Nitric oxide and S-nitrosothiols in human blood
Abstract
The hypothesis that endothelial-derived relaxing factor (EDRF) is nitric oxide has stimulated a wealth of research into the significance of this novel intriguing molecule. Given its short life, many storage forms of NO as well as targets have been postulated. Among these, a pool of derivatives of NO (S-nitrosothiols, RSNOs) covalently bound to SH groups of proteins and low molecular weight thiols (e.g., glutathione) have been identified in various biological systems. The importance of RSNOs results from the very similar biological actions exhibited by both NO and RSNOs in vivo as well as in vitro. In particular, it has been observed that in the bloodstream, these molecules are able to provoke vasodilatation with a consequent fall in blood pressure and an antithrombotic effect by inhibition of platelet aggregation. Many hypotheses have been postulated about the biochemical species and the mechanisms involved in these processes, but many aspects have not yet been clarified. In addition, some RSNOs have been recently proposed to be clinical parameters, whose levels may vary under some pathological conditions. The therapeutic utility of RSNOs as an alternative to classic NO donors has also been suggested.Here, we provide a critical analysis of the main reports about the biochemical, physiological, pathological and therapeutic properties of RSNOs in the cardiovascular system. Particular attention is addressed to conflicting results and to discrepancies in the methodologies and models utilized. The numerous unanswered questions concerning the role of RSNOs in the control of vascular tone are discussed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064 · see citing works
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · see citing works
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
Bredt, D. S., & Snyder, S. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.682 · Cited by 3,308 · see citing works
Nitric oxide synthases in mammals
Knowles, R. G., & Moncada, S. (1994) · Biochemical Journal · doi:10.1042/bj2980249 · Cited by 2,752 · see citing works
Biochemistry of nitric oxide and its redox-activated forms
Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744 · see citing works
Wink, D. A., & Mitchell, J. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00092-6 · Cited by 1,606 · see citing works
S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control
Jia, L., Bonaventura, C., Bonaventura, J., & Stamler, J. S. (1996) · Nature · doi:10.1038/380221a0 · Cited by 1,586 · see citing works
Nitric Oxide Synthases: Properties and Catalytic Mechanism
Griffith, O. W., & Stuehr, D. J. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003423 · Cited by 1,311 · see citing works
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7674 · Cited by 1,238 · see citing works
Myers, P. R., Minor, R. L., Guerra, R., Bates, J. N., & Harrison, D. G. (1990) · Nature · doi:10.1038/345161a0 · Cited by 973 · see citing works
Ignarro, L. J. (1989) · Circulation Research · doi:10.1161/01.res.65.1.1 · Cited by 964 · see citing works
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans
Liu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J., & Stamler, J. S. (2001) · Nature · doi:10.1038/35068596 · Cited by 913 · see citing works
Nitric Oxide: Pathophysiological Mechanisms
Gross, S. S., & Wolin, M. S. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003513 · Cited by 888 · see citing works
Methods in nitric oxide research
Feelisch, M., & Stamler, J. S. (1996) · Wiley-Blackwell eBooks · Cited by 819 · see citing works
Stuehr, D. J., Cho, H. J., Kwon, N. S., Weise, M. F., & Nathan, C. F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7773 · Cited by 816 · see citing works
Nitric oxide: mediator, murderer, and medicine
Änggård, E. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92405-8 · Cited by 814 · see citing works
Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn
Roberts, J. D., Fineman, J. R., Morin, F. C., Shaul, P. W., Rimar, S., Schreiber, M. D., Polin, R. A., Zwass, M. S., Zayek, M. M., Gross, I., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199702273360902 · Cited by 800 · see citing works
A scheme for the colorimetric determination of microgram amounts of thiols
Saville, B. (1958) · The Analyst · doi:10.1039/an9588300670 · Cited by 752 · see citing works
Methods in Nitric Oxide Research
Young, J. (1997) · Physiological Measurement · doi:10.1088/0967-3334/18/1/008 · Cited by 750 · see citing works
Simulation of the diffusion and reaction of endogenously produced nitric oxide.
Lancaster, J. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.17.8137 · Cited by 689 · see citing works
Gally, J. A., Montague, P. R., Reeke, G. N., & Edelman, G. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.9.3547 · Cited by 644 · see citing works
Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways.
