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Cited by 122Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling

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Milosevic, Ira·2018·Frontiers in Cellular Neuroscience
DOI 10.3389/fncel.2018.00027PMC PMC5807904
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Abstract

Without robust mechanisms to efficiently form new synaptic vesicles (SVs), the tens to hundreds of SVs typically present at the neuronal synapse would be rapidly used up, even at modest levels of neuronal activity. SV recycling is thus critical for synaptic physiology and proper function of sensory and nervous systems. Yet, more than four decades after it was originally proposed that the SVs are formed and recycled locally at the presynaptic terminals, the mechanisms of endocytic processes at the synapse are heavily debated. Clathrin-mediated endocytosis, a type of endocytosis that capitalizes on the clathrin coat, a number of adaptor and accessory proteins, and the GTPase dynamin, is well understood, while the contributions of clathrin-independent fast endocytosis, kiss-and-run, bulk endocytosis and ultrafast endocytosis are still being evaluated. This review article revisits and summarizes the current knowledge on the SV reformation with a focus on clathrin-mediated endocytosis, and it discusses the modes of SV formation from endosome-like structures at the synapse. Given the importance of this topic, future advances in this active field are expected to contribute to better comprehension of neurotransmission, and to have general implications for neuroscience and medicine.

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  • Ultrafast bulk endocytosis and activity-dependent bulk endocytosis are also responsible for recycling of vesicles.

    “Apart from those mechanisms, several other mechanisms, such as ultrafast bulk endocytosis and activity-dependent bulk endocytosis, are also responsible for the recycling of the vesicles [150,151].”

    From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [150]

    In “Biogenesis and Recycling of Synaptic Vesicles at the Neuronal Synapse” (page unavailable), the paper discusses ultrafast endocytosis and bulk endocytosis as mechanisms associated with synaptic vesicle recycling, and links bulk endocytosis to stronger stimulation. It treats them as separate forms, however; it does not identify an “ultrafast bulk endocytosis” mechanism. Its description of the stimulation-linked bulk form is also tentative (“may represent bulk endocytosis”). (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Milosevic, I.
Venue
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Published
2018-02-06
Volume
12
Pages
27-27
ISSN
1662-5102 (ISSN-L)
DOI
10.3389/fncel.2018.00027
PMC
PMC5807904
OpenAlex
W2791550087
Cited by
122
References
6
Citations by year
2026: 13 · 2025: 10 · 2024: 10 · 2023: 12 · 2022: 10 · 2021: 12 · 2020: 31 · 2019: 14 · 2018: 9
FWCI
1.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
Funders
Deutsche Forschungsgemeinschaft (Emmy Noether Young Investigator Award MI-1702/1, SFB889/2/A08 and SFB1190/P02)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
clathrin-mediated endocytosis, synaptic vesicle recycling, synaptic vesicle formation, presynaptic terminals, dynamin, kiss-and-run, bulk endocytosis, endosomes, neurotransmission

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