Neural Circuitry of Salience and Reward Processing in Psychosis

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Mesolimbic dopamine signals the value of work

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Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia

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Deficits in domains of social cognition in schizophrenia: a meta-analysis of the empirical evidence

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Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

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Half a century of antipsychotics and still a central role for dopamine D2 receptors

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Substantia nigra/ventral tegmental reward prediction error disruption in psychosis

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Reward Processing in Schizophrenia: A Deficit in the Representation of Value

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Transient and Selective Overexpression of Dopamine D2 Receptors in the Striatum Causes Persistent Abnormalities in Prefrontal Cortex Functioning

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Absolute Coding of Stimulus Novelty in the Human Substantia Nigra/VTA

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Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release

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Beyond the “at risk mental state” concept: transitioning to transdiagnostic psychiatry

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Expected value and prediction error abnormalities in depression and schizophrenia

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Disrupted prediction-error signal in psychosis: Evidence for an associative account of delusions

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A Review of Reward Processing and Motivational Impairment in Schizophrenia

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The anticipation and outcome phases of reward and loss processing: A neuroimaging meta‐analysis of the monetary incentive delay task

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Novelty or Surprise?

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Dopamine Synthesis Capacity in Patients With Treatment-Resistant Schizophrenia

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Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology

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Dopamine Synthesis Capacity Before Onset of Psychosis: A Prospective [ ¹⁸ F]-DOPA PET Imaging Study

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Ventral Striatal Activation During Reward Processing in Psychosis

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Antipsychotic Treatment Resistance in Schizophrenia Associated with Elevated Glutamate Levels but Normal Dopamine Function

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Dopamine, psychosis and schizophrenia: the widening gap between basic and clinical neuroscience

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Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics

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Treatment resistant schizophrenia: Clinical, biological, and therapeutic perspectives

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An integrative perspective on the role of dopamine in schizophrenia

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Dopaminergic dysfunction in alcoholism and schizophrenia—psychopathological and behavioral correlates

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Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex

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Do patients with schizophrenia exhibit aberrant salience?

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Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging

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Opioids for hedonic experience and dopamine to get ready for it

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Striatal Presynaptic Dopamine in Schizophrenia, Part II: Meta-Analysis of [18F/11C]-DOPA PET Studies

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Striatal dysfunction during reversal learning in unmedicated schizophrenia patients

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Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine

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Ventral striatal dopamine reflects behavioral and neural signatures of model-based control during sequential decision making

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Dopaminergic basis of salience dysregulation in psychosis

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From prediction error to psychosis: Ketamine as a pharmacological model of delusions

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Brain-Wide Analysis of Functional Connectivity in First-Episode and Chronic Stages of Schizophrenia

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Amotivation in Schizophrenia: Integrated Assessment With Behavioral, Clinical, and Imaging Measures

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Corticostriatal Control of Goal-Directed Action Is Impaired in Schizophrenia

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Patients with Schizophrenia have a Reduced Neural Response to Both Unpredictable and Predictable Primary Reinforcers

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Multifaceted Contributions by Different Regions of the Orbitofrontal and Medial Prefrontal Cortex to Probabilistic Reversal Learning

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Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis

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Anterior Cingulate Glutamate Levels Related to Clinical Status Following Treatment in First-Episode Schizophrenia

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Reinforcement and Reversal Learning in First-Episode Psychosis

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Pavlovian Reward Prediction and Receipt in Schizophrenia: Relationship to Anhedonia

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The Circuitry of Dopamine System Regulation and its Disruption in Schizophrenia: Insights Into Treatment and Prevention

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Improvement of Brain Reward Abnormalities by Antipsychotic Monotherapy in Schizophrenia

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What Is the Relationship between Dopamine and Effort?