Gaston, B. M., Reilly, J., Drazen, J. M., Fackler, J. C., Ramdev, P., Arnelle, D. R., Mullins, M. E., Sugarbaker, D. J., Chee, C., Singel, D. J., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.10957 · Cited by 620 · see citing works
Förstermann, U., Pollock, J. S., Schmidt, H. H. H. W., Heller, M., & Murad, F. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.5.1788 · Cited by 592 · see citing works
Redox state of glutathione in human plasma
Jones, D. P., Carlson, J. L., Mody, V. C., Cai, J., Lynn, M., & Sternberg, P. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00275-0 · Cited by 587 · see citing works
Export by red blood cells of nitric oxide bioactivity
Pawloski, J. R., Hess, D. T., & Stamler, J. S. (2001) · Nature · doi:10.1038/35054560 · Cited by 579 · see citing works
Production of Nitric Oxide by Mitochondria
Giulivi, C., Poderoso, J. J., & Boveris, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.11038 · Cited by 572 · see citing works
Nitric Oxide: A New Paradigm for Second Messengers
Kerwin, J. F., Lancaster, J. R., & Feldman, P. L. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00022a001 · Cited by 567 · see citing works
Reactions between nitric oxide and haemoglobin under physiological conditions
Gow, A. J., & Stamler, J. S. (1998) · Nature · doi:10.1038/34402 · Cited by 562 · see citing works
Identification of the enzymatic mechanism of nitroglycerin bioactivation
Chen, Z., Zhang, J., & Stamler, J. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122225199 · Cited by 541 · see citing works
Nitric Oxide Reversibly Inhibits Seven Members of the Caspase Family via S-Nitrosylation
Li, J., Billiar, T. R., Talanian, R. V., & Kim, Y. M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7672 · Cited by 529 · see citing works
Nitric Oxide Donors and Cardiovascular Agents Modulating the Bioactivity of Nitric Oxide
Ignarro, L. J., Claudio Napoli, A., & Loscalzo, J. (2002) · Circulation Research · doi:10.1161/hh0102.102330 · Cited by 489 · see citing works
Nitric oxide in the human respiratory cycle
McMahon, T., Moon, R. E., Luschinger, B. P., Carraway, M. S., Stone, A. E., Stolp, B. W., Gow, A. J., Pawloski, J. R., Watke, P., Singel, D. J., et al. (2002) · Nature Medicine · doi:10.1038/nm718 · Cited by 462 · see citing works
Gladwin, M. T., Shelhamer, J. H., Schechter, A. N., Pease-Fye, M. E., Waclawiw, M. A., Panza, J. A., Ognibene, F. P., & Cannon, R. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11482 · Cited by 441 · see citing works
Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin
Doherty, D. H., Doyle, M. P., Curry, S. R., Vali, R. J., Fattor, T., Olson, J. S., & Lemon, D. D. (1998) · Nature Biotechnology · doi:10.1038/nbt0798-672 · Cited by 428 · see citing works
The oxyhemoglobin reaction of nitric oxide
Gow, A. J., Luchsinger, B. P., Pawloski, J. R., Singel, D. J., & Stamler, J. S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9027 · Cited by 414 · see citing works
The Biochemistry and Physiology of S-Nitrosothiols
Hogg, N. (2002) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.42.092501.104328 · Cited by 412 · see citing works
Feelisch, M., Rassaf, T., Mnaimneh, S., Singh, N., Bryan, N. S., Jourd'Heuil, D., & Kelm, M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0363com · Cited by 401 · see citing works
S-Nitrosothiols signal the ventilatory response to hypoxia
Lipton, A. S., Johnson, M. A., Macdonald, T. L., Lieberman, M. W., Gozal, D., & Gaston, B. M. (2001) · Nature · doi:10.1038/35093117 · Cited by 321 · see citing works
Clancy, R. M., Levartovsky, D., Leszczynska-Piziak, J., Yegudin, J., & Abramson, S. B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.3680 · Cited by 308 · see citing works
The nitrovasodilators. New ideas about old drugs.
Harrison, D. G., & Bates, J. N. (1993) · Circulation · doi:10.1161/01.cir.87.5.1461 · Cited by 307 · see citing works
Butler, A. R., Flitney, F. W., & Williams, D. L. H. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)88968-3 · Cited by 302 · see citing works
Cannon, R. O., Schechter, A. N., Panza, J. A., Ognibene, F. P., Pease-Fye, M. E., Waclawiw, M. A., Shelhamer, J. H., & Gladwin, M. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200112761 · Cited by 298 · see citing works
Khatsenko, O. G., Gross, S. S., Rifkind, A. B., & Vane, J. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11147 · Cited by 291 · see citing works
Cannon, R. O., Schechter, A. N., Panza, J. A., Ognibene, F. P., Pease‐Fye, M. E., Waclawiw, M. A., Shelhamer, J. H., & Gladwin, M. T. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12761 · Cited by 289 · see citing works
Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms
Wink, D. A., Hanbauer, I., Grisham, M. B., Laval, F., Nims, R. W., Laval, J., Cook, J. C., Pacelli, R., Liebmann, J., Krishna, M. C., et al. (1996) · Current topics in cellular regulation · doi:10.1016/s0070-2137(96)80006-9 · Cited by 288 · see citing works
Gladwin, M. T., Ognibene, F. P., Pannell, L. K., Nichols, J. S., Pease‐Fye, M. E., Shelhamer, J. H., & Schechter, A. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.180155397 · Cited by 274 · see citing works
Biological chemistry and clinical potential of S-nitrosothiols
Hogg, N. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00248-3 · Cited by 272 · see citing works
Biological activity of S-nitrosothiols: the role of nitric oxide.
Mathews, W. R., & Kerr, S. W. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39447-4 · Cited by 252 · see citing works
Organic nitrate esters: clinical use and mechanisms of actions.
Ahlner, J., Andersson, R., Torfgård, K., & Axelsson, K. L. (1991) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06667-0 · Cited by 243 · see citing works
Marks, D. S., Vita, J. A., Folts, J. D., Keaney, J. F., Welch, G. N., & Loscalzo, J. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118328 · Cited by 230 · see citing works
Evidence for in vivo transport of bioactive nitric oxide in human plasma
Rassaf, T., Preik, M., Kleinbongard, P., Lauer, T., Heiß, C., Strauer, B. E., Feelisch, M., & Kelm, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14995 · Cited by 224 · see citing works
Joshi, M. S., Ferguson, T. B., Han, T. H., Hyduke, D. R., Liao, J. C., Rassaf, T., Bryan, N., Feelisch, M., & Lancaster, J. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152149699 · Cited by 216 · see citing works
Progress in the Development of Selective Nitric Oxide Synthase (NOS) Inhibitors
