Roles of diacylglycerols and ceramides in hepatic insulin resistance

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W. Z., Strowig, T., Thaiss, C. A., Kau, A. L., Eisenbarth, S. C., Jurczak, M. J., et al. (2012) · Nature · doi:10.1038/nature10809 · Cited by 2,435 · see citing works

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086 · see citing works

Association of nonalcoholic fatty liver disease with insulin resistance

Marchesini, G., Brizi, M., Morselli‐Labate, A. M., Bianchi, G. P., Bugianesi, E., McCullough, A. J., Forlani, G., & Melchionda, N. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00271-5 · Cited by 1,564 · see citing works

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease

Samuel, V. T., Liu, Z.-X., Qu, X., Elder, B. D., Bilz, S., Befroy, D., Romanelli, A. J., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313478200 · Cited by 1,322 · see citing works

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232 · see citing works

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Perry, R. J., Samuel, V. T., Petersen, K. F., & Shulman, G. I. (2014) · Nature · doi:10.1038/nature13478 · Cited by 1,136 · see citing works

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

Shulman, G. I. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1011035 · Cited by 1,126 · see citing works

Mechanism by which metformin reduces glucose production in type 2 diabetes.

Hundal, R. S., Krssak, M., Dufour, S., Laurent, D., Lebon, V, Chandramouli, V, Inzucchi, S. E., Schumann, W. C., Petersen, K. F., Landau, B. R., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2063 · Cited by 1,052 · see citing works

Prevalence of Nonalcoholic Fatty Liver Disease and Its Association With Cardiovascular Disease Among Type 2 Diabetic Patients

Targher, G., Bertolini, L., Padovani, R., Rodella, S., Tessari, R., Zenari, L., Day, C. P., & Arcaro, G. (2007) · Diabetes Care · doi:10.2337/dc06-2247 · Cited by 990 · see citing works

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

Fabbrini, E., Magkos, F., Mohammed, B. S., Pietka, T., Abumrad, N. A., Patterson, B. W., Okunade, A., & Klein, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904944106 · Cited by 972 · see citing works

Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911 · see citing works

Insulin resistance: a metabolic pathway to chronic liver disease

Bugianesi, E., McCullough, A. J., & Marchesini, G. (2005) · Hepatology · doi:10.1002/hep.20920 · Cited by 900 · see citing works

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Fullerton, M. D., Galic, S., Marcinko, K., Sikkema, S., Pulinilkunnil, T., Chen, Z.-P., O'Neill, H. M., Ford, R. J., Palanivel, R., O'Brien, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3372 · Cited by 893 · see citing works

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

Holland, W. L., Miller, R. A., Wang, Z. V., Sun, K., Barth, B. M., Bui, H. H., Davis, K. E., Bikman, B. T., Halberg, N., Rutkowski, J. M., et al. (2011) · Nature Medicine · doi:10.1038/nm.2277 · Cited by 892 · see citing works

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

Magnusson, I., Rothman, D. L., Katz, L. D., Shulman, R. G., & Shulman, G. I. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115997 · Cited by 757 · see citing works

Prevention of fat-induced insulin resistance by salicylate

Kim, J. K., Kim, Y.-J., Fillmore, J. J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z. W., Karin, M., Perret, P., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11559 · Cited by 737 · see citing works

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

Perry, R. J., Camporez, J.-P. G., Kursawe, R., Titchenell, P. M., Zhang, D., Perry, C. J., Jurczak, M. J., Abudukadier, A., Han, M. S., Zhang, X.-M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.012 · Cited by 719 · see citing works

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

Holland, W. L., Bikman, B. T., Wang, L.-P., Yuguang, G., Sargent, K. M., Bulchand, S., Knotts, T. A., Shui, G., Clegg, D. J., Wenk, M. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43378 · Cited by 705 · see citing works

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

Turpin-Nolan, S. M., Nicholls, H. T., Willmes, D. M., Mourier, A., Brodesser, S., Wunderlich, C. M., Mauer, J., Xu, E., Hammerschmidt, P., Brönneke, H. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.08.002 · Cited by 693 · see citing works

Applying the Bradford Hill criteria in the 21st century: how data integration has changed causal inference in molecular epidemiology

Fedak, K. M., Bernal, A. J., Capshaw, Z. A., & Gross, S. A. (2015) · Emerging Themes in Epidemiology · doi:10.1186/s12982-015-0037-4 · Cited by 682 · see citing works

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

Petersen (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215001 · Cited by 622 · see citing works

A Ceramide-Centric View of Insulin Resistance

Chavez, J. A., & Summers, S. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.002 · Cited by 617 · see citing works

Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate

Schmitz-Peiffer, C., Craig, D. L., & Biden, T. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24202 · Cited by 592 · see citing works

Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects.

Korenblat, K. M., Fabbrini, E., Mohammed, B. S., & Klein, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.075 · Cited by 592 · see citing works

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance

Lotta, L. A., Gulati, P., Day, F. R., Payne, F., Ongen, H., van de Bunt, M., Gaulton, K. J., Eicher, J. D., Sharp, S. J., Luan, J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3714 · Cited by 587 · see citing works

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Kumashiro, N., Erion, D. M., Zhang, D., Kahn, M., Beddow, S. A., Chu, X., Still, C. D., Gerhard, G. S., Han, X., Dziura, J., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113359108 · Cited by 585 · see citing works

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

Matsuzaka, T., Shimano, H., Yahagi, N., Kato, T., Atsumi, A., Yamamoto, T., Inoue, N., Ishikawa, M., Okada, S., Ishigaki, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1662 · Cited by 542 · see citing works

Prevalence and associated factors of non‐alcoholic fatty liver disease in patients with type‐2 diabetes mellitus

Leite, N. C., Salles, G. F., Araujo, A. L. E., Villela‐Nogueira, C. A., & Cardoso, C. R. L. (2009) · Liver International · doi:10.1111/j.1478-3231.2008.01718.x · Cited by 531 · see citing works

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

Monetti, M., Levin, M. C., Watt, M. J., Sajan, M. P., Marmor, S., Hubbard, B. K., Stevens, R. D., Bain, J. R., Newgard, C. B., Farese, R. V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.005 · Cited by 511 · see citing works

Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

Samuel, V. T., Liu, Z.-X., Wang, A., Beddow, S. A., Geisler, J. G., Kahn, M., Zhang, X.-M., Monia, B. P., Bhanot, S., & Shulman, G. I. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30400 · Cited by 497 · see citing works

Animal models of nonalcoholic fatty liver disease

Hebbard, L., & George, J. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.191 · Cited by 495 · see citing works

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

Wilson, C. G., Tran, J. L., Erion, D. M., Vera, N. B., Febbraio, M., & Weiss, E. J. (2015) · Endocrinology · doi:10.1210/en.2015-1866 · Cited by 461 · see citing works

Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease

Luukkonen, P. K., Zhou, Y., Sädevirta, S., Leivonen, M., Arola, J., Orešič, M., Hyötyläinen, T., & Yki-Järvinen, H. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.002 · Cited by 461 · see citing works

