Cited by 433Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.

Understanding opioid reward

Open access

Fields, Howard L., Margolis, Elyssa B.·2015·Trends in Neurosciences

DOI 10.1016/j.tins.2015.01.002PMC PMC4385443

Open this paper in CoChat — free account

Abstract

Opioids are the most potent analgesics in clinical use; however, their powerful rewarding properties can lead to addiction. The scientific challenge is to retain analgesic potency while limiting the development of tolerance, dependence, and addiction. Both rewarding and analgesic actions of opioids depend upon actions at the mu opioid (MOP) receptor. Systemic opioid reward requires MOP receptor function in the midbrain ventral tegmental area (VTA) which contains dopaminergic neurons. VTA dopaminergic neurons are implicated in various aspects of reward including reward prediction error, working memory, and incentive salience. It is now clear that subsets of VTA neurons have different pharmacological properties and participate in separate circuits. The degree to which MOP receptor agonists act on different VTA circuits depends upon the behavioral state of the animal, which can be altered by manipulations such as food deprivation or prior exposure to MOP receptor agonists.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.tins.2015.01.002

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,133
Stereotaxic mapping of the monoamine pathways in the rat brain
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb10998.x · Cited by 3,819
Dopamine in motivational control: rewarding, aversive, and alerting
Bromberg-Martin, E. S., Matsumoto, M., & Hikosaka, O. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.022 · Cited by 2,396
Dopamine neuron systems in the brain: An update
Björklund, A., & Dunnett, S. B. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.006 · Cited by 1,777
The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat
Swanson, L. W. (1982) · Brain Research Bulletin · doi:10.1016/0361-9230(82)90145-9 · Cited by 1,718
Opioids excite dopamine neurons by hyperpolarization of local interneurons
Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637
The mysterious motivational functions of mesolimbic dopamine
Salamone, J. D., & Correa, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.10.021 · Cited by 1,418
REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade
Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336
Neuron-type-specific signals for reward and punishment in the ventral tegmental area
Cohen, J. Y., Haesler, S., Vong, L., Lowell, B. B., & Uchida, N. (2012) · Nature · doi:10.1038/nature10754 · Cited by 1,318
Input-specific control of reward and aversion in the ventral tegmental area
Lammel, S., Lim, B. K., Ran, C., Huang, K. W., Betley, M. J., Tye, K. M., Deisseroth, K., & Malenka, R. C. (2012) · Nature · doi:10.1038/nature11527 · Cited by 1,300