Saleron, L., Sorrenti, V., Giacomo, C. D., Romeo, G., & SIRACUSA, M. A. (2002) · Current Pharmaceutical Design · doi:10.2174/1381612023396375 · Cited by 214 · see citing works
S-Nitrosothiols: a class of nitric oxide-donor drugs
Al‐Sa'doni, H. H., & Ferro, A. (2000) · Clinical Science · doi:10.1042/cs0980507 · Cited by 204 · see citing works
Immunocytochemical Evidence for a Mitochondrially Located Nitric Oxide Synthase in Brain and Liver
Bates, T. E., Loesch, A., Burnstock, G., & Clark, J. B. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2213 · Cited by 204 · see citing works
Inhibition of platelet activity by S-nitrosoglutathione during coronary angioplasty
Ej, L., Brown, A. S., Belder, A. D., Smith, R. E. A., Martin, J., Wainwright, R. J., Thomas, M. R., Radomski, M. W., & Moncada, S. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90287-9 · Cited by 202 · see citing works
Nitrosothiol Formation Catalyzed by Ceruloplasmin
Inoue, K., Akaike, T., Miyamoto, Y., Okamoto, T., Sawa, T., Otagiri, M., Suzuki, S., Yoshimura, T., & Maeda, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.27069 · Cited by 200 · see citing works
A chemiluminescense-based assay for S-nitrosoalbumin and other plasma S-nitrosothiols
Marley, R., Feelisch, M., Holt, S. G., & Moore, K. P. (2000) · Free Radical Research · doi:10.1080/10715760000300011 · Cited by 185 · see citing works
Evidence for in vivo transport of bioactive nitric oxide in human plasma
Rassaf, T., Preik, M., Kleinbongard, P., Lauer, T., Heiß, C., Strauer, B. E., Feelisch, M., & Kelm, M. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214995 · Cited by 183 · see citing works
Direct and indirect effects of nitric oxide in chemical reactions relevant to biology
Wink, D. A., Grisham, M. B., Mitchell, J. B., & Ford, P. C. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68006-9 · Cited by 182 · see citing works
Rassaf, T., Kleinbongard, P., Preik, M., Dejam, A., Gharini, P., Lauer, T., Erckenbrecht, J., Duschin, A., Schulz, R., Heusch, G., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000035038.41739.cb · Cited by 178 · see citing works
Kluge, I., Gutteck‐Amsler, U., Zollinger, M., & Kim, Q. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062599.x · Cited by 174 · see citing works
Gladwin, M. T., Wang, X., Reiter, C. D., Yang, B. K., Vivas, E. X., Bonaventura, C., & Schechter, A. N. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203236200 · Cited by 160 · see citing works
Dynamic state of S-nitrosothiols in human plasma and whole blood
Jourd’heuil, D., Hallén, K., Feelisch, M., & Grisham, M. B. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00257-9 · Cited by 156 · see citing works
NO-aspirins: a class of new anti-inflammatory and antithrombotic agents
Soldato, P. D., Sorrentino, R., & Pinto, A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01353-x · Cited by 148 · see citing works
Mechanism of S-Nitrosothiol Formation and Degradation Mediated by Copper Ions
Stubauer, G., Giuffrè, A., & Sarti, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28128 · Cited by 147 · see citing works
Biochemical Characterization of HumanS-Nitrosohemoglobin
Patel, R. P., Hogg, N., Spencer, N. Y., Kalyanaraman, B., Matalon, S., & Darley-Usmar, V. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.22.15487 · Cited by 133 · see citing works
Liu, Z., Rudd, M. A., Freedman, J. E., & Loscalzo, J. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37255-6 · Cited by 131 · see citing works
Biotransformation of organic nitrates and vascular smooth muscle cell function
Bennett, B. M., McDonald, B. J., Nigam, R., & Simon, W. C. (1994) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(94)90319-0 · Cited by 130 · see citing works
Development of Chemiluminescence-Based Methods for Specific Quantitation of Nitrosylated Thiols
Samouilov, A., & Zweier, J. L. (1998) · Analytical Biochemistry · doi:10.1006/abio.1998.2609 · Cited by 127 · see citing works
Reductive Assays forS-Nitrosothiols: Implications for Measurements in Biological Systems
Fang, K., Ragsdale, N. V., Carey, R. M., Macdonald, T. L., & Gaston, B. M. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9688 · Cited by 127 · see citing works
Biochemical Characterization ofS-Nitrosohemoglobin
Wolzt, M., MacAllister, R. J., Davis, D., Feelisch, M., Moncada, S., Vallance, P. J., & Hobbs, A. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.28983 · Cited by 120 · see citing works
Elevated Levels of <i>S</i> -Nitrosoalbumin in Preeclampsia Plasma
Tyurin, V. A., Liu, S.-X., Tyurina, Y. Y., Sussman, N. B., Hubel, C. A., Roberts, J. M., Taylor, R. N., & Kagan, V. E. (2001) · Circulation Research · doi:10.1161/hh1101.092179 · Cited by 120 · see citing works
[38] Stopped-flow, rapid mixing measurements of ligand binding to hemoglobin and red cells
Olson, J. S. (1981) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(81)76148-2 · Cited by 117 · see citing works
Burgaud, J., Ongini, E., & Soldato, P. D. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04080.x · Cited by 109 · see citing works
Cell-Free and Erythrocytic S -Nitrosohemoglobin Inhibits Human Platelet Aggregation
Pawloski, J. R., Swaminathan, R. V., & Stamler, J. S. (1998) · Circulation · doi:10.1161/01.cir.97.3.263 · Cited by 105 · see citing works
Formation of nanomolar concentrations of S-nitroso-albumin in human plasma by nitric oxide
Marley, R., Patel, R. P., Orie, N. N., CEASER, E. K., Darley-Usmar, V. M., & Moore, K. P. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00627-x · Cited by 104 · see citing works
The kinetics of S-transnitrosation, a reversible second-order reaction
Hogg, N. (1999) · Analytical Biochemistry · doi:10.1006/abio.1999.4199 · Cited by 101 · see citing works
Hallström, S., Gasser, H., Neumayer, C., Fügl, A., Nanobashvili, J., Jakubowski, A., Huk, I., Schlag, G., & Maliñski, T. (2002) · Circulation · doi:10.1161/01.cir.0000018745.11739.9b · Cited by 93 · see citing works
S-NO-actin: S-nitrosylation kinetics and the effect on isolated vascular smooth muscle
Dalle‐Donne, I., Milzani, A., Giustarini, D., Simplicio, P. D., Colombo, R., & Rossi, R. (2000) · Journal of Muscle Research and Cell Motility · doi:10.1023/a:1005671319604 · Cited by 91 · see citing works
Self-citationS-Nitrosothiols and role of metal ions in decomposition to nitric oxide
Williams, D. L. H. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68032-x · Cited by 88 · see citing works
Inhibition of nitric oxide synthase — potential for a novel class of therapeutic agent?
