The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Neural innervation of white adipose tissue and the control of lipolysis
Open accessAbstract
White adipose tissue (WAT) is innervated by the sympathetic nervous system (SNS) and its activation is necessary for lipolysis. WAT parasympathetic innervation is not supported. Fully-executed SNS-norepinephrine (NE)-mediated WAT lipolysis is dependent on β-adrenoceptor stimulation ultimately hinging on hormone sensitive lipase and perilipin A phosphorylation. WAT sympathetic drive is appropriately measured by electrophysiological and neurochemical (NE turnover) in non-human animals and this drive is fat pad-specific preventing generalizations among WAT depots and non-WAT organs. Leptin-triggered SNS-mediated lipolysis is weakly supported, whereas insulin or adenosine inhibition of SNS/NE-mediated lipolysis is strongly supported. In addition to lipolysis control, increases or decreases in WAT SNS drive/NE inhibit and stimulate white adipocyte proliferation, respectively. WAT sensory nerves are of spinal-origin and sensitive to local leptin and increases in sympathetic drive, the latter implicating lipolysis. Transsynaptic viral tract tracer use revealed WAT central sympathetic and sensory circuits including SNS-sensory feedback loops that may control lipolysis.
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Metadata
- Authors
- Bartness, T. J., Liu, Y., Shrestha, Y. B., & Ryu, V.
- Venue
- Frontiers in Neuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 35
- Issue
- 4
- Pages
- 473-493
- ISSN
- 0091-3022 (ISSN-L)
- OpenAlex
- W2020447893
- Cited by
- 365
- References
- 22
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- green
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