Show all 131 references

Sorted by citations

Items 101–200 of 433

Key differences in regulation of opioid receptors localized to presynaptic terminals compared to somas: Relevance for novel therapeutics
Coutens, B., & Ingram, S. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109408 · Cited by 30
Striatal Dopamine Release in Response to Morphine: A [11C]Raclopride Positron Emission Tomography Study in Healthy Men
Spagnolo, P. A., Kimes, A. S., Schwandt, M. L., Kojori, E. S., Thada, S., Phillips, K. A., Diazgranados, N., Preston, K. L., Herscovitch, P., Tomasi, D. G., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.03.965 · Cited by 30
Why Do Birds Flock? A Role for Opioids in the Reinforcement of Gregarious Social Interactions
Riters, L. V., Kelm‐Nelson, C. A., & Spool, J. A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00421 · Cited by 29
Transcriptional profiling aligned with in situ expression image analysis reveals mosaically expressed molecular markers for GABA neuron sub‐groups in the ventral tegmental area
Paul, E. J., Tossell, K., & Ungless, M. A. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14534 · Cited by 33
Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu‐opioid receptor
Zhang, J., Song, C., Dai, J., Li, L., Yang, X., & Chen, Z. (2022) · MedComm · doi:10.1002/mco2.148 · Cited by 32
Cellular and behavioral basis of cannabinioid and opioid interactions: Implications for opioid dependence and withdrawal
Mohammadkhani, A., & Borgland, S. L. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24770 · Cited by 29
Alterations in Rat Accumbens Endocannabinoid and GABA Content during Fentanyl Treatment: The Role of Ghrelin
Šustková-Fišerová, M., Charalambous, C., Havlickova, T., Lapka, M., Jerabek, P., Puskina, N., & Syslová, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112486 · Cited by 29
Oxycodone-Mediated Activation of the Mu Opioid Receptor Reduces Whole Brain Functional Connectivity in Mice
Nasseef, M. T., Singh, J. P., Ehrlich, A. T., McNicholas, M., Park, D. W., Ma, W., Kulkarni, P. P., Kieffer, B. L., & Darcq, E. (2019) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00021 · Cited by 29
Mu Opioid Receptor–Expressing Neurons in the Dorsal Raphe Nucleus Are Involved in Reward Processing and Affective Behaviors
Welsch, L., Colantonio, E., Frison, M., Johnson, D. A., McClain, S. P., Mathis, V., Banghart, M. R., Hamida, S. B., Darcq, E., & Kieffer, B. L. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.05.019 · Cited by 34
Chapter 13. Methadone and Buprenorphine Maintenance Treatment of Opioid-Related Disorders
Strain, E. C., & Stoller, K. B. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb13 · Cited by 27
The Association of Preoperative Opioid Usage With Patient-Reported Outcomes, Adverse Events, and Return to Work After Lumbar Fusion: Analysis From the Michigan Spine Surgery Improvement Collaborative (MSSIC)
Zakaria, H. M., Mansour, T. R., Telemi, E., Asmaro, K. P., Bazydlo, M. S., Schultz, L. R., Nerenz, D. R., Abdulhak, M. M., Khalil, J. G., Easton, R. W., et al. (2019) · Neurosurgery · doi:10.1093/neuros/nyz423 · Cited by 27
Endogenous opioids facilitate intrinsically-rewarded birdsong
Stevenson, S. A., Piepenburg, A., Spool, J. A., Angyal, C. S., Hahn, A. H., Zhao, C., & Riters, L. V. (2020) · Scientific Reports · doi:10.1038/s41598-020-67684-1 · Cited by 31
Sex and age-dependent effects of a maternal junk food diet on the mu-opioid receptor in rat offspring
Gugusheff, J., Bae, S., Rao, A., Clarke, I. J., Poston, L., Taylor, P. D., Coen, C. W., & Mühlhäusler, B. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.027 · Cited by 29
The Nociceptin Receptor (NOP) Agonist AT-312 Blocks Acquisition of Morphine- and Cocaine-Induced Conditioned Place Preference in Mice
Zaveri, N. T., Marquez, P. V., Meyer, M. E., Hamid, A., & Lutfy, K. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00638 · Cited by 27
Chapter 2. Genetics and Epigenetics of Addiction
Gelernter, J. E., & Polimanti, R. A. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb02 · Cited by 26
Chapter 37. Substance-Related Disorders in Adolescents
Roten, A. T., & Gray, K. M. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb37 · Cited by 26
Chapter 3. Epidemiology of Addiction
