Biomarkers in inflammatory bowel disease: current practices and recent advances.

Iskandar, Heba N.; Ciorba, Matthew A.

doi:10.1016/j.trsl.2012.01.001

Cited by 210Inflammatory Bowel DiseaseOcular Diseases and Behçet’s SyndromeSpondyloarthritis Studies and Treatments

Biomarkers in inflammatory bowel disease: current practices and recent advances.

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Iskandar, Heba N., Ciorba, Matthew A.·2012·Translational Research

DOI 10.1016/j.trsl.2012.01.001PMC PMC3308116

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Abstract

Crohn's disease and ulcerative colitis represent the two main forms of the idiopathic chronic inflammatory bowel diseases (IBD). Currently available blood and stool based biomarkers provide reproducible, quantitative tools that can complement clinical assessment to aid clinicians in IBD diagnosis and management. C-reactive protein and fecal based leukocyte markers can help the clinician distinguish IBD from noninflammatory diarrhea and assess disease activity. The ability to differentiate between forms of IBD and predict risk for disease complications is specific to serologic tests including antibodies against Saccharomyces cerevisiae and perinuclear antineutrophil cytoplasmic proteins. Advances in genomic, proteomic, and metabolomic array based technologies are facilitating the development of new biomarkers for IBD. The discovery of novel biomarkers, which can correlate with mucosal healing or predict long-term disease course has the potential to significantly improve patient care. This article reviews the uses and limitations of currently available biomarkers and highlights recent advances in IBD biomarker discovery.

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Tricyclic antidepressants at doses below the usual antidepressant range have been used to control symptoms in irritable bowel syndrome.
“Tricyclic antidepressants (TCAs), at doses below the traditional antidepressant range, have been used for symptom control in IBS.6,7”
From Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease (2014) · cites this paper as [7]
Tricyclic antidepressants are effective for treating irritable bowel syndrome.
“Tricyclic antidepressants (TCAs) have efficacy in treating irritable bowel syndrome (IBS).”
From Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease (2014) · cites this paper as [7]

