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Cited by 116Eating Disorders and BehaviorsGenetic Associations and EpidemiologyChild Nutrition and Feeding Issues

A search for susceptibility loci for anorexia nervosa: methods and sample description

Kaye, Walter H, Lilenfeld, Lisa R, Berrettini, Wade H, Strober, Michael, Devlin, Bernie, Klump, Kelly L, Goldman, David, Bulik, Cynthia M +9 more·2000·Biological Psychiatry
DOI 10.1016/s0006-3223(99)00240-1
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Abstract

Background Eating disorders have not traditionally been viewed as heritable illnesses; however, recent family and twin studies lend credence to the potential role of genetic transmission. The Price Foundation funded an international, multisite study to identify genetic factors contributing to the pathogenesis of anorexia nervosa (AN) by recruiting affective relative pairs. This article is an overview of study methods and the clinical characteristics of the sample.Methods All probands met modified DSM-IV criteria for AN; all affected first, second, and third degree relatives met DSM-IV criteria for AN, bulimia nervosa (BN), or eating disorder not otherwise specified (NOS). Probands and affected relatives were assessed diagnostically with the Structured Interview for Anorexia and Bulimia. DNA was collected from probands, affected relatives and a subset of their biological parents.Results Assessments were obtained from 196 probands and 237 affected relatives, over 98% of whom are of Caucasian ancestry. Overall, there were 229 relative pairs who were informative for linkage analysis. Of the proband-relative pairs, 63% were AN-AN, 20% were AN-BN, and 16% were AN-NOS. For family-based association analyses, DNA has been collected from both biological parents of 159 eating-disordered subjects. Few significant differences in demographic characteristics were found between proband and relative groups.Conclusions The present study represents the first large-scale molecular genetic investigation of AN. Our successful recruitment of over 500 subjects, consisting of affected probands, affected relatives, and their biological parents, will provide the basis to investigate genetic transmission of eating disorders via a genome scan and assessment of candidate genes.

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  • Interviewers at each site completed a training program, and all eating disorder diagnoses were confirmed by the principal investigator at each site after reviewing the SIAB; the project coordinator of the data core independently reviewed every participant's SIAB interview to confirm diagnoses.

    “Briefly, interviewers at each site completed a training program and all eating disorder diagnoses were confirmed by the principal investigator at each site after reviewing the SIAB. Second, the project coordinator of the data core reviewed every participant’s SIAB interview independently to confirm diagnoses (Kaye et al., 2000).”

    From Factors associated with recovery from anorexia nervosa (2013) · cites this paper as Kaye et al., 2000

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Authors
Kaye, W. H., Lilenfeld, L. R., Berrettini, W. H., Strober, M., Devlin, B., Klump, K. L., Goldman, D., Bulik, C. M., Halmi, K. A., Fichter, M. M., Kaplan, A., Woodside, D. B., Treasure, J., Plotnicov, K. H., Pollice, C., Rao, R., & McConaha, C. W.
Affiliations
  • University of Pittsburgh (US)
  • Georgia State University (US)
  • University of Pennsylvania (US)
  • University of California, Los Angeles (US)
  • National Institutes of Health (US)
  • Virginia Commonwealth University (US)
  • Cornell University (US)
  • Bethlem Royal Hospital (GB)
Corresponding author
Kaye, Walter H
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2000-05
Volume
47
Issue
9
Pages
794-803
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(99)00240-1
OpenAlex
W2043655880
Cited by
116
References
82
Citations by year
2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 2
FWCI
11.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords
anorexia nervosa, genetic susceptibility, eating disorders, bulimia nervosa, family-based association, genetic linkage, genome scan, candidate genes, heritability, twin studies
MeSH terms
Adult, Anorexia Nervosa, Bulimia, Female, Genotype, Humans, Interview, Psychological, Male, Psychiatric Status Rating Scales, Quality Control, Self-Assessment, Genome, Human, Body Mass Index, Risk Assessment

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