Smith, N., & Cottler, L. B. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb03 · Cited by 25
Day-to-day hedonic and calming effects of opioids, opioid craving, and opioid misuse among patients with chronic pain prescribed long-term opioid therapy
Frimerman, L., Verner, M., Sirois, A., Scott, K., Bruneau, A., Pérez, J., Shir, Y., & Martel, M. O. (2021) · Pain · doi:10.1097/j.pain.0000000000002220 · Cited by 26
Morphine-induced modulation of Nrf2-antioxidant response element signaling pathway in primary human brain microvascular endothelial cells
Reymond, S., Vujić, T., Schvartz, D., & Sanchez, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-08712-0 · Cited by 29
Genetic deletion of the dopamine D3 receptor increases vulnerability to heroin in mice
Zhan, J., Jordan, C. J., Bi, G., He, X., Gardner, E. L., Wang, Y., & Xi, Z. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.016 · Cited by 29
Chapter 48. Trauma- and Stressor-Related Disorders
Fitzpatrick, S., Jarnecke, A. M., Back, S. E., Straus, E., Norman, S., & Hien, D. A. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb48 · Cited by 25
Histone modifications in cocaine, methamphetamine and opioids
Cheng, J., He, Z., Chen, Q., Jiang, L., Peng, Y., Zhang, J., Yan, X., Yan, J., & Niu, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e16407 · Cited by 26
Glutamate inputs send prediction error of reward, but not negative value of aversive stimuli, to dopamine neurons
Amo, R., Uchida, N., & Watabe‐Uchida, M. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.019 · Cited by 23
Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation
Nam, M., Won, W., Han, K., & Lee, C. J. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03595-8 · Cited by 26
Traumatic Stress-Induced Vulnerability to Addiction: Critical Role of the Dynorphin/Kappa Opioid Receptor System
Leconte, C., Mongeau, R., & Noble, F. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.856672 · Cited by 25
Intravenous morphine self-administration alters accumbal microRNA profiles in the mouse brain
Im, H., Moon, C., & Kim, J. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.224374 · Cited by 25
Chapter 35. Prevention of Substance Use Disorders
Champion, K. E., Newton, N. C., & Teesson, M. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb35 · Cited by 24
Current Understanding of the Neurobiology of Opioid Use Disorder: an Overview
Moningka, H., Lichenstein, S. D., & Yip, S. W. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-0170-4 · Cited by 24
Chapter 23. Cognitive-Behavioral Therapy
Carroll, K. M., & Kiluk, B. D. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb23 · Cited by 23
Chapter 27. Family Therapy
Steinglass, P. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb27 · Cited by 23
Chapter 25. Motivational Enhancement
Shulman, M., Pruzan, K., & Carpenter, K. M. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb25 · Cited by 23
Chapter 44. Mood Disorders
Wai, J. M., Shulman, M., & Nunes, E. V. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb44 · Cited by 23
Converging circuits between pain and depression: the ventral tegmental area as a therapeutic hub
Flores-García, M., Rizzo, A., Garçon-Poca, M. Z., Fernández‐Dueñas, V., & Bonaventura, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1278023 · Cited by 25
The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area
Zhang, H., Lipinski, A. A., Liktor‐Busa, E., Smith, A. F., Moutal, A., Khanna, R., Langlais, P. R., Largent‐Milnes, T. M., & Vanderah, T. W. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.632757 · Cited by 24
Neurotransmitters crosstalk and regulation in the reward circuit of subjects with behavioral addiction
Peng, Z., Jia, Q., Mao, J., Luo, X., Huang, A., Zheng, H., Jiang, S., Ma, Q., Ma, C., & Yi, Q. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1439727 · Cited by 29
Apparent Effects of Opioid Use on Neural Responses to Reward in Chronic Pain
Martucci, K. T., MacNiven, K. H., Borg, N., Knutson, B. D., & Mackey, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-45961-y · Cited by 20
Novel treatments for chronic pain: moving beyond opioids
O’Brien, J. B., & Roman, D. L. (2021) · Translational research · doi:10.1016/j.trsl.2021.03.008 · Cited by 22