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Assessment of appropriate laboratory measurements to supplement the Crohn's disease activity index.
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A new, highly sensitive assay for C-reactive protein can aid the differentiation of inflammatory bowel disorders from constipation- and diarrhoea-predominant functional bowel disorders
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Antibodies to flagellin indicate reactivity to bacterial antigens in IBS patients
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Clinically active Crohn's disease in the presence of a low C-reactive protein
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Questions and answers on the role of fecal lactoferrin as a biological marker in inflammatory bowel disease
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Utility of serological markers in inflammatory bowel diseases: Gadget or magic?
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GCMS-based metabolomic study in mice with colitis induced by dextran sulfate sodium
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Metabolism of the colonic mucosa in patients with inflammatory bowel diseases: an in vitro proton magnetic resonance spectroscopy study
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Association of the novel serologic anti-glycan antibodies anti-laminarin and anti-chitin with complicated Crohnʼs disease behavior
Rieder, F., Schleder, S., Wolf, A., Dirmeier, A., Strauch, U., Obermeier, F., Lopez, R., Spector, L., Fire, E., Yarden, J., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21046 · Cited by 101 · see citing works
Induction of IDO-1 by Immunostimulatory DNA Limits Severity of Experimental Colitis
Ciorba, M. A., Bettonville, E. E., McDonald, K. G., Metz, R. A., Prendergast, G. C., Newberry, R. D., & Stenson, W. F. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0900291 · Cited by 99 · see citing works
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Fecal Lactoferrin and Calprotectin After Ileocolonic Resection for Crohn's Disease
Scarpa, M., Renata D'Incà, Basso, D., Ruffolo, C., Polese, L., Bertin, E., Luise, A., Frego, M., Plebani, M., Sturniolo, G. C., et al. (2007) · Diseases of the Colon & Rectum · doi:10.1007/s10350-007-0225-6 · Cited by 97 · see citing works
Predictors of Infliximab Failure After Azathioprine Withdrawal in Crohn's Disease Treated With Combination Therapy
Oussalah, A., Chevaux, J., Fay, R., Sandborn, W. J., Bigard, M., & Peyrin‐Biroulet, L. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.158 · Cited by 96 · see citing works
Faecal calprotectin in children with clinically quiescent inflammatory bowel disease
Sipponen, T. M., & Kolho, K. (2010) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521003782389 · Cited by 88 · see citing works
Update of fecal markers of inflammation in inflammatory bowel disease
Judd, T. A., Day, A. S., Lemberg, D. A., Turner, D., & Leach, S. T. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06846.x · Cited by 83 · see citing works
IBD serological panels: Facts and perspectives
Peyrin‐Biroulet, L., Standaert‐Vitse, A., Branche, J., & Chamaillard, M. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20226 · Cited by 83 · see citing works
Fecal Lactoferrin: A New Parameter to Monitor Infliximab Therapy
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Purine, Kynurenine, Neopterin and Lipid Peroxidation Levels in Inflammatory Bowel Disease
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Serological markers in inflammatory bowel diseases
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111Indium autologous granulocytes in the detection of inflammatory bowel disease.
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Metabolomic Analysis Identifies Inflammatory and Noninflammatory Metabolic Effects of Genetic Modification in a Mouse Model of Crohn’s Disease
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Metabolic Assessment of Gradual Development of Moderate Experimental Colitis in IL-10 Deficient Mice
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Proteomics for prediction and characterization of response to infliximab in Crohn's disease: A pilot study
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Levels of Purine, Kynurenine and Lipid Peroxidation Products in Patients with Inflammatory Bowel Disease
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Blood platelets and inflammation: Their relationship with liver and digestive diseases
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Anti-outer membrane of porin C and anti-I2 antibodies in indeterminate colitis
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Proteomic profiling of mucosal and submucosal colonic tissues yields protein signatures that differentiate the inflammatory colitides
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Inflamed Intestinal Mucosa Features a Specific Epithelial Expression Pattern of Indoleamine 2,3-Dioxygenase
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Nontargeted Urinary Metabolite Profiling of a Mouse Model of Crohn’s Disease
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Shortcomings of the Inflammatory Bowel Disease Serology 7 Panel
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Using metabolomic analysis to understand inflammatory bowel diseases
Lin, H., Helsby, N. A., Rowan, D. D., & Ferguson, L. R. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21426 · Cited by 60 · see citing works
Phenotypic associations of Crohnʼs disease with antibodies to flagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a swiss cohort
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Gene expression patterns in experimental colitis in IL-10-deficient mice
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Applications of proteomics in the study of inflammatory bowel diseases
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The platelet count as a simple measure to distinguish inflammatory bowel disease from infective diarrhoea
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Increased serum levels of L-arginine in ulcerative colitis and correlation with disease severity
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Relevance of serologic studies in inflammatory bowel disease
Vernier, G., Sendid, B., Poulain, D., & Colombel, J. (2004) · Current Gastroenterology Reports · doi:10.1007/s11894-004-0070-x · Cited by 46 · see citing works
Moderate performance of serum S100A12, in distinguishing inflammatory bowel disease from irritable bowel syndrome
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Blood-based biomarkers can differentiate ulcerative colitis from crohnʼs disease and noninflammatory diarrhea
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Sustained improvement of health-related quality of life in Crohnʼs disease patients treated with infliximab and azathioprine for 4 years
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Faecal Parameters in the Assessment of Activity in Inflammatory Bowel Disease
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Serum protein profiling in patients with inflammatory bowel diseases using selective solid‐phase bulk extraction, matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry and chemometric data analysis
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Serologic Antiglycan Antibodies in Inflammatory Bowel Disease
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Utilization of Health-Care Resources by Patients With IBD in Manitoba: A Profile of Time Since Diagnosis
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Antiglycan antibodies as serological markers in the differential diagnosis of inflammatory bowel disease
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New proteomic approaches for biomarker discovery in inflammatory bowel disease
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Detection of Antisynthetic Mannoside Antibodies (AΣMA) Reveals Heterogeneity in the ASCA Response of Crohn's Disease Patients and Contributes to Differential Diagnosis, Stratification, and Prediction
Khoury, P. V.-E., Colombel, J., Joossens, S. B. A., Standaert‐Vitse, A., Collot, M., Halfvarson, J., Ayadi, A., Landers, C. J., Vermeire, S., Rutgeerts, P. J., et al. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01648.x · Cited by 26 · see citing works
Long-Term Outcome of Crohn's Disease Following Corticosteroid-Induced Remission
Papi, C., Festa, V., Leandro, G., Moretti, A., Tanga, M., Koch, M., & Capurso, L. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01055.x · Cited by 25 · see citing works
Identification of Urinary Biomarkers of Colon Inflammation in IL10-/- Mice Using Short‐Column LCMS Metabolomics
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Enhanced platelet adhesion induces angiogenesis in intestinal inflammation and inflammatory bowel disease microvasculature
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Serum Tryptophan in Crohn’s Disease
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The Placebo Response Rate in Irritable Bowel Syndrome and Inflammatory Bowel Disease
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Value of mucosal assessment and biomarkers in inflammatory bowel disease
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Serologies in Crohn’s Disease: Can We Change the Gray Zone to Black and White?
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Differential diagnosis in inflammatory bowel disease colitis: State of the art and future perspectives
Tontini, G. E. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i1.21 · Cited by 220 · see citing works
Gut microbiota, metabolome and immune signatures in patients with uncomplicated diverticular disease
Barbara, G., Scaioli, E., Barbaro, M. R., Biagi, E., Laghi, L., Cremon, C., Marasco, G., Colecchia, A., Picone, G., Salfi, N. C. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-312377 · Cited by 210 · see citing works
Neutrophil Extracellular Traps in Ulcerative Colitis
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The Immunological Basis of Inflammatory Bowel Disease
Silva, F. A. R., Rodrigues, B. L., Ayrizono, M. D. L. S., & Leal, R. F. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/2097274 · Cited by 178 · see citing works
Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery
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Label-free microfluidic cell sorting and detection for rapid blood analysis
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Microfluidic Blood Cell Sorting: Now and Beyond
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Additional Candida albicans administration enhances the severity of dextran sulfate solution induced colitis mouse model through leaky gut-enhanced systemic inflammation and gut-dysbiosis but attenuated by Lactobacillus rhamnosus L34
Panpetch, W., Hiengrach, P., Nilgate, S., Tumwasorn, S., Somboonna, N., Wilantho, A., Chatthanathon, P., Prueksapanich, P., & Leelahavanichkul, A. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1662712 · Cited by 151 · see citing works
Laboratory markers in ulcerative colitis: Current insights and future advances
Cioffi, M. (2015) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v6.i1.13 · Cited by 132 · see citing works
Indoleamine 2,3 dioxygenase in intestinal disease
Ciorba, M. A. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835c9cb3 · Cited by 116 · see citing works
Self-citation
Biomarkers: hopes and challenges in the path from discovery to clinical practice
Frangogiannis, N. G. (2012) · Translational research · doi:10.1016/j.trsl.2012.01.023 · Cited by 112 · see citing works
EMerging BiomARKers in Inflammatory Bowel Disease (EMBARK) Study Identifies Fecal Calprotectin, Serum MMP9, and Serum IL-22 as a Novel Combination of Biomarkers for Crohn's Disease Activity: Role of Cross-Sectional Imaging
Faubion, W. A., Fletcher, J. G., O’Byrne, S., Feagan, B. G., de Villiers, W. J. S., Salzberg, B. A., Plevy, S. E., Proctor, D. D., Valentine, J. F., Higgins, P., et al. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.354 · Cited by 108 · see citing works
Trimethylamine-N-oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease
Wilson, A. S., Teft, W. A., Morse, B. L., Choi, Y., Woolsey, S., DeGorter, M. K., Hegele, R. A., Tirona, R. G., & Kim, R. B. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3797-3 · Cited by 97 · see citing works
Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease
Iskandar, H. N., Cassell, B., Kanuri, N., Gyawali, C. P., Gutierrez, A., Dassopoulos, T., Ciorba, M. A., & Sayuk, G. S. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000049 · Cited by 96 · see citing works
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Vedolizumab Effectiveness and Safety Over the First Year of Use in an IBD Clinical Practice
Vivio, E. E., Kanuri, N. D., Gilbertsen, J. J., Monroe, K. M., Dey, N., Chen, C.-H., Gutierrez, A. M., & Ciorba, M. A. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv226 · Cited by 95 · see citing works
Self-citation
Proteomic analysis of ascending colon biopsies from a paediatric inflammatory bowel disease inception cohort identifies protein biomarkers that differentiate Crohn's disease from UC
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Authors: Iskandar, H. N., & Ciorba, M. A.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Ciorba, Matthew A.
ORCID: Ciorba, Matthew A.
Venue: Translational Research
Publisher: Elsevier BV
Published: 2012-04
Volume: 159
Issue: 4
Pages: 313-325
ISSN: 1878-1810 (ISSN-L)
1931-5244
DOI: 10.1016/j.trsl.2012.01.001
PMC: PMC3308116
OpenAlex: W2100688872
Cited by: 210
References: 140
Citations by year: 2026: 8 · 2025: 15 · 2024: 13 · 2023: 14 · 2022: 10 · 2021: 11 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 16 · 2016: 22 · 2015: 19 · 2014: 21 · 2013: 15 · 2012: 6
FWCI: 2.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Translational research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000448)
National Institute of Diabetes and Digestive and Kidney Diseases (K08DK089016, T32DK007130)
National Center for Research Resources (L30-RR030244)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
Keywords: inflammatory bowel disease, biomarkers, Crohn's disease, ulcerative colitis, C-reactive protein, fecal calprotectin, ASCA, mucosal healing, disease activity assessment, biomarker discovery, proteomics, metabolomics, genomics
MeSH terms: Humans, Predictive Value of Tests, Inflammatory Bowel Diseases, Biomarkers

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Biomarkers in inflammatory bowel disease: current practices and recent advances.

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