Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure
Abstract
We analyzed temperature homeostasis in oxytocin-deficient (Oxt(-/-)) mice and found that Oxt(-/-) mice exhibited lower body temperatures than wild-type animals when they were exposed to cold. Oxt(-/-) mice also showed slightly more weight gain, but there were no obvious differences in the morphology of white and brown adipose tissues as between wild-type and Oxt(-/-) mice. In cold-exposed conditions, oxytocin neurons containing c-Fos immunoreactivity existed in the paraventricular nucleus of the hypothalamus. These results suggest that the central oxytocin neurons constitute part of the thermoregulatory system involved in maintaining body temperature in cold environments.
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Oxytocin promotes energy expenditure.
“These studies suggest that oxytocin promotes energy expenditure.”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [6]
Oxytocin induces weight loss in rodents, and this effect may be related to increased energy expenditure and lipolysis in addition to appetite suppression.
“Oxytocin induces weight loss in rodents, and this effect may be related to increased energy expenditure and lipolyis in addition to appetite suppression(6, 7, 8, 9, 10, 11).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [6]
Oxytocin and oxytocin receptor knockout mice develop obesity and reduced thermogenesis without a change in nutrient intake.
“Oxytocin and oxytocin receptor knockout mice develop obesity and reduced thermogenesis without a change in nutrient intake(6, 32).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [6]
Oxytocin has been implicated in the regulation of energy metabolism.
“In addition to its role in food intake, oxytocin has been implicated in the regulation of energy metabolism.”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [6]
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Cites
The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,879 · see citing works
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451 · see citing works
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,448 · see citing works
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379 · see citing works
βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance
Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., & Lowell, B. B. (2002) · Science · doi:10.1126/science.1073160 · Cited by 782 · see citing works
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734 · see citing works
Self-citationArgiolas, A., & GESSA, G. L. (1991) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80002-8 · Cited by 364 · see citing works
Muscatelli, F. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.20.3101 · Cited by 330 · see citing works
Oldfield, B. J., Giles, M., Watson, A. M. D., Anderson, C. R., Colvill, L. M., & McKinley, M. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00555-3 · Cited by 317 · see citing works
Zingg, H. H., & Laporte, S. A. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00080-8 · Cited by 316 · see citing works
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 289 · see citing works
Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats
Olson, B. R., Drutarosky, M. D., Chow, M.-S., Hruby, V. J., Stricker, E. M., & Verbalis, J. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90176-p · Cited by 283 · see citing works
Thermoregulation and non-shivering thermogenesis in the genetically obese (ob/ob) mouse
Trayhurn, P., & James, W. P. T. (1978) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00584859 · Cited by 257 · see citing works
Vasopressin, oxytocin and social behaviour
Keverne, E. B., & Curley, J. P. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.10.006 · Cited by 215 · see citing works
Oxytocin, Vasopressin, and Autism: Is There a Connection?
