Cited by 433Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research

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Understanding opioid reward

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Fields, Howard L., Margolis, Elyssa B.·2015·Trends in Neurosciences

DOI 10.1016/j.tins.2015.01.002PMC PMC4385443

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Abstract

Opioids are the most potent analgesics in clinical use; however, their powerful rewarding properties can lead to addiction. The scientific challenge is to retain analgesic potency while limiting the development of tolerance, dependence, and addiction. Both rewarding and analgesic actions of opioids depend upon actions at the mu opioid (MOP) receptor. Systemic opioid reward requires MOP receptor function in the midbrain ventral tegmental area (VTA) which contains dopaminergic neurons. VTA dopaminergic neurons are implicated in various aspects of reward including reward prediction error, working memory, and incentive salience. It is now clear that subsets of VTA neurons have different pharmacological properties and participate in separate circuits. The degree to which MOP receptor agonists act on different VTA circuits depends upon the behavioral state of the animal, which can be altered by manipulations such as food deprivation or prior exposure to MOP receptor agonists.

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Chapter 29. Digitally Delivered Therapies
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Chapter 17. Treatment of Cannabis-Related Disorders
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Chapter 15. Neurobiology and Treatment of Hallucinogen Use Disorder
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Chapter 32. Cannabis Policy and Use
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Chapter 41. Substance-Related Disorders in Older Adults
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Chapter 9. Treatment of Alcohol-Related Disorders
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Chapter 31. The U.S. Opioid Crisis
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Chapter 53. Addiction in the Workplace
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Chapter 33. HIV/AIDS and Hepatitis C Virus
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Chapter 42. Behavioral Addictive Disorders
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Chapter 12. Neurobiology of Opioids
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Chapter 26. Alcoholics Anonymous and Twelve-Step Facilitation
Ries, R. K. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb26
Chapter 50. Testing for Substances of Abuse
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Chapter 16. Neurobiology of Marijuana
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Chapter 30. Mindfulness, Exercise, and Other Alternative Therapies
Bowen, S. W., Wilson, A. D., & Laue, C. S. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb30
Touching upon affiliation: On the roles of the opioid and oxytocin systems in human social-emotional behavior
Meier, I. M. (2020) · Utrecht University Repository (Utrecht University) · doi:10.33540/425
Polimorfismos genéticos del sistema dopaminérgico, GABA, BDNF Y NPY y su relación con la dependencia alcohólica
Lesmes, S. P. G. (2020) · Gredos (University of Salamanca) · doi:10.14201/gredos.145336
Network and Cellular Effects of the Mu Opioid Receptor in Cortical Interneurons
Dutkiewicz, A. P. (2021) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
The Behavioral Role of Mu Opioid Receptors in Glutamatergic Neurons
Reeves, K. C. (2021) · IUScholarWorks (Indiana University) · doi:10.7912/c2/2088
Chapter 28. Network Therapy
Galanter, M. S. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb28
Analgesics
Stein, C. (2021) · Springer eBooks · doi:10.1007/978-3-030-57401-7_6
Chapter 45. Anxiety Disorders
Brady, K. T., & Back, S. E. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb45

Authors: Fields, H. L., & Margolis, E. B.
Affiliations: University of California, San Francisco (US)
Corresponding author: Fields, Howard L.
ORCID: Fields, Howard L.
Margolis, Elyssa B.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2015-04
Volume: 38
Issue: 4
Pages: 217-225
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2015.01.002
PMC: PMC4385443
OpenAlex: W2035419353
Cited by: 432
References: 131
Citations by year: 2026: 23 · 2025: 33 · 2024: 22 · 2023: 36 · 2022: 37 · 2021: 93 · 2020: 43 · 2019: 50 · 2018: 31 · 2017: 26 · 2016: 23 · 2015: 15
FWCI: 3.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute on Drug Abuse (R01DA029776)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: opioid reward, mu-opioid receptor, ventral tegmental area, dopaminergic neurons, opioid use disorder, analgesia, reward prediction error, incentive salience, working memory, behavioral state, food deprivation, opioid tolerance
MeSH terms: Analgesics, Opioid, Animals, Humans, Receptors, Opioid, Reinforcement, Psychology, Reward, Receptors, Opioid, mu, Ventral Tegmental Area, Dopaminergic Neurons

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