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Disambiguating ventral striatum fMRI-related bold signal during reward prediction in schizophrenia

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Effort-Based Decision Making: A Novel Approach for Assessing Motivation in Schizophrenia:

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Dopamine and the aberrant salience hypothesis of schizophrenia

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Neural Response to Emotional Salience in Schizophrenia

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Meta-analysis of human prediction error for incentives, perception, cognition, and action

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Dynamic Nigrostriatal Dopamine Biases Action Selection

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The Roles of Reward, Default, and Executive Control Networks in Set-Shifting Impairments in Schizophrenia

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Looking at the other side of the coin: A meta-analysis of self-reported emotional arousal in people with schizophrenia

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Translational assessment of reward and motivational deficits in psychiatric disorders

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How dopamine dysregulation leads to psychotic symptoms? Abnormal mesolimbic and mesostriatal prediction error signalling in psychosis

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Translational studies of goal-directed action as a framework for classifying deficits across psychiatric disorders

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Effort-cost decision-making in psychosis and depression: could a similar behavioral deficit arise from disparate psychological and neural mechanisms?

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Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis

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Dopamine, Prediction Error and Beyond

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Attention to Irrelevant Cues Is Related to Positive Symptoms in Schizophrenia

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Anterior cingulate neurons in the rat map anticipated effort and reward to their associated action sequences

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Adaptive prediction error coding in the human midbrain and striatum facilitates behavioral adaptation and learning efficiency

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Altered Associations Between Motivated Performance and Frontostriatal Functional Connectivity During Reward Anticipation in Schizophrenia

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Verbal and visual learning ability in patients with treatment-resistant schizophrenia: A 1-year follow-up study

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Altered Neurobehavioral Reward Response Predicts Psychotic-Like Experiences in Youth Exposed to Cannabis Prenatally

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Acute and Lifetime Stress and Psychotic Illness: The Roles of Reward and Salience Networks

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Distinct personality profiles associated with disease risk and diagnostic status in eating disorders

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A generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries

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A multicentre study on grey matter morphometric biomarkers for classifying early schizophrenia and parkinson’s disease psychosis

Knolle, F., Arumugham, S. S., Barker, R. A., Chee, M. W. L., Justicia, A., Kamble, N. L., Lee, J., Liu, S., Lenka, A., Lewis, S. J. G., et al. (2023) · npj Parkinson s Disease · doi:10.1038/s41531-023-00522-z · Cited by 5 · see citing works

Reversal learning in those with early psychosis features contingency-dependent changes in loss response and learning

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Activating the dorsomedial and ventral midbrain projections to the striatum differentially impairs goal-directed action in male mice

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Cognitive subgroups of affective and non-affective psychosis show differences in medication and cortico-subcortical brain networks

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Suppression of the dorsomedial striatum impairs reversal learning in response to probabilistic uncertainty and disrupts corticostriatal function in mice

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EEG microstates, acute phase negative symptoms of schizophrenia and antipsychotic treatment response

Pieri, M. D., Rochas, V., Apostolopoulou, D., Kirschner, M., Sabé, M., Bartolomei, J., Bègue, I., Koenig, T. W., & Kaiser, S. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111466 · Cited by 3 · see citing works

Neural and Behavioral Markers of Negative Symptoms and Cognitive Impairment in Patients with Psychosis

van Gool, R., Cay, M., van der Heijden, H. C., Golden, E., Cao, A., Ren, B., Gonzalez–Heydrich, J., Shinn, A. K., & Upadhyay, J. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0039-25.2025 · Cited by 3 · see citing works

Targeting disrupted networks in schizophrenia: Can muscarinic drugs make a fundamental difference?

Pratt, J. A., & MORRIS, B. J. (2025) · Journal of Psychopharmacology · doi:10.1177/02698811251375104 · Cited by 2 · see citing works

Distinct neurobiological alterations during hedonic experience of rewards in attention deficit hyperactivity disorder and autism spectrum disorder: Multimodal evidence from neuroimaging meta-analyses

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Applications of Behavioral Economics and Neuroeconomics in Mental Health

Abdullaeva, B. S., Àbdullaev, D., Djuraeva, L., Sagdullaeva, D. K., & Kholikov, A. (2024) · Iranian Journal of Psychiatry · doi:10.18502/ijps.v20i1.17404 · Cited by 6 · see citing works

The Translational Utility of Circuit-Based Manipulations in Preclinical Models

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The Salience of Psychotic Experiences: Neural Correlates in the General Population

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Inner speech and the neurobiology of psychosis

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A cortical insula–orbitofrontal circuit drives stress-induced dopamine system dysfunction

