Differential modulatory effects of norepinephrine on synaptically driven responses of layer V barrel field cortical neurons
Abstract
The effects of norepinephrine (NE) and the alpha-1 agonist phenylephrine (PE) on synaptically evoked responses of electrophysiologically identified pyramidal neurons in layer V of rat somatosensory cortex were studied in brain slices using intracellular recording techniques. When added to the bathing medium NE (10 microM) tended to increase the synaptic responsiveness of regular spiking neurons and decrease the responsiveness of intrinsic burst neurons. NE had mixed effects on layer V cells which were characterized as intermediate types between regular spiking and intrinsic burst neurons. PE exerted a similar spectrum of actions on layer V cortical neurons. For both adrenergic agents the greatest facilitating effect was observed on responses to low intensity synaptic stimulation. These results suggest that NE exerts different modulatory actions on different electrophysiologically-defined classes of layer V sensory cortical neurons.
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Effects of noradrenaline on individual pyramidal neurons are heterogeneous.
“However, similar to ACh, the effects of noradrenaline on individual pyramidal neurons are heterogeneous192,193.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [193]
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- Authors
- Waterhouse, B. D., Mouradian, R., Sessler, F. M., & Lin, R. C. S.
- Corresponding author
- Waterhouse, Barry D.
- ORCID
- Waterhouse, Barry D.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 868
- Issue
- 1
- Pages
- 39-47
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1983415281
- Cited by
- 45
- References
- 47
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 1 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 2 · 2013: 1 · 2012: 4
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01 NS 32461, R01NS032461)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- norepinephrine, phenylephrine, alpha-1 adrenergic agonists, somatosensory cortex, pyramidal neurons, regular-spiking neurons, adrenergic modulation, synaptic facilitation, barrel cortex
- MeSH terms
- Action Potentials, Animals, Cells, Cultured, Electrophysiology, Evoked Potentials, Male, Neurons, Norepinephrine, Phenylephrine, Receptors, Adrenergic, alpha, Somatosensory Cortex, Stimulation, Chemical, Sympathomimetics, Synapses, Rats, Long-Evans, Rats
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