Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training

Gould, Thomas J.; Stephen Higgins, J.

doi:10.1016/s1074-7427(03)00057-1

Cited by 123Memory and Neural MechanismsNicotinic Acetylcholine Receptors StudySmoking Behavior and Cessation

Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training

Gould, Thomas J., Stephen Higgins, J.·2003·Neurobiology of Learning and Memory

DOI 10.1016/s1074-7427(03)00057-1

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Abstract

Nicotine has been demonstrated to enhance learning processes. The present experiments extend these results to examine the effects of nicotine on acquisition and consolidation of contextual and cued fear conditioning, and the duration of nicotine's enhancement of conditioned fear. C57BL/6 mice were trained with two pairings of an auditory CS and a foot shock US. Multiple doses of nicotine were given before or immediately after training and on testing day (0.0, 0.050, 0.125, 0.250, and 0.375 mg/kg, i.p). Freezing to both the context and auditory CS was measured 24h after training and again 1 week after training. Mice did not receive nicotine for the 1-week retest. Nicotine (0.125 and 0.250 mg/kg) given on both training and testing days enhanced freezing to the context at 24h. In addition, elevated freezing to the context was seen 1 week post-training in mice previously treated with 0.125 and 0.250 mg/kg nicotine. Thus, nicotine-treated mice did show elevated levels of freezing when retested 1 week later, even though no nicotine was administered at the 1-week retest. Mice that received nicotine on training day or testing day only and mice that received nicotine with mecamylamine, a nicotinic receptor antagonist, were not different from saline-treated mice. In addition, post-training administration of nicotine did not enhance fear conditioning. The present results indicate that nicotine enhancement of contextual fear conditioning depends on administration of nicotine on training and test days but results in a long-lasting enhancement of memories of contextual fear conditioning that remains in the absence of nicotine.

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Acute nicotine exposure enhances fear conditioning in mice.
“For example, acute nicotine exposure enhances fear conditioning in mice (Gould and Higgins 2003).”
From The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse (2018) · cites this paper as Gould and Higgins 2003