Ogden, J. E., & Moore, P. K. (1995) · Trends in biotechnology · doi:10.1016/s0167-7799(00)88908-8 · Cited by 87 · see citing works
Feelisch, M. (1993) · European Heart Journal · doi:10.1093/eurheartj/14.suppl.1 · Cited by 86 · see citing works
Albumin Is an Important Vascular Tonus Regulator as a Reservoir of Nitric Oxide
Minamiyama, Y., Takemura, S., & Inoue, M. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1138 · Cited by 84 · see citing works
Haemoglobin: NO transporter, NO inactivator or NOne of the above?
Hobbs, A. J., Gladwin, M. T., Patel, R. P., Williams, D. L. H., & Butler, A. R. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02067-9 · Cited by 84 · see citing works
S-Nitrosothiol Formation in Blood of Lipopolysaccharide-Treated Rats
Jourd’heuil, D., Gray, L. T., & Grisham, M. B. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2892 · Cited by 83 · see citing works
Different Metabolizing Ability of Thiol Reactants in Human and Rat Blood
Rossi, R., Milzani, A., Dalle‐Donne, I., Giannerini, F., Giustarini, D., Lusini, L., Colombo, R., & Simplicio, P. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005156200 · Cited by 81 · see citing works
Self-citationl -Arginine and S -Nitrosoglutathione Reduce Embolization in Humans
Káposzta, Z., Baskerville, P., Madge, D. J., Fraser, S. C. A., Martin, J. F., & Markus, H. S. (2001) · Circulation · doi:10.1161/01.cir.103.19.2371 · Cited by 80 · see citing works
Hughes, M., & Cammack, R. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)01092-7 · Cited by 78 · see citing works
Modification of creatine kinase by S-nitrosothiols: S-nitrosation vs. S-thiolation
Konorev, E. A., Kalyanaraman, B., & Hogg, N. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00281-1 · Cited by 74 · see citing works
Inhibition of Clotting Factor XIII Activity by Nitric Oxide
Catani, M. V., Bernassola, F., Rossi, A., & Melino, G. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9130 · Cited by 73 · see citing works
Increased formation of S-nitrothiols and nitrotyrosine in cirrhotic rats during endotoxemia
Ottesen, L. H., Harry, D. S., Frost, M., Davies, S. E., Khan, K., Halliwell, B. B., & Moore, K. P. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00647-5 · Cited by 72 · see citing works
S-Nitrosothiols: a class of nitric oxide-donor drugs
Al‐Sa'doni, H. H., & Ferro, A. (2000) · Clinical Science · doi:10.1042/cs19990267 · Cited by 72 · see citing works
A discussion of mechanisms of NO genotoxicty: Implication of inhibition of DNA repair proteins
Laval, F., Wink, D. A., & Laval, J. (1997) · Springer eBooks · doi:10.1007/3-540-61992-5_8 · Cited by 63 · see citing works
Nitrosothiol Quantification in Human Plasma
Goldman, R. K., Vlessis, A. A., & Trunkey, D. D. (1998) · Analytical Biochemistry · doi:10.1006/abio.1998.2651 · Cited by 61 · see citing works
Rossi, R., Lusini, L., Giannerini, F., Giustarini, D., Lungarella, G., & Simplicio, P. D. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2424 · Cited by 61 · see citing works
Self-citationRossi, R., Barra, D., Bellelli, A., Boumis, G., Canofeni, S., Simplicio, P. D., Lusini, L., Pascarella, S., & Amiconi, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.19198 · Cited by 59 · see citing works
Self-citationSingh, R. J., Hogg, N., Neese, F., Joseph, J., & Kalyanaraman, B. (1995) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1995.tb08616.x · Cited by 55 · see citing works
Zhang, Y., & Hogg, N. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00829-8 · Cited by 53 · see citing works
Effect of Thiol Status on Nitric Oxide Metabolism in the Circulation
Minamiyama, Y., Takemura, S., & Inoue, M. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.9956 · Cited by 49 · see citing works
Measurement of S-nitrosoalbumin by gas chromatography–mass spectrometry
Tsikas, D., Sandmann, J., & Frölich, J. C. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00121-6 · Cited by 48 · see citing works
Physiological Levels of S -Nitrosothiols in Human Plasma
Rossi, R., Giustarini, D., Milzani, A., Colombo, R., Dalle‐Donne, I., & Simplicio, P. D. (2001) · Circulation Research · doi:10.1161/res.89.12.e47 · Cited by 48 · see citing works
Self-citationSalas, E., Langford, E. J., Marrinan, M. T., Martin, J. F., Moncada, S., & de Belder, A. (1998) · Heart · doi:10.1136/hrt.80.2.146 · Cited by 47 · see citing works
Inhaled NO impacts vascular but not extravascular compartments in postischemic peripheral organs
Kubes, P., Payne, D., Grisham, M. B., Jourd’heuil, D., & Fox‐Robichaud, A. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h676 · Cited by 47 · see citing works
Chloride Bound to Oxidized Cytochrome c Oxidase Controls the Reaction with Nitric Oxide
Giuffrè, A., Stubauer, G., Brunori, M., Sarti, P., Torres, J., & Wilson, M. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32475 · Cited by 46 · see citing works
Nitric Oxide Inhibits the HIV-1 Reverse Transcriptase Activity
Persichini, T., Colasanti, M., Fraziano, M., Colizzi, V., Medana, C., Polticelli, F., Venturini, G., & Ascenzi, P. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0581 · Cited by 41 · see citing works
Deem, S. A., Kim, J.-U., Manjula, B. N., Acharya, A. S., Kerr, M. E., Patel, R. P., Gladwin, M. T., & Swenson, E. R. (2002) · Circulation Research · doi:10.1161/01.res.0000036268.47509.02 · Cited by 38 · see citing works
Warnholtz, A., Tsilimingas, N., Wendt, M., & Münzel, T. F. (2002) · Heart Failure Reviews · doi:10.1023/a:1020710417337 · Cited by 37 · see citing works
Alpert, C. S., Ramdev, N., George, D., & Loscalzo, J. (1997) · Analytical Biochemistry · doi:10.1006/abio.1996.9947 · Cited by 37 · see citing works
Akhter, S., Vignini, A., Wen, Z., English, A., Wang, P. G., & Mutus, B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142136499 · Cited by 37 · see citing works
Is ceruloplasmin an important catalyst for S-nitrosothiol generation in hypercholesterolemia?
