Cited by 157Single-cell and spatial transcriptomicsNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

The problem of neuronal cell types: a physiological genomics approach

Nelson, Sacha B., Sugino, Ken, Hempel, Chris M.·2006·Trends in Neurosciences

Abstract

Neural circuits within the vertebrate brain are composed of highly diverse cell types. The exact extent of this diversity is a matter of continuing debate. For example, do cortical interneurons comprise a few, dozens or >100 distinct cell types? Recently, several groups have used microarrays to measure genome-wide gene expression profiles for specific neuronal cell types. These methods can offer an objective basis for neuronal classification. In this review, we argue that this approach should now be carried out more broadly and that it should be coupled to large-scale efforts to generate mouse driver lines in which tools for genetic manipulation, such as the Cre recombinase, are expressed in identified cell types within the brain. This would enable neuroscientists to begin to investigate more systematically the roles of specific genes in establishing particular cellular phenotypes, and also the roles of particular cell types within brain circuits. This review is part of the TINS special issue on The Neural Substrates of Cognition.

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Crossref · 10.1016/j.tins.2006.05.004

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Authors
Nelson, S. B., Sugino, K., & Hempel, C. M.
Affiliations
Brandeis University (US)
Corresponding author
Nelson, Sacha B.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2006-06
Volume
29
Issue
6
Pages
339-345
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2014405654
Cited by
157
References
56
Citations by year
2026: 2 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 11 · 2016: 5 · 2015: 16 · 2014: 13 · 2013: 8 · 2012: 10
FWCI
0.98
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuronal cell types, cortical interneurons, gene expression profiling, neuron classification, Cre recombinase, neural circuits, cell type diversity, physiological genomics
MeSH terms
Animals, Brain, Humans, Nerve Net, Neurons, Gene Expression Profiling, Genomics

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