Effects of Inhibitor of κB Kinase Activity in the Nucleus Accumbens on Emotional Behavior
Open accessAbstract
Inhibitor of κB kinase (IκK) has historically been studied in the context of immune response and inflammation, but recent evidence demonstrates that IκK activity is necessary and sufficient for regulation of neuronal function. Chronic social defeat stress of mice increases IκK activity in the nucleus accumbens (NAc) and this increase is strongly correlated to depression-like behaviors. Inhibition of IκK signaling results in a reversal of chronic social defeat stress-induced social avoidance behavior. Here, we more completely define the role of IκK in anxiety and depressive-like behaviors. Mice underwent stereotaxic microinjection of a herpes simplex virus expressing either green fluorescent protein, a constitutively active form of IκK (IκKca), or a dominant negative form of IκK into the NAc. Of all three experimental groups, only mice expressing IκKca show a behavioral phenotype. Expression of IκKca results in a decrease in the time spent in the non-periphery zones of an open field arena and increased time spent immobile during a forced swim test. No baseline differences in sucrose preference were observed, but following the acute swim stress we noted a marked reduction in sucrose preference. To determine whether IκK activity alters responses to other acute stressors, we examined behavior and spine morphology in mice undergoing an acute social defeat stress. We found that IκKca enhanced social avoidance behavior and promoted thin spine formation. These data show that IκK in NAc is a critical regulator of both depressive- and anxiety-like states and may do so by promoting the formation of immature excitatory synapses.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Social defeat stress induces downstream inflammatory signaling pathways, such as NFkB, and increases monocyte trafficking throughout a number of CNS structures known to control depression and anxiety behavior.
“Our results are interesting in light of recent studies showing that social defeat stress induces downstream inflammatory signaling pathways, such as NFkB (26, 35 -37), and increases monocyte trafficking (29) throughout a number of CNS structures known to control depression and anxiety behavior.”
From Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress (2014) · cites this paper as [37]
Pro-susceptibility Dnmt3a overexpression or constitutively active IKK both increase MSN spine density.
“Pro-susceptibility Dnmt3a overexpression [143] or constitutively active IκB kinase (IKK) [156, 157] both increase MSN spine density.”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [157]
In the absence of stress, constitutively active IKK increases thin spine density, increases forced-swim immobility, and decreases sucrose preference after acute stress.
“In the absence of stress, constitutively active IKK increases thin spine density, increases forced-swim immobility, and decreases sucrose preference after acute stress [156, 157].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [157]
CSDS increases IKK and NF-κB, along with the number of immature dendritic spines in the NAc of susceptible mice.
“CSDS increases IKK and NF-κB, along with the number of immature dendritic spines in the NAc of susceptible mice [156, 157].”
From The molecular and cellular mechanisms of depression: a focus on reward circuitry (2019) · cites this paper as [157]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Behavioural despair in rats: A new model sensitive to antidepressant treatments
Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138 · see citing works
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331 · see citing works
Krishnan, V., Han, M.-H., Graham, D. L., Berton, O., Renthal, W., Russo, S. J., LaPlant, Q., Graham, A., Lutter, M., Lagace, D. C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.09.018 · Cited by 2,307 · see citing works
Self-citationEssential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
Self-citationIKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M. S., Mann, M., Manning, A. M., et al. (1997) · Science · doi:10.1126/science.278.5339.860 · Cited by 2,042 · see citing works
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
Self-citationRegulation and Function of IKK and IKK-Related Kinases
Häcker, H., & Karin, M. (2006) · Science s STKE · doi:10.1126/stke.3572006re13 · Cited by 1,269 · see citing works
Shaping the nuclear action of NF-κB
Chen, L., & Greene, W. C. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1368 · Cited by 1,219 · see citing works
Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
Sheng, M., Cummings, J., Roldan, L. A., Jan, Y. N., & Jan, L. Y. (1994) · Nature · doi:10.1038/368144a0 · Cited by 1,170 · see citing works
Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948 · see citing works
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
Lobo, M. K., Covington, H. E., Chaudhury, D., Friedman, A. K., Sun, H., Damez-Werno, D., Dietz, D. M., Zaman, S., Koo, J. W., Kennedy, P. J., et al. (2010) · Science · doi:10.1126/science.1188472 · Cited by 880 · see citing works
Self-citationBewernick, B. H., Hurlemann, R., Matusch, A., Kayser, S., Grubert, C., Hadrysiewicz, B., Axmacher, N., Lemke, M., Cooper-Mahkorn, D., Cohen, M. X., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.013 · Cited by 865 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
The IKK Complex, a Central Regulator of NF- B ActivationPreprint
Israël, A. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000158 · Cited by 853 · see citing works
NF-kB: a crucial transcription factor for glial and neuronal cell function
O'Neill, L. A. J., & Kaltschmidt, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01035-1 · Cited by 849 · see citing works
Do thin spines learn to be mushroom spines that remember?