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Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms
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Withdrawal from Chronic Nicotine Administration Impairs Contextual Fear Conditioning in C57BL/6 Mice
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The long-term cognitive consequences of adolescent exposure to recreational drugs of abuse
Mooney-Leber, S. M., & Gould, T. J. (2018) · Learning & Memory · doi:10.1101/lm.046672.117 · Cited by 140 · see citing works
“For example, acute nicotine exposure enhances fear conditioning in mice (Gould and Higgins 2003).”
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Involvement of the cholinergic system in conditioning and perceptual memory
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L-kynurenine treatment alters contextual fear conditioning and context discrimination but not cue-specific fear conditioning
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The use of cognitive enhancers in animal models of fear extinction.
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Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning
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Negative affective states and cognitive impairments in nicotine dependence
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Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders
Kutlu, M. G., & Gould, T. J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.07.029 · Cited by 97 · see citing works
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Cholinergic regulation of fear learning and extinction
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The Role of Muscarinic and Nicotinic Cholinergic Neurotransmission in Aversive Conditioning: Comparing Pavlovian Fear Conditioning and Inhibitory AvoidancePreprint
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Differential nicotinic regulation of the nigrostriatal and mesolimbic dopaminergic pathways: Implications for drug development
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Developmental effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning
Portugal, G. S., Wilkinson, D. S., Turner, J. R., Blendy, J. A., & Gould, T. J. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.04.003 · Cited by 79 · see citing works
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Reactivation of cocaine reward memory engages the Akt/GSK3/mTOR signaling pathway and can be disrupted by GSK3 inhibition
Shi, X., Miller, J. S., Harper, L. J., Poole, R. L., Gould, T. J., & Unterwald, E. M. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3491-8 · Cited by 79 · see citing works
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Nicotine Enhances Contextual Fear Conditioning and Ameliorates Ethanol-Induced Deficits in Contextual Fear Conditioning.
Gould, T. J., & Lommock, J. A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1276 · Cited by 79 · see citing works
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The effects of DHBE and MLA on nicotine-induced enhancement of contextual fear conditioning in C57BL/6 mice
Davis, J. A., & Gould, T. J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0047-y · Cited by 78 · see citing works
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Nicotine enhances trace cued fear conditioning but not delay cued fear conditioning in C57BL/6 mice
Gould, T. J., Feiro, O., & Moore, D. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.009 · Cited by 78 · see citing works
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Nicotine, adolescence, and stress: A review of how stress can modulate the negative consequences of adolescent nicotine abuse
Holliday, E. D., & Gould, T. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.003 · Cited by 75 · see citing works
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β2 subunit-containing nicotinic receptors mediate the enhancing effect of nicotine on trace cued fear conditioning in C57BL/6 mice
Davis, J. A., & Gould, T. J. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0624-8 · Cited by 72 · see citing works
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Cognitive Dysfunction, Affective States, and Vulnerability to Nicotine Addiction: A Multifactorial Perspective
Besson, M., & Forget, B. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00160 · Cited by 73 · see citing works
Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research
Portugal, G. S., & Gould, T. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.05.006 · Cited by 71 · see citing works
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The effects of acute, chronic, and withdrawal from chronic nicotine on novel and spatial object recognition in male C57BL/6J mice
Kenney, J. W., Adoff, M. D., Wilkinson, D. S., & Gould, T. J. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2283-7 · Cited by 67 · see citing works
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Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning
Gould, T. J., & Leach, P. T. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.004 · Cited by 68 · see citing works
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β2 subunit containing acetylcholine receptors mediate nicotine withdrawal deficits in the acquisition of contextual fear conditioning
Portugal, G. S., Kenney, J. W., & Gould, T. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.05.002 · Cited by 66 · see citing works
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Nicotine’s effect on cognition, a friend or foe?
Wang, Q., Du, W., Wang, H., Geng, P., Sun, Y., Zhang, J., Wang, W., & Jin, X. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110723 · Cited by 66 · see citing works
Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning
Kenney, J. W., Raybuck, J. D., & Gould, T. J. (2012) · Hippocampus · doi:10.1002/hipo.22003 · Cited by 65 · see citing works
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Nicotine enhances both foreground and background contextual fear conditioning
Davis, J. A., Porter, J., & Gould, T. J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.026 · Cited by 65 · see citing works
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Nicotine addiction and psychiatric disorders
