Cited by 367Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

Sixteen years and counting: an update on leptin in energy balance

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Gautron, Laurent, Elmquist, Joel K.·2011·Journal of Clinical Investigation

Abstract

Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and secreted by white adipose tissue. Since its discovery, leptin has been found to have profound effects on behavior, metabolic rate, endocrine axes, and glucose fluxes. Leptin deficiency in mice and humans causes morbid obesity, diabetes, and various neuroendocrine anomalies, and replacement leads to decreased food intake, normalized glucose homeostasis, and increased energy expenditure. Here, we provide an update on the most current understanding of leptin-sensitive neural pathways in terms of both anatomical organization and physiological roles.

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  1. Kowalski TJ, Liu SM, Leibel RL, Chua SC Jr. Trans- genic complementation of leptin-receptor defi- ciency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene. Diabetes. 2001;50(2):425-435.
  2. Hausberg M, Morgan DA, Mitchell JL, Sivitz WI, Mark AL, Haynes WG. Leptin potentiates ther- mogenic sympathetic responses to hypother- mia: a receptor-mediated effect. Diabetes. 2002; 51(8):2434-2440.

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Authors
Gautron, L., & Elmquist, J. K.
Affiliations
The University of Texas Southwestern Medical Center (US)
Corresponding author
Elmquist, Joel K.
Venue
Journal of Clinical Investigation
Published
2011-06-01
Volume
121
Issue
6
Pages
2087-2093
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2068769790
Cited by
367
References
128
Citations by year
2026: 6 · 2025: 6 · 2024: 4 · 2023: 11 · 2022: 8 · 2021: 10 · 2020: 18 · 2019: 17 · 2018: 17 · 2017: 26 · 2016: 28 · 2015: 33 · 2014: 52 · 2013: 52 · 2012: 66
FWCI
5.92
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Michigan
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
leptin, ob gene, energy balance, white adipose tissue, leptin deficiency, morbid obesity, diabetes mellitus, glucose homeostasis, dietary intake, energy expenditure, neuroendocrine regulation, metabolic rate
MeSH terms
Adaptation, Physiological, Animals, Body Weight, Brain, Disease Models, Animal, Energy Metabolism, Feeding Behavior, Glucose, Humans, Hypothalamus, Mice, Obese, Models, Biological, Pro-Opiomelanocortin, Starvation, Sympathetic Nervous System, Leptin, Receptor, Melanocortin, Type 4, Overnutrition, Mice, Adipose Tissue, White, Receptors, Leptin

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