Insel, T. R., O’Brien, D. J., & Leckman, J. F. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0049 · Cited by 211 · see citing works
Neuropeptide expression in rat paraventricular hypothalamic neurons that project to the spinal cord
Hallbeck, M., Larhammar, D., & Blomqvist, A. G. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1137 · Cited by 135 · see citing works
Jimenez, M., Léger, B., Canola, K., Lehr, L., Arboit, P., Seydoux, J., Russell, A. P., Giacobino, J., Muzzin, P., & Preitner, F. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03387-2 · Cited by 126 · see citing works
Central administration of peptides alters thermoregulation in the rabbit
Lipton, J. M., & Glyn, J. R. (1980) · Peptides · doi:10.1016/0196-9781(80)90029-7 · Cited by 111 · see citing works
Thermoregulation in the diabetic-obese (db/db) mouse
Trayhurn, P. (1979) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00582901 · Cited by 108 · see citing works
Cerebrospinal fluid levels of oxytocin in Prader–Willi syndrome: a preliminary report
Martin, A., State, M., Anderson, G. M., Kaye, W. M., Hanchett, J. M., McConaha, C. W., North, W. G., & Leckman, J. F. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00190-5 · Cited by 89 · see citing works
Temperature Homeostasis in Transgenic Mice Lacking Thyroid Hormone Receptor-α Gene Products
Marrif, H. I., Schifman, A. L., Stepanyan, Z., Gillis, M., Calderone, A., Weiss, R. E., Samarut, J., & Silva, J. E. (2005) · Endocrinology · doi:10.1210/en.2004-1544 · Cited by 66 · see citing works
Cholecystokinin and D-fenfluramine inhibit food intake in oxytocin-deficient mice
Mantella, R. C., Rinaman, L., Vollmer, R. R., & Amico, J. A. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00383.2002 · Cited by 44 · see citing works
Investigation of thermoregulatory characteristics in patients with Prader‐Willi syndrome
Williams, M. S., Rooney, B. L., Williams, J. L., Josephson, K. D., & Pauli, R. M. (1994) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320490312 · Cited by 38 · see citing works
Oxytocin immunoreactivity in the hypothalamus of female hamsters
Whitman, D. C., & Albers, H. E. (1998) · Cell and Tissue Research · doi:10.1007/s004410050993 · Cited by 24 · see citing works
Mason, G., Caldwell, J. D., Stanley, D. A., Hatley, O. L., Prange, A. J., & Pedersen, C. A. (1986) · Regulatory Peptides · doi:10.1016/0167-0115(86)90008-x · Cited by 24 · see citing works
Kimura, T., & Ivell, R. (1999) · Results and problems in cell differentiation · doi:10.1007/978-3-540-49421-8_7 · Cited by 22 · see citing works
Catecholaminergic enzymes, vasopressin and oxytocin distribution in Siberian hamster brain
Shi, H., & Bartness, T. J. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00429-9 · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Knobil, E., and Neill, J. D., Raven Press, New York, pp. 1099-1129 (1994).
Cited by
Sorted by citations
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works
Peripheral oxytocin suppresses food intake and causes weight loss in diet-induced obese rats
Morton, G. J., Thatcher, B. S., Reidelberger, R. D., Ogimoto, K., Wolden-Hanson, T., Baskin, D. G., Schwartz, M. W., & Blevins, J. E. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2011 · Cited by 213 · see citing works
Oxytocin reduces caloric intake in men
Lawson, E. A., Marengi, D. A., DeSanti, R. L., Holmes, T. M., Schoenfeld, D. A., & Tolley, C. J. (2015) · Obesity · doi:10.1002/oby.21069 · Cited by 208 · see citing works
Hypothalamic control of energy expenditure and thermogenesis
Tran, L. T., Park, S., Kim, S. K., Lee, J. S., Kim, K. W., & Kwon, O. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00741-z · Cited by 208 · see citing works
The effects of oxytocin on eating behaviour and metabolism in humans
Lawson, E. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.115 · Cited by 196 · see citing works
An obligate role of oxytocin neurons in diet induced energy expenditure
Wu, Z., Xu, Y., Zhu, Y., Sutton, A. K., Zhao, R., Lowell, B. B., Olson, D. P., & Tong, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045167 · Cited by 181 · see citing works
Cold-blooded loneliness: Social exclusion leads to lower skin temperatures