Kutlu, M. G., Parikh, V., & Gould, T. J. (2015) · International Review of Neurobiology · doi:10.1016/bs.irn.2015.08.004 · Cited by 65 · see citing works
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Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory
Kutlu, M. G., & Gould, T. J. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.12.008 · Cited by 62 · see citing works
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Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice.
Raybuck, J. D., Portugal, G. S., Lerman, C., & Gould, T. J. (2008) · Behavioral Neuroscience · doi:10.1037/a0012601 · Cited by 62 · see citing works
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Substance abuse, memory, and post-traumatic stress disorder
Tipps, M. E., Raybuck, J. D., & Lattal, K. M. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.12.002 · Cited by 62 · see citing works
Nicotine and Hippocampus-Dependent Learning: Implications for Addiction
Gould, T. J. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:2:93 · Cited by 61 · see citing works
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Acute Ethanol Has Biphasic Effects on Short‐ and Long‐Term Memory in Both Foreground and Background Contextual Fear Conditioning in C57BL/6 Mice
Gulick, D., & Gould, T. J. (2007) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00458.x · Cited by 60 · see citing works
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Strain-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning
Portugal, G. S., Wilkinson, D. S., Kenney, J. W., Sullivan, C., & Gould, T. J. (2012) · Behavior Genetics · doi:10.1007/s10519-011-9489-7 · Cited by 58 · see citing works
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Performance of α7 nicotinic receptor null mutants is impaired in appetitive learning measured in a signaled nose poke task
Keller, J. J., Keller, A. B., Bowers, B. J., & Wehner, J. M. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.004 · Cited by 57 · see citing works
The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation
Gould, T. J., Portugal, G. S., André, J. M., Tadman, M. P., Marks, M. J., Kenney, J. W., Yildirim, E., & Adoff, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.003 · Cited by 56 · see citing works
“During training and testing, each mouse was judged as either freezing or active once every 10 s (Gould and Higgins, 2003).”
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Nicotine withdrawal‐induced deficits in trace fear conditioning in C57BL / 6 mice – a role for high‐affinity β2 subunit‐containing nicotinic acetylcholine receptors
Raybuck, J. D., & Gould, T. J. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06580.x · Cited by 53 · see citing works
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Atomoxetine Reverses Nicotine Withdrawal-Associated Deficits in Contextual Fear Conditioning
Davis, J. A., & Gould, T. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301315 · Cited by 52 · see citing works
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Bupropion dose-dependently reverses nicotine withdrawal deficits in contextual fear conditioning
Portugal, G. S., & Gould, T. J. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.08.004 · Cited by 51 · see citing works
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Exposure to Kynurenic Acid During Adolescence Produces Memory Deficits in Adulthood
Akagbosu, C., Evans, G. C., Gulick, D., Suckow, R. F., & Bucci, D. J. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq151 · Cited by 50 · see citing works
Associative Learning, the Hippocampus, and Nicotine Addiction
Gould, T. J., & Davis, J. A. (2008) · Current Drug Abuse Reviews · doi:10.2174/1874473710801010009 · Cited by 49 · see citing works
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Interactive effects of ethanol and nicotine on learning in C57BL/6J mice depend on both dose and duration of treatment
Gulick, D., & Gould, T. J. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0982-x · Cited by 49 · see citing works
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Prior chronic nicotine impairs cued fear extinction but enhances contextual fear conditioning in rats
Tian, S., Gao, J., Han, L., Fu, J., Li, C., & Li, Z. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.005 · Cited by 48 · see citing works
Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event–related potential and evoked gamma
Phillips, J. M., Ehrlichman, R. S., & Siegel, S. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.003 · Cited by 47 · see citing works
Nicotine enhances context learning but not context-shock associative learning.
Kenney, J. W., & Gould, T. J. (2008) · Behavioral Neuroscience · doi:10.1037/a0012807 · Cited by 45 · see citing works
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Nicotine withdrawal disrupts new contextual learning
Portugal, G. S., & Gould, T. J. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.11.001 · Cited by 43 · see citing works
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Involvement of Hippocampal Jun-N Terminal Kinase Pathway in the Enhancement of Learning and Memory by Nicotine
Kenney, J. W., Florian, C., Portugal, G. S., Abel, T. G., & Gould, T. J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.153 · Cited by 42 · see citing works
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Acute nicotine delays extinction of contextual fear in mice
Kutlu, M. G., & Gould, T. J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.01.031 · Cited by 42 · see citing works
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Nicotinic Receptors, Memory, and Hippocampus
Kutlu, M. G., & Gould, T. J. (2015) · Current topics in behavioral neurosciences · doi:10.1007/978-3-319-13665-3_6 · Cited by 41 · see citing works
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Atomoxetine and nicotine enhance prepulse inhibition of acoustic startle in C57BL/6 mice
Gould, T. J., Rukstalis, M. R., & Lewis, M. C. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.073 · Cited by 40 · see citing works
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Chronic nicotine exposure induces a long-lasting and pathway-specific facilitation of LTP in the amygdalaPreprint
