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Cited by 38Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

Integration of Synaptic Vesicle Cargo Retrieval with Endocytosis at Central Nerve Terminals

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Cousin, Michael A.·2017·Frontiers in Cellular Neuroscience
DOI 10.3389/fncel.2017.00234PMC PMC5541026
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Abstract

Central nerve terminals contain a limited number of synaptic vesicles (SVs) which mediate the essential process of neurotransmitter release during their activity-dependent fusion. The rapid and accurate formation of new SVs with the appropriate cargo is essential to maintain neurotransmission in mammalian brain. Generating SVs containing the correct SV cargo with the appropriate stoichiometry is a significant challenge, especially when multiple modes of endocytosis exist in central nerve terminals, which occur at different locations within the nerve terminals. These endocytosis modes include ultrafast endocytosis, clathrin-mediated endocytosis (CME) and activity-dependent bulk endocytosis (ADBE) which are triggered by specific patterns of neuronal activity. This review article will assess the evidence for the role of classical adaptor protein complexes in SV retrieval, discuss the role of monomeric adaptors and how interactions between specific SV cargoes can facilitate retrieval. In addition it will consider the evidence for preassembled plasma membrane cargo complexes and their role in facilitating these endocytosis modes. Finally it will present a unifying model for cargo retrieval at the presynapse, which integrates endocytosis modes in time and space.

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  • Neurons possess redundant mechanisms for removing excess membrane from axon terminals, including CDE, activity-dependent bulk endocytosis, and ultrafast endocytosis.

    “Fortunately for Rlip KO mice, neurons possess redundant mechanisms for removing excess membrane from axon terminals. These include CDE, activity-dependent bulk endocytosis, and ultrafast endocytosis [89].”

    From Rlip76: An Unexplored Player in Neurodegeneration and Alzheimer’s Disease? (2022) · cites this paper as [89]

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Cited by

Sorted by citations

Authors
Cousin, M. A.
Affiliations
University of Edinburgh (GB)
Corresponding author
Cousin, Michael A.
ORCID
Cousin, Michael A.
Venue
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Published
2017-08-03
Volume
11
Pages
234-234
ISSN
1662-5102 (ISSN-L)
DOI
10.3389/fncel.2017.00234
PMC
PMC5541026
OpenAlex
W2743824659
Cited by
38
References
4
Citations by year
2025: 4 · 2024: 1 · 2023: 5 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 8 · 2018: 8 · 2017: 3
FWCI
0.74
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (publishedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Biotechnology and Biological Sciences Research Council (BB/L019329/1)
  • Wellcome Trust (204954/Z/16/Z)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
synaptic vesicle retrieval, synaptic vesicle endocytosis, presynaptic terminals, neurotransmitter release, clathrin-mediated endocytosis, adaptor protein complexes

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