IJzerman, H., Gallucci, M., Pouw, W. T. J. L., Weißgerber, S. C., Doesum, N. J. V., & Williams, K. D. (2012) · Acta Psychologica · doi:10.1016/j.actpsy.2012.05.002 · Cited by 162 · see citing works
Roles of Oxytocin in Stress Responses, Allostasis and Resilience
Takayanagi, Y., & Onaka, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010150 · Cited by 164 · see citing works
Self-citationMcCormack, S. E., Blevins, J. E., & Lawson, E. A. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz012 · Cited by 140 · see citing works
Central Nervous System Regulation of Brown Adipose Tissue
Morrison, S. F., & Madden, C. J. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140013 · Cited by 151 · see citing works
IJzerman, H., & Koole, S. L. (2011) · Psychological Bulletin · doi:10.1037/a0022373 · Cited by 123 · see citing works
Hypothalamic control of brown adipose tissue thermogenesis
Labbé, S. M., Caron, A., Lanfray, D., Monge-Roffarello, B., Bartness, T. J., & Richard, D. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00150 · Cited by 108 · see citing works
Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00118.2014 · Cited by 102 · see citing works
Ablation of Sim1 Neurons Causes Obesity through Hyperphagia and Reduced Energy Expenditure
Xi, D., Gandhi, N. M., Lai, M., & Kublaoui, B. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036453 · Cited by 100 · see citing works
Nishimori, K., Takayanagi, Y., YOSHIDA, M., Kasahara, Y., YOUNG, L., & Kawamata, M. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00408-1 · Cited by 98 · see citing works
Self-citationThe role of oxytocin in regulation of appetitive behaviour, body weight and glucose homeostasis
Lawson, E. A., Olszewski, P. K., Weller, A., & Blevins, J. E. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12805 · Cited by 97 · see citing works
Kasahara, Y., Sato, K., Takayanagi, Y., Mizukami, H., Ozawa, K., Hidema, S., So, K.-H., Kawada, T., Inoue, N., Ikeda, I., et al. (2013) · Endocrinology · doi:10.1210/en.2012-2206 · Cited by 96 · see citing works
Self-citationThe Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans
Kerem, L., & Lawson, E. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147737 · Cited by 94 · see citing works
Oxytocin and behavior: lessons from knockout mice
Caldwell, H. K., Aulino, E. A., Freeman, A. R., Miller, T. V., & Witchey, S. K. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22431 · Cited by 79 · see citing works
Benrick, A., Schéle, E., Pinnock, S. B., Asterholm, I. W., Dickson, S. L., Karlsson-Lindahl, L., & Jansson, J. (2009) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2009.01879.x · Cited by 79 · see citing works
Appetite- and Weight-Regulating Neuroendocrine Circuitry in Hypothalamic Obesity
Gan, H., Cerbone, M., & Dattani, M. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad033 · Cited by 71 · see citing works
Gutnick, A., Blechman, J., Kaslin, J., Herwig, L., Belting, H., Affolter, M., Bonkowsky, J. L., & Levkowitz, G. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.004 · Cited by 67 · see citing works
Buemann, B., & Uvnäs-Moberg, K. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109597 · Cited by 66 · see citing works
Altirriba, J., Poher, A.-L., & Rohner‐Jeanrenaud, F. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00119 · Cited by 63 · see citing works
PVN pathways controlling energy homeostasis
Hill, J. W. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105581 · Cited by 62 · see citing works
What's Love Got to do with it: Role of oxytocin in trauma, attachment and resilience
Sharma, S. R., Gonda, X., Dome, P., & Tarazi, F. I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107602 · Cited by 61 · see citing works
Toward a radically embodied neuroscience of attachment and relationships
Beckes, L., IJzerman, H., & Mattie Tops, A. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00266 · Cited by 67 · see citing works
Szatkowski, C., Vallet, J., Dormishian, M., Messaddeq, N., Valet, P., Boulberdaa, M., METZGER, D., Chambon, P., & Nebigil, C. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081175 · Cited by 52 · see citing works
The interplay of oxytocin and sex hormones
Quintana, D. S., Glaser, B. D., Kang, H., Kildal, E. S.-M., Audunsdottir, K., Sartorius, A. M., & Barth, C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105765 · Cited by 54 · see citing works