Moriel, P., Pereira, I. R. O., Bertolami, M. C., & Abdalla, D. S. P. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00467-6 · Cited by 37 · see citing works
Tsikas, D., Denker, K., & Frölich, J. C. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)00634-3 · Cited by 36 · see citing works
Nitrosating Agents: Is Peroxynitrite a Likely Candidate?
Williams, D. L. H. (1997) · Nitric Oxide · doi:10.1006/niox.1997.0159 · Cited by 34 · see citing works
Tullett, J. M., Rees, D. D., Shuker, D. E. G., & Gescher, A. J. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00750-x · Cited by 28 · see citing works
Hoque, A., Bates, J. N., & Lewis, S. J. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00686-x · Cited by 24 · see citing works
[30] Quantitation of S-nitrosothiols in cells and biological fluids
Tyurin, V. A., Tyurina, Y. Y., Liu, S., Bayır, H., Hubel, C. A., & Kagan, V. E. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)52032-2 · Cited by 22 · see citing works
Hemodynamic effects of S-nitrosocysteine, an intravenous regional vasodilator
Stuesse, D. C., Giraud, G. D., Vlessis, A. A., Starr, A., & Trunkey, D. D. (2001) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1067/mtc.2001.115699 · Cited by 11 · see citing works
Rossi, R. et al. Physiological levels of S-nitrosothiols in human plasma. Circ. Res. 89, E47-E47
Rossi, R., Giustarini, D., Milzani, A., Colombo, R., Dalle‐Donne, I., & Simplicio, P. D. (2002) · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
2 of the 120 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Tsikas, D. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.07.054 · Cited by 897 · see citing works
Dalle‐Donne, I., Scaloni, A., Giustarini, D., Cavarra, E., Tell, G., Lungarella, G., Colombo, R., Rossi, R., & Milzani, A. (2004) · Mass Spectrometry Reviews · doi:10.1002/mas.20006 · Cited by 448 · see citing works
Self-citationOxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers
Giustarini, D., Dalle‐Donne, I., Tsikas, D., & Rossi, R. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408360903142326 · Cited by 443 · see citing works
Self-citationGiustarini, D., Rossi, R., Milzani, A., & Dalle‐Donne, I. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)00823-3 · Cited by 381 · see citing works
Self-citationMolecular Mechanisms and Potential Clinical Significance of S -Glutathionylation
Dalle‐Donne, I., Milzani, A., Gagliano, N., Colombo, R., Giustarini, D., & Rossi, R. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1716 · Cited by 296 · see citing works
Self-citationNanotechnology for angiogenesis: opportunities and challenges
Kargozar, S., Baino, F., Hamzehlou, S., Hamblin, M. R., & Mozafari, M. (2020) · Chemical Society Reviews · doi:10.1039/c8cs01021h · Cited by 270 · see citing works
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Vascular nitric oxide: formation and function
Loscalzo, J., & Jin (2010) · Journal of Blood Medicine · doi:10.2147/jbm.s7000 · Cited by 228 · see citing works
Nitric Oxide Donors for Cardiovascular Implant Applications
Naghavi, N., de Mel, A., Alavijeh, O. S., Cousins, B. G., & Seifalian, A. M. (2013) · Small · doi:10.1002/smll.201200458 · Cited by 188 · see citing works
The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy
Barnett, S. D., & Buxton, I. L. O. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1304353 · Cited by 174 · see citing works
Mechanisms of Reductive Nitrosylation in Iron and Copper Models Relevant to Biological Systems
Ford, P. C., Fernandez, B. O., & Lim, M. D. (2005) · Chemical Reviews · doi:10.1021/cr0307289 · Cited by 168 · see citing works
An improved HPLC measurement for GSH and GSSG in human blood
Giustarini, D., Dalle‐Donne, I., Colombo, R., Milzani, A., & Rossi, R. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.08.013 · Cited by 158 · see citing works
Self-citationAhmed, R., Augustine, R., Chaudhry, M., Akhtar, U. A., Zahid, A. A., Tariq, M., Falahati, M., Ahmad, I., & Hasan, A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112707 · Cited by 147 · see citing works
Endogenous Mechanisms of Inhibition of Platelet Function
Jin, R. C., Voetsch, B., & Loscalzo, J. (2005) · Microcirculation · doi:10.1080/10739680590925493 · Cited by 141 · see citing works
Neufeld, M. J., Harding, J. L., & Reynolds, M. M. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b08773 · Cited by 116 · see citing works
The quest for blood-compatible materials: Recent advances and future technologies
Hedayati, M., Neufeld, M. J., Reynolds, M. M., & Kipper, M. J. (2019) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2019.06.002 · Cited by 105 · see citing works
Nitric oxide-enhancing or -releasing agents as antithrombotic drugs
Gresele, P., Momi, S., & Guglielmini, G. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.05.030 · Cited by 93 · see citing works
Jin, G., Gao, Z., Liu, Y., Zhao, J., Ou, H., Xu, F., & Ding, D. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001550 · Cited by 92 · see citing works
Zahid, A. A., Ahmed, R., Rehman, S. R. U., Augustine, R., Tariq, M., & Hasan, A. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.06.136 · Cited by 90 · see citing works
Tang, C., & Grimm, E. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310821200 · Cited by 90 · see citing works
B-type natriuretic peptide at early reperfusion limits infarct size in the rat isolated heart
Burley, D. S., & Baxter, G. F. (2007) · Basic Research in Cardiology · doi:10.1007/s00395-007-0672-1 · Cited by 86 · see citing works
Nitric oxide based strategies for applications of biomedical devices
Yang, Y., Qi, P., Yang, Z., & Huang, N. (2015) · Biosurface and Biotribology · doi:10.1016/j.bsbt.2015.08.003 · Cited by 85 · see citing works
McCarthy, C. W., Guillory, R. J., Goldman, J., & Frost, M. C. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b00145 · Cited by 83 · see citing works
Hwang, S., & Meyerhoff, M. E. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.02.004 · Cited by 82 · see citing works
de Souza, G. F. P., Yokoyama-Yasunaka, J. K. U., Seabra, A. B., Miguel, D. C., de Oliveira, M. G., & Uliana, S. R. B. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.01.011 · Cited by 80 · see citing works
Measurement of Nitric Oxide Levels in the Red Cell
Wang, X., Bryan, N. S., MacArthur, P. H., Rodriguez, J., Gladwin, M. T., & Feelisch, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603953200 · Cited by 79 · see citing works
Fast Reductive Ligation of S‐Nitrosothiols
Wang, H., & Xian, M. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200801654 · Cited by 80 · see citing works
Detection of Human Red Blood Cell-bound Nitric Oxide
Rogers, S. C., Khalatbari, A., Gapper, P. W., Frenneaux, M. P., & James, P. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501179200 · Cited by 77 · see citing works
Neufeld, M. J., Lutzke, A., Tapia, J. B., & Reynolds, M. M. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b14937 · Cited by 73 · see citing works
Harding, J. L., Metz, J. M., & Reynolds, M. M. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201402529 · Cited by 67 · see citing works
Wu, Y., & Meyerhoff, M. E. (2008) · Talanta · doi:10.1016/j.talanta.2007.06.022 · Cited by 65 · see citing works
Nitric oxide and blood: a review
Wallis, J. P. (2005) · Transfusion Medicine · doi:10.1111/j.1365-3148.2005.00542.x · Cited by 67 · see citing works
Hwang, S., Cha, W., & Meyerhoff, M. E. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200503588 · Cited by 60 · see citing works
Melvin, A. C., Jones, W. M., Lutzke, A., Allison, C. L., & Reynolds, M. M. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.08.002 · Cited by 57 · see citing works
Exploiting synergistic effect of CO/NO gases for soft tissue transplantation using a hydrogel patch
Tang, X., Ren, J., Wei, X., Wang, T., Li, H., Sun, Y., Liu, Y., Chi, M., Zhu, S., Lu, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37959-y · Cited by 54 · see citing works
Transnitrosation of Nitrosothiols: Characterization of an Elusive Intermediate
Perissinotti, L. L., Turjanski, A. G., Estrin, D. A., & Doctorovich, F. A. (2004) · Journal of the American Chemical Society · doi:10.1021/ja044056v · Cited by 54 · see citing works
Neufeld, M. J., Lutzke, A., Jones, W. M., & Reynolds, M. M. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b11846 · Cited by 52 · see citing works
de Souza, G. F. P., Denadai, J. P., Picheth, G. F., & de Oliveira, M. G. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.01.002 · Cited by 52 · see citing works
Seabra, A. B., da Silva, R., & de Oliveira, M. G. (2005) · Biomacromolecules · doi:10.1021/bm050216z · Cited by 51 · see citing works
Wang, Y., Chen, S., Pan, Y., Gao, J., Tang, D., Kong, D., & Wang, S. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb02080h · Cited by 50 · see citing works
Cha, W., & Meyerhoff, M. E. (2006) · Langmuir · doi:10.1021/la0612116 · Cited by 50 · see citing works
Seabra, A. B., de Souza, G. F. P., da Rocha, L. L., Eberlin, M. N., & de Oliveira, M. G. (2004) · Nitric Oxide · doi:10.1016/j.niox.2004.09.005 · Cited by 47 · see citing works
Harding, J. L., & Reynolds, M. M. (2014) · J. Mater. Chem. B · doi:10.1039/c3tb21458c · Cited by 43 · see citing works
Dou, J., Wang, Y., Jin, X., Li, P., Wang, L., Yuan, J., & Shen, J. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110246 · Cited by 41 · see citing works
Zhang, S., Çelebi‐Ölçüm, N., Melzer, M. M., Houk, K. N., & Warren, T. H. (2013) · Journal of the American Chemical Society · doi:10.1021/ja406476y · Cited by 40 · see citing works
Oliveira, C. P. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i12.1905 · Cited by 39 · see citing works
de Oliveira, C. P. M. S., de Lima, V. M. R., Simplicio, F. I., Soriano, F. G., de Mello, E. S., de Souza, H. P., Alves, V. A. F., Laurindo, F. R. M., Carrilho, F. J., & de Oliveira, M. G. (2008) · Journal of the American College of Nutrition · doi:10.1080/07315724.2008.10719703 · Cited by 38 · see citing works
Massy, Z. A., Fumeron, C., Borderie, D., Tuppin, P., Nguyen‐Khoa, T., Benoit, M., Jacquot, C., Buisson, C., Drüeke, T. B., Ekindjian, O. G., et al. (2004) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000106716.22153.bb · Cited by 38 · see citing works
Ye, Y., Wang, H., Xu, L., Liu, W., Liu, B., Tashiro, S., Onodera, S., & Ikejima, T. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.53 · Cited by 37 · see citing works
Conversion of nitrite to nitric oxide at zinc via S-nitrosothiols
Cardenas, A. J. P., Abelman, R. A., & Warren, T. H. (2013) · Chemical Communications · doi:10.1039/c3cc46102e · Cited by 36 · see citing works
Puiu, S. C., Zhou, Z., White, C. C., Neubauer, L. J., Zhang, Z., Lange, L. E., Mansfield, J. A., Meyerhoff, M. E., & Reynolds, M. M. (2009) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31391 · Cited by 35 · see citing works
S-nitrosation of cysteine as evidenced by IRMPD spectroscopy
