SIRT3 regulates progression and development of diseases of aging
Open accessAbstract
The mitochondrial sirtuin SIRT3 is a protein deacylase that influences almost every major aspect of mitochondrial biology, including nutrient oxidation, ATP generation, reactive oxygen species (ROS) detoxification, mitochondrial dynamics, and the mitochondrial unfolded protein response (UPR). Interestingly, mice lacking SIRT3 (SIRT3KO), either spontaneously or when crossed with mouse models of disease, develop several diseases of aging at an accelerated pace, such as cancer, metabolic syndrome, cardiovascular disease, and neurodegenerative diseases, and, thus, might be a valuable model of accelerated aging. In this review, we discuss functions of SIRT3 in pathways involved in diseases of aging and how the lack of SIRT3 might accelerate the aging process. We also suggest that further studies on SIRT3 will help uncover important new pathways driving the aging process.
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SIRT3 is involved in cancer progression, neurodegenerative and cardiovascular disease as well as metabolic syndromes, and is likely a critical participant in many age-related disease processes.
“SIRT3 is involved in cancer progression, neurodegenerative and cardiovascular disease as well as metabolic syndromes [212], and is likely a critical participant in many age-related disease processes.”
From Redox control of senescence and age-related disease. (2017) · cites this paper as [212]
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Targeting Mitochondrial Sirtuins in Age-Related Neurodegenerative Diseases and Fibrosis
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Wang, C., Scott, S. M., Subramanian, K., Loguercio, S., Zhao, P., Hutt, D. M., Farhat, N. Y., Porter, F. D., & Balch, W. E. (2019) · Nature Communications · doi:10.1038/s41467-019-12969-x · Cited by 27 · see citing works
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Roles of SIRT3 in cardiovascular and neurodegenerative diseases
Cheng, Y., Zhao, A., Li, Y., Li, C., Miao, X., Yang, W., & Wang, Y. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102654 · Cited by 25 · see citing works
Genetic and Functional Sequence Variants of the SIRT3 Gene Promoter in Myocardial Infarction
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- Authors
- McDonnell, E., Peterson, B. S., Bomze, H. M., & Hirschey, M. D.
- Affiliations
- Duke University (US)
- Corresponding author
- Hirschey, Matthew D.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 26
- Issue
- 9
- Pages
- 486-492
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC4558250
- OpenAlex
- W1491563504
- Cited by
- 217
- References
- 97
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 18 · 2023: 21 · 2022: 31 · 2021: 21 · 2020: 17 · 2019: 22 · 2018: 16 · 2017: 23 · 2016: 18 · 2015: 2
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA022146)
- National Institute on Aging (R01AG045351, P30AG028716)
- National Cancer Institute (T32CA059365)
- National Institute of General Medical Sciences (T32GM007184, T32GM007105)
- National Institute of Diabetes and Digestive and Kidney Diseases (R24DK085610)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- SIRT3, mitochondrial sirtuins, aging, age-related diseases, SIRT3 knockout mice, accelerated aging, mitochondrial dynamics, mitochondrial unfolded protein response, reactive oxygen species scavenging, cancer, metabolic syndrome, cardiovascular disease, neurodegenerative diseases
- MeSH terms
- Aging, Animals, Disease, Humans, Longevity, Mice, Sirtuin 3
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