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

Raichur, S., Wang, S. T., Chan, P. W., Li, Y., Ching, J., Chaurasia, B., Dogra, S. K., Öhman, M. K., Takeda, K., Sugii, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.015 · Cited by 456 · see citing works

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

Savage, D. B. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27300 · Cited by 447 · see citing works

Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice

Kim, J. K., Gavrilova, O., Chen, Y., Reitman, M. L., & Shulman, G. I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8456 · Cited by 443 · see citing works

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2913-1 · Cited by 430 · see citing works

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

Montgomery, M. K., Hallahan, N., Brown, S. H. J., Liu, M., Mitchell, T. W., Cooney, G. J., & Turner, N. A. (2013) · Diabetologia · doi:10.1007/s00125-013-2846-8 · Cited by 416 · see citing works

Regulation of Insulin Action by Ceramide

Stratford, S., Hoehn, K. L., Liu, F., & Summers, S. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406499200 · Cited by 410 · see citing works

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

Raichur, S., Wang, S. T., Chan, P. W., Li, Y., Ching, J., Chaurasia, B., Dogra, S. K., Öhman, M. K., Takeda, K., Sugii, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.007 · Cited by 385 · see citing works

Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance

Choi, C. S., Savage, D. B., Kulkarni, A., Yu, X. X., Liu, Z.-X., Morino, K., Kim, S., Distefano, A., Samuel, V. T., Neschen, S., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704213200 · Cited by 383 · see citing works

Evolving Concepts in the Pathogenesis of NASH: Beyond Steatosis and Inflammation

Peverill, W., Powell, L. W., & Skoien, R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058591 · Cited by 380 · see citing works

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

Ussher, J. R., Koves, T. R., Cadete, V. J. J., Zhang, L., Jaswal, J. S., Swyrd, S. J., Lopaschuk, D. G., Proctor, S. D., Keung, W., Muoio, D. M., et al. (2010) · Diabetes · doi:10.2337/db09-1293 · Cited by 363 · see citing works

Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

Xia, J. Y., Holland, W. L., Kusminski, C. M., Sun, K., Sharma, A. X., Pearson, M. J., Sifuentes, A. J., McDonald, J. G., Gordillo, R., & Scherer, P. E. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.007 · Cited by 348 · see citing works

Inhibition of Akt Kinase by Cell-permeable Ceramide and Its Implications for Ceramide-induced Apoptosis

Zhou, H., Summers, S. A., Birnbaum, M. J., & Pittman, R. N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16568 · Cited by 347 · see citing works

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Sun, Z., Miller, R. A., Patel, R. T., Chen, J., Dhir, R., Wang, H., Zhang, D., Graham, M. J., Unterman, T. G., Shulman, G. I., et al. (2012) · Nature Medicine · doi:10.1038/nm.2744 · Cited by 335 · see citing works

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Choi, C. S., Savage, D. B., Abu-Elheiga, L., Liu, Z.-X., Kim, S., Kulkarni, A., Distefano, A., Hwang, Y.-J., Reznick, R. M., Codella, R., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706794104 · Cited by 325 · see citing works

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

Takayama, S., White, M. F., & Kahn, C. R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69090-8 · Cited by 317 · see citing works

Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance

Jornayvaz, F. R., & Shulman, G. I. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.005 · Cited by 315 · see citing works

Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes.

Krssak, M., Brehm, A., Bernroider, E., Anderwald, C., Nowotny, P., Man, C. D., Cobelli, C., Cline, G. W., Shulman, G. I., Waldhäusl, W., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.12.3048 · Cited by 313 · see citing works

Liver pathology in morbidly obese patients with and without diabetes.

Silverman, J. F., O’Brien, K. F., Long, S., Leggett-Frazier, N., Khazanie, P. G., Pories, W. J., Norris, H. T., & F., J. (1990) · PubMed · Cited by 301 · see citing works

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

Yang, G., Badeanlou, L., Bielawski, J., Roberts, A. J., Hannun, Y. A., & Samad, F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91014.2008 · Cited by 295 · see citing works

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

Zhang, D., Liu, Z.-X., Choi, C. S., Tian, L., Kibbey, R., Dong, J., Cline, G. W., Wood, P. A., & Shulman, G. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707060104 · Cited by 291 · see citing works

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

Tao, H., Zhang, Y., Zeng, X., Shulman, G. I., & Jin, S. (2014) · Nature Medicine · doi:10.1038/nm.3699 · Cited by 288 · see citing works

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

Perry, R. J., Zhang, D., Zhang, X.-M., Boyer, J. L., & Shulman, G. I. (2015) · Science · doi:10.1126/science.aaa0672 · Cited by 283 · see citing works

Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473

Schubert, K. M., Scheid, M. P., & Duronio, V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13330 · Cited by 277 · see citing works

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

Turinsky, J., O'Sullivan, D. M., & Bayly, B. P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44844-7 · Cited by 269 · see citing works

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

Neschen, S., Morino, K., Hammond, L. E., Zhang, D., Liu, Z.-X., Romanelli, A. J., Cline, G. W., Pongratz, R. L., Zhang, X.-M., Choi, C. S., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.006 · Cited by 261 · see citing works

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

Jaworski, K., Ahmadian, M., Duncan, R. E., Sarkadi‐Nagy, E., Varady, K. A., Hellerstein, M. K., Lee, H., Samuel, V. T., Shulman, G. I., Kim, K.-H., et al. (2009) · Nature Medicine · doi:10.1038/nm.1904 · Cited by 260 · see citing works

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

Takayama, S., White, M. F., Lauris, V., & Kahn, C. R. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.24.7797 · Cited by 257 · see citing works

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

Petersen, M. C., Madiraju, A. K., Gassaway, B. M., Marcel, M., Nasiri, A. R., Butrico, G. M., Marcucci, M., Zhang, D., Abulizi, A., Zhang, X., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86013 · Cited by 242 · see citing works

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

Perry, R. J., Kim, T.-H., Zhang, X., Lee, H., Pesta, D. H., Popov, V., Zhang, D., Rahimi, Y., Jurczak, M. J., Cline, G. W., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.004 · Cited by 230 · see citing works

Cellular Mechanisms by Which FGF21 Improves Insulin Sensitivity in Male Mice

Camporez, J. P., Jornayvaz, F. R., Petersen, M. C., Pesta, D. H., Guigni, B. A., Serr, J., Zhang, D., Kahn, M., Samuel, V. T., Jurczak, M. J., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1191 · Cited by 226 · see citing works

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

Magkos, F., Su, X., Bradley, D. P., Fabbrini, E., Conte, C., Eagon, J. C., Varela, J. E., Brunt, E. M., Patterson, B. W., & Klein, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.03.003 · Cited by 223 · see citing works

Studies on the Substrate and Stereo/Regioselectivity of Adipose Triglyceride Lipase, Hormone-sensitive Lipase, and Diacylglycerol-O-acyltransferases

Eichmann, T. O., Kumari, M., Haas, J. T., Farese, R. V., Zimmermann, R., Lass, A., & Zechner, R. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400416 · Cited by 216 · see citing works

Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity.

