Cited by 139Microbial Metabolic Engineering and BioproductionBiofuel production and bioconversionAnaerobic Digestion and Biogas Production

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Acetone production with metabolically engineered strains of Acetobacterium woodii

Hoffmeister, Sabrina, Gerdom, Marzena, Bengelsdorf, Frank R., Linder, Sonja, Flüchter, Sebastian, Öztürk, Hatice, Blümke, Wilfried, May, Antje, Fischer, Ralf-Jörg, Bahl, Hubert, Dürre, Peter·2016·Metabolic Engineering

DOI 10.1016/j.ymben.2016.03.001

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Abstract

Expected depletion of oil and fossil resources urges the development of new alternative routes for the production of bulk chemicals and fuels beyond petroleum resources. In this study, the clostridial acetone pathway was used for the formation of acetone in the acetogenic bacterium Acetobacterium woodii. The acetone production operon (APO) containing the genes thlA (encoding thiolase A), ctfA/ctfB (encoding CoA transferase), and adc (encoding acetoacetate decarboxylase) from Clostridium acetobutylicum were cloned under the control of the thlA promoter into four vectors having different replicons for Gram-positives (pIP404, pBP1, pCB102, and pCD6). Stable replication was observed for all constructs. A. woodii [pJIR_actthlA] achieved the maximal acetone concentration under autotrophic conditions (15.2±3.4mM). Promoter sequences of the genes ackA from A. woodii and pta-ack from C. ljungdahlii were determined by primer extension (PEX) and cloned upstream of the APO. The highest acetone production in recombinant A. woodii cells was achieved using the promoters PthlA and Ppta-ack. Batch fermentations using A. woodii [pMTL84151_actthlA] in a bioreactor revealed that acetate concentration had an effect on the acetone production, due to the high Km value of the CoA transferase. In order to establish consistent acetate concentration within the bioreactor and to increase biomass, a continuous fermentation process for A. woodii was developed. Thus, acetone productivity of the strain A. woodii [pMTL84151_actthlA] was increased from 1.2mgL(-1)h(-1) in bottle fermentation to 26.4mgL(-1)h(-1) in continuous gas fermentation.

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Authors: Hoffmeister, S., Gerdom, M., Bengelsdorf, F. R., Linder, S., Flüchter, S., Öztürk, H., Blümke, W., May, A., Fischer, R.-J., Bahl, H., & Dürre, P.
Affiliations: Universität Ulm (DE)
Evonik (Germany) (DE)
University of Rostock (DE)
Corresponding author: Hoffmeister, Sabrina
ORCID: Bengelsdorf, Frank R.
Fischer, Ralf-Jörg
Dürre, Peter
Venue: Metabolic Engineering
Publisher: Elsevier BV
Published: 2016-07
Volume: 36
Pages: 37-47
ISSN: 1096-7176 (ISSN-L)
DOI: 10.1016/j.ymben.2016.03.001
OpenAlex: W2294276789
Cited by: 139
References: 42
Citations by year: 2026: 9 · 2025: 5 · 2024: 12 · 2023: 18 · 2022: 24 · 2021: 17 · 2020: 15 · 2019: 17 · 2018: 6 · 2017: 9 · 2016: 7
FWCI: 6.75
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Metabolic Engineering (publishedVersion)
PubMed (publishedVersion)
Funders: Bundesministerium für Bildung und Forschung (01RC1105A/C)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Anaerobic Digestion and Biogas Production
Keywords: acetone production, Acetobacterium woodii, CoA transferase, acetoacetate decarboxylase, promoter cloning, acetogenic bacteria, Clostridium acetobutylicum
MeSH terms: Acetates, Acetone, Carbon Dioxide, Recombinant Proteins, Genetic Enhancement, Acetobacterium, Metabolic Networks and Pathways, Biosynthetic Pathways, Metabolic Engineering

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Acetone production with metabolically engineered strains of Acetobacterium woodii

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