Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!
Abstract
Concentration of neurotransmitter receptors at synapses is thought to result from stable binding to subsynaptic scaffold proteins. Recent data on synaptic plasticity have shown that changes in synaptic strength derive partly from modification of postsynaptic receptor numbers. This has led to the notion of receptor trafficking into and out of synapses. The proposed underlying mechanisms have under-evaluated the role of extrasynaptic receptors. Recent technological advances have allowed imaging of receptor movements at the single-molecule level, and these experiments demonstrate that receptors switch at unexpected rates between extrasynaptic and synaptic localizations by lateral diffusion. Variation in receptor numbers at postsynaptic sites is therefore likely to depend on regulation of diffusion by modification of the structure of the membrane and/or by transient interactions with scaffolding proteins. This review is part of the TINS Synaptic Connectivity series.
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Live-cell imaging techniques like FRAP and single molecule tracking changed the view that glutamate receptors are restricted to synapses.
“Whereas reports based on static EM suggested that glutamate receptors are restricted to synapses (Nusser, 2000), live-cell imaging techniques like FRAP and single molecule tracking changed this view radically (Richards et al., 2004; Triller and Choquet, 2005).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Triller and Choquet, 2005
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- Authors
- Triller, A., & Choquet, D.
- Affiliations
- Inserm (FR)
- Centre National de la Recherche Scientifique (FR)
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 28
- Issue
- 3
- Pages
- 133-139
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2110493620
- Cited by
- 285
- References
- 5
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 15 · 2016: 11 · 2015: 12 · 2014: 14 · 2013: 14 · 2012: 10
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- neurotransmitter receptors, receptor trafficking, synaptic receptors, extrasynaptic receptors, lateral diffusion, synaptic plasticity, postsynaptic scaffolding proteins, single-molecule imaging, receptor mobility, membrane structure
- MeSH terms
- Animals, Models, Neurological, Synaptic Transmission, Synapses, Synaptic Membranes, Receptors, Neurotransmitter, Protein Transport
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