The Regulation of Oxytocin Receptor Gene Expression during Adipogenesis
Yi, K., So, K. H., Hata, Y., Suzuki, Y., Kato, D., Watanabe, K., Aso, H., Kasahara, Y., Nishimori, K., Chen, C., et al. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12268 · Cited by 51 · see citing works
Self-citationOxytocin Secretion Is Related to Measures of Energy Homeostasis in Young Amenorrheic Athletes
Lawson, E. A., Ackerman, K. E., Slattery, M. J., Marengi, D. A., Clarke, H., & Misra, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4136 · Cited by 48 · see citing works
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Dong, X., Long, C., Lai, M., Casella, A., O’Lear, L., Kublaoui, B. M., & Roizen, J. D. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00136 · Cited by 46 · see citing works
Birth signalling hormones and the developmental consequences of caesarean delivery
Kenkel, W. M. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12912 · Cited by 45 · see citing works
Kaneko, T., & Kibayashi, K. (2012) · Brain Research · doi:10.1016/j.brainres.2012.05.001 · Cited by 42 · see citing works
Blechman, J., Amir-Zilberstein, L., Gutnick, A., Ben‐Dor, S., & Levkowitz, G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1798-11.2011 · Cited by 40 · see citing works
Harshaw, C., Leffel, J. K., & Alberts, J. R. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2017.12.007 · Cited by 39 · see citing works
An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow
Fukushima, A., Kataoka, N., & Nakamura, K. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111380 · Cited by 40 · see citing works
Adipose Tissue and Energy Expenditure: Central and Peripheral Neural Activation Pathways
Blaszkiewicz, M., & Townsend, K. L. (2016) · Current Obesity Reports · doi:10.1007/s13679-016-0216-9 · Cited by 34 · see citing works
Kasahara, Y., Tateishi, Y., Hiraoka, Y., Otsuka, A., Mizukami, H., Ozawa, K., Sato, K., Hidema, S., & Nishimori, K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00180 · Cited by 32 · see citing works
Self-citationSnider, B. M., Geiser, A., Yu, X.-P., Beebe, E., Willency, J. A., Qing, K., Guo, L., Lu, J., Wang, X., Yang, Q., et al. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00004 · Cited by 32 · see citing works
Romano, A., Friuli, M., Cifani, C., & Gaetani, S. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108082 · Cited by 30 · see citing works
Oxytocin as an Anti-obesity Treatment
Niu, J., Tong, J., & Blevins, J. E. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.743546 · Cited by 30 · see citing works
The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease
Aulinas, A., & Lawson, E. A. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf008 · Cited by 30 · see citing works
Terminal addition in a cellular world
Torday, J. S., & Miller, W. B. (2017) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2017.12.003 · Cited by 26 · see citing works
Brown Adipose Tissue: A Metabolic Regulator in a Hypothalamic Cross Talk?
Henningsen, J. B., & Scheele, C. C. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-032420-042950 · Cited by 24 · see citing works
Central Nervous System Regulation of Brown Adipose Tissue
Morrison, S. F., & Madden, C. J. (2014) · Comprehensive physiology · doi:10.1002/j.2040-4603.2014.tb00592.x · Cited by 24 · see citing works
Love and longevity: A Social Dependency Hypothesis
Horn, A. J., & Carter, C. S. (2021) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2021.100088 · Cited by 22 · see citing works
Conceptual Metaphor Theory: Basing on Theories of Embodied Cognition
Rong, Y. I. N., Dequan, S. U., & Ye, H. (2013) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2013.00220 · Cited by 21 · see citing works
Skinner, J. A., Campbell, E. J., Dayas, C. V., Garg, M. L., & Burrows, T. L. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.09.002 · Cited by 21 · see citing works
The New Frontier in Oxytocin Physiology: The Oxytonic Contraction
Camerino, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145144 · Cited by 21 · see citing works
Sinden, D. S., Holman, C. D., Bare, C. J., Sun, X., Gade, A. R., Cohen, D. E., & Pitt, G. S. (2019) · The FASEB Journal · doi:10.1096/fj.201901178r · Cited by 20 · see citing works
The origin of REM sleep: A hypothesis.
