Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

Mitochondria, Oxidants, and Aging

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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

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Metabolic control through the PGC-1 family of transcription coactivators

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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

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Sirtuins in mammals: insights into their biological function

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CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

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PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

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Superoxide activates mitochondrial uncoupling proteins

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Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

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Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α

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A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

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Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

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Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

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Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

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PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

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Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

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Identification of a new class of steroid hormone receptors

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Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

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SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes

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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

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ERRα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

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The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis

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The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide–dependent deacetylase

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SIRT3, a human SIR2 homologue, is an NAD- dependent deacetylase localized to mitochondria

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Sirtuins: critical regulators at the crossroads between cancer and aging

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PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells

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PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3

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Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells

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SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

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Activation of AMP-Activated Protein Kinase Reduces Hyperglycemia-Induced Mitochondrial Reactive Oxygen Species Production and Promotes Mitochondrial Biogenesis in Human Umbilical Vein Endothelial Cells

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Peroxisome Proliferator-activated Receptor Coactivator-1α (PGC-1α) Coactivates the Cardiac-enriched Nuclear Receptors Estrogen-related Receptor-α and -γ

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SirT3 is a nuclear NAD + -dependent histone deacetylase that translocates to the mitochondria upon cellular stressPreprint

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Genome-wide Orchestration of Cardiac Functions by the Orphan Nuclear Receptors ERRα and γ

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To ERR in the estrogen pathway

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Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor α.

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A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages

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PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity.

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PGC-1α Coactivates PDK4 Gene Expression via the Orphan Nuclear Receptor ERRα: a Mechanism for Transcriptional Control of Muscle Glucose Metabolism

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Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

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SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

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Estrogen receptor-related receptors: orphan receptors desperately seeking a ligand

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Mutation of Succinate Dehydrogenase Subunit C Results in Increased O2·−, Oxidative Stress, and Genomic Instability

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Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production

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Regulation of mitochondrial biogenesis during myogenesis

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Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

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SIRT1: Linking Adaptive Cellular Responses to Aging-Associated Changes in Organismal Physiology

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Estrogen-related Receptor α Is a Repressor of Phosphoenolpyruvate Carboxykinase Gene Transcription

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Specific gene inhibition by adenovirus-mediated expression of small interfering RNA

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Cloning and Characterization of Two Mouse Genes with Homology to the Yeast Sir2 Gene

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A New Splice Variant of the Mouse SIRT3 Gene Encodes the Mitochondrial Precursor Protein

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Primary hepatocyte culture in collagen gel mixture and collagen sandwich

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Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Enhances Antiproliferative Activity of 5′-Deoxy-5-Fluorouridine in Cancer Cells through Induction of Uridine Phosphorylase

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Transcriptional integration of mitochondrial biogenesis

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SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

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SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

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SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

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The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals

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Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise and metabolic and excitatory challenges

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The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications

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SIRT3 regulation of mitochondrial oxidative stress

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Role of PGC-1α Signaling in Skeletal Muscle Health and Disease

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SIRT3-AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction

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Mitochondrial sirtuins: regulators of protein acylation and metabolism

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Sirtuin catalysis and regulation

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Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

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Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of the Sirt3 Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype

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Beneficial effects of exercise on age‐related mitochondrial dysfunction and oxidative stress in skeletal muscle

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Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

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SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism

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Gastro-Intestinal and Oral Microbiome Signatures Associated with Healthy Aging

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Genomic integrity and the ageing brain

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Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype

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Dietary restriction.; mitochondrial function and aging: From yeast to humans

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Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

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Intensified mitophagy in skeletal muscle with aging is downregulated by PGC-1alpha overexpression in vivo

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SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation mediate endothelial cell responses to hypoxia

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Update on mitochondria and muscle aging: All wrong roads lead to sarcopenia

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