Naloxone precipitated withdrawal increases dopamine release in the dorsal striatum of opioid dependent men
Kojori, E. S., Wang, G., & Volkow, N. D. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01548-8 · Cited by 23
Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors
Wang, X., Bao, C., Li, Z., Yue, L., & Hu, L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19042387 · Cited by 24
Aerobic Fitness Is Associated with Cerebral μ-Opioid Receptor Activation in Healthy Humans
Saanijoki, T., Kantonen, T., Pekkarinen, L., Kalliokoski, K. K., Hirvonen, J., Malén, T., Tuominen, L. J., Tuulari, J. J., Arponen, E., Nuutila, P., et al. (2022) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002895 · Cited by 23
Pain vulnerability and DNA methyltransferase 3a involved in the affective dimension of chronic pain
Wang, W., Li, C., Cai, Y., & Pan, Z. Z. (2017) · Molecular Pain · doi:10.1177/1744806917726713 · Cited by 23
m-Trifluoromethyl-diphenyl diselenide (m-CF3-PhSe)2 modulates the hippocampal neurotoxic adaptations and abolishes a depressive-like phenotype in a short-term morphine withdrawal in mice
Martins, C. C., Rosa, S. G., Recchi, A. M. S., Nogueira, C. W., & Zeni, G. R. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109803 · Cited by 21
A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder
Galaj, E., Bi, G., Klein, B., Hempel, B. J., Shaik, A. B., Gogarnoiu, E. S., Friedman, J., Lam, J., Rais, R., Reed, J. F., et al. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01379-1 · Cited by 21
Behavioral, Neural, and Molecular Mechanisms of Conditioned Mate Preference: The Role of Opioids and First Experiences of Sexual Reward
Quintana, G. R., Cionnaith, C. E. M., & Pfaus, J. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168928 · Cited by 23
Extracellular vesicle-mediated delivery of anti-miR-106b inhibits morphine-induced primary ciliogenesis in the brain
Ma, R., Kutchy, N. A., Wang, Z., & Hu, G. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.03.030 · Cited by 21
Enhancing translation: A need to leverage complex preclinical models of addictive drugs to accelerate substance use treatment options
Corley, C. L., Craig, A. J., Sadek, S. M., Marusich, J. A., Chehimi, S. N., White, A. M., Holdiness, L. J., Reiner, B. C., & Gipson, C. D. (2024) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2024.173836 · Cited by 23
Effects of NOP-Related Ligands in Nonhuman Primates
Kiguchi, N., & Ko, M. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_211 · Cited by 21
Naltrexone Use in Treating Hypersexuality Induced by Dopamine Replacement Therapy: Impact of OPRM1 A/G Polymorphism on Its Effectiveness
Verholleman, A., Victorri‐Vigneau, C., Laforgue, E., Derkinderen, P., Verstuyft, C., & Grall‐Bronnec, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21083002 · Cited by 23
Targeting mitochondrial dynamics of morphine-responsive dopaminergic neurons ameliorates opiate withdrawal
Jiang, C., Huang, H., Yang, X., Le, Q., Liu, X., Ma, L., & Wang, F. (2024) · Journal of Clinical Investigation · doi:10.1172/jci171995 · Cited by 21
Deletion of the type 2 metabotropic glutamate receptor increases heroin abuse vulnerability in transgenic rats
Gao, J., Jordan, C. J., Bi, G., He, Y., Yang, H.-J., Gardner, E. L., & Xi, Z. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0231-5 · Cited by 21
The role of antipsychotics and other drugs on the development and progression of neuroleptic malignant syndrome
Kyotani, Y., Zhao, J., Nakahira, K., & Yoshizumi, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-45783-z · Cited by 20
GIRK Channel Plasticity and Implications for Drug Addiction
de Velasco, E. M. F., McCall, N. M., & Wickman, K. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.05.011 · Cited by 21
Clinical Neuroscience of Addiction: Similarities and Differences Between Alcohol and Other Drugs
Karoly, H. C., YorkWilliams, S. L., & Hutchison, K. E. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12884 · Cited by 19
Pharmacological Effects of a Monoclonal Antibody against 6-Monoacetylmorphine upon Heroin-Induced Locomotor Activity and Pharmacokinetics in Mice
Kvello, A. M. S., Andersen, J. M., Øiestad, E. L., Mørland, J. G., & Bogen, I. L. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.233510 · Cited by 19
