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Cited by 130Posttraumatic Stress Disorder ResearchTraumatic Brain Injury ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Alterations in the neural circuitry for emotion and attention associated with posttraumatic stress symptomatology

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Pannu Hayes, Jasmeet, LaBar, Kevin S., Petty, Christopher M., McCarthy, Gregory, Morey, Rajendra A.·2009·Psychiatry Research: Neuroimaging
DOI 10.1016/j.pscychresns.2008.05.005PMC PMC2692949
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Abstract

Information processing models of posttraumatic stress disorder (PTSD) suggest that PTSD is characterized by preferential allocation of attentional resources to potentially threatening stimuli. However, few studies have examined the neural pattern underlying attention and emotion in association with PTSD symptomatology. In the present study, combat veterans with PTSD symptomatology engaged in an emotional oddball task while undergoing functional magnetic resonance imaging (fMRI). Veterans were classified into a high or low symptomatology group based on their scores on the Davidson Trauma Scale (DTS). Participants discriminated infrequent target stimuli (circles) from frequent standards (squares) while emotional and neutral distractors were presented infrequently and irregularly. Results revealed that participants with greater PTSD symptomatology showed enhanced neural activity in ventral-limbic and dorsal regions for emotional stimuli and attenuated activity in dorsolateral prefrontal and parietal regions for attention targets. In the anterior cingulate gyrus, participants with fewer PTSD symptoms showed equivalent responses to attentional and emotional stimuli while the high symptom group showed greater activation for negative emotional stimuli. Taken together, the results suggest that hyperresponsive ventral-limbic activity coupled with altered dorsal-attention and anterior cingulate function may be a neural marker of attention bias in PTSD.

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  • Exaggerated activation of the dACC has been well described in individuals with PTSD and is associated with increased attention bias to threat.

    “Exaggerated activation of the dACC has been well described in individuals with PTSD (Felmingham et al, 2009;Milad et al, 2009;Pannu Hayes et al, 2009;Shin et al, 2007;Shin et al, 2001) and is associated with increased attention bias to threat (Fani et al, 2012a).”

    From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Pannu Hayes et al, 2009

    Section 4.3 reports greater dorsal ACC activity for emotional distractors in participants with high PTSD symptomatology, supporting the activation finding. But the same section says the literature is conflicting and that most earlier studies found ACC deactivation or no activation, so this paper does not support describing exaggerated activation as well established across individuals with PTSD. The attention-bias clause is cited to Fani et al., not this source. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Schizophrenia and post-traumatic stress disorder are both characterized by prefrontal dysfunction during tasks that require sustained attention.

    “schizophrenia and post-traumatic stress disorder are both characterized by prefrontal dysfunction during tasks that require sustained attention [4,5].”

    From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [5]

  • At least two imaging studies have found heightened vmPFC activity in PTSD patients.

    “at least two imaging studies have revealed heightened vmPFC activity in patients with PTSD (66, 67).”

    From Functional anatomy of ventromedial prefrontal cortex: implications for mood and anxiety disorders (2012) · cites this paper as [67]

  • A well-replicated finding in the PTSD literature is disrupted cognitive control in individuals with PTSD, evidenced by greater distractibility from task-irrelevant stimuli and difficulty inhibiting responses to task-irrelevant stimuli.

    “A well-replicated finding in the PTSD literature is that of disrupted cognitive control in individuals with PTSD, evidenced by greater distractibility from task irrelevant stimuli and difficulty inhibiting responses to task irrelevant stimuli”

    From Exercise Intervention in PTSD: A Narrative Review and Rationale for Implementation (2019) · cites this paper as [72]

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Authors
Pannu Hayes, J., LaBar, K. S., Petty, C. M., McCarthy, G., & Morey, R. A.
Affiliations
Duke University (US)
ORCID
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2009-04
Volume
172
Issue
1
Pages
7-15
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2008.05.005
PMC
PMC2692949
OpenAlex
W2109873096
Cited by
130
References
59
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 8 · 2016: 13 · 2015: 8 · 2014: 10 · 2013: 9 · 2012: 15
FWCI
12.34
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (VA999999)
  • National Institute of Mental Health (K23MH073091)
  • NIH Clinical Center
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
post-traumatic stress disorder, combat veterans, attentional bias, emotional processing, neural circuits, dorsal attention network, anterior cingulate cortex, Davidson Trauma Scale, negative emotional stimuli, attentional resources
MeSH terms
Attention, Brain, Brain Mapping, Combat Disorders, Emotions, Gyrus Cinguli, Humans, Functional Laterality, Magnetic Resonance Imaging, Neural Pathways, Neuropsychological Tests, Stress Disorders, Post-Traumatic, Task Performance and Analysis

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