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Functional connectivity in a monetary and social incentive delay task in medicated patients with schizophrenia

Hanewald, B., Lockhofen, D. E. L., Sammer, G., Stingl, M., Gallhofer, B., Mulert, C., & Iffland, J. R. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1200860 · Cited by 2 · see citing works

Linking Substance Use and Schizophrenia

Mutlu, E., Özden, H. C., & Ertuğrul, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-32046-0_179-1 · Cited by 1 · see citing works

Altered neural signalling during reward anticipation in children and early adolescents with high psychotic-like experiences

Sen, P., & Knolle, F. (2025) · NeuroImage Clinical · doi:10.1016/j.nicl.2025.103756 · Cited by 1 · see citing works

Subcortical Origin of Salience Processing Deficits in Schizophrenia

Palaniyappan, L. K. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.12.008 · Cited by 1 · see citing works

Grey matter morphometric biomarkers for classifying early schizophrenia and PD psychosis: a multicentre studyPreprint

Knolle, F., Arumugham, S. S., Barker, R. A., Chee, M. W. L., Justicia, A., Kamble, N. L., Lee, J., Liu, S., Lenka, A., Lewis, S. J. G., et al. (2022) · medRxiv · doi:10.1101/2022.05.06.22274674 · Cited by 1 · see citing works

Association between increased anterior cingulate glutamate and psychotic-like symptoms, but not autistic traitsPreprint

Demler, V. F., Sterner, E., Wilson, M., Zimmer, C., & Knolle, F. (2023) · medRxiv · doi:10.1101/2023.02.01.23285183 · Cited by 1 · see citing works

A comprehensive study on the cognitive mechanisms and neural substrates of hallucination proneness

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Insights into psychosis risk: Unveiling impaired reinforcement learning through a behavioral and functional near-infrared spectroscopy-based optical neuroimaging study

Klaassen, A.-L., Michel, C., Stüble, M., Scholkmann, F., Kaess, M., & Kindler, J. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.01.051

Multifaceted Life Skills Training and Job-Orientation Supports For Individuals in Vocational Rehabilitation Programming

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Spatiotemporal dissociation of physical salience and stimulus evaluation in the human midbrain

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Endocannabinoids regulation of the mesolimbic system

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Altered striatal dopamine dynamics and behavior in Grin2a mutant mice, a genetic mouse model of schizophreniaPreprint

Hall, A., Jacoby, J., Gangal, H., Rochman, E., Shephard, N., Song, B., Farsi, Z., Datta, S. R., Sheng, M., & Kunwar, P. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.24.690326 · Cited by 1 · see citing works

Linking Substance Use and Schizophrenia

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Mapping Individual Neuroanatomical Alterations to Schizophrenia Psychopathology with Normative ModelingPreprint

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Rapid connectivity alterations of thalamic nuclei during initial learning of goal-directed behaviourPreprint

Jarrett, C. E., Fregni, S., von Kriegstein, K., & Ruge, H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.15.725154

Deep Brain Stimulation of the Nucleus Accumbens Modulates Effort‐Based Decision‐Making and Phasic Dopamine Release in Male Wistar Rats

McCullough, S., Varela, R. B., Houghton, T., Macpherson, H. K., & Tye, S. J. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70485

The experiential self-state as affective salience: a dual-self states framework for consciousness and self-transcendence

van Mulukom, V. (2026) · Neuroscience of Consciousness · doi:10.1093/nc/niag033

Valuation as a bridge between aesthetics and creativity

Vartanian, O. A., Skov, M., Nadal, M., & Chatterjee, A. (2026) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2026.08.005

Psychiatrists’ and psychiatry trainees’ perspectives of treatment priorities and the role of cognitive symptoms in supporting people with psychotic disorders

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Nucleus Accumbens-Anterior Limb of Internal Capsule Deep Brain Stimulation for Treatment-Resistant Schizophrenia: An Open-label Pilot StudyPreprint

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Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI studyPreprint

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The relevance of reward pathways for schizophrenia

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Modulation of motivational salience processing during the early stages of psychosis

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Symptom dimensions are associated with reward processing in unmedicated persons at risk for psychosis

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Aberrant salience attribution and psychosis

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