Caro, J. F., Ittoop, O., Pories, W. J., Meelheim, D., Flickinger, E. G., Thomas, F., Jenquin, M., Silverman, J. F., Khazanie, P. G., & Sinha, M. K. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112558 · Cited by 215 · see citing works

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

Birkenfeld, A. L., Lee, H., Guebre‐Egziabher, F., Alves, T. C., Jurczak, M. J., Jornayvaz, F. R., Zhang, D., Hsiao, J. J., Martín‐Montalvo, A., Fischer‐Rosinsky, A., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.009 · Cited by 212 · see citing works

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

Jornayvaz, F. R., Jurczak, M. J., Lee, H., Birkenfeld, A. L., Frederick, D. W., Zhang, D., Zhang, X., Samuel, V. T., & Shulman, G. I. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00361.2010 · Cited by 212 · see citing works

The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance

Farese, R. V., Zechner, R., Newgard, C. B., & Walther, T. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.004 · Cited by 207 · see citing works

Inhibition of PKB/Akt1 by C2-Ceramide Involves Activation of Ceramide-Activated Protein Phosphatase in PC12 Cells

Salinas, M., López‐Valdaliso, R., Martı́n, D., Alvarez, A. M., & Cuadrado, A. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0813 · Cited by 199 · see citing works

Cellular Mechanism by Which Estradiol Protects Female Ovariectomized Mice From High-Fat Diet-Induced Hepatic and Muscle Insulin Resistance

Camporez, J. P., Jornayvaz, F. R., Lee, H., Kanda, S., Guigni, B. A., Kahn, M., Samuel, V. T., Carvalho, C. R. D. O., Petersen, K. F., Jurczak, M. J., et al. (2013) · Endocrinology · doi:10.1210/en.2012-1989 · Cited by 194 · see citing works

Obesity and Type 2 Diabetes Impair Insulin-Induced Suppression of Glycogenolysis as Well as Gluconeogenesis

Basu, R., Chandramouli, V., Dicke, B. A., Landau, B. R., & Rizza, R. A. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1942 · Cited by 190 · see citing works

Targeting Foxo1 in Mice Using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action

Samuel, V. T., Choi, C. S., Phillips, T. G., Romanelli, A. J., Geisler, J. G., Bhanot, S., McKay, R. A., Monia, B. P., Shutter, J. R., Lindberg, R. A., et al. (2006) · Diabetes · doi:10.2337/db05-0705 · Cited by 177 · see citing works

Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis

Holland, W. L., Xia, J. Y., Johnson, J. A., Sun, K., Pearson, M. J., Sharma, A. X., Quittner-Strom, E. B., Tippetts, T. S., Gordillo, R., & Scherer, P. E. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.01.002 · Cited by 176 · see citing works

Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes

Yamazaki, H., Tsuboya, T., Tsuji, K., Dohke, M., & Maguchi, H. (2015) · Diabetes Care · doi:10.2337/dc15-0140 · Cited by 171 · see citing works

Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus

Boden, G. H., Chen, X., & Stein, T. P. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.1.e23 · Cited by 167 · see citing works

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

ter Horst, K. W., Gilijamse, P. W., Versteeg, R. I., Ackermans, M. T., Nederveen, A. J., la Fleur, S. E., Romijn, J. A., Nieuwdorp, M., Zhang, D., Samuel, V. T., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.035 · Cited by 166 · see citing works

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

Jornayvaz, F. R., Birkenfeld, A. L., Jurczak, M. J., Kanda, S., Guigni, B. A., Jiang, D. C., Zhang, D., Lee, H., Samuel, V. T., & Shulman, G. I. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103451108 · Cited by 164 · see citing works

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

Minehira, K., Young, S. G., Villanueva, C. J., Yetukuri, L., Orešič, M., Hellerstein, M. K., Farese, R. V., Horton, J. D., Preitner, F., Thorens, B., et al. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800248-jlr200 · Cited by 163 · see citing works

Liver‐Fat Accumulation and Insulin Resistance in Obese Women with Previous Gestational Diabetes

Tiikkainen, M., Tamminen, M., Häkkinen, A., Bergholm, R., Vehkavaara, S., Halavaara, J. T., Teramo, K., Rissanen, A., & Yki‐Järvinen, H. (2002) · Obesity Research · doi:10.1038/oby.2002.118 · Cited by 161 · see citing works

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

Cantley, J. L., Yoshimura, T., Camporez, J. P., Zhang, D., Jornayvaz, F. R., Kumashiro, N., Guebre‐Egziabher, F., Jurczak, M. J., Kahn, M., Guigni, B. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219456110 · Cited by 159 · see citing works

CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

Brown, J. M., Betters, J. L., Lord, C. C., Ma, Y., Han, X., Yang, K., Alger, H. M., Melchior, J., Sawyer, J. K., Shah, R., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m010256 · Cited by 154 · see citing works

Peripheral effects of insulin dominate suppression of fasting hepatic glucose production

Ader, M., & Bergman, R. N. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.6.e1020 · Cited by 148 · see citing works

Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice

Jurczak, M. J., Lee, A., Jornayvaz, F. R., Lee, H., Birkenfeld, A. L., Guigni, B. A., Kahn, M., Samuel, V. T., Glimcher, L. H., & Shulman, G. I. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.316760 · Cited by 142 · see citing works

The direct and indirect effects of insulin on hepatic glucose production in vivo

Cherrington, A. D., Edgerton, D. S., & Sindelar, D. K. (1998) · Diabetologia · doi:10.1007/s001250051021 · Cited by 137 · see citing works

The stereospecific activation of protein kinase C

Rando, R. R., & Young, N. D. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80107-2 · Cited by 137 · see citing works

Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

Lee, H., Birkenfeld, A. L., Jornayvaz, F. R., Jurczak, M. J., Kanda, S., Popov, V., Frederick, D. W., Zhang, D., Guigni, B. A., Bharadwaj, K. G., et al. (2011) · Hepatology · doi:10.1002/hep.24571 · Cited by 134 · see citing works

Distinct Effects of Fatty Acids on Translocation of γ- and ε-Subspecies of Protein Kinase C

Shirai, Y., Kashiwagi, K., Yagi, K., Sakai, N., & Saito, N. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.511 · Cited by 133 · see citing works

Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance

Nagle, C. A., An, J., Shiota, M., Torres, T. P., Cline, G. W., Liu, Z., Wang, S., Catlin, R. L., Shulman, G. I., Newgard, C. B., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611550200 · Cited by 132 · see citing works

Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease

Kurek, K., Ziembicka, D., Wiesiołek‐Kurek, P., Łukaszuk, B., Chabowski, A., Górski, J., & Żendzian‐Piotrowska, M. (2013) · Liver International · doi:10.1111/liv.12331 · Cited by 132 · see citing works

Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis

Bikman, B. T., Guan, Y., Shui, G., Siddique, M. M., Holland, W. L., Kim, J. Y., Fabriàs, G., Wenk, M. R., & Summers, S. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.359950 · Cited by 131 · see citing works

Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity

Zhu, L., Martinez, M. N., Emfinger, C. H., Palmisano, B. T., & Stafford, J. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00579.2013 · Cited by 130 · see citing works

