J., Santanna, J., Strom, B. L., & Berlin, J. A. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.483 · Cited by 336

Localized delivery of growth factors for bone repair

Luginbuehl, V., Meinel, L., Merkle, H. P., & Gander, B. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.03.004 · Cited by 332

Investigation of platelet-rich plasma in rabbit cranial defects: A pilot study

Aghaloo, T. L., Moy, P. K., & Freymiller, E. G. (2002) · Journal of Oral and Maxillofacial Surgery · doi:10.1053/joms.2002.34994 · Cited by 316

Autogenous Injectable Bone for Regeneration with Mesenchymal Stem Cells and Platelet-Rich Plasma: Tissue-Engineered Bone Regeneration

Yamada, Y., Ueda, M., Naiki, T., Takahashi, M., Hata, K.-I., & Nagasaka, T. (2004) · Tissue Engineering · doi:10.1089/1076327041348284 · Cited by 309

Effect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion: Evidence for a Dose-Dependent Effect

Hendel, R. C., Henry, T. D., Rocha-Singh, K., Isner, J. M., Kereiakes, D. J., Giordano, F. J., Simons, M., & Bonow, R. O. (2000) · Circulation · doi:10.1161/01.cir.101.2.118 · Cited by 295

Potential applications and delivery strategies for bone morphogenetic proteins

Kirker-Head, C. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00078-8 · Cited by 294

Fibrin glue: the perfect operative sealant?

Gibble, J. W., & Ness, P. M. (1990) · Transfusion · doi:10.1046/j.1537-2995.1990.30891020337.x · Cited by 293

Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis—a preliminary result of three cases

Kitoh, H., Kitakoji, T., Tsuchiya, H., Mitsuyama, H., Nakamura, H., Katoh, M., & Ishiguro, N. (2004) · Bone · doi:10.1016/j.bone.2004.06.013 · Cited by 271

Effect of platelet-rich plasma on bone growth and osseointegration in human maxillary sinus grafts: three bilateral case reports.

Froum, S., Wallace, S. S., Tarnow, D. P., & Cho, S. (2002) · PubMed · Cited by 264

Platelets stimulate proliferation of bone cells: involvement of platelet‐derived growth factor, microparticles and membranes

Gruber, R., Varga, F., Fischer, M. B., et al. (2002) · Clinical Oral Implants Research · doi:10.1034/j.1600-0501.2002.130513.x · Cited by 240

Platelet‐Rich Plasma Combined With a Porous Hydroxyapatite Graft for the Treatment of Intrabony Periodontal Defects in Humans: A Comparative Controlled Clinical Study

Okuda, K., 田井, 秀., Tanabe, K., Suzuki, H., Sato, T., Kawase, T., Saito, Y., Wolff, L. F., & Yoshiex, H. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.6.890 · Cited by 233

Platelet-rich plasma: a promising innovation in dentistry.

Tözüm, T. F., & Demiralp, B. (2003) · PubMed · Cited by 231

Autologous fibrin matrices: A potential source of biological mediators that modulate tendon cell activities

Anitua, E., Sanchez, M., Nurden, A. T., Zalduendo, M., de la Fuente, M., Orive, G., Azofra, J., & Andia, I. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30585 · Cited by 188

Does platelet‐rich plasma promote remodeling of autologous bone grafts used for augmentation of the maxillary sinus floor?

Raghoebar, G. M., Schortinghuis, J., Liem, R. S. B., Ruben, J. L., Van Der Wal, J. E., & Vissink, A. (2005) · Clinical Oral Implants Research · doi:10.1111/j.1600-0501.2005.01115.x · Cited by 187

Use of Autologous Platelet-Rich Plasma (PRP) in Periodontal Defect Treatment After Extraction of Impacted Mandibular Third Molars

Sammartino, G., Tia, M., Marenzi, G., Espedito di Lauro, A., D’Agostino, E., & Claudio, P. P. (2005) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2005.02.010 · Cited by 186

Platelet-rich plasma: ready or not?

Freymiller, E. G., & Aghaloo, T. L. (2004) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2003.08.021 · Cited by 184

EFFECT OF SERUM ON HUMAN BONE MARROW STROMAL CELLS: EX VIVO EXPANSION AND IN VIVO BONE FORMATION

Kuznetsov, S. A., Mankani, M. H., & Robey, P. G. (2000) · Transplantation · doi:10.1097/00007890-200012270-00018 · Cited by 178

Differential growth factor retention by platelet-rich plasma composites

Tsay, R. C., Vo, J., Burke, A., Eisig, S. B., Lu, H. H., & Landesberg, R. (2005) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2004.09.012 · Cited by 165

What do we mean by the term “inflammation”? A contemporary basic science update for sports medicine

Scott, A., Khan, K. M., Roberts, C. R., Cook, J. L., & Duronio, V (2004) · British Journal of Sports Medicine · doi:10.1136/bjsm.2004.011312 · Cited by 164

Influence of platelet-rich plasma on osseous healing of dental implants: a histologic and histomorphometric study in minipigs.

Zechner, W., Tangl, S., Tepper, G., et al. (2003) · PubMed · Cited by 164

Transforming growth factor-β1 modulates the expression of vascular endothelial growth factor by osteoblasts

Saadeh, P. B., Mehrara, B. J., Steinbrech, D. S., Dudziak, M. E., Greenwald, J. A., Luchs, J. S., Spector, J. A., Ueno, H., Gittes, G. K., & Longaker, M. T. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.4.c628 · Cited by 164

The importance of drug delivery systems in tissue engineering

Tabata, Y. (2000) · Pharmaceutical Science & Technology Today · doi:10.1016/s1461-5347(00)00242-x · Cited by 160

The Influence of Locally Applied Platelet-Derived Growth Factor-BB on Free Tendon Graft Remodeling after Anterior Cruciate Ligament Reconstruction

Weiler, A., Förster, C., Hunt, P., Falk, R., Jung, T., Unterhauser, F. N., Bergmann, V., Schmidmaier, G., & Haas, N. P. (2004) · The American Journal of Sports Medicine · doi:10.1177/0363546503261711 · Cited by 131

Differential growth factor retention by platelet-rich plasma composites

Tsay, R. C., Vo, J., Burke, A., Eisig, S. B., Lu, H. H., & Landesberg, R. (2004) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2004.05.182 · Cited by 131

Reciprocal Actions of Platelet-Secreted TGF-??1 on the Production of VEGF and HGF by Human Tendon Cells

Anitua, E., Sánchez, M., Nurden, A. T., Zalduendo, M., de la Fuente, M., Azofra, J., & Andı́a, I. (2007) · Plastic & Reconstructive Surgery · doi:10.1097/01.prs.0000255543.43695.1d · Cited by 114

Evaluation of platelet-rich plasma in combination with anorganic bovine bone in the rabbit cranium: a pilot study.

Aghaloo, T. L., Moy, P. K., & FREYMILLER, E. G. (2004) · PubMed · Cited by 111

Risks of using platelet rich plasma gel

Landesberg, R., Moses, M., & Karpatkin, M. (1998) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/s0278-2391(98)90286-5 · Cited by 104

An Economic Survey of the Emerging Tissue Engineering Industry

Lysaght, M. J., Nguy, N. A. P., & Sullivan, K. (1998) · Tissue Engineering · doi:10.1089/ten.1998.4.231 · Cited by 89

Factors in the Fracture Microenvironment Induce Primary Osteoblast Angiogenic Cytokine Production

Bouletreau, P. J., Warren, S. M., Spector, J. A., Steinbrech, D. S., Mehrara, B. J., & Longaker, M. T. (2002) · Plastic & Reconstructive Surgery · doi:10.1097/00006534-200207000-00025 · Cited by 73

Osteogenic potential of injectable tissue‐engineered bone: A comparison among autogenous bone, bone substitute (Bio‐Oss®), platelet‐rich plasma, and tissue‐engineered bone with respect to their mechanical properties and histological findings

Ito, K., Yamada, Y., Nagasaka, T., et al. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30248 · Cited by 72

Effects of Nonsteroidal Antiinflammatory Medication on Satellite Cell Proliferation During Muscle Regeneration

Thorsson, O., Rantanen, J., Hurme, T., & Kalimo, H. (1998) · The American Journal of Sports Medicine · doi:10.1177/03635465980260020401 · Cited by 69

A Call for Standardization in Platelet-Rich Plasma Preparation Protocols and Composition Reporting: A Systematic Review of the Clinical Orthopaedic Literature

Chahla, J., Cinque, M. E., Piuzzi, N. S., Mannava, S., Geeslin, A. G., Murray, I. R., Dornan, G. J., Muschler, G. F., & LaPrade, R. F. (2017) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.16.01374 · Cited by 504

Human platelet lysate can replace fetal bovine serum for clinical‐scale expansion of functional mesenchymal stromal cells

Schallmoser, K., Bartmann, C., Rohde, E., Reinisch, A., Kashofer, K., Stadelmeyer, E., Drexler, C., Lanzer, G., Linkesch, W., & Strunk, D. (2007) · Transfusion · doi:10.1111/j.1537-2995.2007.01220.x · Cited by 503

Ligamentization of Tendon Grafts Treated With an Endogenous Preparation Rich in Growth Factors: Gross Morphology and Histology

Sánchez, M., Anitua, E., Azofra, J., Prado, R., Muruzabal, F., & Andia, I. (2010) · Arthroscopy · doi:10.1016/j.arthro.2009.08.019 · Cited by 235

The differential effects of leukocyte-containing and pure platelet-rich plasma (PRP) on tendon stem/progenitor cells - implications of PRP application for the clinical treatment of tendon injuries

Zhou, Y., Zhang, J., Wu, H., Hogan, M. V., & Wang, J. H.-C. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0172-4 · Cited by 187

Intratendon Delivery of Leukocyte-Poor Platelet-Rich Plasma Improves Healing Compared With Leukocyte-Rich Platelet-Rich Plasma in a Rabbit Achilles Tendinopathy Model

Yan, R., Gu, Y., Ran, J., Hu, Y., Zheng, Z., Zeng, M., Heng, B. C., Chen, X., Yin, Z., Chen, W., et al. (2017) · The American Journal of Sports Medicine · doi:10.1177/0363546517694357 · Cited by 124