Cited by 189Functional Brain Connectivity StudiesNeural dynamics and brain functionTraumatic Brain Injury Research

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Neural Correlates of Unconsciousness in Large-Scale Brain Networks

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Mashour, George A., Hudetz, Anthony G.·2018·Trends in Neurosciences

DOI 10.1016/j.tins.2018.01.003PMC PMC5835202

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Abstract

The biological basis of consciousness is one of the most challenging and fundamental questions in 21st century science. A related pursuit aims to identify the neural correlates and causes of unconsciousness. We review current trends in the investigation of physiological, pharmacological, and pathological states of unconsciousness at the level of large-scale functional brain networks. We focus on the roles of brain connectivity, repertoire, graph-theoretical techniques, and neural dynamics in understanding the functional brain disconnections and reduced complexity that appear to characterize these states. Persistent questions in the field, such as distinguishing true correlates, linking neural scales, and understanding differential recovery patterns, are also addressed.

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Authors: Mashour, G. A., & Hudetz, A. G.
Affiliations: University of Michigan (US)
Corresponding author: Mashour, George A.
ORCID: Mashour, George A.
Hudetz, Anthony G.
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 2018-03
Volume: 41
Issue: 3
Pages: 150-160
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/j.tins.2018.01.003
PMC: PMC5835202
OpenAlex: W2786504149
Cited by: 189
References: 97
Citations by year: 2026: 19 · 2025: 43 · 2024: 21 · 2023: 21 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 18 · 2018: 8
FWCI: 2.30
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences of the National Institutes of Health (R01GM098578, R01GM111293, R01124248, R01GM056398)
James S. McDonnell Foundation
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Keywords: loss of consciousness, neural correlates of consciousness, large-scale brain networks, brain connectivity, graph theory, neural dynamics, consciousness
MeSH terms: Animals, Brain, Brain Mapping, Consciousness, Electroencephalography, Humans, Neural Pathways, Unconsciousness

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Neural Correlates of Unconsciousness in Large-Scale Brain Networks

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