Tsoukalas, I. (2012) · Dreaming · doi:10.1037/a0030790 · Cited by 18 · see citing works
The Role of the Oxytocin/Arginine Vasopressin System in Animal Models of Autism Spectrum Disorder
Zhang, R., Xu, X., Zhang, H.-F., Han, S., & Han, J. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-52498-6_8 · Cited by 16 · see citing works
Marazziti, D., Diep, P.-T., Carter, C. S., & Carbone, M. G. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220727120646 · Cited by 16 · see citing works
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Colleluori, G., Galli, C., Severi, I., Perugini, J., & Giordano, A. (2022) · Cells · doi:10.3390/cells11040623 · Cited by 15 · see citing works
Thermoregulatory disorders in Huntington disease
Weydt, P., Dupuis, L., & Petersén, Å. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64074-1.00047-1 · Cited by 13 · see citing works
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Hong, S. M., Ko, J.-K., Moon, J., & Kim, Y. (2021) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes20098 · Cited by 13 · see citing works
Toward a Radically Embodied Neuroscience of Attachment and Relationships?Preprint
Beckes, L., IJzerman, H., & Mattie Tops, A. (2014) · SSRN Electronic Journal · doi:10.2139/ssrn.2429522 · Cited by 13 · see citing works
Modulation of the thermosensory system by oxytocin
Zayan, U., Prato, L. C. D., Muscatelli, F., & Matarazzo, V. A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1075305 · Cited by 12 · see citing works
Energy Homeostasis: Paraventricular Nucleus System☆
Timofeeva, E., Caron, A., & Richard, D. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.02753-x · Cited by 11 · see citing works
Robust Reductions of Body Weight and Food Intake by an Oxytocin Analog in Rats
Elfers, C., Blevins, J. E., Lawson, E. A., Pittner, R. A., Silva, D., Kiselyov, A. S., & Roth, C. L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.726411 · Cited by 11 · see citing works
Harshaw, C., Lanzkowsky, J., Tran, A.-Q. D., Bradley, A. R., & Jaime, M. (2021) · Hormones and Behavior · doi:10.1016/j.yhbeh.2021.104981 · Cited by 10 · see citing works
Asla, Q., Garrido, M., Urgell, E., Terzan, S., Vives, A. S., Fernández-Miró, M., Varghese, N., Atila, C., Calabrese, A., Biagetti, B., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-86566-y · Cited by 9 · see citing works
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Biddinger, J. E., Elson, A. E. T., Fathi, P. A., Sweet, S. R., Nishimori, K., Ayala, J. E., & Simerly, R. B. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2403810121 · Cited by 9 · see citing works
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Fırat, F. (2017) · Turkish Journal of Trauma and Emergency Surgery · doi:10.5505/tjtes.2017.25730 · Cited by 8 · see citing works
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Greenwood, M. A., & Hammock, E. A. D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00474 · Cited by 7 · see citing works
Torday, J. S., & Miller, W. B. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170035 · Cited by 7 · see citing works
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Segev-Hadar, A., Krispin, S., Olthof, A. M., Hyatt, K. C., Haller, L. Y., Barki, A., Nitzan, T., Levkowitz, G., Kanadia, R., Cnaani, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.20.472748 · Cited by 5 · see citing works
Edwards, M. M., Nguyen, H. K., Dodson, A. D., Herbertson, A. J., Honeycutt, M. K., Slattery, J. D., Rambousek, J. R., Tsui, E. W., Wolden‐Hanson, T., Wietecha, T., et al. (2024) · Frontiers in Drug Delivery · doi:10.3389/fddev.2024.1497746 · Cited by 4 · see citing works
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Beckes, L., & IJzerman, H. (2017) · doi:10.31234/osf.io/am8jd · Cited by 3 · see citing works
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Tong, S., Chang, C., Shih, S., Chua, F. Z., Hwang, P., & Chou, M. (2025) · The FASEB Journal · doi:10.1096/fj.202500161r · Cited by 2 · see citing works