Mu-Opioid Receptors Expressed in Glutamatergic Neurons are Essential for Morphine Withdrawal
Zhang, X., Li, Q., Dong, Y., Yan, W., Song, K., Lin, Y., & Sun, Y.-G. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00515-5 · Cited by 19
Mesolimbic opioid-dopamine interaction is disrupted in obesity but recovered by weight loss following bariatric surgery
Karlsson, H. K., Tuominen, L. J., Helin, S., Salminen, P. T. P., Nuutila, P., & Nummenmaa, L. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01370-2 · Cited by 21
Dopamine and relapse to drug seeking
Liu, Y., & McNally, G. P. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15309 · Cited by 19
Aerobic exercise as a promising nonpharmacological therapy for the treatment of substance use disorders
Marrero‐Cristobal, G., Gelpi‐Dominguez, U., Silva, R. J. M., Alvarado-Torres, J. K., Perez‐Torres, J., Perez‐Perez, Y., & Sepulveda-Orengo, M. T. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24990 · Cited by 20
The reward for placebos: mechanisms underpinning placebo-induced effects on motor performance
Brietzke, C., Cesario, J., Hettinga, F. J., & Pires, F. O. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-05029-8 · Cited by 18
Interleukin-10 enhances activity of ventral tegmental area dopamine neurons resulting in increased dopamine release
Ronström, J. W., Williams, S. B., Payne, A., Obray, J. D., Hafen, C. W., Burris, M., Weber, K. S., Steffensen, S. C., & Yorgason, J. T. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.07.007 · Cited by 22
Delta Opioid Pharmacology in Relation to Alcohol Behaviors
Alongkronrusmee, D., Chiang, T., & van Rijn, R. M. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_30 · Cited by 20
Mindfulness-Oriented Recovery Enhancement reduces opioid craving, pain, and negative affect among chronic pain patients on long-term opioid therapy: An analysis of within- and between-person state effects
Parisi, A. B., Hanley, A. W., & Garland, E. L. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104066 · Cited by 18
Gestational Buprenorphine Exposure Disrupts Dopamine Neuron Activity and Related Behaviors in Adulthood
Elam, H. B., Donegan, J. J., Hsieh, J., & Lodge, D. J. (2022) · eNeuro · doi:10.1523/eneuro.0499-21.2022 · Cited by 18
Opioid Receptors Modulate Firing and Synaptic Transmission in the Paraventricular Nucleus of the Thalamus
Hou, G., Jiang, S., Chen, G., Deng, X., Li, F., Xu, H. Z., Chen, B., & Zhu, Y. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1766-22.2023 · Cited by 17
Cell-type specific molecular architecture for mu opioid receptor function in pain and addiction circuits
Ochandarena, N. E., Niehaus, J. K., Tassou, A., & Scherrer, G. (2023) · Neuropharmacology · doi:10.1016/j.neuropharm.2023.109597 · Cited by 20
Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia
Martínez-Rivera, A., Fetcho, R. N., Birmingham, L., Xu, J., Yang, R., Foord, C., Scala-Chávez, D., Mekawy, N., Pleil, K. E., Pickel, V. M., et al. (2024) · Science Advances · doi:10.1126/sciadv.adq4779 · Cited by 17
Mechanisms underlying δ- and μ-opioid receptor agonist-induced increases in extracellular dopamine level in the nucleus accumbens of freely moving rats
Saigusa, T., Aono, Y., & Waddington, J. L. (2017) · Journal of Oral Science · doi:10.2334/josnusd.16-0874 · Cited by 17
Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine
Zeng, Y., Luo, H., Gao, Z., Zhu, X., Shen, Y., Li, Y., Hu, J., & Yang, J. (2021) · iScience · doi:10.1016/j.isci.2021.102213 · Cited by 17
Development of New Analgesics: An Answer to Opioid Epidemic
Yaksh, T. L., Hunt, M. A., & dos Santos, G. G. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.10.003 · Cited by 17
Annual Research Review: Prenatal opioid exposure – a two‐generation approach to conceptualizing neurodevelopmental outcomes
Conradt, E. D., Camerota, M., Maylott, S. E., & Lester, B. M. (2023) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13761 · Cited by 18
Effect of germ-free status on transcriptional profiles in the nucleus accumbens and transcriptomic response to chronic morphine
Sens, J. P., Hofford, R. S., & Kiraly, D. D. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103874 · Cited by 15
