Cited by 125Cytokine Signaling Pathways and InteractionsGenomics and Chromatin DynamicsNF-κB Signaling Pathways

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Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation

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Schuringa, Jan-Jacob, Schepers, Hein, Vellenga, Edo, Kruijer, Wiebe·2001·FEBS Letters

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Abstract

Activation of the signal transducer and activator of transcription 3 (STAT3) in response to interleukin-6 (IL-6) type cytokines involves both phosphorylation of Tyr705, which enables dimerization, nuclear translocation and DNA binding, as well as ser727 phosphorylation. Here, we describe that the 65 C-terminal amino acids of STAT3 can function as an independent transcription activation domain (TAD), particularly when a negative charge is introduced at position 727 by mutation of the serine residue into aspartate. The strong transcriptional activity of the C-terminal STAT3 Ser727Asp TAD is coupled to a constitutive association with the co-activator p300. In HepG2 cells, p300 associates with STAT3 upon IL-6 stimulation, and overexpression of p300 enhances the transcriptional activity of STAT3alpha, but not of STAT3beta or STAT3 Ser727Ala. We conclude that Ser727 phosphorylation in the C-terminal region of STAT3 is required for transactivation by association with p300.

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Authors: Schuringa, J.-J., Schepers, H., Vellenga, E., & Kruijer, W.
Affiliations: Sofia University "St. Kliment Ohridski" (BG)
Venue: FEBS Letters
Publisher: Wiley
Published: 2001-04-19
Volume: 495
Issue: 1-2
Pages: 71-76
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/s0014-5793(01)02354-7
OpenAlex: W11322950
Cited by: 124
References: 31
Citations by year: 2026: 2 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 10 · 2012: 7
FWCI: 1.47
Type: journal article
Language: en
Open access: green
doaj.org
Licence: cc-by-sa
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Bollettino del CILEA (CILEA) (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Hystrix (cc-by-nc)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: STAT3, P300, interleukin-6, transactivation domain, transcriptional coactivator, STAT3β, cytokine signaling
MeSH terms: Animals, Cell Line, DNA-Binding Proteins, Carcinoma, Hepatocellular, Humans, Nuclear Proteins, Phosphorylation, Protein Binding, Serine, Transcriptional Activation, Trans-Activators, Interleukin-6, Mutagenesis, Site-Directed, Protein Structure, Tertiary, Amino Acid Substitution, STAT3 Transcription Factor

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Ser727-dependent transcriptional activation by association of p300 with STAT3 upon IL-6 stimulation

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