Cerrito, P., & Spear, J. K. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105437 · Cited by 2 · see citing works
Mendez, A. J., Szeto, A., Boulina, M. E., Westwright, J. S., Rahman, H., Abushamma, S., Schneider, R., & McCabe, P. M. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1465818 · Cited by 1 · see citing works
Paparella, R., Bei, A., Bernabei, I., Fiorentini, C., Iafrate, N., Lucibello, R., Marchetti, L., Pastore, F., Maglione, V., Niceta, M., et al. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47120982 · Cited by 1 · see citing works
Young, W. S. (2013) · Endocrinology · doi:10.1210/en.2013-1885 · Cited by 1 · see citing works
Oxytocin as a Metabolic Modulator
Bhatt, N. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97630 · Cited by 1 · see citing works
Intranasal oxytocin as a treatment for obesity: safety and efficacy
Balestrino, R., Losa, M., Albano, L., Barzaghi, L. R., & Mortini, P. (2023) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2023.2216794 · Cited by 2 · see citing works
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Kim, Y., Hong, S. M., & Moon, J. (2020) · Springer eBooks · doi:10.1007/978-3-030-43562-2_17 · Cited by 1 · see citing works
Oxytocin Receptor-Expressing Neurons and Nuclei in the Regulation of Social Behaviors
Nishimori, K., Sato, K., Hidema, S., Yoshida, M., & Mizukami, H. (2015) · Interdisciplinary Information Sciences · doi:10.4036/iis.2015.b.14
Self-citationTorday, J. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-93691-4_17
Torday, J. S., & Miller, W. B. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00026.x
The impact of SERE training on selected neurotransmitter secretion in special forces soldiers
Grzesik, M., Łach, K., Brożyna, M., Przednówek, K., & Podgórski, R. (2025) · Scientific Reports · doi:10.1038/s41598-025-06270-9
Conventional ambient temperature housing impacts central oxytocin levels in mice
Kenkel, W. M., Partie, M. E., Rogers, K., & Watanasriyakul, W. T. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.70126
Neural correlates of adversity-overcoming pup rescue behavior in female mice
Prokofeva, K., Shibamiya, M., Kawata, R., Yoshihara, C., & Kuroda, K. O. (2026) · Scientific Reports · doi:10.1038/s41598-026-35639-7
Bertoni, A. (2019) · theses.fr (ABES) · doi:10.70675/d43fcf44zc66ez47a1zae43zd20439e2b233
Podolak, M., Serafin, A., Baran, K., Suchołbiak, A., Grygutis, I., Jarzęcka, U., Karandys, M., Denkiewicz, A., & Hajduk, M. (2026) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.2(50).2026.5847
Williams, A. L., & Blevins, J. E. (2026) · Current Diabetes Reports · doi:10.1007/s11892-026-01640-7
- Authors
- KASAHARA, Y., TAKAYANAGI, Y., KAWADA, T., ITOI, K., & NISHIMORI, K.
- Affiliations
- Tohoku University (JP)
- Jichi Medical University (JP)
- Kyoto University (JP)
- Venue
- Bioscience Biotechnology and Biochemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-12-23
- Volume
- 71
- Issue
- 12
- Pages
- 3122-3126
- ISSN
- 0916-8451 (ISSN-L)
- 1347-6947
- OpenAlex
- W2102380773
- Cited by
- 89
- References
- 31
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 4 · 2012: 6
- FWCI
- 1.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioscience Biotechnology and Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Jichi Medical University
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Keywords
- oxytocin, thermoregulation, cold exposure, body temperature, hypothalamic paraventricular nucleus, c-fos, white adipose tissue, brown adipose tissue, weight gain
- MeSH terms
- Animals, Body Temperature Regulation, Body Weight, Adipose Tissue, Brown, Cold Temperature, Neurons, Oxytocin, Paraventricular Hypothalamic Nucleus, Proto-Oncogene Proteins c-fos, Mice, Knockout, Mice, Adipose Tissue, White
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