Bourne, J., & Harris, K. M. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.009 · Cited by 843 · see citing works
Repeated Stress Induces Dendritic Spine Loss in the Rat Medial Prefrontal Cortex
Radley, J. J., Rocher, A. B., Miller, M., Janssen, W. G. M., Liston, C., Hof, P. R., McEwen, B. S., & Morrison, J. H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhi104 · Cited by 820 · see citing works
NF-κB functions in synaptic signaling and behavior
Meffert, M. K., Chang, J. M., Wiltgen, B. J., Fanselow, M. S., & Baltimore, D. (2003) · Nature Neuroscience · doi:10.1038/nn1110 · Cited by 690 · see citing works
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
Russo, S. J., Dietz, D. M., Dumitriu, D., Morrison, J. H., Malenka, R. C., & Nestler, E. J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.002 · Cited by 654 · see citing works
Self-citationIKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway
Lee, D., Kuo, H.-P., Chen, C., Hsu, J.-M., Chou, C., Wei, Y., Sun, H., Li, L., Ping, B., Huang, W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.058 · Cited by 639 · see citing works
Antidepressant Actions of Histone Deacetylase Inhibitors
Covington, H. E., Maze, I., LaPlant, Q. C., Vialou, V. F., Ohnishi, Y. N., Berton, O., Fass, D. M., Renthal, W., Rush, A. J., Wu, E. Y., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1758-09.2009 · Cited by 624 · see citing works
Self-citationNuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910658107 · Cited by 607 · see citing works
Self-citationRodriguez, A., Ehlenberger, D. B., Dickstein, D. L., Hof, P. R., & Wearne, S. L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001997 · Cited by 571 · see citing works
Papp, M., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02244188 · Cited by 542 · see citing works
Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502 · see citing works
ΔFosB in brain reward circuits mediates resilience to stress and antidepressant responses
Vialou, V., Robison, A. J., LaPlant, Q. C., Covington, H. E., Dietz, D. M., Ohnishi, Y. N., Mouzon, E., Rush, A. J., Watts, E. L., Wallace, D. L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2551 · Cited by 479 · see citing works
Self-citationRepeated stress alters dendritic spine morphology in the rat medial prefrontal cortex
Radley, J. J., Rocher, A. B., Rodriguez, A., Ehlenberger, D. B., Dammann, M., McEwen, B. S., Morrison, J. H., Wearne, S. L., & Hof, P. R. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21588 · Cited by 374 · see citing works
Lee, K.-W., Kim, Y. D., Kim, A. M., Helmin, K. A., Nairn, A. C., & Greengard, P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511244103 · Cited by 354 · see citing works
Abbasi, S.-H., Hosseini, F., Modabbernia, A., Ashrafi, M., & Akhondzadeh, S. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.03.033 · Cited by 344 · see citing works
Structural and synaptic plasticity in stress-related disorders
Christoffel, D. J., Golden, S. A., & Russo, S. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.044 · Cited by 334 · see citing works
Self-citationIκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex
Mercurio, F., Murray, B. W., Shevchenko, A., Bennett, B. L., Young, D. B., Li, J. W., Pascual, G., Motiwala, A., Zhu, H., Mann, M., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1526 · Cited by 325 · see citing works
Prolonged behavioral stress enhances synaptic connectivity in the basolateral amygdala
Vyas, A., Jadhav, S., & Chattarji, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.08.003 · Cited by 299 · see citing works
IκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works
Self-citationUp-regulation of BDNF in Astrocytes by TNF-α: A Case for the Neuroprotective Role of Cytokine
Saha, R. N., Liu, X., & Pahan, K. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9020-8 · Cited by 258 · see citing works
Nuclear Factor κB Signaling Regulates Neuronal Morphology and Cocaine Reward
Russo, S. J., Wilkinson, M. B., Mazei‐Robison, M. S., Dietz, D., Maze, I. S., Krishnan, V., Renthal, W. R., Graham, A., Birnbaum, S. G., Green, T. A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.6173-08.2009 · Cited by 248 · see citing works
Self-citationThe IκB Kinase Regulates Chromatin Structure during Reconsolidation of Conditioned Fear Memories
Lubin, F. D., & Sweatt, J. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.039 · Cited by 234 · see citing works
Kaltschmidt, B., Ndiaye‐Lobry, D., Körte, M., Pothion, S., Arbibe, L., Prüllage, M., Pfeiffer, J., Lindecke, A., Staiger, V., Israël, A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2936-2946.2006 · Cited by 229 · see citing works
Brain synapses contain inducible forms of the transcription factor NF-κB
Kaltschmidt, C., Kaltschmidt, B., & Baeuerle, P. A. (1993) · Mechanisms of Development · doi:10.1016/0925-4773(93)90031-r · Cited by 220 · see citing works