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

Turpin-Nolan, S. M., Hoy, A. J., Brown, R. D., Rudaz, C. G., Honeyman, J. E., Matzaris, M., & Watt, M. J. (2010) · Diabetologia · doi:10.1007/s00125-010-1895-5 · Cited by 129 · see citing works

Insulin’s direct hepatic effect explains the inhibition of glucose production caused by insulin secretion

Edgerton, D. S., Kraft, G., Smith, M. S., Farmer, B., Williams, P. E., Coate, K. C., Printz, R. L., O’Brien, R. M., & Cherrington, A. D. (2017) · JCI Insight · doi:10.1172/jci.insight.91863 · Cited by 126 · see citing works

Adipose Triglyceride Lipase-Null Mice Are Resistant to High-Fat Diet–Induced Insulin Resistance Despite Reduced Energy Expenditure and Ectopic Lipid Accumulation

Hoy, A. J., Bruce, C. R., Turpin-Nolan, S. M., Morris, A. J., Febbraio, M. A., & Watt, M. J. (2010) · Endocrinology · doi:10.1210/en.2010-0661 · Cited by 117 · see citing works

Prevention of Hepatic Steatosis and Hepatic Insulin Resistance by Knockdown of cAMP Response Element-Binding Protein

Erion, D. M., Ignatova, I. D., Yonemitsu, S., Nagai, Y., Chatterjee, P., Weismann, D., Hsiao, J. J., Zhang, D., Iwasaki, T., Stark, R., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.007 · Cited by 108 · see citing works

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

Galbo, T., Perry, R. J., Jurczak, M. J., Camporez, J. P., Alves, T. C., Kahn, M., Guigni, B. A., Serr, J., Zhang, D., Bhanot, S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311176110 · Cited by 100 · see citing works

C16:0-Ceramide Signals Insulin Resistance

Hla, T., & Kolesnick, R. N. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.017 · Cited by 97 · see citing works

Increased Whole‐Body Adiposity Without a Concomitant Increase in Liver Fat is Not Associated With Augmented Metabolic Dysfunction

Magkos, F., Fabbrini, E., Mohammed, B. S., Patterson, B. W., & Klein, S. (2010) · Obesity · doi:10.1038/oby.2010.90 · Cited by 95 · see citing works

Targeting ceramide metabolism in obesity.

Aburasayn, H., Batran, R. A., & Ussher, J. (2016) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.00133.2016 · Cited by 94 · see citing works

Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species

Montgomery, M. K., Brown, S. H. J., Lim, X. Y., Fiveash, C. E., Osborne, B., Bentley, N. L., Braude, J. P., Mitchell, T. W., Coster, A. C. F., Don, A. S., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.08.016 · Cited by 88 · see citing works

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

Kumashiro, N., Yoshimura, T., Cantley, J. L., Majumdar, S. K., Guebre‐Egziabher, F., Kursawe, R., Vatner, D. F., Fat, I., Kahn, M., Erion, D. M., et al. (2012) · Hepatology · doi:10.1002/hep.26170 · Cited by 88 · see citing works

TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1

Ryu, D., Oh, K., Jo, H.-Y., Hedrick, S. A., Kim, Y.-N., Hwang, Y.-J., Park, T., Han, J., Choi, C. S., Montminy, M., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.01.007 · Cited by 86 · see citing works

Resistance to High-Fat Diet-Induced Obesity and Insulin Resistance in Mice with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency

Zhang, D., Christianson, J., Liu, Z., Tian, L., Choi, C. S., Neschen, S., Dong, J., Wood, P. A., & Shulman, G. I. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.012 · Cited by 84 · see citing works

Thyroid Hormone Receptor-α Gene Knockout Mice Are Protected from Diet-Induced Hepatic Insulin Resistance

Jornayvaz, F. R., Lee, H., Jurczak, M. J., Alves, T. C., Guebre‐Egziabher, F., Guigni, B. A., Zhang, D., Samuel, V. T., Silva, J. E., & Shulman, G. I. (2011) · Endocrinology · doi:10.1210/en.2011-1793 · Cited by 76 · see citing works

Dipeptidyl Peptidase-4 Inhibition Ameliorates Western Diet–Induced Hepatic Steatosis and Insulin Resistance Through Hepatic Lipid Remodeling and Modulation of Hepatic Mitochondrial Function

Aroor, A. R., Habibi, J., Ford, D. A., Nistala, R., Lastra, G., Manrique, C. M., Dunham, M. M., Ford, K. D., Thyfault, J. P., Parks, E. J., et al. (2015) · Diabetes · doi:10.2337/db14-0804 · Cited by 76 · see citing works

Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice

Hall, A. M., Soufi, N., Chambers, K. T., Chen, Z., Schweitzer, G. G., McCommis, K. S., Erion, D. M., Graham, M. J., Su, X., & Finck, B. N. (2014) · Diabetes · doi:10.2337/db13-1502 · Cited by 68 · see citing works

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice

Raddatz, K., Turner, N. A., Frangioudakis, G., Liao, B. M., Pedersen, D. J., Cantley, J., Wilks, D. L., Preston, E., Hegarty, B. D., Leitges, M., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2073-0 · Cited by 67 · see citing works

Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance?

Shmueli, E., Alberti, K. G. M. M., & Record, C. O. (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb00761.x · Cited by 61 · see citing works

Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance

Ryu, D., Seo, W., Yoon, Y.-S., Kim, Y.-N., Kim, S. S., Kim, H., Park, T., Choi, C. S., & Koo, S. (2011) · Diabetes · doi:10.2337/db10-1046 · Cited by 61 · see citing works

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content

Camporez, J. P., Kanda, S., Petersen, M. C., Jornayvaz, F. R., Samuel, V. T., Bhanot, S., Petersen, K. F., Jurczak, M. J., & Shulman, G. I. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m054080 · Cited by 60 · see citing works

Alteration of Insulin-Receptor Kinase Activity by High-Fat Feeding

Watarai, T., Kobayashi, M., Takata, Y., Sasaoka, T., Iwasaki, M., & Shigeta, Y. (1988) · Diabetes · doi:10.2337/diab.37.10.1397 · Cited by 60 · see citing works

Inhibiting Monoacylglycerol Acyltransferase 1 Ameliorates Hepatic Metabolic Abnormalities but Not Inflammation and Injury in Mice

Soufi, N., Hall, A. M., Chen, Z., Yoshino, J., Collier, S. L., Mathews, J. C., Brunt, E. M., Albert, C. J., Graham, M. J., Ford, D. A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.595850 · Cited by 51 · see citing works

Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice

Jordy, A. B., Kraakman, M. J., Gardner, T., Estévez, E., Kammoun, H. L., Weir, J. M., Kiens, B., Meikle, P. J., Febbraio, M. A., & Henstridge, D. C. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00547.2014 · Cited by 51 · see citing works

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

Galbo, T., Perry, R. J., Nishimura, E., Samuel, V. T., Quistorff, B., & Shulman, G. I. (2013) · Aging · doi:10.18632/aging.100611 · Cited by 50 · see citing works

CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance

Summers, S. A., & Goodpaster, B. H. (2016) · The Journal of Physiology · doi:10.1113/jp271676 · Cited by 48 · see citing works

Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice

Trevino, M. B., Mazur-Hart, D. J., Machida, Y., King, T., Nadler, J., Galkina, E., Poddar, A., Dutta, S. M., & Imai, Y. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1069 · Cited by 47 · see citing works

Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?

