Cited by 230PI3K/AKT/mTOR signaling in cancerDevelopmental Biology and Gene RegulationHippo pathway signaling and YAP/TAZ

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PTENless means more

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Stiles, Bangyan, Groszer, Matthias, Wang, Shunyou, Jiao, Jing, Wu, Hong·2004·Developmental Biology

DOI 10.1016/j.ydbio.2004.06.008

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Abstract

Recent studies indicate that certain key molecules that are vital for various developmental processes, such as Wnt, Shh, and Notch, cause cancer when dysregulated. PTEN, a tumor suppressor that antagonizes the PI3 kinase pathway, is the newest one on the list. The biological function of PTEN is evolutionarily conserved from C. elegans to humans, and the PTEN-controlled signaling pathway regulates cellular processes crucial for normal development, including cell proliferation, soma growth, cell death, and cell migration. In this review, we will focus on the function of PTEN in murine development and its role in regulating stem cell self-renewal and proliferation. We will summarize the organomegaly phenotypes associated with Pten tissue-specific deletion and discuss how PTEN controls organ size, a fundamental aspect of development. Last, we will review the role of PTEN in hormone-dependent, adult-onset mammary and prostate gland development.

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Authors: Stiles, B., Groszer, M., Wang, S., Jiao, J., & Wu, H.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Wu, Hong
ORCID: Stiles, Bangyan
Groszer, Matthias
Jiao, Jing
Wu, Hong
Venue: Developmental Biology
Publisher: Elsevier BV
Published: 2004-09
Volume: 273
Issue: 2
Pages: 175-184
ISSN: 0012-1606 (ISSN-L)
DOI: 10.1016/j.ydbio.2004.06.008
OpenAlex: W2001800178
Cited by: 230
References: 110
Citations by year: 2025: 1 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 12 · 2014: 9 · 2013: 13 · 2012: 8
FWCI: 1.50
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3277 d)
Locations: Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Cancer Institute (CA-98-013)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords: PTEN, tumor suppressor, PI3 kinase pathway, organomegaly, organ size control, stem cell self-renewal, cell proliferation, mammary gland development, developmental signaling, Wnt, Sonic hedgehog, notches
MeSH terms: Animals, Cell Movement, Female, Embryonic and Fetal Development, Hormones, Humans, Male, Models, Biological, Stem Cells, Signal Transduction, Protein Tyrosine Phosphatases, Gene Expression Regulation, Developmental, Tumor Suppressor Proteins, PTEN Phosphohydrolase, Mice

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