Comprehensive Perioperative Management Considerations in Patients Taking Methadone
Cornett, E. M., Kline, R. J., Robichaux, S., Green, J. B., Anyama, B. C., Gennuso, S. A., Okereke, E. C., & Kaye, A. D. (2019) · Current Pain and Headache Reports · doi:10.1007/s11916-019-0783-z · Cited by 16
Blunted opioid regulation of the HPA stress response during nicotine withdrawal: therapeutic implications
Al’Absi, M., Nakajima, M., DeAngelis, B. N., Grant, J. E., King, A. C., Grabowski, J. G., Hatsukami, D. K., & ALLEN, S. S. (2020) · Stress · doi:10.1080/10253890.2020.1823367 · Cited by 16
Epitranscriptome of the ventral tegmental area in a deep brain-stimulated chronic unpredictable mild stress mouse model
Song, N., Du, J., Gao, Y., & Yang, S. (2020) · Translational Neuroscience · doi:10.1515/tnsci-2020-0146 · Cited by 15
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis
Yan, P., Li, N., Ma, M., Liu, Z., Yang, H., Li, J., Wan, C., Gao, S., Li, S., Zheng, L. T., et al. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01578-2 · Cited by 15
Emergence of restless legs syndrome during opioid discontinuation
McCarter, S. J., Labott, J. R., Mazumder, M., Gebhard, J., Cunningham, J. L., Loukianova, L. L., Gilliam, W. P., & Lipford, M. C. (2023) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10436 · Cited by 15
Convergent Balancing Selection on the Mu-Opioid Receptor in Primates
Sweeney, C. G., Rando, J. M., Panas, H. N., Miller, G. M., Platt, D. M., & Vallender, E. J. (2017) · Molecular Biology and Evolution · doi:10.1093/molbev/msx105 · Cited by 16
Opioid and nondopamine reward circuitry and state‐dependent mechanisms
Fujita, M., Ide, S., & Ikeda, K. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13605 · Cited by 15
Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study
Murray, K. D., Lin, Y., Makary, M. M., Whang, P. G., & Geha, P. (2021) · Molecular Pain · doi:10.1177/1744806921990938 · Cited by 15
μ-opioid receptor agonists and psychedelics: pharmacological opportunities and challenges
Salinsky, L. M., Merritt, C. R., Zamora, J. C., Giacomini, J. L., Anastasio, N. C., & Cunningham, K. A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1239159 · Cited by 14
Intrinsic motivation for singing in songbirds is enhanced by temporary singing suppression and regulated by dopamine
Kim, Y., Sojeong, K., Rajan, R., Mori, C., & Kojima, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-99456-w · Cited by 14
Interleukin-1 receptor-associated kinase 4 (IRAK4) in the nucleus accumbens regulates opioid-seeking behavior in male rats
Wu, R., Liu, J., Vu, J., Huang, Y., Dietz, D., & Li, J. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.12.014 · Cited by 15
Involvement of opioid signaling in food preference and motivation
Morales, I., Font, L., Currie, P. J., & Pastor, R. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.06.002 · Cited by 15
Local μ-Opioid Receptor Antagonism Blunts Evoked Phasic Dopamine Release in the Nucleus Accumbens of Rats
Gómez‐A, A., Shnitko, T. A., Barefoot, H. M., Brightbill, E. L., Sombers, L. A., Nicola, S. M., & Robinson, D. L. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00437 · Cited by 16
Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone
Jones, J. D., Mumtaz, M., Manubay, J. M., Mogali, S., Sherwin, E., Martinez, S., & Comer, S. D. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172778 · Cited by 13
Opioidergic tuning of social attachment: reciprocal relationship between social deprivation and opioid abuse
Soares, J. A. G., Sutley-Koury, S. N., Pomrenze, M. B., & Tucciarone, J. (2025) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2024.1521016 · Cited by 14
Risk for opioid misuse in chronic pain patients is associated with endogenous opioid system dysregulation
Ballester, J., Baker, A. K., Martikainen, I. K., Koppelmans, V., Zubieta, J.-K., & Love, T. (2022) · Translational Psychiatry · doi:10.1038/s41398-021-01775-z · Cited by 13
Neuronal mechanisms mediating pathological reward-related behaviors: A focus on silent synapses in the nucleus accumbens
McDevitt, D. S., & Graziane, N. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.08.025 · Cited by 13
Activation of μ‐opioid receptors by MT‐45 (1‐cyclohexyl‐4‐(1,2‐diphenylethyl)piperazine) and its fluorinated derivatives