Lanucara, F., Chiavarino, B., Crestoni, M. E., Scuderi, D., Sinha, R. K., Maı̂tre, P., & Fornarini, S. (2012) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2012.07.003 · Cited by 36 · see citing works
A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: Sustained vascular response
Nacharaju, P., Tuckman-Vernon, C., Maier, K. E., Chouake, J. S., Friedman, A., Cabrales, P., & Friedman, J. M. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.06.003 · Cited by 34 · see citing works
Gao, J., Jiang, L., Liang, Q., Shi, J., Hou, D., Tang, D., Chen, S., Kong, D., & Wang, S. (2018) · Regenerative Biomaterials · doi:10.1093/rb/rby003 · Cited by 33 · see citing works
Effect of albumin on the transformation of dinitrosyl iron complexes with thiourea ligands
Pokidova, O. V., Luzhkov, V. B., Emel’yanova, N. S., Krapivin, V. B., Kotelnikov, A. I., Санина, Н. А., & Aldoshin, S. M. (2020) · Dalton Transactions · doi:10.1039/d0dt02452j · Cited by 32 · see citing works
Vibrational Signatures of S -Nitrosoglutathione as Gaseous, Protonated Species
Gregori, B., Guidoni, L., Chiavarino, B., Scuderi, D., Nicol, É., Frison, G., Fornarini, S., & Crestoni, M. E. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp5072742 · Cited by 31 · see citing works
Carneiro, M. F. H., Machado, A. R. T., Antunes, L. M. G., Souza, T. E., de Freitas, V. A. A., Oliveira, L. C. A., Rodrigues, J. L., Pereira, M. C., & Barbosa, F. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01799-z · Cited by 30 · see citing works
A Copper(II) Thiolate from Reductive Cleavage of an S-Nitrosothiol
Melzer, M. M., Mossin, S., Cardenas, A. J. P., Williams, K., Zhang, S., Meyer, K., & Warren, T. H. (2012) · Inorganic Chemistry · doi:10.1021/ic301356h · Cited by 30 · see citing works
Liu, K., & Meyerhoff, M. E. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm32726k · Cited by 30 · see citing works
Measurement of physiological S-nitrosothiols: a problem child and a challenge
Tsikas, D. (2003) · Nitric Oxide · doi:10.1016/s1089-8603(03)00044-2 · Cited by 30 · see citing works
Amperometric S-nitrosothiol sensor with enhanced sensitivity based on organoselenium catalysts
Cha, W., Anderson, M. R., Zhang, F., & Meyerhoff, M. E. (2008) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2008.12.022 · Cited by 29 · see citing works
The reactivity of human serum albumin toward trans‐4‐hydroxy‐2‐nonenal
Liu, Q., Simpson, D. C., & Gronert, S. (2012) · Journal of Mass Spectrometry · doi:10.1002/jms.2037 · Cited by 28 · see citing works
Reversible RS–NO bond cleavage and formation at copper(i) thiolates
Melzer, M. M., Li, E., & Warren, T. H. (2009) · Chemical Communications · doi:10.1039/b911643e · Cited by 28 · see citing works
Li, X., Shen, F., Wang, K., Lin, S., Zhou, L., Chen, S., Wang, J., & Huang, N. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01976b · Cited by 27 · see citing works
Chen, S., An, J., Weng, L., Li, Y., Han, X., Wang, Y., Ding, D., Kong, D., & Wang, S. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.09.040 · Cited by 27 · see citing works
Annich, G. M., Zaulan, O., Neufeld, M. J., WAGNER, D. S., & Reynolds, M. M. (2017) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-017-0229-0 · Cited by 26 · see citing works
Choi, M. S. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.179 · Cited by 26 · see citing works
de Oliveira, C. P. M. S., Stefano, J. T., de Lima, V. M. R., de Sá, S. V., Simplicio, F. I., de Mello, E. S., Corrêa‐Giannella, M. L., Alves, V. A. F., Laurindo, F. R. M., de Oliveira, M. G., et al. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.05.017 · Cited by 26 · see citing works
Routes for Formation of S-Nitrosothiols in Blood
Nagababu, E., & Rifkind, J. M. (2011) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-011-9321-2 · Cited by 25 · see citing works
Roles and current applications of S-nitrosoglutathione in anti-infective biomaterials
Hu, Q., Ye, Z., Pi, L., & Ao, J. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100419 · Cited by 25 · see citing works
Darder, M., Karan, A., del Real, G., & DeCoster, M. (2020) · Materials Science and Engineering C: Materials for Biological Applications · doi:10.1016/j.msec.2019.110369 · Cited by 20 · see citing works
Visible Photolysis and Amperometric Detection of S-Nitrosothiols
Riccio, D. A., Nutz, S. T., & Schoenfisch, M. H. (2011) · Analytical Chemistry · doi:10.1021/ac2031805 · Cited by 24 · see citing works
Hunter, R. A., & Schoenfisch, M. H. (2015) · Analytical Chemistry · doi:10.1021/ac503220z · Cited by 23 · see citing works
S‐nitrosothiols as selective antithrombotic agents – possible mechanisms
Gordge, M. P., & Xiao, F. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00670.x · Cited by 22 · see citing works
Determinants of basal nitric oxide concentration in the renal medullary microcirculation
Zhang, W., Pibulsonggram, T., & Edwards, A. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00125.2004 · Cited by 21 · see citing works
In Situ Generated Medical Devices
Cohn, D., Sloutski, A., Elyashiv, A., Varma, V. B., & Ramanujan, R. V. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801066 · Cited by 20 · see citing works
Shalansky, S. J., Vu, T., Pate, G. E., Levin, A., Humphries, K. H., & Webb, J. G. (2005) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.2005.25.8.1095 · Cited by 21 · see citing works
Metabolism of oxidants by blood from different mouse strains
