Influencing connectivity and cross-frequency coupling by real-time source localized neurofeedback of the posterior cingulate cortex reduces tinnitus related distress
Open accessAbstract
BACKGROUND: In this study we are using source localized neurofeedback to moderate tinnitus related distress by influencing neural activity of the target region as well as the connectivity within the default network. HYPOTHESIS: We hypothesize that up-training alpha and down-training beta and gamma activity in the posterior cingulate cortex has a moderating effect on tinnitus related distress by influencing neural activity of the target region as well as the connectivity within the default network and other functionally connected brain areas. METHODS: Fifty-eight patients with chronic tinnitus were included in the study. Twenty-three tinnitus patients received neurofeedback training of the posterior cingulate cortex with the aim of up-training alpha and down-training beta and gamma activity, while 17 patients underwent training of the lingual gyrus as a control situation. A second control group consisted of 18 tinnitus patients on a waiting list for future tinnitus treatment. RESULTS: This study revealed that neurofeedback training of the posterior cingulate cortex results in a significant decrease of tinnitus related distress. No significant effect on neural activity of the target region could be obtained. However, functional and effectivity connectivity changes were demonstrated between remote brain regions or functional networks as well as by altering cross frequency coupling of the posterior cingulate cortex. CONCLUSION: This suggests that neurofeedback could remove the information, processed in beta and gamma, from the carrier wave, alpha, which transports the high frequency information and influences the salience attributed to the tinnitus sound. Based on the observation that much pathology is the result of an abnormal functional connectivity within and between neural networks various pathologies should be considered eligible candidates for the application of source localized EEG based neurofeedback training.
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sLORETA permits selection of any cortical region for feedback of current density using voxels selected based on Montreal Neurological Institute coordinates.
“sLORETA permits the selection of any cortical region for feedback of the current density using voxels selected based on Montreal Neurological Institute (MNI) coordinates [211].”
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Self-citationThe difference between uni- and bilateral auditory phantom percept
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Validation of the Dutch and the French version of the Tinnitus Questionnaire.
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Self-citationTransient reduction of tinnitus intensity is marked by concomitant reductions of delta band power
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Self-citationReliability of self‐rated tinnitus distress and association with psychological symptom patterns
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Synchrony Makes Neurons Fire in Sequence, and Stimulus Properties Determine Who Is Ahead
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Self-citationTHE EFFECTS OF NEUROFEEDBACK TRAINING IN THE COGNITIVE DIVISION OF THE ANTERIOR CINGULATE GYRUS
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Self-citationThe Effects of Neurofeedback on Oscillatory Processes Related to Tinnitus
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Surgical brain modulation for tinnitus: the past, present and future.
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Self-citationThe Darwinian plasticity hypothesis for tinnitus and pain
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Stress-Related Functional Connectivity Changes Between Auditory Cortex and Cingulate in Tinnitus
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Self-citationResults of leucotomy operations for tinnitus
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LORETA Neurofeedback in the Precuneus
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Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Goebel G. Hiller W. The tinnitus questionnaire (tq) - a standardized instrument for grading the severity of tinnitus - results of A Multicenter study using the tq Hno 42 3 1994 166 172 8175381
- Vanneste S. The difference between uni- and bilateral auditory phantom percept Clin. Neurophysiol. 122 3 2011 578 587 20801079
Cited by
Sorted by citations
Leong, S. L., Vanneste, S., Lim, J., Smith, M., Manning, P., & De Ridder, D. (2018) · Scientific Reports · doi:10.1038/s41598-018-30181-7 · Cited by 46 · see citing works
Self-citationPerez, T. M., Glue, P., Adhia, D. B., Navid, M. S., Zeng, J., Dillingham, P., Smith, M., Niazi, I. K., Young, C. K., & De Ridder, D. (2022) · Trials · doi:10.1186/s13063-022-06863-z · Cited by 8 · see citing works
“sLORETA permits the selection of any cortical region for feedback of the current density using voxels selected based on Montreal Neurological Institute (MNI) coordinates [211].”
MethodSelf-citation
- Authors
- Vanneste, S., Joos, K., Ost, J., & De Ridder, D.
- Affiliations
- The University of Texas at Dallas (US)
- Antwerp University Hospital (BE)
- Corresponding author
- Vanneste, Sven
- Venue
- Neurobiology of Stress
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 8
- Pages
- 211-224
- ISSN
- 2352-2895 (ISSN-L)
- PMC
- PMC5991329
- OpenAlex
- W2559441517
- Cited by
- 45
- References
- 130
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 2 · 2013: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neurobiology of Stress (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Keywords
- tinnitus, tinnitus distress, posterior cingulate cortex, default mode network, functional connectivity, cross-frequency coupling, alpha band, lingual gyrus, neurofeedback, chronic tinnitus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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