Baptista‐Hon, D. T., Smith, M. A., Singleton, S., Antonides, L. H., Daéid, N. N., McKenzie, C., & Hales, T. G. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15064 · Cited by 13
Toxicological aspects of the interesterified-fat from processed foods: Influences on opioid system and its reward effects in rats
Milanesi, L. H., Roversi, K., Antoniazzi, C. T. D. D., Segat, H. J., Kronbauer, M., D’avila, L. F., Dias, V. T., Sari, M. H. M., Barcelos, R. C. S., Maurer, L. H., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.09.048 · Cited by 14
The role of ghrelin/GHS-R1A signaling in nonalcohol drug addictions
Sustkova-Fiserova, M., Charalambous, C., Khryakova, A., Certilina, A., Lapka, M., & Šlamberová, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020761 · Cited by 12
Opioid analgesic effects on subjective well‐being in the operating theatre*
Eikemo, M., Meier, I. M., Løseth, G. E., Trøstheim, M., Ørstavik, N., Jensen, E. N., Garland, E. L., Berna, C., Ernst, G., & Leknes, S. (2023) · Anaesthesia · doi:10.1111/anae.16069 · Cited by 14
Fentanyl self‐administration is accelerated by methamphetamine co‐use and results in worsened hypodopaminergia in male, but not female rats
Dawes, M. H., Ortelli, O. A., Holleran, K. M., & Jones, S. R. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16533 · Cited by 12
In vivo pharmacokinetic, pharmacodynamic and brain concentration comparison of fentanyl and para-fluorofentanyl in rats
Canfield, J. R., & Sprague, J. E. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03887-z · Cited by 12
Integrative opioid-GABAergic neuronal mechanisms regulating dopamine efflux in the nucleus accumbens of freely moving animals
Saigusa, T., Aono, Y., & Waddington, J. L. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00249-9 · Cited by 12
Viral vector-mediated gene therapy for opioid use disorders
Wang, T., Zhu, X., Yi, H., Gu, J., Liu, S., Izenwasser, S., Lemmon, V., Roy, S., & Hao, S. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113710 · Cited by 12
Genetic implications in quality palliative care and preventing opioid crisis in cancer‐related pain management
Sumitani, M., Nishizawa, D., Hozumi, J., & Ikeda, K. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24756 · Cited by 12
Ineffective VTA Disinhibition in Protracted Opiate Withdrawal
Barrot, M. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.08.004 · Cited by 12
Uridine attenuates morphine-induced conditioned place preference and regulates glutamate/GABA levels in mPFC of mice
Liu, P., Che, X., Yu, L., Yang, X., An, N., Wu, S., Wu, C., & Yang, J. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.10.004 · Cited by 12
Lateral preoptic area glutamate neurons relay nociceptive information to the ventral tegmental area
Barker, D. J., Zhang, S., Wang, H., Estrin, D. J., Miranda-Barrientos, J. A., Liu, B., Kulkarni, R. J., de Deus, J. L., & Morales, M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113029 · Cited by 12

Authors: Fields, H. L., & Margolis, E. B.
Affiliations: University of California, San Francisco (US)
Corresponding author: Fields, Howard L.
ORCID: Fields, Howard L.
Margolis, Elyssa B.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2015-04
Volume: 38
Issue: 4
Pages: 217-225
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2015.01.002
PMC: PMC4385443
OpenAlex: W2035419353
Cited by: 432
References: 131
Citations by year: 2026: 23 · 2025: 33 · 2024: 22 · 2023: 36 · 2022: 37 · 2021: 93 · 2020: 43 · 2019: 50 · 2018: 31 · 2017: 26 · 2016: 23 · 2015: 15
FWCI: 3.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute on Drug Abuse (R01DA029776)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: opioid reward, mu-opioid receptor, ventral tegmental area, dopaminergic neurons, opioid use disorder, analgesia, reward prediction error, incentive salience, working memory, behavioral state, food deprivation, opioid tolerance
MeSH terms: Analgesics, Opioid, Animals, Humans, Receptors, Opioid, Reinforcement, Psychology, Reward, Receptors, Opioid, mu, Ventral Tegmental Area, Dopaminergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Understanding opioid reward

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks