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Cited by 440

The DOI matches its Crossref record; 322 of the 322 references it cites were found in a registry or an index.

The genetics of sex differences in brain and behavior

Open access
Ngun, Tuck C., Ghahramani, Negar, Sánchez, Francisco J., Bocklandt, Sven, Vilain, Eric·2011·Frontiers in Neuroendocrinology

Abstract

Biological differences between men and women contribute to many sex-specific illnesses and disorders. Historically, it was argued that such differences were largely, if not exclusively, due to gonadal hormone secretions. However, emerging research has shown that some differences are mediated by mechanisms other than the action of these hormone secretions and in particular by products of genes located on the X and Y chromosomes, which we refer to as direct genetic effects. This paper reviews the evidence for direct genetic effects in behavioral and brain sex differences. We highlight the `four core genotypes' model and sex differences in the midbrain dopaminergic system, specifically focusing on the role of Sry. We also discuss novel research being done on unique populations including people attracted to the same sex and people with a cross-gender identity. As science continues to advance our understanding of biological sex differences, a new field is emerging that is aimed at better addressing the needs of both sexes: gender-based biology and medicine. Ultimately, the study of the biological basis for sex differences will improve healthcare for both men and women.

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Metadata

Authors
Ngun, T. C., Ghahramani, N., Sánchez, F. J., Bocklandt, S., & Vilain, E.
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2011-04
Volume
32
Issue
2
Pages
227-246
ISSN
0091-3022 (ISSN-L)
OpenAlex
W2073692957
Cited by
440
References
322
FWCI
4.84
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The genetics of sex differences in brain and behavior. https://app.cochat.ai/papers/10.1016/j.yfrne.2010.10.001
The paper
Ngun, T. C., Ghahramani, N., Sánchez, F. J., Bocklandt, S., & Vilain, E. (2011). The genetics of sex differences in brain and behavior. Frontiers in Neuroendocrinology. https://doi.org/10.1016/j.yfrne.2010.10.001

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.