Huang, Y.-Y., Kandel, E. R., & Levine, A. A. (2008) · Learning & Memory · doi:10.1101/lm.975308 · Cited by 40 · see citing works
Long‐term effects of chronic nicotine on emotional and cognitive behaviors and hippocampus cell morphology in mice: comparisons of adult and adolescent nicotine exposure
Holliday, E. D., Nucero, P., Kutlu, M. G., Oliver, C., Connelly, K. L., Gould, T. J., & Unterwald, E. M. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13398 · Cited by 38 · see citing works
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Nicotine withdrawal disrupts both foreground and background contextual fear conditioning but not pre-pulse inhibition of the acoustic startle response in C57BL/6 mice
André, J. M., Gulick, D., Portugal, G. S., & Gould, T. J. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.018 · Cited by 38 · see citing works
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The role of working memory and declarative memory in trace conditioning
Connor, D. A., & Gould, T. J. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.009 · Cited by 39 · see citing works
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Varenicline ameliorates ethanol-induced deficits in learning in C57BL/6 mice
Gulick, D., & Gould, T. J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.03.002 · Cited by 37 · see citing works
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Nicotine and extinction of fear conditioning
Elias, G. A., Gulick, D., Wilkinson, D. S., & Gould, T. J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2009.11.022 · Cited by 36 · see citing works
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Exposure to Kynurenic Acid during Adolescence Increases Sign-Tracking and Impairs Long-Term Potentiation in Adulthood
DeAngeli, N. E., Todd, T. P., Chang, S. E., Yeh, H. H., Yeh, P. W. L., & Bucci, D. J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00451 · Cited by 35 · see citing works
The interactive effects of nicotinic and muscarinic cholinergic receptor inhibition on fear conditioning in young and aged C57BL/6 mice
Feiro, O., & Gould, T. J. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.11.005 · Cited by 34 · see citing works
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Coantagonism of glutamate receptors and nicotinic acetylcholinergic receptors disrupts fear conditioning and latent inhibition of fear conditioningPreprint
Gould, T. J., & Lewis, M. C. (2005) · Learning & Memory · doi:10.1101/lm.89105 · Cited by 33 · see citing works
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Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine.
Raybuck, J. D., & Gould, T. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.5.1119 · Cited by 33 · see citing works
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Nicotine ameliorates NMDA receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus
André, J. M., Leach, P. T., & Gould, T. J. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.12.004 · Cited by 32 · see citing works
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Nicotine enhances contextual fear memory reconsolidation in rats
Tian, S., Huang, F., Li, P., Zhen-bang, L. I., Zhou, S., Deng, H., & Yang, Y. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.10.058 · Cited by 31 · see citing works
Learning and Nicotine Interact to Increase CREB Phosphorylation at the jnk1 Promoter in the Hippocampus
Kenney, J. W., Poole, R. L., Adoff, M. D., Logue, S. F., & Gould, T. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039939 · Cited by 30 · see citing works
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Administration of kynurenine during adolescence, but not during adulthood, impairs social behavior in rats
Batterman, K. V., & Bucci, D. J. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.08.014 · Cited by 30 · see citing works
Interactive effects of ethanol and nicotine on learning, anxiety, and locomotion in C57BL/6 mice in the plus-maze discriminative avoidance task
Gulick, D., & Gould, T. J. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.05.007 · Cited by 26 · see citing works
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Dissociation of tolerance and nicotine withdrawal-associated deficits in contextual fear
Gould, T. J., Wilkinson, D. S., Yildirim, E., Blendy, J. A., & Adoff, M. D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.02.038 · Cited by 25 · see citing works
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Basolateral amygdala, nicotinic cholinergic receptors, and nicotine: Pharmacological effects and addiction in animal models and humans
Sharp, B. M. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13970 · Cited by 25 · see citing works
Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory
Gould, T. J., Wilkinson, D. S., Yildirim, E., Poole, R. L., Leach, P. T., & Simmons, S. J. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.01.009 · Cited by 24 · see citing works
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Comparison of the performance of DBA/2 and C57BL/6 mice in transitive inference and foreground and background contextual fear conditioning.
André, J. M., Cordero, K. A., & Gould, T. J. (2012) · Behavioral Neuroscience · doi:10.1037/a0027048 · Cited by 24 · see citing works
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The Hippocampus and Cingulate Cortex Differentially Mediate the Effects of Nicotine on Learning Versus on Ethanol-Induced Learning Deficits Through Different Effects at Nicotinic Receptors
Gulick, D., & Gould, T. J. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.45 · Cited by 23 · see citing works
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Stress and nicotine during adolescence disrupts adult hippocampal‐dependent learning and alters stress reactivity
Holliday, E. D., Logue, S. F., Oliver, C. F., Bangasser, D. A., & Gould, T. J. (2019) · Addiction Biology · doi:10.1111/adb.12769 · Cited by 23 · see citing works
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Choline ameliorates adult learning deficits and reverses epigenetic modification of chromatin remodeling factors related to adolescent nicotine exposure
Gitik, M., Holliday, E. D., Leung, M., Yuan, Q., Logue, S. F., Tikkanen, R., Goldman, D., & Gould, T. J. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.08.009 · Cited by 21 · see citing works