A Requirement for Nuclear Factor-κB in Developmental and Plasticity-Associated Synaptogenesis
Boersma, M. C. H., Dresselhaus, E. C., De Biase, L. M., Mihalas, A. B., Bergles, D. E., & Meffert, M. K. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2456-10.2011 · Cited by 168 · see citing works
Ahn, H. J., Hernandez, C. M., Levenson, J. M., Lubin, F. D., Liou, H.-C., & Sweatt, J. D. (2008) · Learning & Memory · doi:10.1101/lm.866408 · Cited by 144 · see citing works
Schmeißer, M. J., Baumann, B., Johannsen, S., Vindedal, G. F., Jensen, V., Hvalby, Ø., Sprengel, R., Seither, J., Maqbool, A., Magnutzki, A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0111-12.2012 · Cited by 137 · see citing works
Role of Nuclear Factor κB in Ovarian Hormone-Mediated Stress Hypersensitivity in Female Mice
LaPlant, Q., Chakravarty, S., Vialou, V., Mukherjee, S., Koo, J. W., Kalahasti, G., Bradbury, K. R., Taylor, S. V., Maze, I., Kumar, A., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.024 · Cited by 136 · see citing works
Self-citationBunting, K. L., Rao, S., Hardy, K., Woltring, D., Denyer, G. S., Wang, J., Gerondakis, S., & Shannon, M. F. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7097 · Cited by 117 · see citing works
NF-κB/Rel Regulates Inhibitory and Excitatory Neuronal Function and Synaptic Plasticity
O'Mahony, A., Raber, J., Montano, M., Foehr, E., Han, V., Lu, S.-M., Kwon, H., LeFevour, A., Chakraborty-Sett, S., & Greene, W. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00510-06 · Cited by 110 · see citing works
Glutamate activates NF‐κB through calpain in neurons
Schölzke, M. N., Potrovita, I., Subramaniam, S., Prinz, S., & Schwaninger, M. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.03079.x · Cited by 84 · see citing works
Nakamori, Y., Emoto, M., Fukuda, N., Taguchi, A., Okuya, S., Tajiri, M., Miyagishi, M., Taira, K., Wada, Y., & Tanizawa, Y. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200601065 · Cited by 65 · see citing works
Nuclear Factor κB Signaling in Opioid Functions and Receptor Gene Expression
Chen, Y. L., Law, P., & Loh, H. H. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9028-0 · Cited by 58 · see citing works
Dopamine receptor agonists in brain research and as therapeutic agents
Fuxé, K. (1979) · Trends in Neurosciences · doi:10.1016/0166-2236(79)90002-x · Cited by 34 · see citing works
Lehmann, M. L., Brachman, R. A., Listwak, S. J., & Herkenham, M. A. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.04.005 · Cited by 33 · see citing works
Characterization of a neuregulin-1 gene promoter: Positive regulation of type I isoforms by NF-κB
Frensing, T., Kaltschmidt, C., & Schmitt‐John, T. (2007) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2007.11.007 · Cited by 29 · see citing works
Viral-Mediated Gene Transfer to Study the Behavioral Correlates of CREB Function
Carlezon, W. A., & Neve, R. L. (2003) · Humana Press eBooks · doi:10.1385/1-59259-358-5:331 · Cited by 25 · see citing works
Self-citationRichter, M., Suau, P., & Ponte, I. (2002) · Gene · doi:10.1016/s0378-1119(02)00833-8 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870 · see citing works
Self-citationRusso, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206 · see citing works
Self-citationHodes, G. E., Pfau, M. L., Leboeuf, M., Golden, S. A., Christoffel, D. J., Bregman, D., Rebusi, N., Heshmati, M., Aleyasin, H., Warren, B. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415191111 · Cited by 692 · see citing works
Self-citationPathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
Self-citationImmune and neuroendocrine mechanisms of stress vulnerability and resilience
Ménard, C., Pfau, M. L., Hodes, G. E., & Russo, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.90 · Cited by 374 · see citing works
Self-citationMolecular adaptations of the blood–brain barrier promote stress resilience vs. depression
Dudek, K. A., Dion-Albert, L., Lebel, M., LeClair, K., Labrecque, S., Tuck, E., Ferrer Perez, C., Golden, S. A., Tamminga, C., Turecki, G., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914655117 · Cited by 361 · see citing works
Self-citationEpigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
Golden, S. A., Christoffel, D. J., Heshmati, M., Hodes, G. E., Magida, J., Davis, K., Cahill, M. E., Dias, C., Ribeiro, E., Ables, J. L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3090 · Cited by 322 · see citing works
Self-citationMetabolic disturbances connecting obesity and depression
Hryhorczuk, C., Sharma, S., & Fulton, S. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00177 · Cited by 322 · see citing works
Wang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., Golden, S. A., Bi, W., Menard, C., Kana, V., Leboeuf, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02794-5 · Cited by 274 · see citing works
Self-citationIntegrating Interleukin-6 into depression diagnosis and treatment