Giustarini, D., Dalle‐Donne, I., Cavarra, E., Fineschi, S., Lungarella, G., Milzani, A., & Rossi, R. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.03.015 · Cited by 20 · see citing works
Self-citationEffect of pH and Metal Ions on the Decomposition Rate of S-nitrosocysteine
Gu, J. J., & Lewis, R. S. (2007) · Annals of Biomedical Engineering · doi:10.1007/s10439-007-9327-5 · Cited by 20 · see citing works
Karmakar, S., Patra, S., Halder, R., Karmakar, S., & Majumdar, A. (2024) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.4c03555 · Cited by 20 · see citing works
Self-activated antibacterial MOF-based coating on medically relevant polypropylene
Skvortsova, A., Kocianova, A., Guselnikova, O., Elashnikov, R., Burtsev, V., Rimpelová, S., Pavlíčková, V. S., Fitl, P., Lukesova, M., Kolská, Z., et al. (2023) · Applied Surface Science · doi:10.1016/j.apsusc.2023.157048 · Cited by 18 · see citing works
Atta, S., Mandal, A., Saha, R., & Majumdar, A. (2023) · Dalton Transactions · doi:10.1039/d3dt03768a · Cited by 18 · see citing works
Activators, receptors and signal transduction pathways of blood platelets
Shaturny, V. I., Сергеевич, Ш. С., Sveshnikova, A. N., & Panteleev, M. A. (2014) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20146002182 · Cited by 17 · see citing works
Pavlović, R., & Santaniello, E. (2007) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.59.12.0011 · Cited by 17 · see citing works
Hwang, S., Cha, W., & Meyerhoff, M. E. (2007) · Electroanalysis · doi:10.1002/elan.200704053 · Cited by 16 · see citing works
Hossain, M. K., Basak, A., & Majumdar, A. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c01529 · Cited by 15 · see citing works
Hwang, S., Cha, W., & Meyerhoff, M. E. (2006) · Angewandte Chemie · doi:10.1002/ange.200503588 · Cited by 15 · see citing works
Recent Progress in Antibacterial Surfaces for Implant Catheters
Hu, J., Yu, Q., Wang, L., Shi, H., & Luan, S. (2024) · BME Frontiers · doi:10.34133/bmef.0063 · Cited by 14 · see citing works
S-Nitroso-N-Acetylcysteine: A Promising Drug for Early Ischemia/Reperfusion Injury in Rat Liver
de Fraga, R. S., Camacho, V. R. R., de Souza, G. F. P., Cerski, C. T. S., de Oliveira, J. R., de Oliveira, M. G., & Álvares‐da‐Silva, M. R. (2010) · Transplantation Proceedings · doi:10.1016/j.transproceed.2010.09.152 · Cited by 13 · see citing works
An, J., Chen, S., Gao, J., Zhang, X., Wang, Y., Li, Y., Mikhalovsky, S. V., Kong, D., & Wang, S. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4870-z · Cited by 13 · see citing works
Stefano, J. T., Cogliati, B., dos Santos, F. M., de Lima, V. M. R., Mazo, D. F. D. C., Matte, Ú. D. S., Álvares‐da‐Silva, M. R., da Silveira, T. R., Carrilho, F. J., & de Oliveira, C. P. M. S. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.07.001 · Cited by 12 · see citing works
Giustarini, D., Tsikas, D., & Rossi, R. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.07.011 · Cited by 12 · see citing works
Self-citationMondal, A., Maffe, P., Wilson, S. N., Ghalei, S., Palacio, R., Handa, H., & Brisbois, E. J. (2023) · Materials Advances · doi:10.1039/d3ma00191a · Cited by 12 · see citing works
Polycarbonateurethane films containing complex of copper(II) catalyzed generation of nitric oxide
Zhao, H., Feng, Y., & Guo, J. (2011) · Journal of Applied Polymer Science · doi:10.1002/app.34056 · Cited by 11 · see citing works
Höfler, L., & Meyerhoff, M. E. (2011) · Analytical Chemistry · doi:10.1021/ac1021979 · Cited by 11 · see citing works
Huang, C., Brisbois, E. J., & Meyerhoff, M. E. (2011) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-4840-7 · Cited by 11 · see citing works
Atta, S., Mandal, A., Patra, S., & Majumdar, A. (2025) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.5c00753 · Cited by 10 · see citing works
Reexamination of the Direct Electrochemical Reduction of S‐Nitrosothiols
Peng, B., & Meyerhoff, M. E. (2013) · Electroanalysis · doi:10.1002/elan.201200445 · Cited by 10 · see citing works
VV extracorporeal life support for the Third Millennium: will we need anticoagulation?
Eytan, D., Bitterman, Y., & Annich, G. M. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.11.89 · Cited by 9 · see citing works
Thiols in Nitric Oxide Synthase-Containing Nocardia sp. Strain NRRL 5646
Lee, S., Bergeron, H., Lau, P. C. K., & Rosazza, J. P. N. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02809-06 · Cited by 9 · see citing works
- Authors
- Giustarini, D., Milzani, A., Colombo, R., Dalle-Donne, I., & Rossi, R.
- Affiliations
- University of Siena (IT)
- University of Milan (IT)
- Corresponding author
- Rossi, Ranieri
- Venue
- Clinica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 330
- Issue
- 1-2
- Pages
- 85-98
- ISSN
- 0009-8981 (ISSN-L)
- OpenAlex
- W2004649932
- Cited by
- 136
- References
- 120
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 3 · 2023: 5 · 2022: 4 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 7 · 2014: 5 · 2013: 5 · 2012: 8
- FWCI
- 4.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- nitric oxide, S-nitrosothiols, endothelium-derived relaxing factor, human blood, vasodilation, antithrombotic activity, platelet aggregation, glutathione, cardiovascular system, vascular tone, nitric oxide donors, blood pressure
- MeSH terms
- Animals, Chemistry Techniques, Analytical, Hemoglobins, Humans, Nitric Oxide, Vasodilator Agents, Reproducibility of Results, Nitric Oxide Donors, Reactive Nitrogen Species, S-Nitrosothiols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review