The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Neural Correlates of Unconsciousness in Large-Scale Brain Networks
Open accessAbstract
The biological basis of consciousness is one of the most challenging and fundamental questions in 21st century science. A related pursuit aims to identify the neural correlates and causes of unconsciousness. We review current trends in the investigation of physiological, pharmacological, and pathological states of unconsciousness at the level of large-scale functional brain networks. We focus on the roles of brain connectivity, repertoire, graph-theoretical techniques, and neural dynamics in understanding the functional brain disconnections and reduced complexity that appear to characterize these states. Persistent questions in the field, such as distinguishing true correlates, linking neural scales, and understanding differential recovery patterns, are also addressed.
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“increases in modularity (which reduces the capacity for information integration [151]) observed in association with anesthesia, sleep, and pathologic unconsciousness [152].”
From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [152]
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Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery
Hemmings, H. C., Riegelhaupt, P. M., Kelz, M. B., Solt, K., Eckenhoff, R. G., Orser, B. A., & Goldstein, P. A. (2019) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2019.05.001 · Cited by 244
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Kelz, M. B., & Mashour, G. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.071 · Cited by 151
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Anterior insula regulates brain network transitions that gate conscious access
Huang, Z., Tarnal, V., Vlisides, P. E., Janke, E., McKinney, A., Picton, P., Mashour, G. A., & Hudetz, A. G. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109081 · Cited by 122
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Metadata
- Authors
- Mashour, G. A., & Hudetz, A. G.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Mashour, George A.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 41
- Issue
- 3
- Pages
- 150-160
- ISSN
- 0166-2236 (ISSN-L)
- PMC
- PMC5835202
- OpenAlex
- W2786504149
- Cited by
- 189
- References
- 97
- Citations by year
- 2026: 19 · 2025: 43 · 2024: 21 · 2023: 21 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 18 · 2018: 8
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences of the National Institutes of Health (R01GM098578, R01GM111293, R01124248, R01GM056398)
- James S. McDonnell Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- loss of consciousness, neural correlates of consciousness, large-scale brain networks, brain connectivity, graph theory, neural dynamics, consciousness
- MeSH terms
- Animals, Brain, Brain Mapping, Consciousness, Electroencephalography, Humans, Neural Pathways, Unconsciousness
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