Cited by 45Hearing, Cochlea, Tinnitus, GeneticsTranscranial Magnetic Stimulation StudiesEEG and Brain-Computer Interfaces

Influencing connectivity and cross-frequency coupling by real-time source localized neurofeedback of the posterior cingulate cortex reduces tinnitus related distress

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Vanneste, Sven, Joos, Kathleen, Ost, Jan, De Ridder, Dirk·2018·Neurobiology of Stress

Abstract

BACKGROUND: In this study we are using source localized neurofeedback to moderate tinnitus related distress by influencing neural activity of the target region as well as the connectivity within the default network. HYPOTHESIS: We hypothesize that up-training alpha and down-training beta and gamma activity in the posterior cingulate cortex has a moderating effect on tinnitus related distress by influencing neural activity of the target region as well as the connectivity within the default network and other functionally connected brain areas. METHODS: Fifty-eight patients with chronic tinnitus were included in the study. Twenty-three tinnitus patients received neurofeedback training of the posterior cingulate cortex with the aim of up-training alpha and down-training beta and gamma activity, while 17 patients underwent training of the lingual gyrus as a control situation. A second control group consisted of 18 tinnitus patients on a waiting list for future tinnitus treatment. RESULTS: This study revealed that neurofeedback training of the posterior cingulate cortex results in a significant decrease of tinnitus related distress. No significant effect on neural activity of the target region could be obtained. However, functional and effectivity connectivity changes were demonstrated between remote brain regions or functional networks as well as by altering cross frequency coupling of the posterior cingulate cortex. CONCLUSION: This suggests that neurofeedback could remove the information, processed in beta and gamma, from the carrier wave, alpha, which transports the high frequency information and influences the salience attributed to the tinnitus sound. Based on the observation that much pathology is the result of an abnormal functional connectivity within and between neural networks various pathologies should be considered eligible candidates for the application of source localized EEG based neurofeedback training.

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  1. Goebel G. Hiller W. The tinnitus questionnaire (tq) - a standardized instrument for grading the severity of tinnitus - results of A Multicenter study using the tq Hno 42 3 1994 166 172 8175381
  2. Vanneste S. The difference between uni- and bilateral auditory phantom percept Clin. Neurophysiol. 122 3 2011 578 587 20801079

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Authors
Vanneste, S., Joos, K., Ost, J., & De Ridder, D.
Affiliations
  • The University of Texas at Dallas (US)
  • Antwerp University Hospital (BE)
Corresponding author
Vanneste, Sven
Venue
Neurobiology of Stress
Publisher
Elsevier BV
Published
2018-02
Volume
8
Pages
211-224
ISSN
2352-2895 (ISSN-L)
OpenAlex
W2559441517
Cited by
45
References
130
Citations by year
2026: 4 · 2025: 8 · 2024: 8 · 2023: 2 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 2 · 2013: 1
FWCI
1.49
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Stress (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Keywords
tinnitus, tinnitus distress, posterior cingulate cortex, default mode network, functional connectivity, cross-frequency coupling, alpha band, lingual gyrus, neurofeedback, chronic tinnitus

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