The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
Open accessAbstract
In the past decade since the discovery of NAD-dependent deacetylase activity of the SIR2 (silent information regulator 2) family, now called “sirtuins,” many exciting connections between protein deacetylation and energy metabolism have been revealed. The importance of sirtuins have been firmly established in the regulation of many fundamental biological responses to a variety of nutritional and environmental stimuli. Sirtuins have also emerged as critical regulators for aging and longevity in model organisms. Their absolute requirement of NAD has revived an enthusiasm in the study of mammalian NAD biosynthesis. Furthermore, sirtuin-targeted pharmaceutical and nutriceutical interventions against age-associated diseases are now on the horizon. This review will summarize the recent progress in sirtuin research, particularly in the field of mammalian sirtuin biology, and reevaluate the connection between sirtuins, metabolism, and age-associated diseases, such as type 2 diabetes, to set a milepost for the next 10 years of sirtuin research.
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Citations
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Metadata
- Authors
- Imai, S.-I., & Guarente, L.
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 31
- Issue
- 5
- Pages
- 212-220
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2019548769
- Cited by
- 390
- References
- 38
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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