Finck, B. N., & Hall, A. M. (2015) · BioMed Research International · doi:10.1155/2015/104132 · Cited by 47 · see citing works

A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice

Abulizi, A., Perry, R. J., Camporez, J. P. G., Jurczak, M. J., Petersen, K. F., Aspichueta, P., & Shulman, G. I. (2017) · The FASEB Journal · doi:10.1096/fj.201700001r · Cited by 41 · see citing works

Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism

Brown, W. H., Gillum, M. P., Lee, H., Camporez, J. P., Zhang, X., Jeong, J. K., Alves, T. C., Erion, D. M., Guigni, B. A., Kahn, M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212887109 · Cited by 35 · see citing works

Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species

Kamiya, Y., Mizuno, S., Komenoi, S., Sakai, H., & Sakane, F. (2016) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2016.07.017 · Cited by 34 · see citing works

CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance

Petersen, M. C., & Jurczak, M. J. (2016) · The Journal of Physiology · doi:10.1113/jp271677 · Cited by 31 · see citing works

Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice

Chan, S. M. H., Zeng, X., Sun, R., Jo, E., Zhou, X., Wang, H., Li, S., Xu, A., Watt, M. J., & Ye, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.04.005 · Cited by 26 · see citing works

Second‐generation antisense oligonucleotides against β‐catenin protect mice against diet‐induced hepatic steatosis and hepatic and peripheral insulin resistance

Popov, V., Jornayvaz, F. R., Akgül, E. Ö., Kanda, S., Jurczak, M. J., Zhang, D., Abulizi, A., Majumdar, S. K., Guigni, B. A., Petersen, K. F., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-271999 · Cited by 24 · see citing works

ARF1-regulated coatomer directs the steady-state localization of protein kinase C epsilon at the Golgi apparatus

Peterson, T. A., & Stamnes, M. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.11.011 · Cited by 7 · see citing works

Duodenal‐jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice

Shang, J., Castro‐Perez, J. M., Shen, X., Zhu, Y., Liu, H., Qian, Y., Previs, S. F., Howard, A. D., Erion, M. D., Kelley, D. E., et al. (2016) · Obesity · doi:10.1002/oby.21583 · Cited by 5 · see citing works

Mechanisms of Insulin Action and Insulin Resistance

Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028 · see citing works

Adipose tissue dysfunction as determinant of obesity-associated metabolic complications

Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G. A., Beguinot, F., & Miele, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092358 · Cited by 1,575 · see citing works

Non-alcoholic fatty liver disease: causes, diagnosis, cardiometabolic consequences, and treatment strategies

Stefan, N., Häring, H., & Cusi, K. J. (2018) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(18)30154-2 · Cited by 848 · see citing works

Metabolites as regulators of insulin sensitivity and metabolism

Yang, Q., Vijayakumar, A., & Kahn, B. B. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0044-8 · Cited by 681 · see citing works

Metabolic-associated fatty liver disease and lipoprotein metabolism

Heeren, J., & Scheja, L. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101238 · Cited by 666 · see citing works

Nonalcoholic Fatty Liver Disease and Risk of Incident Type 2 Diabetes: A Meta-analysis

Mantovani, A., Byrne, C. D., Bonora, E., & Targher, G. (2018) · Diabetes Care · doi:10.2337/dc17-1902 · Cited by 634 · see citing works

Pathophysiology of obesity and its associated diseases

Jin, X., Qiu, T., Li, L., Yu, R., Chen, X., Li, C., Proud, C. G., & Jiang, T. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.01.012 · Cited by 552 · see citing works

Non-alcoholic fatty liver disease and risk of incident diabetes mellitus: an updated meta-analysis of 501 022 adult individuals

Mantovani, A., Petracca, G., Beatrice, G., Tilg, H., Byrne, C. D., & Targher, G. (2021) · Gut · doi:10.1136/gutjnl-2020-322572 · Cited by 481 · see citing works

Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging

Correa-de-Araujo, R., Addison, O., Miljkovic, I., Goodpaster, B. H., Bergman, B. C., Clark, R. V., Elena, J. W., Esser, K. A., Ferrucci, L., Harris-Love, M. O., et al. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00963 · Cited by 468 · see citing works

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests

Masoodi, M., Gastaldelli, A., Hyötyläinen, T., Arretxe, E., Alonso, C., Gaggini, M., Brosnan, J., Anstee, Q. M., Millet, O., Ortiz, P., et al. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00502-9 · Cited by 451 · see citing works

Role of Insulin Resistance in MAFLD

Sakurai, Y., Kubota, N., Yamauchi, T., & Kadowaki, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084156 · Cited by 448 · see citing works

Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

Fang, Y., Chen, H., Wang, C., & Liang, L. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i27.2974 · Cited by 383 · see citing works

Saroglitazar, a PPAR-α/γ agonist, for treatment of NAFLD: a randomized controlled double-blind phase 2 trial

Gawrieh, S., Noureddin, M., Loo, N., Mohseni, R., Awasty, V., Cusi, K., Kowdley, K. V., Lai, M., Schiff, E., Parmar, D., et al. (2021) · Hepatology · doi:10.1002/hep.31843 · Cited by 379 · see citing works

Mitochondrial dysfunction in metabolic syndrome

Prasun, P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165838 · Cited by 375 · see citing works

Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities

Opazo-Ríos, L., Mas, S., Marín-Royo, G., Mezzano, S., Gómez-Guerrero, C., Moreno, J. A., & Egido, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072632 · Cited by 363 · see citing works

Dietary sugar consumption and health: umbrella review

Huang, Y., Chen, Z., Chen, B., Li, J., Yuan, X., Li, J., Wang, W., Dai, T., Chen, H., Wang, Y., et al. (2023) · BMJ · doi:10.1136/bmj-2022-071609 · Cited by 348 · see citing works

Nonalcoholic fatty liver disease increases risk of incident chronic kidney disease: A systematic review and meta-analysis

Mantovani, A., Zaza, G., Byrne, C. D., Lonardo, A., Zoppini, G., Bonora, E., & Targher, G. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.003 · Cited by 348 · see citing works

Sphingolipids in metabolic disease: The good, the bad, and the unknown

Green, C. D., Maceyka, M. W., Cowart, L. A., & Spiegel, S. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.06.006 · Cited by 336 · see citing works

Metabolic Messengers: ceramides

Summers, S., Chaurasia, B., & Holland, W. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0134-8 · Cited by 267 · see citing works

Hepatic Selective Insulin Resistance at the Intersection of Insulin Signaling and Metabolic Dysfunction-Associated Steatotic Liver Disease

Bo, T., Gao, L., Yao, Z., Shao, S., Wang, X., Proud, C. G., & Zhao, J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.006 · Cited by 293 · see citing works

The role of CD36 in cardiovascular disease

Shu, H., Peng, Y., Hang, W., Nie, J., Zhou, N., & Wang, D. W. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa319 · Cited by 278 · see citing works

Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists

Sinha, R. A., Bruinstroop, E., Singh, B. K., & Yen, P. M. (2019) · Thyroid · doi:10.1089/thy.2018.0664 · Cited by 272 · see citing works

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease

Luukkonen, P. K., Dufour, S., Lyu, K., Zhang, X., Hakkarainen, A., Lehtimäki, T. E., Cline, G. W., Petersen, K. F., Shulman, G. I., & Yki‐Järvinen, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922344117 · Cited by 253 · see citing works

Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial

Geidl-Flueck, B., Hochuli, M., Németh, Á., Eberl, A., Derron, N., Köfeler, H. C., Tappy, L., Berneis, K., Spinas, G. A., & Gerber, P. A. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.02.027 · Cited by 238 · see citing works

Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease

Svegliati‐Baroni, G., Pierantonelli, I., Torquato, P., Marinelli, R., Ferreri, C., Chatgilialoglu, C., Bartolini, D., & Galli, F. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.029 · Cited by 250 · see citing works

Cardiometabolic-Based Chronic Disease, Adiposity and Dysglycemia Drivers

Mechanick, J. I., Farkouh, M. E., Newman, J. D., & Garvey, W. T. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.11.044 · Cited by 243 · see citing works

Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review

Bjornstad, P., & Eckel, R. H. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1101-6 · Cited by 245 · see citing works

Nonalcoholic fatty liver disease in adults: current concepts in etiology, outcomes, and management

Marjot, T., Moolla, A., Cobbold, J. F., Hodson, L., & Tomlinson, J. W. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz009 · Cited by 228 · see citing works

An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease

Lee, E., Korf, H., & Vidal‐Puig, A. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.01.024 · Cited by 228 · see citing works

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

Kolczynska, K., Loza-Valdes, A., Hawro, I., & Sumara, G. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01286-8 · Cited by 199 · see citing works

Interorgan Metabolic Crosstalk in Human Insulin Resistance

Gancheva, S., Jeleník, T., Álvarez-Hernández, E., & Roden, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00015.2017 · Cited by 192 · see citing works

Hepatic lipid droplet homeostasis and fatty liver disease

Seebacher, F., Zeigerer, A., Kory, N., & Krahmer, N. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.04.011 · Cited by 190 · see citing works

Muscle and adipose tissue insulin resistance: malady without mechanism?

Fazakerley, D. J., Krycer, J. R., Kearney, A. L., HOCKING, S. L., & James, D. E. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r087510 · Cited by 181 · see citing works

Insulin-regulated serine and lipid metabolism drive peripheral neuropathy

Handzlik, M. K., Gengatharan, J. M., Frizzi, K. E., McGregor, G. H., Martino, C., Rahman, G., Gonzalez, A., Moreno, A. M., Green, C. R., Guernsey, L. S., et al. (2023) · Nature · doi:10.1038/s41586-022-05637-6 · Cited by 185 · see citing works

Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice

Dong, B., Zhou, Y., Wang, W., Scott, J., Kim, K., Sun, Z., Guo, Q., Yang, L., Gonzales, N. M., Wu, H., et al. (2019) · Hepatology · doi:10.1002/hep.30937 · Cited by 185 · see citing works

Homeostasis of Glucose and Lipid in Non-Alcoholic Fatty Liver Disease

Chao, H., Chao, S.-W., Lin, H., Ku, H., & Cheng, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020298 · Cited by 183 · see citing works

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

Lyu, K., Zhang, Y., Zhang, D., Kahn, M., ter Horst, K. W., Rodrigues, M. R. D. S., Gaspar, R. C., Hirabara, S. M., Luukkonen, P. K., Lee, S., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.08.001 · Cited by 173 · see citing works

SGLT-2 Inhibitors in NAFLD: Expanding Their Role beyond Diabetes and Cardioprotection

Ανδρουτσάκος, Θ., Ansari, N. N., Bakasis, A., Kyrou, I., EFSTATHOPOULOS, E. P., Randeva, H. S., & Kassi, E. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063107 · Cited by 172 · see citing works

Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss

Al-Mrabeh, A. H., Zhyzhneuskaya, S. V., Peters, C. N., Barnes, A. C., Melhem, S., Jesuthasan, A., Aribisala, B. S., Hollingsworth, K. G., Lietz, G., Mathers, J. C., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.018 · Cited by 163 · see citing works

Deciphering the Role of Lipid Droplets in Cardiovascular Disease

Goldberg, I. J., Reue, K., Abumrad, N. A., Bickel, P. E., Cohen, S., Fisher, E. A. A., Galis, Z. S., Granneman, J. G., Lewandowski, E. D., Murphy, R. C., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.033704 · Cited by 153 · see citing works

Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice

Li, X., Zhang, D., Vatner, D. F., Goedeke, L., Hirabara, S. M., Zhang, Y., Perry, R. J., & Shulman, G. I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922169117 · Cited by 150 · see citing works

Lipid Metabolism in Metabolic-Associated Steatotic Liver Disease (MASLD)

Syed‐Abdul, M. M. (2023) · Metabolites · doi:10.3390/metabo14010012 · Cited by 153 · see citing works

Lipid metabolism in MASLD and MASH: From mechanism to the clinic

Carli, F., Della Pepa, G., Sabatini, S., Vidal Puig, A., & Gastaldelli, A. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101185 · Cited by 147 · see citing works

Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain

Ruegsegger, G. N., Vanderboom, P. M., Dasari, S., Klaus, K. A., Kabiraj, P., McCarthy, C. B., Lucchinetti, C. F., & Nair, K. S. (2019) · JCI Insight · doi:10.1172/jci.insight.130681 · Cited by 137 · see citing works

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

Aryal, B. K., Singh, A. K., Zhang, X., Varela, L., Rotllán, N., Goedeke, L., Chaube, B., Camporez, J. P., Vatner, D. F., Horváth, T. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97918 · Cited by 131 · see citing works

Sphingolipid Metabolism: New Insight into Ceramide-Induced Lipotoxicity in Muscle Cells

Bandet, C. L., Tan, S., Bourron, O., Stunff, H. L., & Hajduch, É. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030479 · Cited by 123 · see citing works

Roles of Ceramides in Non-Alcoholic Fatty Liver Disease

Hajduch, É., Lachkar, F., Ferré, P., & Foufelle, F. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10040792 · Cited by 113 · see citing works

Ectopic Fat Accumulation in Distinct Insulin Resistant Phenotypes; Targets for Personalized Nutritional Interventions

Trouwborst, I., Bowser, S. M., Goossens, G. H., & Blaak, E. E. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00077 · Cited by 115 · see citing works

MAFLD vs. NAFLD: shared features and potential changes in epidemiology, pathophysiology, diagnosis, and pharmacotherapy

Xian, Y., Weng, J., & Xu, F. L. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001263 · Cited by 106 · see citing works

Ellagic Acid Alleviates Hepatic Oxidative Stress and Insulin Resistance in Diabetic Female Rats

