Nicotinic treatment of Alzheimer’s disease

The cholinergic hypothesis of geriatric memory dysfunction

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Pragmatics of measuring recognition memory: Applications to dementia and amnesia.

Snodgrass, J. G., & Corwin, J. (1988) · Journal of Experimental Psychology General · doi:10.1037//0096-3445.117.1.34 · Cited by 3,093 · see citing works

Pragmatics of measuring recognition memory: Applications to dementia and amnesia.

Snodgrass, J. G., & Corwin, J. (1988) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.117.1.34 · Cited by 2,527 · see citing works

Human Memory and the Cholinergic System

Drachman, D. A. (1974) · Archives of Neurology · doi:10.1001/archneur.1974.00490320001001 · Cited by 1,398 · see citing works

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease

Mulnard, R. A., Cotman, C. W., Kawas, C. H., van Dyck, C. H., Sano, M. C., Doody, R. S., Koss, E., Pfeiffer, E., Jin, S., Gamst, A., et al. (2000) · JAMA · doi:10.1001/jama.283.8.1007 · Cited by 984 · see citing works

Neuronal nicotinic receptors in the human brain

Paterson, D., & Nordberg, A. K. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00045-3 · Cited by 782 · see citing works

Normalization of auditory physiology by cigarette smoking in schizophrenic patients

Adler, L. E., Hoffer, L., Wiser, A., & Freedman, R. (1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.12.1856 · Cited by 679 · see citing works

Basal forebrain neurons in the dementia of Parkinson disease

Whitehouse, P. J., Hedreen, J. C., White, C. L., & Price, D. L. (1983) · Annals of Neurology · doi:10.1002/ana.410130304 · Cited by 535 · see citing works

Nicotinic acetylcholine binding sites in Alzheimer's disease

Whitehouse, P. J., Martino, A. M., Antuono, P., Lowenstein, P. R., Coyle, J. T., Price, D. L., & Kellar, K. J. (1986) · Brain Research · doi:10.1016/0006-8993(86)90819-x · Cited by 485 · see citing works

Effects of acute subcutaneous nicotine on attention, information processing and short-term memory in alzheimer's disease

Jones, G., Sahakian, B. J., Levy, R., Warburton, D. M., & Gray, J. A. (1992) · Psychopharmacology · doi:10.1007/bf02247426 · Cited by 476 · see citing works

A randomized controlled trial of prednisone in Alzheimer’s disease

Aisen, P. S., Davis, K. L., Berg, J. D., Schafer, K., Campbell, K., Thomas, R. G., Weiner, M. F., Farlow, M. R., Sano, M., Grundman, M., et al. (2000) · Neurology · doi:10.1212/wnl.54.3.588 · Cited by 464 · see citing works

Cholinergic Switching Within Neocortical Inhibitory Networks

Xiang, Z., Huguenard, J. R., & Prince, D. A. (1998) · Science · doi:10.1126/science.281.5379.985 · Cited by 438 · see citing works

Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics

Adler, L. E., Hoffer, L., Griffith, J. M., Waldo, M. C., & Freedman, R. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90073-9 · Cited by 412 · see citing works

Alteration in nicotine binding sites in Parkinson's disease, Lewy body dementia and Alzheimer's disease: Possible index of early neuropathology

Perry, E. K., Morris, C. M., COURT, J. A., Cheng, A. V., FAIRBAIRN, A. F., McKeith, I. G., Irving, D., Brown, A. J., & Perry, R. H. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00410-7 · Cited by 386 · see citing works

A randomized controlled trial of prednisone in Alzheimer’s disease

Koch, H. J., & Szecsey, A. (2000) · Neurology · doi:10.1212/wnl.55.7.1067 · Cited by 381 · see citing works

Nicotine and smoking: A review of effects on human performance.

