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Cited by 116Schizophrenia research and treatmentAdvanced MRI Techniques and ApplicationsMental Health and Psychiatry

Cognitive impairment and in vivo metabolites in first-episode neuroleptic-naive and chronic medicated schizophrenic patients: a proton magnetic resonance spectroscopy study

Ohrmann, Patricia, Siegmund, Ansgar, Suslow, Thomas, Pedersen, Anya, Spitzberg, Katharina, Kersting, Anette, Rothermundt, Matthias, Arolt, Volker +2 more·2007·Journal of Psychiatric Research
DOI 10.1016/j.jpsychires.2006.07.002
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Abstract

Involvement of the prefrontal cortex in schizophrenia has been implicated by neuropsychological, as well as neuropathological and imaging studies. Reductions of N-acetylaspartate (NAA), an in vivo marker of neuronal integrity, have repeatedly been detected in the frontal lobes of patients with schizophrenia by proton magnetic resonance spectroscopy (1H-MRS). In chronic medicated patients, a positive correlation between NAA levels of the prefrontal cortex and cognitive functioning has been observed, but to date, there have been no studies in first-episode neuroleptic-naive patients. In this study, single-voxel 1H-MRS was used to investigate neuronal function of the dorsolateral prefrontal cortex in 15 first-episode and 20 chronic schizophrenic patients. Outcomes were compared to 20 age-matched healthy controls to assess the relationship between prefrontal metabolism and neuropsychological performance. Patients with chronic schizophrenia had significant reductions of NAA, glutamate/glutamine, and choline levels compared to first-episode patients and healthy controls. Furthermore, creatine and phosphocreatine were significantly reduced in both patient groups compared to healthy controls. In the neuropsychological tests, chronic schizophrenic patients performed significantly poorer in the Auditory Verbal Learning Task (AVLT) compared to first-episode patients. In both patient groups, NAA levels of the left frontal lobe significantly correlated with performances in verbal learning and memory. These results corroborate data from recent structural and spectroscopic imaging studies of the frontal lobes in schizophrenia, in which cortical gray matter reductions after onset of symptoms as well as reduced levels of NAA in chronic, but not in first-episode schizophrenic patients have been reported.

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  • Changes in the membrane metabolism in schizophrenia may also be implicated in the changed concentrations of glutamate in schizophrenia.

    “Changes in the membrane metabolism in schizophrenia may also be implicated in the changed concentrations of glutamate in schizophrenia.31”

    From Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies (2013) · cites this paper as [31]

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Authors
Ohrmann, P., Siegmund, A., Suslow, T., Pedersen, A., Spitzberg, K., Kersting, A., Rothermundt, M., Arolt, V., Heindel, W., & Pfleiderer, B.
Affiliations
University of Münster (DE)
Corresponding author
Ohrmann, Patricia
ORCID
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
2007-10
Volume
41
Issue
8
Pages
625-634
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/j.jpsychires.2006.07.002
OpenAlex
W2087779979
Cited by
116
References
89
Citations by year
2026: 1 · 2025: 6 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 8 · 2014: 7 · 2013: 9 · 2012: 11
FWCI
5.31
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
schizophrenia, first-episode schizophrenia, neuroleptic-naive patients, N-acetylaspartate, prefrontal cortex, dorsolateral prefrontal cortex, cognitive impairment, verbal learning and memory, glutamate/glutamine, choline, 1H NMR
MeSH terms
Adult, Aged, Aspartic Acid, Choline, Chronic Disease, Cognition Disorders, Creatine, Dominance, Cerebral, Energy Metabolism, Female, Frontal Lobe, Glutamine, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neurons, Magnetic Resonance Spectroscopy, Phosphocreatine, Psychiatric Status Rating Scales, Mental Recall, Reference Values, Schizophrenia, Antipsychotic Agents, Verbal Learning, Prefrontal Cortex, Glutamic Acid

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