Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system

Hunter, Steven J; Garvey, W.Timothy

doi:10.1016/s0002-9343(98)00300-3

Cited by 200Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system

Hunter, Steven J, Garvey, W.Timothy·1998·The American Journal of Medicine

DOI 10.1016/s0002-9343(98)00300-3

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1016/s0002-9343(98)00300-3

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Activation of insulin signal transduction in skeletal muscle stimulates glucose transport by translocating intracellular GLUT4-containing vesicles to the plasma membrane and activating them after insertion.
“Activation of the insulin signal transduction system in skeletal muscle stimulates glucose transport through a mechanism that involves translocation of a large intracellular pool of glucose transporters (associated with low-density microsomes) to the plasma membrane and their subsequent activation after insertion into the cell membrane [181, 182].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [182]
In insulin-resistant individuals with T2DM, glucose transport activity is severely impaired.
“In insulin resistant individuals with T2DM, glucose transport activity is severely impaired [156, 181, 182, 187–189].”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [182]

Handbook of Physiology.
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388 · see citing works
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,626 · see citing works
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630 · see citing works
Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth
Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., Phipps, K., & Clark, P. M. S. (1993) · Diabetologia · doi:10.1007/bf00399095 · Cited by 2,468 · see citing works
Insulin Resistance in Essential Hypertension
Ferrannini, E., Buzzigoli, G., Bonadonna, R., Giorico, M. A., Oleggini, M., Graziadei, L., Pedrinelli, R., Brandi, L., & Bevilacqua, S. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708063170605 · Cited by 2,344 · see citing works
Pathogenesis of NIDDM. A balanced overview.
DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085 · see citing works
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028 · see citing works
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Dunaif, A., Segal, K. R., Futterweit, W., & Dobrjansky, A. (1989) · Diabetes · doi:10.2337/diab.38.9.1165 · Cited by 1,967 · see citing works
Disruption of IRS-2 causes type 2 diabetes in mice
Withers, D., Gutiérrez, J., Towery, H., Burks, D., Ren, J.-M., Previs, S., Zhang, Y., Bernal, D., Pons, S., Shulman, G., et al. (1998) · Nature · doi:10.1038/36116 · Cited by 1,850 · see citing works
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
Sun, X. J., Rothenberg, P., Kahn, C. R., Backer, J. M., Araki, E., Wilden, P. A., Cahill, D. A., Goldstein, B. J., & White, M. F. (1991) · Nature · doi:10.1038/352073a0 · Cited by 1,574 · see citing works
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of pima indians
Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508 · see citing works
Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
Modan, M., Halkin, H., Almog, S., Lusky, A., Eshkol, A., Shefi, M., Shitrit, A., & Fuchs, Z. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111776 · Cited by 1,465 · see citing works
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J. C., Cavallo, F., Forni, G., Nicoletti, I., Grignani, F., Pawson, T. J., & Pelicci, P. G. (1992) · Cell · doi:10.1016/0092-8674(92)90536-l · Cited by 1,326 · see citing works
Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation
Kohn, A. D., Summers, S. A., Birnbaum, M. J., & Roth, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31372 · Cited by 1,284 · see citing works
Quantitation of Muscle Glycogen Synthesis in Normal Subjects and Subjects with Non-Insulin-Dependent Diabetes by<sup>13</sup>C Nuclear Magnetic Resonance Spectroscopy
Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248 · see citing works
Pathophysiology of insulin resistance in human disease
Reaven, G. M. (1995) · Physiological Reviews · doi:10.1152/physrev.1995.75.3.473 · Cited by 1,235 · see citing works
Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor
Kasuga, M., Karlsson, F. A., & Kahn, C. R. (1982) · Science · doi:10.1126/science.7031900 · Cited by 1,132 · see citing works
Protein kinase activity associated with the avian sarcoma virus src gene product.
Collett, M. S., & Erikson, R. L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.4.2021 · Cited by 1,106 · see citing works
The Syndromes of Insulin Resistance and Acanthosis Nigricans
Kahn, C. R., Flier, J. S., Bar, R. S., Archer, J. A., Görden, P., Martin, M. M., & Roth, J. (1976) · New England Journal of Medicine · doi:10.1056/nejm197604012941401 · Cited by 1,101 · see citing works
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
Warram, J. H., Martin, B. C., Krolewski, A. S., Soeldner, J. S., & Kahn, C. R. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-12-909 · Cited by 1,038 · see citing works
Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.
Laakso, M., Edelman, S. V., Brechtel, G., & Baron, A. D. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114644 · Cited by 930 · see citing works
Improvement in Endocrine and Ovarian Function during Dietary Treatment of Obese Women with Polycystic Ovary Syndrome
Kiddy, D. S., Hamilton‐Fairley, D., Bush, A., Short, F., Anyaoku, V., Reed, M. J., & Franks, S. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02909.x · Cited by 921 · see citing works
Insulin Action and the Insulin Signaling Network*
Cheatham, B., & Kahn, C. R. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-2-117 · Cited by 878 · see citing works
Role of IRS-2 in insulin and cytokine signalling
Sun, X. J., Wang, L.-M., Zhang, Y., Yenush, L., Myers, M. G., Glasheen, E. M., Lane, W. S., Pierce, J. H., & White, M. F. (1995) · Nature · doi:10.1038/377173a0 · Cited by 847 · see citing works
Insulin resistance, insulin insensitivity, and insulin unresponsiveness: A necessary distinction
Kahn, C. R. (1978) · Metabolism · doi:10.1016/s0026-0495(78)80007-9 · Cited by 793 · see citing works
Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man
Lillioja, S., Young, A. A., Culter, C. L., Ivy, J. L., Abbott, W. G., Zawadzki, J. K., Yki-Järvinen, H., Christin, L., Secomb, T. W., & Bogardus, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113088 · Cited by 782 · see citing works
The diversity of Rab proteins in vesicle transport
Novick, P., & Zerial, M. (1997) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(97)80025-7 · Cited by 767 · see citing works
Decreases in Ovarian Cytochrome P450c17α Activity and Serum Free Testosterone after Reduction of Insulin Secretion in Polycystic Ovary Syndrome
Nestler, J. E., & Jakubowicz, D. J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199608293350902 · Cited by 743 · see citing works
Diabetes and Cardiovascular Disease: The “Common Soil” Hypothesis
Stern, M. P. (1995) · Diabetes · doi:10.2337/diab.44.4.369 · Cited by 739 · see citing works
Specificity and regulation of a synaptic vesicle docking complex
Pevsner, J., Hsu, S.-C., Braun, J. E. A., Calakos, N., Ting, A. E., Bennett, M. K., & Scheller, R. H. (1994) · Neuron · doi:10.1016/0896-6273(94)90352-2 · Cited by 592 · see citing works
Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.
Dunaif, A., Xia, J., Book, C. B., Schenker, E., & Tang, Z. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118126 · Cited by 561 · see citing works
The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome
Dunaif, A. E., Scott, D., Finegood, D. T., Quintana, B., & Whitcomb, R. W. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784087 · Cited by 560 · see citing works
A Molecular Basis for Insulin Resistance
Paz, K., Hemi, R., LeRoith, D., Karasik, A., Elhanany, E., Kanety, H., & Zick, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.47.29911 · Cited by 553 · see citing works
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.
Goodyear, L. J., Giorgino, F., Sherman, L., Carey, J., Smith, R. J., & Dohm, G. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117909 · Cited by 525 · see citing works
Polycystic Ovary Syndrome as a Form of FunctionalOvarian Hyperandrogenism Due to Dysregulation ofAndrogen Secretion*
EHRMAN, D. A., Barnes, R. B., & Rosenfield, R. L. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-322 · Cited by 502 · see citing works
Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women with Polycystic Ovary Syndrome<sup>1</sup>
Ehrmann, D. A., Schneider, D. J., Sobel, B. E., Cavaghan, M. K., Imperial, J., Rosenfield, R. L., & Polonsky, K. S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4069 · Cited by 461 · see citing works
Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance
Garvey, W. T., Maianu, L., Zhu, J. H., Brechtel-Hook, G., Wallace, P., & Baron, A. D. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1557 · Cited by 459 · see citing works
Self-citation
The Gonadotropic Function of Insulin*
Poretsky, L., & Kalin, M. F. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-132 · Cited by 449 · see citing works
DIABETES MELLITUS
Himsworth, H. P. (1936) · The Lancet · doi:10.1016/s0140-6736(01)36134-2 · Cited by 441 · see citing works
Tumor Necrosis Factor α-induced Phosphorylation of Insulin Receptor Substrate-1 (IRS-1)
Kanety, H., Feinstein, R., Papa, M. Z., Hemi, R., & Karasik, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23780 · Cited by 435 · see citing works
Insulin Receptor: Evidence That It Is a Protein Kinase
Roth, R. A., & Cassell, D. J. (1983) · Science · doi:10.1126/science.6849137 · Cited by 409 · see citing works
Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion
Ehrmann, D. A. (1995) · Endocrine Reviews · doi:10.1210/er.16.3.322 · Cited by 394 · see citing works
A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family
Lavan, B. E., Fantin, V. R., Chang, E. T., Lane, W. S., Keller, S. R., & Lienhard, G. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21403 · Cited by 381 · see citing works
The 60-kDa Phosphotyrosine Protein in Insulin-treated Adipocytes Is a New Member of the Insulin Receptor Substrate Family
Lavan, B. E., Lane, W. S., & Lienhard, G. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11439 · Cited by 353 · see citing works
The role of hyperinsulinemia in the pathogenesis of ovarian hyperandrogenism
Wallach, E. E., Barbieri, R. L., Smith, S., & Ryan, K. J. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60060-2 · Cited by 348 · see citing works
Correlation between muscle glycogen synthase activity and in vivo insulin action in man
Bogardus, C., Lillioja, S., Stone, K., & Mott, D. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111304 · Cited by 335 · see citing works
Plasma Insulin Concentrations in Nondiabetic and Early Diabetic Subjects: Determinations by a New Sensitive Immuno-assay Technic
Yalow, R. S., & Berson, S. A. (1960) · Diabetes · doi:10.2337/diab.9.4.254 · Cited by 330 · see citing works
Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity.
Garvey, W. T., Maianu, L., Huecksteadt, T. P., Birnbaum, M. J., Molina, J. M., & Ciaraldi, T. P. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115068 · Cited by 324 · see citing works
Self-citation
Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.
Peraldi, P., Xu, M., & Spiegelman, B. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119715 · Cited by 313 · see citing works
Insulin transport across capillaries is rate limiting for insulin action in dogs.
Yang, Y. J., Hope, I. D., Ader, M., & Bergman, R. N. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114339 · Cited by 303 · see citing works
Moving GLUT4: The Biogenesis and Trafficking of GLUT4 Storage Vesicles
Rea, S. L., & James, D. E. (1997) · Diabetes · doi:10.2337/diab.46.11.1667 · Cited by 300 · see citing works
An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
Dohm, G. L., Tapscott, E. B., Pories, W. J., Dabbs, D. J., Flickinger, E. G., Meelheim, D., Fushiki, T., Atkinson, S., Elton, C. W., & Caro, J. F. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113622 · Cited by 297 · see citing works
Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: A common endocrinopathy with distinct pathophysiologic features
Barbieri, R. L., & Ryan, K. J. (1983) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(83)90091-1 · Cited by 295 · see citing works
Gene Expression of GLUT4 in Skeletal Muscle From Insulin-Resistant Patients With Obesity, IGT, GDM, and NIDDM
Garvey, W. T., Maianu, L., Hancock, J. A., Golichowski, A. M., & Baron, A. (1992) · Diabetes · doi:10.2337/diab.41.4.465 · Cited by 289 · see citing works
Self-citation
Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles
Calera, M. R., Martı́nez, C., Liu, H., Jack, A. K. E., Birnbaum, M. J., & Pilch, P. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7201 · Cited by 245 · see citing works
Quantitative Ultrastructure of Mammalian Skeletal Muscle
Eisenberg, B. R. (1983) · Comprehensive physiology · doi:10.1002/cphy.cp100103 · Cited by 241 · see citing works
Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity.
Baron, A., Zhu, J. S., Zhu, J. H., Weldon, H., Maianu, L., & Garvey, W. T. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118349 · Cited by 239 · see citing works
Self-citation
The effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle.
Kelley, D. E., Mintun, M. A., Watkins, S. C., Simoneau, J. A., Jadali, F., Fredrickson, A., Beattie, J., & Thériault, R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118724 · Cited by 228 · see citing works
From receptor to transporter: insulin signalling to glucose transport
Holman, G. D., & Kasuga, M. (1997) · Diabetologia · doi:10.1007/s001250050780 · Cited by 216 · see citing works
Suppression of Hyperandrogenism Does not Improve Peripheral or Hepatic Insulin Resistance in the Polycystic Ovary Syndrome*
Dunaif, A. E., Green, G., Futterweit, W., & Dobrjansky, A. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-3-699 · Cited by 198 · see citing works
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.
Freidenberg, G. R., Reichart, D. R., Olefsky, J. M., & Henry, R. R. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113744 · Cited by 194 · see citing works
Excess Insulin Binding to Insulin-Like Growth Factor Receptors: Proposed Mechanism for Acanthosis Nigricans
Cruz, P. D., & Hud, J. A. (1992) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12462293 · Cited by 194 · see citing works
Insulin Receptor: Structure and Function
Jacobs, S., & Cuatrecasas, P. (1981) · Endocrine Reviews · doi:10.1210/edrv-2-3-251 · Cited by 186 · see citing works
Glucose and insulin co-regulate the glucose transport system in primary cultured adipocytes. A new mechanism of insulin resistance.
Garvey, W. T., Olefsky, J. M., Matthaei, S., & Marshall, S. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75908-0 · Cited by 180 · see citing works
Self-citation
A structurally abnormal insulin causing human diabetes
Tager, H. S., Given, B. D., Baldwin, D., Mako, M. E., Markese, J., Rubenstein, A. H., Olefsky, J. M., Kobayashi, M., Kolterman, O., & Poucher, R. (1979) · Nature · doi:10.1038/281122a0 · Cited by 179 · see citing works
Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation.
King, P. A., Horton, E. D., Hirshman, M. F., & Horton, E. S. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116025 · Cited by 172 · see citing works
gp160, a tissue-specific marker for insulin-activated glucose transport.
Kandror, K. V., & Pilch, P. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8017 · Cited by 167 · see citing works
Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes.
Bonadonna, R. C., Del Prato, S., Saccomani, M. P., Bonora, E., Gulli, G., Ferrannini, E., Bier, D., Cobelli, C., & DeFronzo, R. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116592 · Cited by 149 · see citing works
Multiple Defects in the Adipocyte Glucose Transport System Cause Cellular Insulin Resistance in Gestational Diabetes: Heterogeneity in the Number and a Novel Abnormality in Subcellular Localization of GLUT4 Glucose Transporters
Garvey, W. T., Maianu, L., Zhu, J.-H., Hancock, J. A., & Golichowski, A. M. (1993) · Diabetes · doi:10.2337/diab.42.12.1773 · Cited by 141 · see citing works
Self-citation
Coeliac disease in children and adolescents with IDDM: clinical characteristics and response to gluten-free diet
Acerini, C. L., Ahmed, M. L., Ross, K. M., Sullivan, P. B., Bird, G., & Dunger, D. B. (1998) · Diabetic Medicine · doi:10.1002/(sici)1096-9136(199801)15:1 · Cited by 137 · see citing works
Troglitazone Improves Defects in Insulin Action, Insulin Secretion, Ovarian Steroidogenesis, and Fibrinolysis in Women With Polycystic Ovary Syndrome
Ehrmann, D. A., Schneider, D. J., Sobel, B. E., Cavaghan, M. K., Imperial, J., Rosenfield, R. L., & Polonsky, K. S. (1998) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199801000-00017 · Cited by 129 · see citing works
Maturity-onset diabetes of the young
Fajans, S. S., Bell, G. I., Bowden, D. W., Halter, J. B., & Polonsky, K. S. (1994) · Life Sciences · doi:10.1016/0024-3205(94)90052-3 · Cited by 118 · see citing works
Compartmentalization of protein traffic in insulin-sensitive cells.
Kandror, K., & Pilch, P. (1996) · American Journal of Physiology · doi:10.1152/ajpendo.1996.271.1.e1 · Cited by 117 · see citing works
Insulin Resistance Caused by Massive Degradation of Subcutaneous Insulin
Paulsen, E. P., Courtney, J. W., & Duckworth, W. C. (1979) · Diabetes · doi:10.2337/diab.28.7.640 · Cited by 115 · see citing works
Diabetes Mellitus: Its differentiation into insulin-sensitive and insulin-insensitive types
Himsworth, H. P. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dyt203 · Cited by 112 · see citing works
Mechanisms of enhanced insulin sensitivity in endurance-trained athletes: effects on blood flow and differential expression of GLUT 4 in skeletal muscles
Hardin, D. S., Azzarelli, B., Edwards, J. E., Wigglesworth, J., Maianu, L., Brechtel, G., Johnson, A., Baron, A., & Garvey, W. T. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.8.7629239 · Cited by 111 · see citing works
Self-citation
Transmembrane signaling by the human insulin receptor kinase. Relationship between intramolecular beta subunit trans- and cis-autophosphorylation and substrate kinase activation.
Frattali, A. L., Treadway, J. L., & Pessin, J. E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41806-6 · Cited by 105 · see citing works
Immunocytochemical Evidence that GLUT4 Resides in a Specialized Translocation Post-endosomal VAMP2-positive Compartment in Rat Adipose Cells in the Absence of Insulin
Malide, D. A., Dwyer, N. K., Blanchette‐Mackie, E. J., & Cushman, S. W. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704500806 · Cited by 99 · see citing works
Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity 1
Ciaraldi, T. P., Morales, A. J., Hickman, M. G., Odom-Ford, R., Olefsky, J. M., & Yen, S. S. C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.5.3961 · Cited by 96 · see citing works
Familial Hyperproinsulinemia
Gabbay, K. H., Deluca, K. J., Fisher, J. N., Mako, M. E., & Rubenstein, A. H. (1976) · New England Journal of Medicine · doi:10.1056/nejm197604222941701 · Cited by 95 · see citing works
Molecular Actions of Insulin on Glucose Transport
Czech, M. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.002301 · Cited by 95 · see citing works
Skeletal muscle is a primary site of insulin resistance in essential hypertension
Capaldo, B., Lembo, G., Napoli, R., Rendina, V., ALBANO, G., Saccà, L., & Trimarco, B. (1991) · Metabolism · doi:10.1016/0026-0495(91)90036-v · Cited by 86 · see citing works
Ototoxicity of erythromycin in peritoneal dialysis patients.
Taylor, R., Is, S., Ramos, J. M., et al. (1981) · PubMed · Cited by 82 · see citing works
No accumulation of glucose in human skeletal muscle during euglycemic hyperinsulinemia
Katz, A., Nyomba, B. L. G., & Bogardus, C. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.6.e942 · Cited by 81 · see citing works
Binding properties of chimeric insulin receptors containing the cysteine-rich domain of either the insulin-like growth factor I receptor or the insulin receptor related receptor
Zhang, B., & Roth, R. A. (1991) · Biochemistry · doi:10.1021/bi00235a001 · Cited by 75 · see citing works
Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes.
Hausdorff, S. F., Frangioni, J. V., & Birnbaum, M. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31813-6 · Cited by 74 · see citing works
Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in the endothelium of the genetic diabetic BB rat
Pieper, G. M., Siebeneich, W., Hilton, G., & Roza, A. M. (1997) · Diabetologia · doi:10.1007/s001250050767 · Cited by 74 · see citing works
Insulin Resistance in Secondary Hypertension
Shamiss, A., Carroll, J., & Rosenthal, T. (1992) · American Journal of Hypertension · doi:10.1093/ajh/5.1.26 · Cited by 74 · see citing works
Activation of Protein Kinase Cα Inhibits Signaling by Members of the Insulin Receptor Family
Danielsen, A. G., Liu, F., Hosomi, Y., Shii, K., & Roth, R. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.37.21600 · Cited by 73 · see citing works
Identification and characterization of two distinct intracellular GLUT4 pools in rat skeletal muscle: evidence for an endosomal and an insulin-sensitive GLUT4 compartment
Aledo, J. C., Lavoie, L., Volchuk, A., Keller, S. R., Klip, A., & Hundal, H. S. (1997) · Biochemical Journal · doi:10.1042/bj3250727 · Cited by 73 · see citing works
Hyperinsulinemia and hyperandrogenemia: in vivo androgen response to insulin infusion.
Stuart, C. A., PRINCE, M. J., Peters, E. J., & Meyer, W. J. (1987) · PubMed · Cited by 73 · see citing works
Cellular Insulin Resistance in Adipocytes from Obese Polycystic Ovary Syndrome Subjects Involves Adenosine Modulation of Insulin Sensitivity
Ciaraldi, T. P. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.5.1421 · Cited by 72 · see citing works
Molecular Biology of Diabetes
(1994) · Humana Press eBooks · doi:10.1007/978-1-4612-0241-7 · Cited by 69 · see citing works
Insulin second messengers
Strålfors, P. (1997) · BioEssays · doi:10.1002/bies.950190410 · Cited by 68 · see citing works
1 Cellular insulin action and insulin resistance
Garvey, W. T., & Birnbaum, M. J. (1993) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80237-x · Cited by 67 · see citing works
Self-citation
INSULIN RESISTANCE: CLINICAL FEATURES, NATURAL COURSE AND EFFECTS OF ADRENAL STEROID TREATMENT.
Shipp, J. C., Cunningham, R. W., Russell, R. O., et al. (1965) · PubMed · Cited by 62 · see citing works
INSULIN RESISTANCE
Shipp, J. C., Cunningham, R. W., Russell, R. O., et al. (1965) · Medicine · doi:10.1097/00005792-196503000-00003 · Cited by 58 · see citing works
Mutant insulin receptors in syndromes of insulin resistance
O’Rahilly, S., & Moller, D. E. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb00945.x · Cited by 53 · see citing works
Molecular Machinery Mediating Vesicle Budding, Docking and Fusion.
Söllner, T. H., & Rothman, J. E. (1996) · Cell Structure and Function · doi:10.1247/csf.21.407 · Cited by 50 · see citing works
Immunologic Insulin Resistance
Davidson, J. K., & DeBra, D. W. (1978) · Diabetes · doi:10.2337/diab.27.3.307 · Cited by 50 · see citing works
Structure and Function of Insulin Receptors
Rosen, O. M. (1989) · Diabetes · doi:10.2337/diab.38.12.1508 · Cited by 49 · see citing works
Advances in Endocrinology and Metabolism
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-1-76_3 · Cited by 38 · see citing works
In vivo stimulation of the insulin receptor kinase in human skeletal muscle. Correlation with insulin-stimulated glucose disposal during euglycemic clamp studies.
Freidenberg, G. R., Suter, S. L., Henry, R. R., Reichart, D. R., & Olefsky, J. M. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115257 · Cited by 34 · see citing works
The Effects of Brefeldin A on the Glucose Transport System in Rat Adipocytes
Bao, S., Smith, R. M., Jarett, L., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.50.30199 · Cited by 29 · see citing works
Trafficking, targeting and translocation of the insulin-responsive glucose transporter, GLUT4, in adipocytes
Rice, J., Livingstone, C., & Gould, G. W. (1996) · Biochemical Society Transactions · doi:10.1042/bst0240540 · Cited by 12 · see citing works

Flagged first, then by citations

Sorted by citations

Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342 · see citing works
Pathogenesis of insulin resistance in skeletal muscle
Abdul-Ghani, M. A., & DeFronzo, R. A. (2010) · Journal of Biomedicine and Biotechnology · doi:10.1155/2010/476279 · Cited by 670 · see citing works
Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
Bays, H., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030723 · Cited by 664 · see citing works
Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation
Fu, Y., Luo, N., Klein, R. L., & Garvey, W. T. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400373-jlr200 · Cited by 666 · see citing works
Self-citation
Normal Pregnancy- A State of Insulin Resistance
Sonagra, A. D. (2014) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2014/10068.5081 · Cited by 268 · see citing works
Dysfunctional fat cells, lipotoxicity and type 2 diabetes
Defronzo, R. A. (2004) · International Journal of Clinical Practice · doi:10.1111/j.1368-504x.2004.00389.x · Cited by 236 · see citing works
Essential Role of Insulin Receptor Substrate-2 in Insulin Stimulation of Glut4 Translocation and Glucose Uptake in Brown Adipocytes
Fasshauer, M., Klein, J., Ueki, K., Kriauciunas, K. M., Benito, M., White, M. F., & Kahn, C. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004046200 · Cited by 176 · see citing works
Role of DPP-4 and SGLT2 Inhibitors Connected to Alzheimer Disease in Type 2 Diabetes Mellitus
Sim, A. Y., Barua, S., Kim, J. Y., Lee, Y.-H., & Lee, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.708547 · Cited by 62 · see citing works

Resistance to Metabolic Actions of Insulin and Its Role in Hypertension
Hall, J. E., Summers, R. L., Brands, M. W., Keen, H. L., & Alonso‐Galicia, M. (1994) · American Journal of Hypertension · doi:10.1093/ajh/7.8.772 · Cited by 84 · see citing works
Molecular Mechanisms of Insulin Resistance That Impact Cardiovascular Biology
Wang, C. C. L., Goalstone, M. L., & Draznin, B. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2735 · Cited by 269 · see citing works
Hyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer’s Disease?
Hegde, V. K., Dhurandhar, N. V., & Reddy, P. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190808 · Cited by 23 · see citing works
[Hypertension and insulin resistance in obese type 2 diabetic Wistar fatty rat].
Suzuki, M., & Odaka, H. (2003) · PubMed · Cited by 2 · see citing works
Insulin resistance and compensatory hyperinsulinemia
Reaven, G. M., & Tsao, P. S. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02982-0 · Cited by 142 · see citing works

Authors: Hunter, S. J., & Garvey, W. T.
Affiliations: Medical University of South Carolina (US)
Corresponding author: Hunter, Steven J
ORCID: Hunter, Steven J
Garvey, W.Timothy
Venue: The American Journal of Medicine
Publisher: Elsevier BV
Published: 1998-10
Volume: 105
Issue: 4
Pages: 331-345
ISSN: 0002-9343 (ISSN-L)
DOI: 10.1016/s0002-9343(98)00300-3
OpenAlex: W1976981100
Cited by: 200
References: 105
Citations by year: 2026: 1 · 2025: 7 · 2024: 12 · 2023: 12 · 2022: 8 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 6 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 3
FWCI: 0.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The American Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p01hl055782-10, 5r01dk038763-10)
National Heart, Lung, and Blood Institute (P01 HL 55782)
National Institute of Diabetes and Digestive and Kidney Diseases (DK-38763, DK42469)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Keywords: insulin resistance, insulin action, insulin receptor defects, signal transduction, glucose transport, type 1 diabetes, type 2 diabetes, hyperinsulinemia, insulin sensitivity
MeSH terms: Biological Transport, Active, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Insulin Resistance, Polycystic Ovary Syndrome, Receptor, Insulin, Severity of Illness Index, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insulin action and insulin resistance: diseases involving defects in insulin receptors, signal transduction, and the glucose transport effector system

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks