The problem of neuronal cell types: a physiological genomics approach
Abstract
Neural circuits within the vertebrate brain are composed of highly diverse cell types. The exact extent of this diversity is a matter of continuing debate. For example, do cortical interneurons comprise a few, dozens or >100 distinct cell types? Recently, several groups have used microarrays to measure genome-wide gene expression profiles for specific neuronal cell types. These methods can offer an objective basis for neuronal classification. In this review, we argue that this approach should now be carried out more broadly and that it should be coupled to large-scale efforts to generate mouse driver lines in which tools for genetic manipulation, such as the Cre recombinase, are expressed in identified cell types within the brain. This would enable neuroscientists to begin to investigate more systematically the roles of specific genes in establishing particular cellular phenotypes, and also the roles of particular cell types within brain circuits. This review is part of the TINS special issue on The Neural Substrates of Cognition.
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The definition of a cell type in the brain remains controversial.
“the definition of a cell type in the brain remains controversial20,21”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [20]
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- Authors
- Nelson, S. B., Sugino, K., & Hempel, C. M.
- Affiliations
- Brandeis University (US)
- Corresponding author
- Nelson, Sacha B.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 29
- Issue
- 6
- Pages
- 339-345
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2014405654
- Cited by
- 157
- References
- 56
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 10 · 2017: 11 · 2016: 5 · 2015: 16 · 2014: 13 · 2013: 8 · 2012: 10
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neuronal cell types, cortical interneurons, gene expression profiling, neuron classification, Cre recombinase, neural circuits, cell type diversity, physiological genomics
- MeSH terms
- Animals, Brain, Humans, Nerve Net, Neurons, Gene Expression Profiling, Genomics
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