Heishma, S. J., Taylor, R. C., & Henningfield, J. E. (1994) · Experimental and Clinical Psychopharmacology · doi:10.1037/1064-1297.2.4.345 · Cited by 366 · see citing works

Comparative Alterations of Nicotinic and Muscarinic Binding Sites in Alzheimer's and Parkinson's Diseases

Aubert, I., Araujo, D. M., Cécyre, D., Robitaille, Y., Gauthier, S. G., & Quirion, R. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09752.x · Cited by 317 · see citing works

Nicotinic receptor stimulation protects neurons against β‐amyloid toxicity

Kihara, T., Shimohama, S., Sawada, H., Kimura, J., Kume, T., Kochiyama, H., Maeda, T., & Akaike, A. (1997) · Annals of Neurology · doi:10.1002/ana.410420205 · Cited by 315 · see citing works

Intravenous nicotine in Alzheimer's disease: a pilot study

NEWHOUSE, P. A., Sunderland, T., Tariot, P. N., Blumhardt, C. L., Weingartner, H., Mellow, A. M., & Murphy, D. L. (1988) · Psychopharmacology · doi:10.1007/bf00174504 · Cited by 308 · see citing works

Characterization of l ‐[3H]Nicotine Binding in Human Cerebral Cortex: Comparison Between Alzheimer's Disease and the Normal

Flynn, D. D., & Mash, D. C. (1986) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1986.tb13113.x · Cited by 284 · see citing works

Noncompetitive functional inhibition at diverse, human nicotinic acetylcholine receptor subtypes by bupropion, phencyclidine, and ibogaine

Fryer, J. D., & Lukas, R. J. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37928-5 · Cited by 283 · see citing works

Selectivity of Cholinesterase Inhibition

Weinstock, M. (1999) · CNS Drugs · doi:10.2165/00023210-199912040-00005 · Cited by 280 · see citing works

Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease

White, H. K., & Levin, E. D. (1999) · Psychopharmacology · doi:10.1007/s002130050931 · Cited by 273 · see citing works

A Pilot Controlled Clinical Trial of ABT-418, a Cholinergic Agonist, in the Treatment of Adults With Attention Deficit Hyperactivity Disorder

Wilens, T. E., Biederman, J., Spencer, T. J., Bostic, J., Prince, J., Monuteaux, M. C., Soriano, J., Fine, C., Abrams, A., Rater, M., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.12.1931 · Cited by 230 · see citing works

Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease

Maelicke, A., & Albuquerque, E. X. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00093-5 · Cited by 222 · see citing works

Kinetic Analysis of Regional (S)(-)11C-Nicotine Binding in Normal and Alzheimer Brains In Vivo Assessment Using Positron Emission Tomography

Nordberg, A. K., Lundqvist, H., Hartvig, P., Lilja, A., & Långström, B. (1995) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199505000-00006 · Cited by 212 · see citing works

Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21

Arendash, G. W., Sengstock, G. J., Sanberg, P. R., & Kem, W. R. (1995) · Brain Research · doi:10.1016/0006-8993(94)01449-r · Cited by 198 · see citing works

Nicotine patches in Alzheimer's disease: Pilot study on learning, memory, and safety

Wilson, A. L., Langley, L. K., Monley, J., Bauer, T., Rottunda, S. J., McFalls, E. O., Kovera, C. A., & McCarten, J. R. (1995) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00043-v · Cited by 196 · see citing works

Reductions in [ 3 H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease

Whitehouse, P. J., Martino, A. M., Wagster, M. V., Price, D. L., Mayeux, R. P., Atack, J. R., & Kellar, K. J. (1988) · Neurology · doi:10.1212/wnl.38.5.720 · Cited by 185 · see citing works

The effects of nicotine on Parkinson's disease.