Polce, S. A., Burke, C., França, L. M., Krämer, B., Paes, A. M. D. A., & Carrillo-Sepúlveda, M. A. (2018) · Nutrients · doi:10.3390/nu10050531 · Cited by 105 · see citing works

Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease

Jouffe, C., Weger, B. D., Martín, E., Atger, F., Weger, M., Gobet, C., Ramnath, D., Charpagne, A., Morin‐Rivron, D., Powell, E. E., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200083119 · Cited by 107 · see citing works

A protective mechanism of probiotic Lactobacillus against hepatic steatosis via reducing host intestinal fatty acid absorption

Jang, H. R., Park, H., Kang, D., Chung, H., Nam, M. H., Lee, Y., Park, J., & Lee, H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0293-4 · Cited by 102 · see citing works

Proposal for a Scientifically Correct and Medically Actionable Disease Classification System (ICD) for Obesity

Garvey, W. T., & Mechanick, J. I. (2020) · Obesity · doi:10.1002/oby.22727 · Cited by 101 · see citing works

Children With Metabolically Healthy Obesity: A Review

Vuković, R., Santos, T. J. D., Ybarra, M., & Atar, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00865 · Cited by 98 · see citing works

Relation of plasma ceramides to visceral adiposity, insulin resistance and the development of type 2 diabetes mellitus: the Dallas Heart Study

Neeland, I. J., Singh, S., McGuire, D. K., Vega, G. L., Roddy, T. P., Reilly, D. F., Castro‐Perez, J. M., Kozlitina, J., & Scherer, P. E. (2018) · Diabetologia · doi:10.1007/s00125-018-4720-1 · Cited by 97 · see citing works

Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle

Park, S. S., & Seo, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21061949 · Cited by 101 · see citing works

Therapeutic potential of mitochondrial uncouplers for the treatment of metabolic associated fatty liver disease and NASH

Goedeke, L., & Shulman, G. I. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101178 · Cited by 97 · see citing works

Lipotoxicity-driven metabolic dysfunction-associated steatotic liver disease (MASLD).

Iturbe-Rey, S., Maccali, C., Arrese, M., Aspichueta, P., Oliveira, C. P., Castro, R. E., Lapitz, A., Izquierdo-Sánchez, L., Bujanda, L., Perugorria, M. J., et al. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.119053 · Cited by 104 · see citing works

Friend or Foe: Lipid Droplets as Organelles for Protein and Lipid Storage in Cellular Stress Response, Aging and Disease

Geltinger, F., Schartel, L., Wiederstein, M., Tevini, J., Aigner, E. S., Felder, T. K., & Rinnerthaler, M. (2020) · Molecules · doi:10.3390/molecules25215053 · Cited by 94 · see citing works

Novel Insights and Mechanisms of Lipotoxicity-Driven Insulin Resistance

Lair, B., Laurens, C., Bosch, B. V. D., & Moro, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176358 · Cited by 89 · see citing works

Fatty Acid Metabolism in Ovarian Cancer: Therapeutic Implications

Yoon, H., & Lee, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042170 · Cited by 89 · see citing works

Cardiometabolic risk factors and neurodegeneration: a review of the mechanisms underlying diabetes, obesity and hypertension in Alzheimer’s disease

Patel, V., & Edison, P. (2024) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2023-332661 · Cited by 80 · see citing works

A round trip from nonalcoholic fatty liver disease to diabetes: molecular targets to the rescue?

Lonardo, A., Lugari, S., Ballestri, S., Nascimbeni, F., Baldelli, E., & Maurantonio, M. (2018) · Acta Diabetologica · doi:10.1007/s00592-018-1266-0 · Cited by 88 · see citing works

Pharmacological treatment for metabolic dysfunction–associated steatotic liver disease and related disorders: Current and emerging therapeutic options

Zhang, X., Lau, H. C.-H., & Yu, J. Q. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2024.100018 · Cited by 94 · see citing works

Sphingolipid metabolism in non-alcoholic fatty liver diseases

Régnier, M., Polizzi, A., Guillou, H., & Loiseau, N. (2018) · Biochimie · doi:10.1016/j.biochi.2018.07.021 · Cited by 85 · see citing works

Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state

Blandin, A., Dugail, I., Hilairet, G., Ponnaiah, M., Ghesquière, V., Froger, J., Ducheix, S., Fizanne, L., Boursier, J., Cariou, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112169 · Cited by 87 · see citing works

Mitochondrial Dysfunction in Obesity and Reproduction

Das, M., Sauceda, C., & Webster, N. J. G. (2020) · Endocrinology · doi:10.1210/endocr/bqaa158 · Cited by 83 · see citing works

Pathophysiological mechanisms and clinical evidence of relationship between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease

Galiero, R., Caturano, A., Vetrano, E., Cesaro, A., Rinaldi, L., Salvatore, T., Marfella, R., Sardu, C., Moscarella, E., Gragnano, F., et al. (2021) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2203082 · Cited by 82 · see citing works

Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes

Goedeke, L., Perry, R. J., & Shulman, G. I. (2019) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104727 · Cited by 76 · see citing works

Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases

Martemucci, G., Fracchiolla, G., Muraglia, M., Tardugno, R., Dibenedetto, R. S., & D‘Alessandro, A. G. (2023) · Antioxidants · doi:10.3390/antiox12122091 · Cited by 81 · see citing works

Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl‐Chain Length and Hepatic Insulin Sensitivity in Mice

Matsuzaka, T., Kuba, M., Koyasu, S., Yamamoto, Y., Motomura, K., Arulmozhiraja, S., Ohno, H., Sharma, R., Shimura, T., Okajima, Y., et al. (2019) · Hepatology · doi:10.1002/hep.30953 · Cited by 74 · see citing works

INT-767 prevents NASH and promotes visceral fat brown adipogenesis and mitochondrial function

Comeglio, P., Cellai, I., Mello, T., Filippi, S., Maneschi, E., Corcetto, F., Corno, C., Sarchielli, E., Morelli, A., Rapizzi, E., et al. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0557 · Cited by 74 · see citing works

The role of the liver in the modulation of glucose and insulin in non alcoholic fatty liver disease and type 2 diabetes

Guerra, S., & Gastaldelli, A. (2020) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2020.10.016 · Cited by 74 · see citing works

The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

Suchacki, K. J., Thomas, B. J., Ikushima, Y. M., Chen, K.-C., Fyfe, C., Tavares, A., Sulston, R. J., Lovdel, A., Woodward, H. J., Han, X., et al. (2023) · eLife · doi:10.7554/elife.88080 · Cited by 71 · see citing works

Metabolism amelioration of Dendrobium officinale polysaccharide on type II diabetic rats

Chen, H., Nie, Q., Hu, J., Huang, X., Huang, W., & Nie, S. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2019.105582 · Cited by 70 · see citing works

Lipodystrophy: A paradigm for understanding the consequences of "overloading" adipose tissue

Lim, K., Haider, A., Adams, C., Sleigh, A., & Savage, D. B. (2020) · Physiological Reviews · doi:10.1152/physrev.00032.2020 · Cited by 68 · see citing works

Dietary anthocyanins as potential natural modulators for the prevention and treatment of non-alcoholic fatty liver disease: A comprehensive review

Mehmood, A., Zhao, L., Wang, Y., Pan, F., Hao, S., Zhang, H., Iftikhar, A., & Usman, M. A. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110180 · Cited by 67 · see citing works

Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates

Goedeke, L., Peng, L., Montalvo-Romeral, V., Butrico, G. M., Dufour, S., Zhang, X., Perry, R. J., Cline, G. W., Kievit, P., Chng, K., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aay0284 · Cited by 65 · see citing works

Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases

Lachkar, F., Ferré, P., Foufelle, F., & Papaioannou, A. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00330.2020 · Cited by 64 · see citing works

Ceramides and diabetes mellitus: an update on the potential molecular relationships

Yaribeygi, H., Bo, S., Ruscica, M., & Sahebkar, A. (2019) · Diabetic Medicine · doi:10.1111/dme.13943 · Cited by 64 · see citing works

Ceramides in Adipose Tissue

Li, Y., Talbot, C. L., & Chaurasia, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00407 · Cited by 63 · see citing works

VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses

Shen, Y., Chen, W., Han, L., Bian, Q., Fan, J., Cao, Z., Jin, X., Ding, T., Xian, Z., Guo, Z., et al. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.07.002 · Cited by 63 · see citing works

High fat diet and its effects on cognitive health: alterations of neuronal and vascular components of brain

Sharma, S. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2021.113528 · Cited by 65 · see citing works

Molecular mechanisms of hepatic insulin resistance in nonalcoholic fatty liver disease and potential treatment strategies

Zhang, C., Zhou, B.-G., Sheng, J., Chen, Y., Cao, Y.-Q., & Chen, C. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104984 · Cited by 62 · see citing works

Insulin Resistance and NAFLD: A Dangerous Liaison beyond the Genetics

Manco, M. (2017) · Children · doi:10.3390/children4080074 · Cited by 63 · see citing works

The Role of Mitochondrial Adaptation and Metabolic Flexibility in the Pathophysiology of Obesity and Insulin Resistance: an Updated Overview

Tsilingiris, D., Tzeravini, E., Koliaki, C. C., Dalamaga, Μ., & Kokkinos, A. D. (2021) · Current Obesity Reports · doi:10.1007/s13679-021-00434-0 · Cited by 60 · see citing works

Epigenetics of Hepatic Insulin Resistance

Maude, H., Sanchez-Cabanillas, C., & Cebola, I. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.681356 · Cited by 60 · see citing works

Adipose tissue insulin resistance and lipidome alterations as the characterizing factors of non‐alcoholic steatohepatitis

Guerra, S., Mocciaro, G., & Gastaldelli, A. (2021) · European Journal of Clinical Investigation · doi:10.1111/eci.13695 · Cited by 60 · see citing works

Insights into the roles and pathomechanisms of ceramide and sphigosine-1-phosphate in nonalcoholic fatty liver disease

Zhu, C., Huai, Q., Zhang, X., Dai, H., Li, X., & Wang, H. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.78525 · Cited by 59 · see citing works

Potentialities of nanomaterials for the management and treatment of metabolic syndrome: A new insight

Adetunji, C. O., Michael, O. S., Rathee, S., Singh, K. R., Ajayi, O. O., Adetunji, J. B., Ojha, A., Singh, J., & Singh, R. P. (2021) · Materials Today Advances · doi:10.1016/j.mtadv.2021.100198 · Cited by 60 · see citing works

Long‐Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress in Rats Fed a High‐Fat/High‐Fructose Diet

Feillet‐Coudray, C., Fouret, G., Vigor, C., Bonafos, B., Jover, B. F., Błachnio-Zabielska, A. U., Rieusset, J., Casas, F., Gaillet, S., Landrier, J., et al. (2019) · Lipids · doi:10.1002/lipd.12128 · Cited by 58 · see citing works

Deranged hepatocyte intracellular Ca2+ homeostasis and the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma

Ali, E. S., Rychkov, G. Y., & Barritt, G. J. (2019) · Cell Calcium · doi:10.1016/j.ceca.2019.102057 · Cited by 58 · see citing works

New Pandemic: Obesity and Associated Nephropathy

Sharma, I., Liao, Y., Zheng, X., & Kanwar, Y. S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.673556 · Cited by 57 · see citing works

Type 2 diabetes mellitus and cardiometabolic outcomes in metabolic dysfunction-associated steatotic liver disease population

Chew, N., Pan, X. H., Chong, B., Chandramouli, C., Muthiah, M. D., & Lam, C. S. P. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111652 · Cited by 57 · see citing works

Inflammation and Metabolic Complications in HIV

Bourgi, K., Wanjalla, C. N., & Koethe, J. R. (2018) · Current HIV/AIDS Reports · doi:10.1007/s11904-018-0411-2 · Cited by 56 · see citing works

Biomarkers of dysfunctional visceral fat

Gugliucci, A. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.03.001 · Cited by 56 · see citing works

Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis

Teng, W., Li, Y., Du, ‬., Lei, X. G., Xie, S., & Ren, F. (2019) · Nutrients · doi:10.3390/nu11051185 · Cited by 55 · see citing works

Key signaling networks are dysregulated in patients with the adipose tissue disorder, lipedema

Ishaq, M., Bandara, N., Morgan, S., Nowell, C. J., Mehdi, A. M., Lyu, R., McCarthy, D. J., Anderson, D., Creek, D. J., Achen, M. G., et al. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-01002-1 · Cited by 54 · see citing works

Clusterin Impairs Hepatic Insulin Sensitivity and Adipocyte Clusterin Associates With Cardiometabolic Risk

Bradley, D. P., Blaszczak, A. M., Yin, Z., Liu, J., Joseph, J. J., Wright, V. P., Anandani, K., NEEDLEMAN, B. J., Noria, S. F., Renton, D., et al. (2019) · Diabetes Care · doi:10.2337/dc18-0870 · Cited by 53 · see citing works

Dihydroceramides in Triglyceride-Enriched VLDL Are Associated with Nonalcoholic Fatty Liver Disease Severity in Type 2 Diabetes

Carlier, A., Phan, F., Szpigel, A., Hajduch, É., Salem, J., Gautheron, J., Goff, W. L., Guérin, M., Lachkar, F., Ratziu, V., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100154 · Cited by 52 · see citing works

Akumulacja lipidów (triacylo-, diacylogliceroli i ceramidów) wewnątrz hepatocytów, a rozwój insulinooporności wątrobowej

Konstantynowicz-Nowicka, K., Mikłosz, A., Stępek, T., & Chabowski, A. (2011) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/17322693.939285 · Cited by 7 · see citing works

COMMENTARY Targeting Ceramide Synthesis to Reverse Insulin Resistance

Schmitz‐Peiffer, C. (2013)

Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?

Finck, B. N., & Hall, A. M. (2015) · BioMed Research International · doi:10.1155/2015/104132 · Cited by 47 · see citing works

Novel Insights and Mechanisms of Lipotoxicity-Driven Insulin Resistance

Lair, B., Laurens, C., Bosch, B. V. D., & Moro, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176358 · Cited by 89 · see citing works

Review Article Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?

Finck, B. N., & Hall, A. M. (2015)