Cited by 230PI3K/AKT/mTOR signaling in cancerDevelopmental Biology and Gene RegulationHippo pathway signaling and YAP/TAZ

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PTENless means more

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Stiles, Bangyan, Groszer, Matthias, Wang, Shunyou, Jiao, Jing, Wu, Hong·2004·Developmental Biology

DOI 10.1016/j.ydbio.2004.06.008

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Abstract

Recent studies indicate that certain key molecules that are vital for various developmental processes, such as Wnt, Shh, and Notch, cause cancer when dysregulated. PTEN, a tumor suppressor that antagonizes the PI3 kinase pathway, is the newest one on the list. The biological function of PTEN is evolutionarily conserved from C. elegans to humans, and the PTEN-controlled signaling pathway regulates cellular processes crucial for normal development, including cell proliferation, soma growth, cell death, and cell migration. In this review, we will focus on the function of PTEN in murine development and its role in regulating stem cell self-renewal and proliferation. We will summarize the organomegaly phenotypes associated with Pten tissue-specific deletion and discuss how PTEN controls organ size, a fundamental aspect of development. Last, we will review the role of PTEN in hormone-dependent, adult-onset mammary and prostate gland development.

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Mammalian Target of Rapamycin: A New Molecular Target for Breast Cancer
Mita, M. M., Mita, A. C., & Rowinsky, E. K. (2003) · Clinical Breast Cancer · doi:10.3816/cbc.2003.n.018 · Cited by 143
Overexpression of Insulin-Like Growth Factor-II in Transgenic Mice Is Associated with Pancreatic Islet Cell Hyperplasia
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Somatic mutation of PTEN in bladder carcinoma
Aveyard, J. S., Skilleter, A., Habuchi, T., & Knowles, M. A. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690439 · Cited by 137
Essential Role of AKT-1/Protein Kinase Bα in PTEN-Controlled Tumorigenesis
Stiles, B. L., Gilman, V., Khanzenzon, N., Lesche, R., Li, A., Qiao, R., Liu, X. Z., & Wu, H. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3842-3851.2002 · Cited by 137
Self-citation
Leukodystrophy incidence in Germany
Heim, P., Claussen, M., Hoffmann, B., Conzelmann, E., Gärtner, J., HARZER, K., HUNNEMAN, D. H., Köhler, W., Kurlemann, G., & Kohlschütter, A. (1997) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19970905)71:4 · Cited by 133
PTEN in Neural Precursor Cells: Regulation of Migration, Apoptosis, and Proliferation
Li, L., Liu, F., Salmonsen, R. A., Turner, T. K., Litofsky, N. S., Cristofano, A. D., Pandolfi, P. P., Jones, S. N., Recht, L. D., & Ross, A. H. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1115 · Cited by 125
Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells.
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Physiological Functions of Pten in Mouse Tissues.
Kishimoto, H., Hamada, K., Saunders, M. E., Backman, S. A., Sasaki, T., Nakano, T., Mak, T. W., & Suzuki, A. (2003) · Cell Structure and Function · doi:10.1247/csf.28.11 · Cited by 114
Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells
Manin, M., Baron, S., Goossens, K., Beaudoin, C., Jean, C., VEYSSIERE, G., Verhoeven, G., & Morel, L. (2002) · Biochemical Journal · doi:10.1042/bj20020585 · Cited by 107
Insulin-like Growth Factor-I Inhibits Transcriptional Responses of Transforming Growth Factor-β by Phosphatidylinositol 3-Kinase/Akt-dependent Suppression of the Activation of Smad3 but Not Smad2
Song, K. W., Cornelius, S. C., Reiß, M., & Danielpour, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304583200 · Cited by 98
Breast Cancer 4
McGuire, W. L. (1981) · Springer eBooks · doi:10.1007/978-1-4615-6571-0 · Cited by 95
Akt/PTEN Signaling Mediates Estrogen-Dependent Proliferation of Primordial Germ Cells in Vitro
Moe-Behrens, G. H. G., Klinger, F. G., Eskild, W., Grotmol, T., Haugen, T. B., & Felici, M. D. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0006 · Cited by 91
PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium
Dupont, J., Renou, J., Shani, M., Hennighausen, L. G., & LeRoith, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13829 · Cited by 88
The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells.
Zheng, X., Stokoe, D., Kane, L., & Weiss, A. (2002) · PubMed · Cited by 82
Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies
Dreher, T., Zentgraf, H., Abel, U. R., Kappeler, A., Michel, M., Bleyl, U., & Grobholz, R. (2004) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-004-1004-6 · Cited by 82
PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium
Dupont, J., Renou, J., Shani, M., Hennighausen, L. G., & LeRoith, D. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213829 · Cited by 79
Expression of the PTEN tumour suppressor protein during human development
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Reduced PTEN expression in the pancreas overexpressing transforming growth factor-beta 1
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PTEN
Stokoe, D. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00303-7 · Cited by 58
Lhermitte—Duclos disease as a component of Cowden's syndrome
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A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor.
Iida, S., Tanaka, Y., Fujii, H., Hayashi, S., Kimura, M., Nagareda, T., & Moriwaki, K. (1998) · International Journal of Molecular Medicine · doi:10.3892/ijmm.1.6.925 · Cited by 17
The Ptentative nature of mouse knockouts
Bradley, A., & Luo, G. (1998) · Nature Genetics · doi:10.1038/3787 · Cited by 6

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Yilmaz, Ö. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature04703 · Cited by 1,113
Self-citation
Pten Regulates Neuronal Arborization and Social Interaction in Mice
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970
Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches
Karantanos, T., Corn, P. G., & Thompson, T. C. (2013) · Oncogene · doi:10.1038/onc.2013.206 · Cited by 894
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
Zhang, J., Grindley, J. C., Yin, T., Jayasinghe, S., He, X. C., Ross, J. T., Haug, J. S., Rupp, D., Porter-Westpfahl, K. S., Wiedemann, L. M., et al. (2006) · Nature · doi:10.1038/nature04747 · Cited by 817
Self-citation
PTEN: Tumor Suppressor and Metabolic Regulator
Chen, C.-Y., Chen, J., He, L., & Stiles, B. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00338 · Cited by 618
Self-citation

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Authors: Stiles, B., Groszer, M., Wang, S., Jiao, J., & Wu, H.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Wu, Hong
ORCID: Stiles, Bangyan
Groszer, Matthias
Jiao, Jing
Wu, Hong
Venue: Developmental Biology
Publisher: Elsevier BV
Published: 2004-09
Volume: 273
Issue: 2
Pages: 175-184
ISSN: 0012-1606 (ISSN-L)
DOI: 10.1016/j.ydbio.2004.06.008
OpenAlex: W2001800178
Cited by: 230
References: 110
Citations by year: 2025: 1 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 12 · 2014: 9 · 2013: 13 · 2012: 8
FWCI: 1.50
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3277 d)
Locations: Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Cancer Institute (CA-98-013)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords: PTEN, tumor suppressor, PI3 kinase pathway, organomegaly, organ size control, stem cell self-renewal, cell proliferation, mammary gland development, developmental signaling, Wnt, Sonic hedgehog, notches
MeSH terms: Animals, Cell Movement, Female, Embryonic and Fetal Development, Hormones, Humans, Male, Models, Biological, Stem Cells, Signal Transduction, Protein Tyrosine Phosphatases, Gene Expression Regulation, Developmental, Tumor Suppressor Proteins, PTEN Phosphohydrolase, Mice

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