Kelton, M., Kahn, H. J., Conrath, C. L., & NEWHOUSE, P. A. (2000) · PubMed · Cited by 180 · see citing works

Acute effects of the selective cholinergic channel activator (nicotinic agonist) ABT-418 in Alzheimer's disease

Potter, A., Corwin, J., Lang, J., Piasecki, M., Lenox, R., & Newhouse, P. A. (1999) · Psychopharmacology · doi:10.1007/s002130050897 · Cited by 163 · see citing works

Cognitive psychology and human memory

Baddeley, A. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90145-2 · Cited by 156 · see citing works

Acute nicotinic blockade produces cognitive impairment in normal humans

NEWHOUSE, P. A., Potter, A., Corwin, J., & Lenox, R. H. (1992) · Psychopharmacology · doi:10.1007/bf02247425 · Cited by 149 · see citing works

Epibatidine and ABT 418 reveal selective losses of α4β2 nicotinic receptors in Alzheimer brains

Berglund, U. W., & Nordberg, A. K. (1995) · Neuroreport · doi:10.1097/00001756-199511270-00033 · Cited by 148 · see citing works

RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization.

Bencherif, M., Lovette, M. E., Fowler, K., Arrington, S. R., Reeves, L., Caldwell, W. S., & Lippiello, P. M. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21302-7 · Cited by 141 · see citing works

Effects of scopolamine on delayed-matching-to-sample and paired associates tests of visual memory and learning in human subjects: comparison with diazepam and implications for dementia

Robbins, T. W., Semple, J., Kumar, R., Truman, M. I., Shorter, J., Ferraro, A., Fox, B., McKay, G., & Matthews, K. (1997) · Psychopharmacology · doi:10.1007/s002130050430 · Cited by 138 · see citing works

Age-Related Effects of the Nicotinic Antagonist Mecamylamine on Cognition and Behavior

NEWHOUSE, P. A., Potter, A., Corwin, J., & Lenox, R. H. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.11 · Cited by 136 · see citing works

Differential responsivity of mood, behavior, and cognition to cholinergic agents in elderly neuropsychiatric populations

Sunderland, T., Tariot, P. N., & NEWHOUSE, P. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)91227-9 · Cited by 134 · see citing works

Selective effects of nicotine on attentional processes

Mancuso, G., Sherwood, N., Tirelli, E., Warburton, D. M., & M�len, M. (1999) · Psychopharmacology · doi:10.1007/s002130051107 · Cited by 106 · see citing works

Improvement in performance of a delayed matching-to-sample task by monkeys following ABT-418: a novel cholinergic channel activator for memory enhancement

Buccafusco, J. J., Jackson, W. J., Terry, A. V., Marsh, K. C., Decker, M. W., & Arnerić, S. P. (1995) · Psychopharmacology · doi:10.1007/bf02311172 · Cited by 100 · see citing works

Central nicotinic receptor agonists ABT-418, ABT-089, and (-)-nicotine reduce distractibility in adult monkeys

Prendergast, M., Jackson, W. J., Terry, A. V., Decker, M. W., Arnerić, S. P., & Buccafusco, J. J. (1998) · Psychopharmacology · doi:10.1007/s002130050538 · Cited by 99 · see citing works

Genetic and environmental aspects of the role of nicotinic receptors in neurodegenerative disorders: Emphasis on Alzheimer's disease and Parkinson's disease

James, J. R., & Nordberg, A. K. (1995) · Behavior Genetics · doi:10.1007/bf02196924 · Cited by 98 · see citing works

Neuroendocrine, physiologic, and behavioral responses following intravenous nicotine in nonsmoking healthy volunteers and in patients with alzheimer's disease

NEWHOUSE, P. A., Sunderland, T., Narang, P. K., Mellow, A. M., Fertig, J. B., LAWLOR, B. A., & Murphy, D. L. (1990) · Psychoneuroendocrinology · doi:10.1016/0306-4530(90)90070-p · Cited by 95 · see citing works

Nicotine reverses GABAergic inhibition of long-term potentiation induction in the hippocampal CA1 region

Fujii, S., Jia, Y., Yang, A., & Sumikawa, K. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02119-3 · Cited by 93 · see citing works

Cholinergic Control of Cognitive Resources

Warburton, D. M., & Rusted, J. M. (2008) · Neuropsychobiology · doi:10.1159/000118998 · Cited by 86 · see citing works

Nicotine modulates the neurotoxic effect of β-amyloid protein(25–35) in hippocampal cultures

Zamani, R., Allen, Y. S., Owen, G. P., & Gray, J. A. (1997) · Neuroreport · doi:10.1097/00001756-199701200-00027 · Cited by 85 · see citing works

Baseline-dependency of nicotine effects: a review

Perkins, K. A. (1999) · Behavioural Pharmacology · doi:10.1097/00008877-199911000-00006 · Cited by 79 · see citing works

Anxiolytic-like effects of the novel cholinergic channel activator ABT-418

Brioni, J. D., O'Neill, A. B., Kim, D. J., Buckley, M. J., Decker, M. W., & Arneric, S. P. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22796-3 · Cited by 77 · cited 1× · see citing works

Differential responsivity of mood, behavior and cognition to cholinergic agents in elderly neuropsychiatric populations

Sunderland, T., Tariot, P. N., & NEWHOUSE, P. A. (1988) · Brain Research Reviews · doi:10.1016/0165-0173(88)90013-6 · Cited by 72 · see citing works

Treatment of Tourette's syndrome with mecamylamine

Sanberg, P. R., Shytle, R. D., & Silver, A. A. (1998) · The Lancet · doi:10.1016/s0140-6736(05)60822-7 · Cited by 71 · see citing works

The potential of subtype-selective neuronal nicotinic acetylcholine receptor agonists as therapeutic agents

Lloyd, G. K., Menzaghi, F., Bontempi, B., Suto, C. M., Siegel, R., AKONG, M., Stauderman, K. A., Veliçelebi, G., Johnson, E. C., Harpold, M. M., et al. (1998) · Life Sciences · doi:10.1016/s0024-3205(98)00114-3 · Cited by 65 · see citing works

Combined Nicotinic and Muscarinic Blockade in Elderly Normal Volunteers: Cognitive, Behavioral, and Physiologic Responses

Little, J. T. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00002-5 · Cited by 65 · see citing works

Nicotine and tetrahydroaminoacradine: Evidence for improved attention in patients with dementia of the Alzheimer type

Sahakian, B. J., & Coull, J. T. (1994) · Drug Development Research · doi:10.1002/ddr.430310112 · Cited by 58 · see citing works

Lu 25-109, a muscarinic agonist, fails to improve cognition in Alzheimer’s disease

Thal, L. J., Forrest, M., Loft, H., et al. (2000) · Neurology · doi:10.1212/wnl.54.2.421 · Cited by 56 · see citing works

Activation and inhibition of rat neuronal nicotinic receptors by ABT‐418

Papke, R. L., Thinschmidt, J. S., Moulton, B., Meyer, E. M., & Poirier, A. E. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700930 · Cited by 55 · see citing works

Effects of nicotine administered via a transdermal delivery system on vigilance: a repeated measure study

Mancuso, G., Andrés, P., Ansseau, M., & Tirelli, E. (1999) · Psychopharmacology · doi:10.1007/s002130050857 · Cited by 53 · see citing works

The Effects of Nicotine in Dermal Plaster on Cognitive Functions in Patients with Alzheimers Disease

Snædal, J., Jóhannesson, T., Jonsson, J., et al. (1996) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106852 · Cited by 43 · see citing works

Effect of long-term treatment with tacrine (THA) in Alzheimer's disease as visualized by PET

Nordberg, A. K. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1993.tb04259.x · Cited by 42 · see citing works

Preclinical Pharmacology of ABT‐418: A Prototypical Cholinergic Channel Activator for the Potential Treatment of Alzheimer's Disease

Arnerić, S. P., Anderson, D. J., Bannon, A. W., Briggs, C. A., Buccafusco, J. J., Brioni, J. D., Cannon, J. B., Decker, M. W., Donnelly‐Roberts, D. L., Gopalakrishnan, M., et al. (1995) · CNS Drug Reviews · doi:10.1111/j.1527-3458.1995.tb00274.x · Cited by 40 · see citing works

EFFECTS OF ATROPINE ON THE REPEATED ACQUISITION AND PERFORMANCE OF RESPONSE SEQUENCES IN HUMANS

Higgins, S. T., Woodward, B. M., & Henningfield, J. E. (1989) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1989.51-5 · Cited by 35 · see citing works

In vivo positron emission tomography studies on the novel nicotinic receptor agonist [11C]MPA compared with [11C]ABT-418 and (S)(−)[11C]nicotine in Rhesus monkeys

Sihver, W., Fasth, K., Ögren, M., Lundqvist, H., Bergström, M., Watanabe, Y., Långström, B., & Nordberg, A. K. (1999) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(99)00034-7 · Cited by 30 · see citing works

Nicotine and Smoking

Kumar, R. C., & LADER, M. H. (1981) · Springer eBooks · doi:10.1007/978-94-011-8123-5_5 · Cited by 26 · see citing works

Clinical Aspects of Nicotinic Agents: Therapeutic Applications in Central Nervous System Disorders

NEWHOUSE, P. A., & Kelton, M. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57079-7_26 · Cited by 14 · see citing works

Nicotine-like behavioral effect after small dose of mecamylamine in roman high-avoidance rats

Driscoll, P. (1976) · Psychopharmacology · doi:10.1007/bf00421559 · Cited by 14 · see citing works

Determinants of nicotine self-administration

Shoaib, M. C. (1996) · Drug Development Research · doi:10.1002/(sici)1098-2299(199607/08)38:3/4 · Cited by 7 · see citing works

Untitled work

Terry (1999) · doi:10.1002/(sici)1098-2299(199907)47:3

Modes and models of forebrain cholinergic neuromodulation of cognition

Hasselmo, M. E., & Sarter, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.104 · Cited by 733 · see citing works

Mid-life smoking and late-life dementia: the Honolulu-Asia Aging Study

Tyas, S. L., White, L. R., Petrovitch, H., Webster Ross, G., Foley, D. J., Heimovitz, H. K., & Launer, L. J. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00156-2 · Cited by 226 · see citing works

Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training

Gould, T. J., & Stephen Higgins, J. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(03)00057-1 · Cited by 123 · see citing works

Leveraging the cortical cholinergic system to enhance attention

Demeter, E., & Sarter, M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.060 · Cited by 75 · see citing works

Cholinergic modulation of response gain in the primary visual cortex of the macaque

Soma, S., Shimegi, S., Osaki, H., & Sato, H. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00330.2011 · Cited by 75 · see citing works

Effect of sorbinicate (nicotinic hexaester of d-glucitol) on the plasma FFA; plasma levels of nicotinic acid after sorbinicate administration

AVOGARO, P., Bittolo-Bon, G., & Cazzolato, G. (1978) · Pharmacological Research Communications · doi:10.1016/s0031-6989(78)80070-8 · Cited by 3 · see citing works

Correlation between the plasma concentration of free nicotinic acid and some of its pharmacological effects in the fasted rat after an oral dose of sorbinicate and of nicotinic acid.

Subissi, A., & Murmann, W. (1978) · PubMed · Cited by 5 · see citing works

The presence of electrocardiographic changes in nicotinic acid deficiency and their elimination by nicotinic acid

Rachmilewitz, M., & Braun, K. (1944) · American Heart Journal · doi:10.1016/s0002-8703(44)90725-8 · Cited by 15 · see citing works

Nicotinic Acid: Pharmacological Effects and Mechanisms of Action

Gille, A., Bodor, E. T., Ahmed, K., & Offermanns, S. (2007) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.48.113006.094746 · Cited by 313 · see citing works

An automated method for the analysis of nicotinic acid in serum

Robinson, W. T., Cosyns, L., & Kraml, M. (1978) · Clinical Biochemistry · doi:10.1016/s0009-9120(78)90667-7 · Cited by 8 · see citing works