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Acute nicotine enhances spontaneous recovery of contextual fear and changes c-fos early gene expression in infralimbic cortex, hippocampus, and amygdalaPreprint
Kutlu, M. G., Tumolo, J. M., Holliday, E. D., Garrett, B., & Gould, T. J. (2016) · Learning & Memory · doi:10.1101/lm.042655.116 · Cited by 21 · see citing works
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Withdrawal from chronic nicotine and subsequent sensitivity to nicotine challenge on contextual learning
Wilkinson, D. S., & Gould, T. J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.053 · Cited by 20 · see citing works
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Nicotine modulates contextual fear extinction through changes in ventral hippocampal GABAergic function
Kutlu, M. G., Connor, D. A., Tumolo, J. M., Cann, C., Garrett, B., & Gould, T. J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.019 · Cited by 20 · see citing works
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Mouse models for studying genetic influences on factors determining smoking cessation success in humans
Hall, F. S., Markou, A., Levin, E. D., & Uhl, G. R. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06415.x · Cited by 18 · see citing works
High-affinity α4β2 nicotinic receptors mediate the impairing effects of acute nicotine on contextual fear extinction
Kutlu, M. G., Holliday, E. D., & Gould, T. J. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.11.021 · Cited by 18 · see citing works
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Impairment of contextual fear extinction by chronic nicotine and withdrawal from chronic nicotine is associated with hippocampal nAChR upregulation
Kutlu, M. G., Oliver, C. F., Huang, P., Liu‐Chen, L., & Gould, T. J. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.06.032 · Cited by 16 · see citing works
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The effects of acute nicotine on contextual safety discrimination
Kutlu, M. G., Oliver, C. F., & Gould, T. J. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114552743 · Cited by 16 · see citing works
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Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning
Mineur, Y. S., Ernstsen, C., Islam, A., Maibom, K. L., & Picciotto, M. R. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12677 · Cited by 14 · see citing works
Pre-adolescent and adolescent mice are less sensitive to the effects of acute nicotine on extinction and spontaneous recovery
Kutlu, M. G., Zeid, D., Tumolo, J. M., & Gould, T. J. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.06.010 · Cited by 14 · see citing works
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Concentration- and age-dependent effects of chronic caffeine on contextual fear conditioning in C57BL/6J mice
Poole, R. L., Braak, D. C., & Gould, T. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.03.045 · Cited by 13 · see citing works
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ABT-089, but not ABT-107, ameliorates nicotine withdrawal-induced cognitive deficits in C57BL6/J mice
Yildirim, E., Connor, D. A., & Gould, T. J. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000111 · Cited by 13 · see citing works
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Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood
Seemiller, L. R., Logue, S. F., & Gould, T. J. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173429 · Cited by 13 · see citing works
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Neuropeptide CART prevents memory loss attributed to withdrawal of nicotine following chronic treatment in mice
Borkar, C. D., Sagarkar, S., Sakharkar, A. J., Subhedar, N. K., & Kokare, D. M. (2017) · Addiction Biology · doi:10.1111/adb.12579 · Cited by 13 · see citing works
Nicotine and ethanol enhancements of acoustic startle reflex are mediated in part by dopamine in C57BL/6J mice
Lewis, M. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00213-2 · Cited by 12 · see citing works
Cholinergic modulation of pavlovian fear conditioning in rats: Differential effects of intrahippocampal infusion of mecamylamine and methyllycaconitine
Vago, D. R., & Kesner, R. P. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.11.001 · Cited by 11 · see citing works
Chronic Nicotine Treatment During Adolescence Attenuates the Effects of Acute Nicotine in Adult Contextual Fear Learning
Holliday, E. D., & Gould, T. J. (2016) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntw176 · Cited by 10 · see citing works
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Effect of 4-Fluoro-N-(4-sulfamoylbenzyl) Benzene Sulfonamide on cognitive deficits and hippocampal plasticity during nicotine withdrawal in rats
Rehman, N. U., Esmaeilpour, K., Joushi, S., Abbas, M., al‐Rashida, M., Rauf, K., & Masoumi‐Ardakani, Y. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110783 · Cited by 10 · see citing works
Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment
Keady, J. V., Hessing, M. C., Songrady, J. C., McLaurin, K. A., & Turner, J. R. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00656-6 · Cited by 9 · see citing works
Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence
Kim, B., & Im, H. (2024) · Behavioral and Brain Functions · doi:10.1186/s12993-024-00227-0 · Cited by 9 · see citing works
Acute nicotine treatment enhances compulsive‐like remifentanil self‐administration that persists despite contextual punishment
Honeycutt, S. C., Paladino, M. S., Camadine, R. D., Mukherjee, A., & Loney, G. C. (2022) · Addiction Biology · doi:10.1111/adb.13170 · Cited by 9 · see citing works
Response disinhibition evoked by the administration of nicotine and nicotine-associated contextual cues
Kirshenbaum, A. P., Johnson, M. W., Schwarz, S. L., & Jackson, E. R. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.06.018 · Cited by 9 · see citing works
Nicotine disrupts safety learning by enhancing fear associated with a safety cue via the dorsal hippocampus
Connor, D. A., Kutlu, M. G., & Gould, T. J. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117695861 · Cited by 8 · see citing works
Self-citation

Nicotine enhancement of contextual fear conditioning
Gould, T. J., & Wehner, J. M. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00157-0 · Cited by 151 · see citing works
Self-citation
Nicotine produces a within-subject enhancement of contextual fear conditioning in C57BL/6 mice independent of sex
Gould, T. J. (2003) · Integrative Psychological and Behavioral Science · doi:10.1007/bf02688830 · Cited by 44 · see citing works
Self-citation
Nicotine enhances both foreground and background contextual fear conditioning
Davis, J. A., Porter, J., & Gould, T. J. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.026 · Cited by 65 · see citing works
Self-citation
Withdrawal from Chronic Nicotine Administration Impairs Contextual Fear Conditioning in C57BL/6 Mice
Davis, J. A., James, J. R., Siegel, S. J., & Gould, T. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2853-05.2005 · Cited by 146 · see citing works
Self-citation
Nicotine Enhances Contextual Fear Conditioning and Ameliorates Ethanol-Induced Deficits in Contextual Fear Conditioning.
Gould, T. J., & Lommock, J. A. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1276 · Cited by 79 · see citing works
Self-citation

Authors: Gould, T. J., & Stephen Higgins, J.
Affiliations: Temple University (US)
Corresponding author: Gould, Thomas J.
ORCID: Gould, Thomas J.
Venue: Neurobiology of Learning and Memory
Publisher: Elsevier BV
Published: 2003-09
Volume: 80
Issue: 2
Pages: 147-157
ISSN: 1074-7427 (ISSN-L)
DOI: 10.1016/s1074-7427(03)00057-1
OpenAlex: W2074624311
Cited by: 123
References: 90
Citations by year: 2024: 4 · 2023: 1 · 2022: 3 · 2020: 6 · 2019: 2 · 2018: 10 · 2017: 4 · 2016: 13 · 2015: 8 · 2014: 8 · 2013: 5 · 2012: 7
FWCI: 3.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Learning and Memory (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords: nicotine, contextual fear conditioning, cued fear conditioning, memory consolidation, long-term memory, mecamylamine, nicotinic acetylcholine receptors, freezing behavior, C57BL/6 mice
MeSH terms: Age Factors, Animals, Conditioning, Psychological, Fear, Ganglionic Stimulants, Male, Mice, Inbred C57BL, Nicotine, Teaching, Mice

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Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training

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