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Cited by 314

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Norovirus disease: changing epidemiology and host susceptibility factors

Open access
Hutson, Anne M, Atmar, Robert L, Estes, Mary K·2004·Trends in Microbiology
DOI 10.1016/j.tim.2004.04.005
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Abstract

Noroviruses cause the majority of acute viral gastroenteritis cases that occur worldwide. The increased recognition of noroviruses as the cause of outbreaks and sporadic disease is due to the recent availability of improved norovirus-specific diagnostics. Transmission of these viruses is facilitated by their high prevalence in the community, shedding of infectious virus particles from asymptomatic individuals and the high stability of the virus in the environment. Currently, the spectrum of clinical disease and the understanding of host susceptibility factors are changing. Cases of chronic norovirus gastroenteritis have been observed in transplant recipients and unusual clinical presentations have been recognized in otherwise healthy adults that are under physical stress. Recently, noroviruses were found to bind to gut-expressed carbohydrates, leading to a correlation between a person's genetically determined carbohydrate expression and their susceptibility to Norwalk virus infection. Greater community surveillance and further investigation of carbohydrate receptor-binding properties could provide further insights into norovirus transmission, susceptibility and pathogenesis, and should aid in developing vaccines and antiviral therapies for this common viral disease.

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Metadata

Authors
Hutson, A. M., Atmar, R. L., & Estes, M. K.
Venue
Trends in Microbiology
Publisher
Elsevier BV
Published
2004-06
Volume
12
Issue
6
Pages
279-287
ISSN
0966-842X (ISSN-L)
DOI
10.1016/j.tim.2004.04.005
OpenAlex
W1987051219
Cited by
314
References
45
FWCI
2.87
Type
journal article
Language
en
Open access
bronze

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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