Hodes, G. E., Ménard, C., & Russo, S. J. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.03.003 · Cited by 271 · see citing works
Self-citationSpine synapse remodeling in the pathophysiology and treatment of depression
Duman, C. H., & Duman, R. S. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.01.022 · Cited by 257 · see citing works
The molecular and cellular mechanisms of depression: a focus on reward circuitry
Fox, M. E., & Lobo, M. K. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0415-3 · Cited by 232 · see citing works
Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.010 · Cited by 219 · see citing works
Zhang, K., Wang, F., Zhai, M., He, M., Hu, Y., Feng, L., Li, Y., Yang, J., & Wu, C. (2023) · Theranostics · doi:10.7150/thno.81067 · Cited by 217 · see citing works
Peripheral and central mechanisms of stress resilience
Pfau, M. L., & Russo, S. J. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.004 · Cited by 170 · see citing works
Self-citationSympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat
McKim, D. B., Patterson, J. M., Wohleb, E. S., Jarrett, B. L., Reader, B. F., Godbout, J. P., & Sheridan, J. F. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.010 · Cited by 137 · see citing works
Bessa, J. M., Morais, M., Marques, F., Pinto, L., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.39 · Cited by 130 · see citing works
Shepard, R., Page, C. E., & Coutellier, L. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.038 · Cited by 118 · see citing works
The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder
Abdallah, C. G., Jackowski, A., Salas, R., Gupta, S., Sato, J. R., Mao, X., Coplan, J. D., Shungu, D. C., & Mathew, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.49 · Cited by 123 · see citing works
Décarie-Spain, L., Sharma, S., Hryhorczuk, C., Issa-Garcia, V., Barker, P. A., Arbour, N., Alquier, T., & Fulton, S. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.018 · Cited by 107 · see citing works
Daskalakis, N. P., Cohen, H., Nievergelt, C. M., Baker, D. G., Buxbaum, J. D., Russo, S. J., & Yehuda, R. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.07.024 · Cited by 105 · see citing works
Self-citationDendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior
Fox, M. E., Chandra, R., Menken, M. S., Larkin, E. J., Nam, H., Engeln, M., Francis, T. C., & Lobo, M. K. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0211-5 · Cited by 100 · see citing works
Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., Sharma, V., Cao, R., Rummel, C., Tanti, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04883-5 · Cited by 82 · see citing works
Haim, A., Sherer, M., & Leuner, B. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12752 · Cited by 76 · see citing works
Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility
Heshmati, M., Aleyasin, H., Menard, C., Christoffel, D. J., Flanigan, M. E., Pfau, M. L., Hodes, G. E., Lepack, A. E., Bicks, L. K., Takahashi, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1719014115 · Cited by 75 · see citing works
Self-citationde la Fuente Revenga, M., Zhu, B., Guevara, C. A., Naler, L. B., Saunders, J. M., Zhou, Z., Toneatti, R., Sierra, S., Wolstenholme, J. T., Beardsley, P. M., et al. (2021) · doi:10.1101/2021.02.24.432725 · Cited by 11 · see citing works
- Authors
- Christoffel, D. J., Golden, S. A., Heshmati, M., Graham, A., Birnbaum, S., Neve, R. L., Hodes, G. E., & Russo, S. J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- The University of Texas Southwestern Medical Center (US)
- Massachusetts Institute of Technology (US)
- Corresponding author
- Russo, Scott J
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2012-07-11
- Volume
- 37
- Issue
- 12
- Pages
- 2615-2623
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3473326
- OpenAlex
- W2039099576
- Cited by
- 78
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 12 · 2018: 13 · 2017: 5 · 2016: 13 · 2015: 4 · 2014: 4 · 2013: 6 · 2012: 1
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- National Institute of Mental Health (R01MH090264, P50MH096890, T32MH087004)
- National Institute on Drug Abuse (P01DA008227)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- nucleus accumbens, chronic social defeat stress, depression-like behavior, anxiety-like behavior, social avoidance, dendritic spine morphology, excitatory synapses, sucrose preference, forced swim test, acute stress, neuroinflammation
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Consummatory Behavior, Depression, Emotions, Enzyme Inhibitors, Genetic Vectors, Interpersonal Relations, Mice, Inbred C57BL, Motor Activity, Nucleus Accumbens, Social Behavior, Stereotaxic Techniques, Synapses, Gene Transfer Techniques, Simplexvirus, Dendritic Spines, Mice, I-kappa B Kinase, Anhedonia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
