Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells
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We are now showing that cultured human melanoma cells can synthesize steroids such as corticosterone from progesterone or deoxycorticosterone. Corticosterone production is strongly responsive to deoxycorticosterone substrate addition (12-fold increase), but unresponsive to the adrenal stimulating factors ACTH and angiotensin II. This is the first demonstration that skin cells (malignant melanocytes) have the capability to synthesize 11-deoxycorticosterone, corticosterone, and 18-hydroxydeoxycorticosterone.
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In skin, induction of steroidogenesis by CRH, ACTH, or factors raising intracellular cAMP is cell type dependent: corticosterone and cortisol formation is induced in normal and malignant epidermal melanocytes and dermal fibroblasts, but not in epidermal keratinocytes.
“In the skin, induction of steroidogenesis by CRH or ACTH, or factors raising intracellular cAMP levels appears to be cell type dependent because induced corticosterone and cortisol formation has been observed in normal and malignant epidermal melanocytes [53, 58] and dermal fibroblasts [57, 60], but not epidermal keratinocytes.”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [53]
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Cites
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Self-citationACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin.
Slominski, A., Ermak, G., & Mihm, M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.7.8675607 · Cited by 216 · see citing works
Self-citationAldosterone Biosynthesis in the Rat Brain1
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Self-citationSlominski, A. T., Ermak, G., Hwang, J., Chakraborty, A. K., Mazurkiewicz, J. E., & Mihm, M. C. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01090-2 · Cited by 160 · see citing works
Self-citationAnimals under the sun: effects of ultraviolet radiation on mammalian skin
Slominski, A. T., & Pawelek, J. M. (1998) · Clinics in Dermatology · doi:10.1016/s0738-081x(98)00023-6 · Cited by 139 · see citing works
Self-citationOn the potential role of proopiomelanocortin in skin physiology and pathology
Slominski, A. T., Paus, R., & Wortsman, J. (1993) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(93)90131-3 · Cited by 136 · see citing works
Self-citationHow the Glucocorticoids Suppress Immunity
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Self-citationCharacterization of Corticotropin-Releasing Hormone (CRH) in Human Skin
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Self-citationAldosterone Biosynthesis in the Rat Brain
Gómez-Sánchez, C. E. (1997) · Endocrinology · doi:10.1210/en.138.8.3369 · Cited by 89 · see citing works
Ultraviolet B stimulates production of corticotropin releasing factor (CRF) by human melanocytes
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Self-citationSynthesis of corticosterone in the vascular wall
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POMC gene expression in mouse and hamster melanoma cells
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Self-citationSlominski, A. T. (1998) · Experimental Dermatology · doi:10.1111/j.1600-0625.1998.tb00326.x · Cited by 48 · see citing works
Self-citationSteroid 21-hydroxylase expression and activity in human lymphocytes
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Regulation of the 11β-hydroxysteroid dehydrogenase in the rat adrenal
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Research works printed but not linked: 1
- Felig, P., Baxter, J.D. and Frohman, L.A. (1995) Endocrinology and Metabolism, McGraw-Hill Inc., New York.
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Melanin pigmentation in mammalian skin and its hormonal regulation
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Self-citationSlominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461 · see citing works
Key role of CRF in the skin stress response system
Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400 · see citing works
Self-citationSteroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
Self-citationDifferential expression of HPA axis homolog in the skin
Slominski, A., Wortsman, J., Tuckey, R. C., & Paus, R. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.012 · Cited by 279 · see citing works
Self-citationCutaneous hypothalamic–pituitary–adrenal axis homolog: regulation by ultraviolet radiation
Skobowiat, C., Dowdy, J. C., Sayre, R. M., Tuckey, R. C., & Slominski, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00217.2011 · Cited by 269 · see citing works
Self-citationSlominski, A., Zjawiony, J., Wortsman, J., Semak, I., Stewart, J., Pisarchik, A., Sweatman, T., Marcos, J., Dunbar, C., & C. Tuckey, R. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04356.x · Cited by 243 · see citing works
Self-citationCRH stimulation of corticosteroids production in melanocytes is mediated by ACTH
Slominski, A., Zbytek, B., Szczesniewski, A., Semak, I., Kaminski, J., Sweatman, T., & Wortsman, J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00519.2004 · Cited by 211 · see citing works
Self-citationCorticotropin releasing hormone and the skin
Slominski, A. (2006) · Frontiers in bioscience · doi:10.2741/1966 · Cited by 157 · see citing works
Self-citationCRH stimulates POMC activity and corticosterone production in dermal fibroblasts
Slominski, A., Zbytek, B., Semak, I., Sweatman, T., & Wortsman, J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.01.014 · Cited by 143 · see citing works
Skin as an endocrine organ: implications for its function
Slominski, A., Wortsman, J., Paus, R., Elias, P. M., Tobin, D. J., & Feingold, K. R. (2008) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2008.04.004 · Cited by 116 · see citing works
Self-citationStress-linked cortisol concentrations in hair: what we know and what we need to know
Sharpley, C. F., McFarlane, J. R., & Slominski, A. (2012) · revneuro · doi:10.1515/rns.2011.058 · Cited by 92 · see citing works
Self-citationCutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity
Slominski, A. T., Manna, P. R., & Tuckey, R. C. (2014) · Experimental Dermatology · doi:10.1111/exd.12376 · Cited by 79 · see citing works
Skin steroidogenesis in health and disease
Nikolakis, G., Stratakis, C. A., Kanaki, T., Slominski, A., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9390-z · Cited by 76 · see citing works
Self-citationCultured human dermal fibroblasts do produce cortisol
Slominski, A., Zbytek, B., Szczesniewski, A., & Wortsman, J. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700204 · Cited by 66 · see citing works
Self-citationGenetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses
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Self-citationSlominski, A., Wortsman, J., Foecking, M. F., Shackleton, C., Gomez-Sanchez, C., & Szczesniewski, A. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01648.x · Cited by 41 · see citing works
Self-citation
- Authors
- Slominski, A., Gomez-Sanchez, C. E., Foecking, M. F., & Wortsman, J.
- Affiliations
- Loyola University Medical Center (US)
- Harry S. Truman Memorial Veterans' Hospital (US)
- SIU Medicine (US)
- Corresponding author
- Slominski, Andrzej
- ORCID
- Slominski, Andrzej
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-07-23
- Volume
- 455
- Issue
- 3
- Pages
- 364-366
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1985720030
- Cited by
- 60
- References
- 16
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 5
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9604364)
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL027255, HL27255)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- progesterone metabolism, deoxycorticosterone, corticosterone, 18-hydroxydeoxycorticosterone, human melanoma cells, steroidogenesis, ACTH, angiotensin II, melanocytes, skin cells
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Aldosterone, Angiotensin II, Corticosterone, Desoxycorticosterone, Humans, Kinetics, Melanoma, Progesterone, Skin, Tumor Cells, Cultured
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